Ubulokhu ufuna indlela yokuthuthukisa impilo yakho yonke kanye nokuphila kahle? Izithako zeCalcium alpha-ketoglutarate ziyisinqumo sakho esihle kakhulu.I-Calcium alpha-ketoglutarate iyinhlanganisela edlala indima ebalulekile ekukhiqizeni amandla omzimba kanye ne-metabolism. Kubuye kube isithako esiyinhloko ekugcineni amathambo aqinile futhi anempilo, okwenza kube isakhi esibalulekile empilweni yonke. Ngokufaka izithasiselo ze-calcium alpha ketoglutarate ohlelweni lwakho lwansuku zonke, ungathola uhla lwezinzuzo zezempilo ezithuthukisa umuzwa wakho wenhlalakahle.
I-Ca-AKGiyinhlanganisela ye-calcium yamaminerali kanye ne-alpha-ketoglutarate molecule. I-Alpha-ketoglutarate iyinto ebalulekile enqubweni yokukhiqiza amandla omzimba, ikakhulukazi kumjikelezo we-tricarboxylic acid, lapho ibalulekile ekukhiqizeni i-adenosine triphosphate (ATP), umthombo wamandla oyinhloko womzimba.
Ngaphezu kwalokho, i-Ca-AKG isebenza njenge-metabolite yomjikelezo we-Kreb futhi i-α-ketoglutarate ikhiqizwa lapho amaseli ephula ama-molecule okudla ukuze athole amandla. Khona-ke igeleza ngaphakathi naphakathi kwamangqamuzana, inikeze amandla izinqubo eziningi ezisekela ukuphila kanye nezinhlelo zokubonisa izimpawu. Ize ibambe iqhaza ekukhulumeni kofuzo, okusebenza njengendlela yokulawula ebonakala ivimbela amaphutha okubhalwa kwe-DNA avame ukuholela ezifweni ezinjengomdlavuza.
Lapho umuntu efinyelela eminyakeni ethile, izinga lemvelo le-α-ketoglutarate emzimbeni liyancipha, futhi lokhu kuncipha kuhlobene nenqubo yokuguga.
Phakathi kwazo, i-α-ketoglutarate i-α-keto acid edlala indima ebalulekile ezinhlobonhlobo zezinqubo zebhayoloji eziyisisekelo. Ukwengeza, i-alpha-ketoglutarate nayo iyikhemikhali engapheli, okusho ukuthi ikhiqizwa ngumzimba. Ngeke itholakale ngokudla, kodwa ezinye izifundo ziphakamisa ukuthi ingagcinwa ngokuzila ukudla nokudla kwe-ketogenic. Kubonakala okungenani kunezindlela ezine ezibalulekile zokwenza. Lokhu kuhlanganisa ukugcinwa kwe-metabolism enempilo, ukukhuthaza ukudluliswa kwama-amino acid abalulekile, ukuvikela i-DNA nokucindezela ukuvuvukala okungapheli.Okwamanje, i-calcium iyimaminerali ebalulekile edlala indima ebalulekile emisebenzini eminingi yomzimba, okuhlanganisa ukugoqa kwemisipha, ukuhanjiswa kwe-neurotransmission, nempilo yamathambo.
Izithako ze-Ca-AKG ziyinhlanganisela ye-calcium ne-alpha-ketoglutarate enikeza izinzuzo ezihlukahlukene ezingaba khona, okuhlanganisa ukusebenza okuthuthukisiwe kwezemidlalo, ukukhula kwemisipha, nokusekelwa kwezempilo kukonke.
I-Alpha-ketoglutarateiyi-molecule edlala indima ebalulekile kumetabolism yamangqamuzana. Kuyinhlanganisela yemvelo etholakala emzimbeni futhi iyatholakala futhi njengesengezo sokudla.
