Emkhakheni wezempilo nokuphila kahle, ukufuna ukuphila isikhathi eside namandla kuye kwaholela ekuhlolweni kwezinhlanganisela zemvelo ezihlukahlukene kanye nezinzuzo zazo ezingaba khona. Enye inhlanganisela enjalo eye yathola ukunakwa eminyakeni yamuva i-urolithin A. Itholakala ku-ellagic acid, i-urolithin A iyi-metabolite ekhiqizwa i-gut microbiota ngemva kokusetshenziswa kokudla okuthile, njengamapomegranati, ama-strawberries, nama-raspberries.
I-Urolithin A (Uro-A) iwuhlobo lwe-ellagitannin-metabolite yamathumbu. Ifomula yayo yamangqamuzana ithi C13H8O4 futhi isisindo sayo samangqamuzana esihlobene singama-228.2. Njengesandulela se-metabolic ye-Uro-A, imithombo yokudla eyinhloko ye-ET amahalananda, ama-strawberry, ama-raspberries, ama-walnuts newayini elibomvu. I-UA ingumkhiqizo we-ETs owenziwe nge-metabolized microorganisms zamathumbu. Eminyakeni yamuva nje, ngokuthuthukiswa kocwaningo, kutholakale ukuthi i-Uro-A idlala indima yokuvikela ezinhlobonhlobo zomdlavuza (njengomdlavuza webele, umdlavuza we-endometrial kanye ne-prostate), izifo zenhliziyo nezinye izifo.
Ngenxa yomphumela wayo onamandla wokulwa nokuvuvukala, i-UA ingavikela izinso futhi ivimbele izifo ezinjenge-colitis, i-osteoarthritis, kanye ne-intervertebral disc degeneration. Ngasikhathi sinye, ucwaningo luye lwathola ukuthi i-UA ilusizo ekwelapheni izifo ze-neurodegenerative okuhlanganisa nesifo i-Alzheimer's nesifo sika-Parkinson. inomphumela obalulekile. Ngaphezu kwalokho, i-UA nayo inomphumela omuhle ekuvimbeleni nasekwelapheni izifo eziningi ze-metabolic. I-UA inamathuba amaningi okusebenza ekuvimbeleni nasekwelapheni izifo eziningi. Ngesikhathi esifanayo, i-UA inezinhlobonhlobo zemithombo yokudla.
Ucwaningo ngemiphumela ye-antioxidant ye-urolithins yenziwe. I-Urolithin-A ayikho esimweni semvelo, kodwa ikhiqizwa uchungechunge lwezinguquko ze-ET ngezitshalo zamathumbu. I-UA ingumkhiqizo we-ETs owenziwe nge-metabolized microorganisms zamathumbu. Ukudla okucebile ku-ET kudlula esiswini namathumbu amancane emzimbeni womuntu, futhi ekugcineni kugaywe ngokuyinhloko ku-Uro-A kukholoni. Inani elincane le-Uro-A lingatholwa futhi emathunjini amancane angaphansi.
Njengezinhlanganisela zemvelo ze-polyphenolic, ama-ET adonse ukunakwa okukhulu ngenxa yemisebenzi yawo yezinto eziphilayo ezifana ne-antioxidant, anti-inflammatory, anti-allergic and anti-viral. Ngaphezu kokutholakala ekudleni okunjengamahalananda, ama-strawberries, ama-walnuts, ama-raspberries, nama-alimondi, ama-ET atholakala emithini yendabuko yamaShayina njengama-gallnuts, ama-pomegranate peels, kanye ne-agrimony. Iqembu le-hydroxyl esakhiweni samangqamuzana e-ETs lifana ne-polar, elingahambisani nokumuncwa ngodonga lwamathumbu, futhi i-bioavailability yayo iphansi kakhulu.
Ucwaningo oluningi luye lwathola ukuthi ngemva kokuba ama-ET efakwe emzimbeni womuntu, ahlanganiswa yizitshalo zamathumbu emathunjini futhi aguqulwe abe yi-urolithin ngaphambi kokumuncwa. Ama-ET afakwa nge-hydrolyzed abe yi-ellagic acid endaweni engenhla ye-gastrointestinal tract, futhi i-EA iphinde icutshungulwe izitshalo zamathumbu bese ilahlekelwa eyodwa Iringi ye-lactone ibhekana nokusabela kwe-dehydroxylation okuqhubekayo ukuze kukhiqize i-urolithin. Kunemibiko yokuthi i-urolithin ingaba yisisekelo sezinto eziphilayo ze-ETs emzimbeni.
I-Urolithin A ne-Mitochondrial Health
Esinye sezici ezithakazelisa kakhulu ze-urolithin A umthelela wayo empilweni ye-mitochondrial. I-Mitochondria ivame ukubizwa ngokuthi i-powerhouse yeseli, idlala indima ebalulekile ekukhiqizweni kwamandla kanye nokusebenza kwamaselula. Njengoba sikhula, umsebenzi we-mitochondria ungancipha, okuholela ezinkingeni zezempilo ezihlobene nobudala. I-Urolithin A ikhonjiswe ukuthi ivuselela i-mitochondria engasebenzi ngenqubo eyaziwa ngokuthi i-mitophagy, ehilela ukususwa kwe-mitochondria eyonakele kanye nokukhuthazwa komsebenzi we-mitochondrial onempilo. Lokhu kuvuselelwa kabusha kwe-mitochondria kunamandla okuthuthukisa wonke amazinga wamandla, ukukhuthaza impilo yamaselula, nokusekela impilo ende.
