I-Alpha-ketoglutarate-magnesium, eyaziwa nangokuthi i-AKG-Mg, iyinhlanganisela enamandla, futhi le nhlanganisela eyingqayizivele ye-Alpha-Ketoglutarate ne-Magnesium iboniswe ukuthi inezinhlobonhlobo zezinzuzo ezingase zibe khona empilweni kanye nokuphila kahle. I-Alpha-ketoglutarate iyingxenye ebalulekile yomjikelezo we-Krebs, umshini oyinhloko womzimba wokukhiqiza amandla. Uma ihlanganiswe ne-magnesium, i-AKG-Mg isiza ukukhulisa amazinga wamandla. Abantu abaningi bathatha i-Alpha-ketoglutarate-magnesium njengesengezo sokudla sezinhlobonhlobo zezinzuzo zezempilo ezingaba khona.
I-Magnesium Alpha-Ketoglutarate, eyaziwa nangokuthi i-AKG-Magnesium, iyinhlanganisela eyenzeka ngokwemvelo edlala indima ebalulekile ekukhiqizeni amandla kanye ne-metabolism emzimbeni.
I-α-Ketoglutarate iwukhiye omaphakathi emjikelezweni we-tricarboxylic acid (TCA), indlela ye-metabolic ekhiqiza amandla ngokusebenzisa i-oxidation yama-carbohydrate, amafutha, namaprotheni. Ngakolunye uhlangothi, i-magnesium iyimaminerali ebalulekile ebamba iqhaza emisebenzini eminingi yomzimba emzimbeni, okuhlanganisa ukusebenzisa izinhlelo ezihlukahlukene zama-enzyme, futhi ibamba iqhaza kumaprotheni kanye ne-fat metabolism. Uma lezi zinhlanganisela ezimbili zihlangana, zakha i-magnesium alpha-ketoglutarate, ekhonjiswe ukuthi inezinzuzo eziningi zezempilo ezingaba khona.
I-Alpha-ketoglutarate-magnesium isekela ikhono lomzimba lokukhiqiza amandla. Njengomdlali oyinhloko kumjikelezo we-TCA, i-Alpha-ketoglutarate-magnesium isiza ukuguqula izakhamzimba zisuka ekudleni zibe i-adenosine triphosphate (ATP), imali eyisisekelo yamandla yeseli. Lokhu kusiza ukukhulisa wonke amazinga wamandla futhi kungase kube usizo ikakhulukazi kubantu abenza umsebenzi womzimba onzima.
Ngaphezu kwendima yayo ekukhiqizeni amandla, i-Alpha-ketoglutarate-magnesium nayo inezindawo zokulwa ne-antioxidant ezisiza ukuvikela umzimba ekucindezelekeni kwe-oxidative kanye nokulimala okubangelwa ama-radicals mahhala.
Sekukonke, i-Alpha-ketoglutarate-magnesium iyinhlanganisela eyenzeka ngokwemvelo eye yafundelwa izinzuzo zayo zezempilo ezingaba khona, okuhlanganisa indima yayo ekukhiqizeni amandla, umsebenzi we-antioxidant, ukululama kwemisipha, nempilo yenhliziyo nemithambo yegazi.
I-Ketoglutarate, eyaziwa nangokuthi i-alpha-ketoglutarate, iyisithako esibalulekile kumjikelezo we-citric acid, umzila we-metabolic omaphakathi wokukhiqiza amandla kumaseli. Iyingxenye ebalulekile ekuguquleni ukudla kube amandla futhi ikhiqizwa amangqamuzana omzimba. Ngaphezu kwendima yayo ekukhiqizeni amandla, i-ketoglutarate itholakale ineminye imisebenzi eminingana ebalulekile emzimbeni.
Okunye ukusetshenziswa okuyinhloko kwe-ketoglutarate indima yayo ku-amino acid metabolism. Ibandakanyeka enqubweni yokudlulisa, okuwukudluliselwa kweqembu le-amino lisuka ku-amino acid liye ku-keto acid. Le nqubo ibalulekile ekuhlanganisweni kwamanye ama-amino acid kanye nokukhiqizwa kwezinhlanganisela ezibalulekile ezihlukahlukene emzimbeni. I-Ketoglutarate iyisandulela sokwenziwa kwe-glutamate, i-neurotransmitter eyinhloko ohlelweni lwezinzwa oluphakathi. Iphinde ihileleke ekuhlanganiseni i-proline ne-arginine, ama-amino acid amabili abalulekile anemisebenzi eminingi emzimbeni.
