I-AKG Anti-Aging: Ungakulibazisa kanjani ukuguga ngokulungisa i-DNA nokulinganisa izakhi zofuzo!

I-AKG idlala izindima eziningi ekulungiseni i-DNA, isiza ekugcineni ubuqotho be-DNA ngalezi zindlela ezilandelayo:

Njenge-cofactor yokusabela kwe-hydroxylation: I-AKG iyi-cofactor yama-dioxygenase amaningi (njengama-enzyme e-TET nama-PHDs enzymes).

Lawa ma-enzyme abandakanyeka ku-DNA demethylation kanye nokuguqulwa kwe-histone, ukugcina ukuzinza kwe-genome nokulawula ukubonakaliswa kofuzo.

I-enzyme ye-TET yenza i-demethylation ye-5-methylcytosine (5mC) futhi iyiguqule ibe yi-5-hydroxymethylcytosine (5hmC), ngaleyo ndlela ilawula ukubonakaliswa kofuzo.

Ngokusekela umsebenzi wala ma-enzyme, i-AKG isiza ukulungisa umonakalo we-DNA futhi igcine ubuqotho bofuzo.

Umphumela we-Antioxidant: I-AKG inganciphisa ukulimala kwe-DNA okubangelwa ukucindezelwa kwe-oxidative ngokuqeda ama-radicals mahhala kanye nezinhlobo ze-oxygen esebenzayo (ROS).

Ukucindezeleka kwe-oxidative kuyisici esibalulekile esiholela ekulimaleni kwe-DNA nokuguga kwamaselula. Ngokuthuthukisa umthamo we-antioxidant wamaseli, i-AKG ingasiza ekuvimbeleni ukulimala kwe-DNA okuhlobene nengcindezi ye-oxidative.

Lungisa amaseli nezicubu

I-AKG idlala indima ebalulekile ekulungiseni amaseli nokuvuselelwa kwezicubu, ikakhulukazi ngalezi zindlela ezilandelayo:

Thuthukisa ukusebenza kwe-stem cell: I-AKG ingathuthukisa umsebenzi namandla okuvuselela ama-stem cells. Ucwaningo lubonisa ukuthi i-AKG inganweba isikhathi sokuphila samaseli e-stem, ikhuthaze ukuhlukaniswa nokwanda kwawo, futhi ngaleyo ndlela ibe negalelo ekuvuseleleni nasekulungiseni izicubu.

Ngokugcina ukusebenza kwama-stem cells, i-AKG ingabambezela ukuguga kwezicubu futhi ithuthukise amandla okuvuselela umzimba.

Thuthukisa i-cell metabolism kanye ne-autophagy: I-AKG ibamba iqhaza kumjikelezo we-tricarboxylic acid (umjikelezo we-TCA) futhi iwumkhiqizo obalulekile ophakathi nendawo we-metabolism yamandla eselula.

Ngokuthuthukisa ukusebenza kahle komjikelezo we-TCA, i-AKG ingakhuphula amazinga wamandla eselula futhi isekele ukulungiswa kwamaseli nokugcinwa kokusebenza.

Ngaphezu kwalokho, i-AKG itholakale ikhuthaza inqubo ye-autophagy, isiza amangqamuzana asuse izingxenye ezilimele futhi agcine impilo yeseli.

Ibhalansi ye-Gene kanye nokulawulwa kwe-epigenetic

I-AKG idlala indima ebalulekile ekulinganiseni kwezakhi zofuzo kanye nokulawulwa kwe-epigenetic, isiza ukugcina umsebenzi ojwayelekile nempilo yamaseli:

Ithonya ukulawulwa kwe-epigenetic: I-AKG ilawula amaphethini wokuvezwa kwezakhi zofuzo ngokubamba iqhaza ekuguqulweni kwe-epigenetic, njenge-demethylation ye-DNA nama-histones.
Ukulawulwa kwe-Epigenetic kuyindlela eyinhloko yokulawula ye-gene expression kanye nokusebenza kwamaseli. Iqhaza le-AKG lingasiza ukugcina ukubonakaliswa okuvamile kwezakhi zofuzo futhi kuvimbele izifo nokuguga okubangelwa ukubonakaliswa kofuzo okungavamile.

Vimbela impendulo yokuvuvukala: I-AKG inganciphisa impendulo yokuvuvukala okungapheli ehambisana nokuguga ngokulawula ukubonakaliswa kofuzo.

Ukuvuvukala okungapheli kungaphansi kwezifo eziningi ezihlobene nokuguga, futhi imiphumela elwa nokuvuvukala ye-AKG ingasiza ekuvimbeleni nasekunciphiseni lezi zimo.

Bambezela ukuguga futhi welaphe izifo ezingamahlalakhona

Izenzo eziningi ze-AKG zinikeza amandla ekubambezelekeni ukuguga nokwelapha izifo ezingamahlalakhona:

Ukulibaziseka ukuguga: Ngokukhuthaza ukulungiswa kwe-DNA, ukuthuthukisa amandla e-antioxidant, ukusekela umsebenzi we-stem cell, ukulawula ukubonakaliswa kofuzo, njll., I-AKG ingabambezela inqubo yokuguga yamaseli nezicubu.

Ucwaningo lwezilwane lukhombisa ukuthi ukwengezela nge-AKG kungalula impilo futhi kuthuthukise impilo ezilwaneni ezindala.

Ukwelashwa kwezifo ezingamahlalakhona: Imiphumela ye-AKG ekuthuthukiseni ukusebenza kwe-metabolic, anti-inflammation, kanye ne-antioxidant ikwenza kube wusizo ekwelapheni izifo ezingamahlalakhona.

Isibonelo, i-AKG ingaba nemiphumela yokuvimbela kanye nokwelapha kushukela, izifo zenhliziyo, izifo ze-neurodeergenerative, njll.

Fingqa

I-AKG ibamba iqhaza ekubambezeleni ukuguga nokwelapha izifo ezingapheli ngokulungisa i-DNA, ukukhuthaza ukulungiswa kwamangqamuzana nezicubu, ukugcina ibhalansi yezakhi zofuzo nokulawula i-epigenetics.

Umthelela we-synergistic walezi zindlela wenza i-AKG ibe yimpokophelo ethembisayo yokungenelela okulwa nokuguga kanye nezifo ezingelapheki.

Ngokuzayo, ucwaningo olwengeziwe luzosiza ukudalula izinzuzo ezingaba khona ze-AKG kanye namathuba okusebenza kwayo.