Ezimpilweni zethu zansuku zonke ezimatasa, kuvamile ukuzizwa ucindezelekile, ukhathazekile, ngisho nokudabuka ngezikhathi ezithile. Le mizwa ingaba nomthelela empilweni yethu yengqondo, ngokuvamile isishiya sifuna izindlela zokuphakamisa umoya wethu. Nakuba kunezindlela eziningi zokuthuthukisa isimo sethu sengqondo, isici esibalulekile okufanele sicatshangelwe i-neurotransmitter, i-serotonin. Evame ukubizwa ngokuthi “ihomoni yokuzizwa ujabule,” i-serotonin idlala indima ebalulekile ekulawuleni isimo sethu sengqondo, imicabango, kanye nokuphila kahle.
Ngakho, yini i-serotonin? I-Serotonin, eyaziwa nangokuthi i-serotonin, iyikhemikhali esebenza njenge-neurotransmitter, okusho ukuthi isebenza njengesithunywa esithwala amasignali phakathi kwamangqamuzana ezinzwa ebuchosheni. Ikhiqizwa ngokuyinhloko ku-brainstem, kodwa futhi itholakala kwezinye izingxenye zomzimba, njengamathumbu. Ngokuvamile ibizwa ngokuthi “i-hormone ejabulisayo” noma “i-molecule yenjabulo” ngoba ihlotshaniswa nemizwa yenjabulo, yokwaneliseka, nenhlalakahle.
Uma i-serotonin isikhiqiziwe, ikhululwa ibe ama-synapse, noma izikhala phakathi kwamangqamuzana ezinzwa. Bese ibophezela kuma-receptors athile ebusweni bamaseli ezinzwa aseduze. Le nqubo yokubopha yenza kube lula ukuxhumana phakathi kwamaseli futhi isiza ukudlulisa amasignali.
I-Serotonin idlala indima ebalulekile ekulawuleni imisebenzi ehlukahlukene emizimbeni yethu, okuhlanganisa ukulala, ukuthanda ukudla, ukugaya ukudla, nenkumbulo. Kuhileleke ekulawulweni kwemizwelo yethu futhi kusiza ukugcina isimo sengqondo esizinzile. Amazinga e-serotonin ebuchosheni bethu angaba nomthelela omkhulu empilweni yethu yengqondo.
I-Serotonin ayithinti nje kuphela impilo yethu engokomzwelo neyengqondo, kodwa futhi idlala indima ebalulekile empilweni yethu engokomzimba. I-Serotonin ilawula imijikelezo yethu yokulala kanye nekhwalithi yokulala iyonke. Amazinga anele e-serotonin ebuchosheni akhuthaza ukulala okuzolile, kuyilapho amazinga aphansi angase abangele ukuphazamiseka kokulala njengokuqwasha.
I-Serotonin iyi-neurotransmitter ebuchosheni enesibopho sokulawula imizwa, imizwa, nokulala. Ivame ukubizwa ngokuthi ikhemikhali "yokuzizwa kahle" ngoba isiza ukuletha umuzwa wenhlalakahle. I-Serotonin idlala indima ebalulekile ekugcineni ibhalansi ebuchosheni, futhi noma yikuphi ukuphazamiseka emazingeni ayo kungaholela ezinkingeni ezihlukahlukene zempilo yengqondo, kuhlanganise nokukhathazeka.
Ucwaningo luthole ukuthi abantu abanezinkinga zokukhathazeka bavame ukuba namazinga e-serotonin angalingani ebuchosheni babo. Amazinga aphansi e-serotonin ahlotshaniswa nengozi eyengeziwe yokuphazamiseka kokukhathazeka, njengoba i-serotonin isiza ukulawula imizwa nokukhathazeka. Lapho amazinga e-serotonin ephansi, abantu bangase babe nezimpawu ezinjengokucasuka, ukungahlaliseki, nokukhathazeka okuphezulu.
I-serotonin reuptake inhibitors (SSRIs) ekhethiwe yizidakamizwa ezilwa nokucindezeleka ezivame ukusetshenziselwa ukwelapha abantu abanezinkinga zokukhathazeka. Le mithi isebenza ngokwandisa amazinga e-serotonin ebuchosheni. Ngokwenza kanjalo, ama-SSRI asiza ukubuyisela ibhalansi ye-serotonin futhi anciphise izimpawu zokukhathazeka. Kodwa-ke, kubalulekile ukuqaphela ukuthi i-serotonin iyingxenye eyodwa kuphela yezindlela ze-neural eziyinkimbinkimbi ezihambisana nokukhathazeka kokukhathazeka, nezinye izici ezifana nezakhi zofuzo, imvelo kanye nokuhlangenwe nakho kokuphila nakho kunomthelela ekuthuthukisweni kwalezi zimo.