Ukuze uphendule lo mbuzo, kubalulekile ukuqonda izindlela eziyisisekelo zokuguga. Ukuguga kuyinqubo eyinkimbinkimbi ehlanganisa uhla lwezinto eziphilayo kanye nemvelo. Esinye sezici eziyinhloko zokuguga ukunqwabelana kokulimala kwamaselula nokungasebenzi kahle ngokuhamba kwesikhathi. Lokhu kungaholela ekwehleni kokusebenza kwezicubu nezitho ezihlukahlukene, ekugcineni kubangele izimpawu zokuguga njengemibimbi, ukuncipha kwamazinga wamandla nokwanda kokungenwa yizifo.
Ucwaningo luphakamisa ukuthi i-alpha-ketoglutarate ingase ibe namandla okuguqula izinguquko ezithile ezihlobene nobudala. Ucwaningo olushicilelwe kujenali Cell Metabolism luthole ukuthi ukwengeza ukudla kwamagundane asebekhulile nge-alpha-ketoglutarate kukhiqiza uhla lwemiphumela enenzuzo. Lokhu kufaka phakathi ukusebenza okuthuthukisiwe komzimba, ukukhula isikhathi eside, nokunciphisa izimpawu zokuguga esibindini nasemisipha yamathambo.
Abacwaningi baphinde bathola ukuthi ukwesekwa kwe-alpha-ketoglutarate kubangele izinguquko emsebenzini wezakhi zofuzo ezihilelekile ekukhiqizeni amandla kanye ne-metabolism. Lokhu kuphakamisa ukuthi i-alpha-ketoglutarate ingase ikwazi ukuvuselela izicubu eziguga ngokuthuthukisa ikhono layo lokukhiqiza amandla nokulungisa umonakalo.
Ngaphezu kwemiphumela yayo kumetabolism, i-alpha-ketoglutarate ikhonjiswe ukuthi inohlu lwezinye izinzuzo. Isibonelo, kuyisandulela sokukhiqizwa kwe-collagen, ingxenye eyinhloko yesikhumba nezinye izicubu ezixhumeneyo. Lokhu kusho ukuthi i-alpha-ketoglutarate ingasiza ekugcineni ukwakheka nokusebenza kwesikhumba, kusize ukukhuthaza ukubukeka kobusha.
I-calcium iyiminerali ebalulekile edlala indima ebalulekile ezinqubweni eziningi zezinto eziphilayo emzimbeni. Omunye wemisebenzi yayo eyaziwa kancane umphumela wayo ku-alpha-ketoglutarate, ingxenye eyinhloko yomjikelezo we-citric acid.
Okokuqala, kubalulekile ukuqonda ukuthi i-alpha-ketoglutarate yenzani emzimbeni. I-Alpha-ketoglutarate iyinhlanganisela ephakathi kumjikelezo we-citric acid (owaziwa nangokuthi umjikelezo we-Krebs) futhi inesibopho sokukhiqiza amandla ngendlela ye-adenosine triphosphate (ATP). Lo mjikelezo uvela ku-mitochondria yeseli futhi ubalulekile ekugayweni kwama-carbohydrate, amafutha, namaprotheni. I-Alpha-ketoglutarate ibamba iqhaza ekuphenduleni kwamakhemikhali ambalwa okubalulekile kumjikelezo we-citric acid, okuhlanganisa ukuguqulwa kwe-isocitrate ibe yi-succinyl-CoA.
Ucwaningo lubonisa ukuthi i-calcium ions idlala indima ebalulekile ekulawuleni ukusebenza kwama-enzyme abandakanyeka kumjikelezo we-citric acid, okuhlanganisa nalawo asebenzisana ne-alpha-ketoglutarate. Ngokukhethekile, ama-calcium ions alawula umsebenzi we-alpha-ketoglutarate dehydrogenase, egqugquzela ukuguqulwa kwe-alpha-ketoglutarate ibe yi-succinyl-CoA. Lokhu kusho ukuthi ukuba khona kwe-calcium kuthinta izinga le-α-ketoglutarate metabolism emjikelezweni we-citric acid.