I-Ketoglutarate nayo idlala indima ekulawuleni amasosha omzimba. Kutholakale ukulinganisa umsebenzi wamangqamuzana omzimba omzimba futhi kunemiphumela yokulwa nokuvuvukala. Ucwaningo luye lwabonisa ukuthi i-ketoglutarate ingavimbela ukukhiqizwa kwama-cytokines ane-pro-inflammatory futhi ikhuthaze ukukhiqizwa kwamaseli e-T alawula ukuvuvukala.
Okunye ukusetshenziswa okubalulekile kwe-ketoglutarate amandla ayo okusekela ukusebenza kwezemidlalo nokululama. Kutholwe ukuthuthukisa ukukhiqizwa kwamandla ngesikhathi sokusebenza ngokomzimba futhi kwandise ukukhuthazela. Ukwengeza, kuye kwaboniswa ukunciphisa ukulimala kwemisipha futhi kukhuthaze ukululama ngokushesha ngemva kokuzivocavoca kanzima.
Ngaphezu kwemiphumela yayo ye-metabolic kanye nokwenza ngcono ukusebenza, i-ketoglutarate iphinde yacwaningwa ngendima yayo engaba khona ekwelapheni izimo ezithile zempilo. Ucwaningo lubonisa ukuthi kungase kube nemiphumela ezuzisayo ezimweni ezifana nesifo sokukhathala okungapheli kanye ne-fibromyalgia, lapho ukukhiqizwa kwamandla nokusebenza kwe-mitochondrial kuphazamiseka. Ukwengeza i-ketoglutarate kungasekela umsebenzi we-mitochondrial futhi kuthuthukise ukukhiqizwa kwamandla ngaphansi kwalezi zimo.
I-Alpha-ketoglutarate iyinhlanganisela yezinto eziphilayo edlala indima ebalulekile kumetabolism yamandla. Iyingxenye ebalulekile yomjikelezo we-citric acid, inqubo amangqamuzana akhiqiza ngayo amandla ngokusebenzisa i-oxidation yama-carbohydrate, amafutha, namaprotheni.
I-Magnesium, ngakolunye uhlangothi, iyiminerali ebalulekile edlala indima ekuphenduleni kwe-enzymatic engaphezu kwama-300 emzimbeni. Ibandakanyeka ekukhiqizeni amandla, ukusebenza kwemisipha, kanye nokuhlanganiswa kwe-DNA ne-RNA. I-Magnesium yaziwa nangokuthi iyakwazi ukusekela impilo yenhliziyo, ithuthukise isimo semizwa, futhi ikhulule ama-muscle nama-spasms.
Lapho i-alpha-ketoglutarate ne-magnesium kuhlangene, imiphumela yabo ye-synergistic ingaba nomthelela omkhulu empilweni yonke. Inzuzo ebaluleke kakhulu yale nhlanganisela ukuthi kokubili i-alpha-ketoglutarate ne-magnesium ihileleke kumetabolism yamandla kanye nokusebenza kwemisipha, okwenza kube kuhle ekuthuthukiseni ukukhuthazela, amandla kanye nokululama. Ukwengeza, i-alpha-ketoglutarate iboniswe ukwandisa ukukhiqizwa kwe-nitric oxide, okuthuthukisa ukugeleza kwegazi futhi kuthuthukise ukulethwa komoya-mpilo emisipha.
Ukwengeza, inhlanganisela ye-alpha-ketoglutarate ne-magnesium ingase isekele ukuguga okunempilo. Njengoba sikhula, imizimba yethu iya ngokuya ingasebenzi kahle ekukhiqizeni amandla nasekulungiseni izicubu ezilimele. I-Alpha-ketoglutarate ne-magnesium ingasiza ekwehliseni le miphumela ngokusekela umsebenzi we-mitochondrial, obalulekile ekukhiqizweni kwamandla nokulungisa amaseli. Ngokulandelayo, lokhu kungasiza ekunciphiseni ingozi yezifo ezihlobene neminyaka futhi kuthuthukise ikhwalithi yokuphila yonke.