Ucwaningo lubonisa ukuthi ukuvivinya umzimba njalo kungakhuphula ukukhiqizwa kwe-serotonin ebuchosheni. Ukuvivinya umzimba akugcini nje ngokukhuthaza ukukhululwa kwe-serotonin, futhi kwandisa ukuzwela kobuchopho kule neurotransmitter, ngaleyo ndlela kuthuthukisa isimo sengqondo nokunciphisa ukukhathazeka.
Ukwengeza, ukwenza amasu okulawula ukucindezeleka njengokuzindla, ukuvivinya umzimba kokuphefumula okujulile, nokucabangela kungasiza ukwandisa amazinga e-serotonin nokunciphisa izimpawu zokukhathazeka. Lezi zindlela zikhuthaza ukuphumula nokuzola, okuvumela ubuchopho ukuthi bukhiqize futhi busebenzise i-serotonin ngokuphumelelayo.
1. Isimo sengqondo esiphakeme nesimo esizinzile
I-Serotonin yaziwa ngamandla ayo okulawula imizwa. Kuyisimo sokuzinza kwemvelo esikhuthaza umuzwa wenhlalakahle nokwaneliseka kuyilapho kunciphisa ukukhathazeka nokucindezeleka. Amazinga e-serotonin anele abalulekile ekuvimbeleni ukuphazamiseka kwemizwelo okunjengokucindezeleka, ukukhathazeka, kanye nesifo sokuphazamiseka kwengqondo. Ngokwandisa amazinga e-serotonin, abantu ngabanye bangase bathole ukuzinza okuthuthukisiwe ngokomzwelo, umuzwa okhulayo wenhlalakahle yonke, kanye nombono oqondile ekuphileni.
2. Thuthukisa ukusebenza kwengqondo
Ngaphezu kwemiphumela yayo kumizwa, i-serotonin nayo idlala indima ebalulekile ekusebenzeni kwengqondo. Le neurotransmitter isiza ukuxhumana phakathi kwamaseli obuchopho, isekela ukwakheka kwenkumbulo nokukhumbula. Amazinga e-serotonin anele ahlotshaniswa nokugxila okuthuthukisiwe, ukunaka, namakhono okuqonda. Ukuqinisekisa ukuhlinzekwa okunempilo kwe-serotonin kungase kusize ukuthuthukisa ukuqonda kwengqondo, ukuthuthukisa ukufunda, nokunciphisa ukuncipha kwengqondo okuhambisana nokuguga.
3. Ukulawulwa kwesifiso sokudla nesisindo
I-Serotonin ithinta kakhulu futhi iyasiza ekulawuleni ukudla kwethu nokuziphatha kwethu kokudla. Amazinga e-Serotonin ebuchosheni athonya umbono wethu wendlala nokusutha, athinta ukukhetha kwethu ukudla kanye nokulawula ingxenye. Ukwengeza, i-serotonin nayo ikhiqizwa emathunjini, futhi ukushoda kwe-serotonin kungaholela ekudleni ngokweqile, ukulangazelela ukudla okune-carbohydrate, kanye nengozi eyengeziwe yokukhuluphala. Ngokugcina amazinga e-serotonin alungile, singakwazi ukulawula kangcono ukudla kwethu, senze ukukhetha okunempilo kokudla, sinciphise izifiso, futhi sigcine isisindo esinempilo.
4. Thuthukisa ukulala okuzolile
Ukulala kwekhwalithi enhle kubalulekile empilweni yethu engokomzimba neyengqondo. I-Serotonin idlala indima ebalulekile ekukhuthazeni amaphethini okulala okunempilo. Kuyasiza ukulawula umjikelezo wokulala nokuvuka, kusivumela ukuthi silale ngokushesha, silale isikhathi eside, futhi sithole ukulala okubuyisela kakhudlwana. Amazinga e-serotonin anganele angabangela ukuqwasha, ukuphazamiseka kokulala, nokulala emini. Ngokuqinisekisa ukuthi kukhiqizwa i-serotonin eyanele, singathuthukisa ikhwalithi yokulala kwethu futhi sivuke sizizwa siqabulekile futhi sinamandla.
5. Sekela impilo yokugaya ukudla
Ngaphezu kwemiphumela yayo ebuchosheni, i-serotonin iphinde ithinte uhlelo lokugaya ukudla. Cishe i-90% ye-serotonin itholakala emathunjini futhi inesibopho sokulawula ukusebenza kwesisu. Kuyasiza ekulawuleni ukunyakaza kwamathumbu, kukhuthaze ukugaya okusebenzayo, futhi kunomthelela empilweni yonke yamathumbu. Ukungalingani kwe-Serotonin kuye kwaxhunyaniswa nokuphazamiseka kokugaya ukudla okufana nesifo samathumbu esicasulayo (IBS) nesifo samathumbu esivuthayo (IBD). Ngokugcina amazinga e-serotonin alungile, singakhuthaza impilo yamathumbu futhi sinciphise ingozi yezinkinga zokugaya ukudla.