Ukwengeza, i-calcium itholakale ithinta amazinga e-alpha-ketoglutarate emzimbeni. Ucwaningo luye lwabonisa ukuthi ukunyuka kwamazinga e-calcium e-intracellular kuholela ekwehleni kokugxila kwe-alpha-ketoglutarate, kuyilapho ukwehla kwamazinga e-calcium kunomphumela ophambene. Lokhu kugqamisa ubudlelwano obuyinkimbinkimbi phakathi kwe-calcium ne-alpha-ketoglutarate, nokuthi ukushintshashintsha kwamazinga e-calcium kuyithinta kanjani i-metabolism yalesi sakhi esibalulekile.
Imiphumela ye-calcium ku-alpha-ketoglutarate idlulela ngale komjikelezo we-citric acid. I-Alpha-ketoglutarate futhi iyisandulela sokuhlanganiswa kwe-glutamate, i-neurotransmitter ebalulekile ohlelweni lwezinzwa oluphakathi. Ukubonisa i-calcium kwatholakala ukulawula umsebenzi wama-enzyme ahilelekile ekukhiqizeni i-glutamate kusuka ku-alpha-ketoglutarate. Lokhu kukhombisa umthelela omkhulu we-calciumI-α-ketoglutarate metabolism, okuhlanganisa nendima yayo ekuhanjisweni kwe-neurotransmission.
1.Ukunqanda ukuguga
I-Ca-AKG ikhonjiswe ukuthi inemiphumela engaba khona yokulwa nokuguga ezingeni lamaselula. Olunye ucwaningo lwathola ukuthi ukwengezwa nge-Ca-AKG kuholele ekwandeni komsebenzi we-mitochondria, izindlu zamandla zamaseli, ezincipha ngokuya ngeminyaka. Ngokusekela umsebenzi we-mitochondrial, i-Ca-AKG ingasiza ekuthuthukiseni impilo yeselula nokululama, okungase kube nemiphumela ejulile kubude bempilo yonke kanye nezifo ezihlobene nokuguga.
Ngaphezu kwalokho, iphepha lango-2019 elishicilelwe kujenali ebuyekezwe ngontanga I-Aging libonise ukuthi i-alpha-ketoglutarate inganweba isikhathi sempilo yama-nematodes (owaziwa nangokuthi ama-roundworms) nokuthi inhlanganisela inganciphisa umsebenzi wendlela ye-mTOR. I-mTOR inhibition ihlotshaniswa nezinzuzo eziningi zezempilo.Ngokuqondile, ukuvinjelwa kwe-mTOR kubonakala kukhuthaza impilo ende yeseli futhi kunciphise ingozi yezifo ezihlobene neminyaka ngokukhulisa i-autophagy.
2.Ilawula Amandla kanye neMetabolism
Enye yezindlela ezibalulekile i-Ca-AKG ethinta ngayo amandla kanye ne-metabolism ingenxa yendima yayo kumjikelezo we-citric acid. Lo mjikelezo unesibopho sokuguqula izakhamzimba ekudleni, njengama-carbohydrate, amafutha, namaprotheni, zibe i-adenosine triphosphate (ATP), umthombo oyinhloko wamandla omzimba. I-Alpha-ketoglutarate iyingxenye ebalulekile yalo mjikelezo njengoba ibamba iqhaza ekuphenduleni okuningana okubalulekile kwe-metabolic. Ngokuhlinzeka umzimba ngomthombo we-alpha-ketoglutarate osesimweni se-Ca-AKG, kucatshangwa ukuthi abantu ngabanye bangakwazi ukusekela izinqubo zabo zokukhiqiza amandla, okungenzeka bathuthukise amazinga wamandla kanye nemetabolism.