Ukwengeza, imiphumela ye-synergistic ye-alpha-ketoglutarate ne-magnesium ingadlulela empilweni yengqondo. Ucwaningo lubonisa ukuthi i-magnesium inamandla okunciphisa ukucindezeleka, ukukhathazeka, nokudangala, kuyilapho i-alpha-ketoglutarate ikhonjisiwe ukusekela ukusebenza kwengqondo. Uma kuhlangene, lezi zinhlanganisela ezimbili zingase zibe nemiphumela ehambisanayo kusimo sengqondo nempilo yomqondo, ngaleyo ndlela kuthuthukiswe impilo yengqondo kanye nezinga lempilo lilonke.
I-Alpha-ketoglutarate-magnesium iyinhlanganisela yezinhlanganisela ezimbili, lapho i-alpha-ketoglutarate iyingxenye emaphakathi kumjikelezo we-Krebs, okuyingxenye ewumgogodla wokuphefumula kwamaselula. Idlala indima ebalulekile ekukhiqizweni kwamandla futhi ibandakanyeka ezinqubweni ezihlukahlukene ze-metabolic. I-Magnesium iyiminerali ebalulekile ehilelekile emisebenzini eminingi yomzimba, okuhlanganisa ukufinyela kwemisipha nokuphumula. Ukuhlanganiswa kwalezi zinhlanganisela ezimbili kukhonjiswe ukuthi kunemiphumela enenzuzo ekusebenzeni kwenkontileka ye-myocardial.
Ucwaningo olushicilelwe kumagazini I-Cardiovascular Therapy luphenye imiphumela ye-alpha-ketoglutarate-magnesium ekusebenzeni kwenkontileka ye-myocardial kumagundane. Abacwaningi bathola ukuthi i-alpha-ketoglutarate-magnesium supplementation ithuthukise kakhulu umsebenzi we-myocardial contractile kumagundane. Ukuhlanganiswa kwalezi zinhlanganisela kwatholakala ukuthuthukisa ikhono lenhliziyo lokufinyela nokukhululeka, ngaleyo ndlela kuthuthukisa ukusebenza kwenhliziyo yonke.
Abacwaningi baphinde babona ukuthi i-alpha-ketoglutarate-magnesium supplementation ibangele amazinga engeziwe e-adenosine triphosphate (ATP) emisipha yenhliziyo. I-ATP iwumthombo oyinhloko wamandla wezinqubo zamaselula, okuhlanganisa ukufinyela kwemisipha. Ngokwandisa amazinga e-ATP, i-Alpha-ketoglutarate-magnesium ithuthukisa ikhono lenhliziyo lokukhiqiza amandla adingekayo ukuze kusebenze isivumelwano sokusebenza okufanele.
Imiphumela yalolu cwaningo igqamisa amandla e-magnesium α-ketoglutarate njengokwelashwa okuthembisayo ukuthuthukisa ukusebenza kwenkontileka ye-myocardial. Inhlanganisela yalezi zinhlanganisela iye yaboniswa ukuthuthukisa ukukhiqizwa kwamandla, ukuthuthukisa ukuphatha i-calcium, futhi ekugcineni ithuthukise ikhono lenhliziyo lokufinyela ngokuphumelelayo nokumpompa igazi.
Ukwengeza, enye yezinzuzo eziyinhloko ze-alpha-ketoglutarate-magnesium indima yayo ekukhiqizeni amandla. I-AKG-Mg ibamba iqhaza kumjikelezo we-citric acid, inqubo eyinhloko ekukhiqizeni i-adenosine triphosphate (ATP), umthombo oyinhloko wamandla omzimba. Ngokusekela le nqubo, i-AKG-Mg ingasiza ekwandiseni amazinga wamandla, iyenze ibe inketho ekhangayo kubantu abafuna ukuthuthukisa ukusebenza komzimba nokukhuthazela.
Ngaphezu kwendima yayo ekukhiqizeni amandla, i-Alpha-ketoglutarate-magnesium ifundelwe izici zayo ezingaba khona zokulwa ne-antioxidant. Ukucindezeleka okwenziwe nge-oxidative okubangelwa ama-radicals mahhala kungaholela ezinkingeni zezempilo ezihlukahlukene, kuhlanganise nokuguga ngaphambi kwesikhathi kanye nesifo esingelapheki. I-AKG-Mg ingasiza ekunciphiseni ama-radicals mahhala futhi inciphise ukulimala kwe-oxidative emzimbeni, isekele impilo yonke kanye nokuphila kahle.