Impilo Yemisipha kanye nokusebenza
Ngaphezu kwemiphumela yayo empilweni ye-mitochondrial, i-urolithin A nayo ixhunywe ekuthuthukisweni kwempilo yemisipha nokusebenza. Ucwaningo luye lwabonisa ukuthi i-urolithin A ingashukumisa ukukhiqizwa kwemicu emisha yemisipha futhi ithuthukise ukusebenza kwemisipha. Lokhu kuthembisa ikakhulukazi kubantu abafuna ukugcina imisipha namandla njengoba bekhula, kanye nakubasubathi abafuna ukuthuthukisa ukusebenza kwabo ngokugcwele. Amandla e-urolithin A okusekela impilo nokusebenza kwemisipha anemithelela ebalulekile enhlalakahleni yonke yomzimba kanye nekhwalithi yokuphila.
Izakhiwo Ze-Anti-Inflammatory kanye Ne-Antioxidant
I-Urolithin A nayo yaziwa ngezakhiwo zayo ezinamandla zokulwa nokuvuvukala kanye ne-antioxidant. Ukuvuvukala okungapheli kanye nengcindezi ye-oxidative yizici eziyisisekelo ekuthuthukisweni kwezifo eziningi ezingalapheki, okuhlanganisa nesifo senhliziyo, ukuphazamiseka kwe-neurodeergenerative, kanye nezinhlobo ezithile zomdlavuza. I-Urolithin A iboniswe ukuthi ishintsha izindlela zokuvuvukala futhi inciphise ukulimala kwe-oxidative, ngaleyo ndlela ibe nemiphumela yokuzivikela ngokumelene nalezi zinqubo ezilimazayo. Ngokunciphisa ukuvuvukala nokucindezeleka okwenziwe nge-oxidative, i-urolithin A inamandla okufaka isandla ekuvimbeleni nasekulawuleni izifo ezihlukahlukene ezihlobene nobudala kanye nendlela yokuphila.
Umsebenzi Wengqondo kanye Nempilo Yengqondo
Umthelela we-urolithin A udlulela ngalé kwempilo engokomzimba, njengoba ucwaningo oluvelayo luphakamisa izinzuzo zayo ezingaba khona ekusebenzeni kwengqondo nempilo yobuchopho. Izimo ze-neurodegenerative, njengesifo i-Alzheimer's, zibonakala ngokuqoqwa kwamaprotheni angavamile kanye nokungasebenzi kahle kwamangqamuzana ebuchosheni. I-Urolithin A ibonise imiphumela ye-neuroprotective, okuhlanganisa ukucaciswa kwamaprotheni anobuthi kanye nokukhuthazwa kokuqina kwe-neuronal. Lokhu okutholakele kubambe isithembiso sokusebenzisa i-urolithin A ekusekeleni impilo yobuchopho nokusebenza kwengqondo, okunikeza indlela entsha yokubhekana nokuncipha kwengqondo okuhlobene nobudala kanye nokuphazamiseka kwe-neurodegenerative.
Impilo Yamathumbu kanye Nempilo Ye-Metabolic
I-gut microbiota idlala indima ebalulekile empilweni yomuntu, ithonya izinqubo ezihlukahlukene zomzimba, okuhlanganisa imetabolism nokusebenza komzimba. I-Urolithin A, njengomkhiqizo we-microbial metabolism, ihlotshaniswe nemiphumela enenzuzo empilweni yamathumbu kanye nokuphila kahle kwe-metabolic. Kuye kwaboniswa ukukhuthaza ukukhula kwamagciwane anenzuzo emathunjini, ukulungisa izindlela ze-metabolic, futhi kuthuthukise ukuzwela kwe-insulin. Le miphumela inemithelela ekulawuleni ukuphazamiseka kwe-metabolic, njengokukhuluphala kanye nesifo sikashukela sohlobo 2, okugqamisa amandla e-urolithin A njengendlela engokwemvelo yokweseka impilo ye-metabolic.
Ikusasa le-Urolithin A: Imithelela Yempilo Nokuphila
Njengoba ucwaningo nge-urolithin A luqhubeka nokuvela, imithelela yayo engaba khona empilweni nempilo iya ngokuya ibonakala. Kusukela kumthelela wayo ekuvuselelweni kabusha kwe-mitochondrial kanye nempilo yemisipha kuya ezintweni zayo zokulwa nokuvuvukala, i-antioxidant, kanye ne-neuroprotective, i-urolithin A imele umshintshi wegeyimu ekuphishekeleni ukuphila isikhathi eside namandla. Ithemba lokusebenzisa izinzuzo ze-urolithin A ngemithombo yokudla noma i-supplementation linesithembiso sokubhekana nokukhathazeka okubanzi kwezempilo kanye nokwenza ngcono impilo yonke.
I-Urolithin A ithole ukunakwa eminyakeni yamuva nje ngezinzuzo zayo zezempilo ezingaba khona, ikakhulukazi endaweni yezempilo yamaselula nokuphila isikhathi eside. Le nhlanganisela yemvelo itholakala ku-ellagic acid, etholakala ezithelweni ezithile namantongomane. Nakuba abantu abaningi bengase babe nentshisekelo yokufaka i-urolithin A ohlelweni lwabo lwezempilo, kubalulekile ukuqonda ukuthi ingase ingafaneli wonke umuntu. Kule bhulogi, sizohlola ukuthi ubani okufanele agweme ukuthatha i-urolithin A nokuthi kungani.
Isikhathi sokuthumela: Jul-30-2024