Ukwengeza, ucwaningo lubonisa ukuthi i-Ca-AKG ingase ibe nezakhiwo ze-antioxidant, ezingase zisekele indima yayo ekulawuleni amandla kanye ne-metabolism. Ukucindezeleka okwenziwe nge-oxidative kwenzeka lapho kunokungalingani phakathi kokukhiqizwa kwama-radicals mahhala kanye nekhono lomzimba lokumelana nemiphumela yawo eyingozi, futhi kuxhunyaniswa nohlu lwezinkinga zempilo, okuhlanganisa ukuphazamiseka kwe-metabolic. Ngokusebenza njenge-antioxidant, i-Ca-AKG ingasiza ekunciphiseni ukucindezelwa kwe-oxidative, ngaleyo ndlela ikhuthaze ukukhiqizwa kwamandla okusebenza kahle kanye ne-metabolism.
3.Healthy Weight Loss and Management
I-Ca-AKG uhlobo lukasawoti lwe-alpha-ketoglutarate, ukhiye omaphakathi emjikelezweni we-citric acid (owaziwa nangokuthi umjikelezo we-Krebs). Lo mjikelezo ubalulekile ekukhiqizeni i-adenosine triphosphate (ATP), umthombo wamandla oyinhloko wamangqamuzana ethu. Ngaphezu kwendima yayo ekukhiqizeni amandla, i-alpha-ketoglutarate nayo idlala indima ebalulekile kumetabolism yama-amino acid.
Olunye ucwaningo luphakamisa ukuthi i-Ca-AKG ingase futhi ibe nomthelela omuhle ekuzweleni kwe-insulin. I-insulin iyi-hormone edlala indima ebalulekile ekulawuleni amazinga kashukela egazini kanye nokugcinwa kwamandla emzimbeni. Ngokusekela ukuzwela kwe-insulin, i-Ca-AKG ingasiza abantu ngabanye ukuphatha kangcono amazinga kashukela egazini futhi banciphise ingozi yokukhuluphala.
Ucwaningo lwezilwane olushicilelwe kujenali i-Aging Cell lubonisa ukuthi i-alpha-ketoglutarate inganciphisa isisindo futhi ithuthukise izici ezithile zokukhuluphala kanye nezifo. Okubalulekile okuthathayo kuhlanganisa:
● amafutha aphansi
● Thuthukisa ukubekezelelwa kweglucose
● Ukwanda kwezicubu ze-adipose ensundu (amafutha)
4.Ilawula Amandla kanye neMetabolism
I-calcium alpha-ketoglutarate ithuthukisa ukukhiqizwa kwamandla ezingeni lamaselula. Ngokusekela umjikelezo we-Krebs, i-Ca-AKG isiza ukuthuthukisa ukuguqulwa kwemisoco ibe yi-ATP, umthombo oyinhloko wamandla wamaseli ethu.
Ukwengeza, i-calcium alpha ketoglutarate ikhonjisiwe ukusekela imetabolism enempilo. I-Metabolism ibhekisela ezinqubweni zamakhemikhali asekela ukuphila ezenzeka emizimbeni yethu, futhi ukusebenza kahle kwemetabolism kubalulekile ekukhiqizeni amandla, ukukhula, nokulungisa. I-Ca-AKG isiza ekulawuleni umzimba ngokukhuthaza ukusetshenziswa kahle kwama-carbohydrate, amafutha, namaprotheni, imithombo yamandla eyinhloko yamangqamuzana.
Ngaphezu kwendima yayo ekukhiqizeni amandla kanye nokulawulwa kwe-metabolic, i-calcium alpha-ketoglutarate nayo inezindawo zokulwa ne-antioxidant. Njenge-antioxidant, i-Ca-AKG isiza ukunciphisa ama-radicals mahhala ayingozi, angalimaza amangqamuzana futhi abe nomthelela ezimeni ezihlukahlukene ezihlanganisa ukucindezeleka kwe-oxidative, ukuvuvukala nokuguga. Ngokunciphisa ukulimala kwe-oxidative, i-calcium alpha-ketoglutarate isekela impilo nokusebenza kwamaseli jikelele.