Funda ngezimpawu zokuntula:
●Isimo sokucindezeleka, isimo sokucindezeleka
●Unenkinga yokulala
●Ukungapholi kahle kwesilonda
● inkumbulo embi
●Izinkinga zokugaya ukudla
●Izithiyo zesitifiketi
●Ukungathandi ukudla
Thola ukuthi kungani:
● Ukudla okungenamsoco: ngokuyinhloko kuhlanganisa ukudla okukodwa, ukudla okungenamsoco kanye ne-bulimia.
● I-Malabsorption: Izimo ezithile, njengesifo se-celiac nesifo samathumbu esivuvukalayo, zingase ziphazamise ukumuncwa komzimba kwezakhi.
●Izidakamizwa: Imithi ethile ingase iphazamise ukumuncwa noma ukusetshenziswa kwezakhi ezithile zomsoco.
● Ukungazinzi ngokomzwelo: ukucindezeleka, ukukhathazeka.
Ama-SSRI asebenza ngokwandisa amazinga e-serotonin ebuchosheni. I-Serotonin iyi-neurotransmitter edlala indima ebalulekile ekulawuleni imizwa, imizwa, kanye nempilo iyonke. Ngokuvimbela ukumuncwa kabusha kwe-serotonin, ama-SSRIs aqinisekisa ukuthi ihlala kuma-synapses isikhathi eside, ngaleyo ndlela ithuthukisa imiphumela yayo ekulawuleni imizwa.
Indlela ama-SSRIs asebenza ngayo
Ama-SSRI asebenza ngokuvimbela ukutholwa kabusha kwe-serotonin ebuchosheni. Indlela yokusebenza ibandakanya ama-SSRI abophezela kusithuthi se-serotonin, ukusivimbela ekumunceni i-serotonin ibuyele kumaseli ezinzwa. Ngenxa yalokho, i-serotonin isala ku-synaptic cleft phakathi kwamangqamuzana ezinzwa, ithuthukisa ukudluliselwa kwayo futhi ikhulise imiphumela yayo yokuguqula isimo.
Kubalulekile ukuqaphela ukuthi ama-SSRI awanyusi ukukhiqizwa kwe-serotonin; kunalokho zishintsha ukutholakala nokusebenza kwe-serotonin ekhona. Ngokuvumela i-serotonin ukuthi ihlale ku-synaptic cleft isikhathi eside, ama-SSRI asiza ukunxephezela amazinga aphansi e-serotonin futhi abuyisele ibhalansi ebuchosheni.
Kuhle ukusho ukuthi i-tianeptine hemisulfate monohydrate iyisithuthukisi se-serotonin reuptake (SSRE) esikhethiwe, okusho ukuthi ithuthukisa ukutholwa kabusha kwe-serotonin ebuchosheni, ngaleyo ndlela iqinise i-hippocampal neurons Synaptic plasticity ukuze kuthuthukiswe izimo zemizwa nezimo zemizwa.
Ama-SSRI kanye nemiphumela emibi
Nakuba ama-SSRI ngokuvamile ebhekwa njengaphephile futhi abekezelelwa kahle, angase eze neminye imiphumela engemihle. Imiphumela emibi evamile ingase ihlanganise isicanucanu, isiyezi, ikhanda, nakuba le miphumela ingase ihluke kumuntu nomuntu. Kubalulekile ukuthi iziguli zikhulume nanoma yiziphi izinkathazo noma imiphumela engemihle kochwepheshe bazo bezokwelapha ukuze kuqashwe eduze kanye nokulungiswa okufanele, uma kunesidingo.
Q: Ingabe ikhona imikhuba yendlela yokuphila engaqeda amazinga e-serotonin?
IMPENDULO: Yebo, ukuphuza ngokweqile, ukudla okungenamsoco, ukungazivocavoci, ukucindezeleka okungapheli, kanye nemithi ethile enjengemithi eqeda ukucindezeleka kungase kuqede amazinga e-serotonin.
Q: Kufanele ibe yini indlela yokukhulisa amazinga e-serotonin ngokwemvelo?
A: Indlela ephelele kufanele yamukelwe ukuze kukhuliswe amazinga e-serotonin ngokwemvelo. Lokhu kuhlanganisa ukulondoloza ukudla okulinganiselayo, ukuvivinya umzimba njalo, ukuthola ilanga elanele, ukulawula ukucindezeleka ngokuphumelelayo, nokucabangela ukwenezela ngaphansi kokuqondisa kochwepheshe uma kudingekile.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Oct-07-2023