Kuhle ukusho ukuthi i-alpha-ketoglutarate-magnesium ixhunywe ekululameni kwemisipha nokusebenza. Olunye ucwaningo lubonisa ukuthi ukugcwalisa nge-AKG-Mg kungasiza ukunciphisa ukukhathala kwemisipha futhi kuthuthukise ukusebenza kwezemidlalo. Ukwengeza, i-AKG-Mg ingase isekele ukululama kwemisipha ngokukhuthaza ukwakheka kwamaprotheni nokunciphisa ukulimala kwemisipha ngemva kokusebenza kanzima ngokomzimba.
Ukwengeza, i-Alpha-ketoglutarate-magnesium inezinzuzo ezingaba khona zenhliziyo nemithambo yegazi. Obunye ubufakazi bubonisa ukuthi i-AKG-Mg ingasiza ekugcineni amazinga omfutho wegazi onempilo futhi isekele ukusebenza kwenhliziyo nemithambo yegazi. Ngokuphromotha ukukhiqizwa kwe-nitric oxide kanye ne-vasodilation, i-AKG-Mg ingasiza ukuthuthukisa ukugeleza kwegazi kanye nempilo yonke yenhliziyo nemithambo yegazi.
Kunezici ezimbalwa ezibalulekile okufanele uzicabangele lapho ukhetha i-alpha-ketoglutarate-magnesium supplement. Okokuqala, kufanele ubheke izithasiselo ezenziwe ngezithako ezisezingeni eliphezulu. Lokhu kusho ukuthi i-alpha-ketoglutarate ne-magnesium esetshenziswa kwizithasiselo kufanele ivele kubahlinzeki abahlonishwayo futhi ikhiqizwe ezikhungweni ezithobela izindinganiso eziqinile zokulawula ikhwalithi. Ukwengeza, ungase uthande ukucabangela ukubheka izithasiselo eziye zahlolwa ezivela eceleni, njengoba lokhu kuqinisekisa ukuthi amandla nokuhlanzeka komkhiqizo kuqinisekiswe ngokuzimele.
Ngaphezu kwekhwalithi yezithako, kufanele futhi unake umthamo we-alpha-ketoglutarate ne-magnesium esengezo. Umthamo ophelele wale misoco ungahluka ngokuya ngezidingo zakho zomuntu siqu kanye nemigomo yezempilo, ngakho-ke kubalulekile ukuthintana nochwepheshe bezempilo ukuze uthole isikali esilungele wena. Ungase futhi ufune ukubheka izithako eziqukethe ezinye izithako ze-synergistic, ezifana namavithamini namaminerali, ezingase zithuthukise imiphumela ye-alpha-ketoglutarate ne-magnesium.
Inkampani engu-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lezithako zokudla okunomsoco kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Q: Iyini i-Alpha-Ketoglutarate-Magnesium (AKG-Mg)?
A: I-AKG-Mg iyinhlanganisela ehlanganisa i-alpha-ketoglutarate, emaphakathi emjikelezweni we-citric acid, ne-magnesium, imineral ebalulekile edlala indima ebalulekile ezinqubweni eziningi zomzimba.
Q: Yiziphi izinzuzo zezempilo ezingaba khona ze-AKG-Mg?
A: I-AKG-Mg iye yafundelwa amandla ayo okusekela ukukhiqizwa kwamandla, ukusebenza kwemisipha, impilo yenhliziyo nemithambo yegazi, nokusebenza kwengqondo. Kungase futhi kusize ekusebenzeni kwezemidlalo nokululama.
Q: I-AKG-Mg isekela kanjani ukukhiqizwa kwamandla?
A: I-AKG-Mg idlala indima ebalulekile kumjikelezo we-citric acid, okuyinqubo amangqamuzana akhiqiza ngayo amandla. Ngokusekela le nqubo, i-AKG-Mg ingasiza ukukhulisa amazinga wamandla namandla.
Umbuzo: Ingabe i-AKG-Mg ingasiza ngokusebenza kwemisipha?
A: Olunye ucwaningo lubonisa ukuthi i-AKG-Mg ingasiza ekuthuthukiseni ukusebenza kwemisipha nokusebenza, ikwenze kube isengezo esingaba khona kubasubathi kanye nabantu abafuna ukusekela ukusebenza kwabo ngokomzimba.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Dec-27-2023