Enye yezinto ezibaluleke kakhulu okufanele icatshangelwe lapho ukhetha isithasiselo se-Ca-AKG yikhwalithi yomkhiqizo. Bheka izithasiselo ezenziwe umkhiqizi ohloniphekile olandela imikhuba emihle yokukhiqiza (GMP) futhi ovela eceleni okuhlolelwe ubumsulwa namandla. Lokhu kuzoqinisekisa ukuthi uthola umkhiqizo wekhwalithi ephezulu ongenazo ukungcola futhi ohlangabezana nezimangalo zelebula.
Okunye okucatshangelwayo okubalulekile lapho ukhetha isengezo se-Ca-AKG yindlela yokwengeza. I-Ca-AKG itholakala ngempushana namafomu e-capsule, ngayinye inezinzuzo zayo kanye nokubi. Izithako eziyimpuphu ngokuvamile zimuncwa kalula ngumzimba futhi zingaxutshwa zibe iziphuzo noma ama-smoothie ukuze zisetshenziswe kalula. Ngakolunye uhlangothi, ama-capsules alula futhi kulula ukuwathwala. Lapho ukhetha ifomu lesengezo elilungele wena, cabangela indlela yakho yokuphila kanye nezinto ozikhethayo.
Ngaphezu kwekhwalithi nefomu, kubalulekile futhi ukucabangela umthamo kanye nokuhlushwa kwe-Ca-AKG ekwengezeni. Bheka imikhiqizo enikeza umthamo owanele we-Ca-AKG ukuhlangabezana nezidingo zakho ngazinye. Kubalulekile futhi ukucabangela ukugcwala kwe-Ca-AKG esithasiselweni - ukugxila okuphezulu kungase kudinge imithamo emincane, okungenzeka kube lula kwabanye abantu.
Ukwengeza, kubalulekile ukucabangela noma yiziphi ezinye izithako ku-Ca-AKG supplements. Ezinye izithasiselo zingaqukatha ama-filler, ama-preservatives, noma izinto ezingezwani nomzimba ongase ufune ukuzigwema. Uma unokungezwani komzimba nezinto ezithile noma imikhawulo yokudla, bheka izithasiselo ezinezithako ezimbalwa ezingeziwe futhi azikho izinto ezingezwani nezivamile.
Okokugcina, cabangela izindleko kanye nenani lesengezo se-Ca-AKG. Nakuba kungase kulinge ukukhetha inketho eshibhe kakhulu, kubalulekile ukucabangela inani eliphelele lesengezo. Thola umkhiqizo onikeza ifomula yekhwalithi ephezulu, enamandla ngentengo ethengekayo. Cabangela izindleko ngokuphakelwa ngakunye kanye nenani eliphelele lesengezo ngokusekelwe kukhwalithi yaso, ifomu, umthamo, nezinye izithako.
Inkampani engu-Suzhou Myland Pharm & Nutrition Inc.ibambe iqhaza ebhizinisini lezithako zokudla okunomsoco kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Q: Iyini iCalcium Alpha Ketoglutarate?
A: I-Calcium Alpha Ketoglutarate iyisengezo esihlanganisa i-calcium ne-alpha ketoglutaric acid, okuyinhlanganisela edlala indima ebalulekile ekukhiqizeni amandla kanye ne-metabolism yezakhi emzimbeni.
Q: Yiziphi izinzuzo zokuthatha izithasiselo zeCalcium Alpha Ketoglutarate?
A: Izithako ze-Calcium Alpha Ketoglutarate ziye zaboniswa ukusekela impilo yamathambo, ukuthuthukisa ukusebenza kwemisipha, ukuthuthukisa ukukhuthazela kokuzivocavoca, nokukhuthaza impilo yonke kanye nokuphila kahle.
Q: Ingabe izithasiselo zeCalcium Alpha Ketoglutarate zingazuzisa abasubathi nabathanda ukuqina?
A: Yebo, izithasiselo zeCalcium Alpha Ketoglutarate zingathuthukisa ukusebenza kokuzivocavoca nokukhuthazela ngokuthuthukisa ukukhiqizwa kwamandla kanye ne-metabolism yezakhi emzimbeni.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Feb-22-2024
