I-N-acetyl-L-cysteine ethyl ester, eyaziwa nangokuthi i-NACET, iyi-antioxidant enamandla futhi iyisengezo esidumile ngezinzuzo zayo zezempilo ezingaba khona. Njengoba kunezinketho eziningi emakethe, ukukhetha isithasiselo esingcono kakhulu se-NACET kungaba yinto enzima kakhulu. Ukukusiza wenze isinqumo unolwazi futhi ukhethe isithasiselo sekhwalithi ephezulu se-NACET esihlangabezana nemigomo yakho yezempilo nempilo enhle. Udinga ukucabangela ngokucophelela ikhwalithi, i-bioavailability, umthamo, ukwakheka, isithunzi, kanye nenani. Ngokucabangela lezi zici nokwenza ucwaningo olunzulu, ungenza isinqumo esinolwazi mayelana nokukhetha isithasiselo esinempilo nesisezingeni eliphezulu se-NACET.
I-NACET, kafushane yokuthiI-N-acetyl-L-cysteine ethyl ester, iwuhlobo lokwengeza lwe-cysteine, i-amino acid ebaluleke kakhulu. Kuthathwa njengokubalulekile ngoba umzimba wakho ungawukhiqiza kwamanye ama-amino acid, okuyi-methionine ne-serine. Kudingeka kuphela lapho izinga lokudla kwe-methionine ne-serine liphansi. I-cysteine itholakala ekudleni okuningi okunamaprotheni amaningi, njengenkukhu, i-turkey, iyogathi, ushizi, amaqanda, imbewu ye-sunflower, nobhontshisi. Yaziwa ngezici zayo ezinamandla zokulwa ne-antioxidant nekhono lokusekela zonke izici zempilo, i-NACET ingaphezu nje kwesengezo, iyifomula enamandla yokulwa ne-antioxidant eklanyelwe ukuthuthukisa kakhulu impilo yobuchopho nempilo yokuzivikela komzimba.
Okwenza i-NACET ihluke ukutholakala kwayo okuphezulu kwe-bioavailability, okuphindwe izikhathi ezingu-20 kune-glutathione evamile nezithasiselo ze-NAC. Lokhu kusho ukuthi uma uthatha i-NACET, umzimba wakho uyisebenzisa ngokuphumelelayo. Futhi lokhu kutholakala kwe-bioavailability okuthuthukisiwe kuhumushela emiphumeleni esebenza ngempumelelo ye-antioxidant, ikakhulukazi ekwandiseni amazinga e-antioxidant glutathione, eyaziwa ngokuthi i-antioxidant enamandla kakhulu emzimbeni.
I-NACET isiza ukuvikela isibindi ekucindezelekeni kwe-oxidative futhi ithuthukise impilo yaso yonke kanye nomsebenzi waso. Akusizi nje kuphela ukuvikela ubuchopho emonakalweni we-radical wamahhala, futhi isekela ukusebenza kwengqondo, okwenza kube umngane ophelele wempilo yobuchopho yesikhathi eside.
I-NACET iphinde yacwaningwa ngamakhono ayo okuxhasa impilo yokuphefumula. Ivame ukusetshenziswa njenge-mucolytic, okusho ukuthi isiza ukuhlukana kanye namafinyila amancane, okwenza kube lula ukusula emgudwini wokuphefumula.
I-NACET ihlanganisa izithako zekhwalithi ephezulu, esekelwa ucwaningo nokuzibophezela kwezempilo, ikwenze kube okungaphezu nje kwesengezo. Futhi ngocwaningo olwengeziwe nokuqonda, i-NACET ingase iqhubeke iyithuluzi elinamandla lokuthuthukisa impilo nokuphila kahle iyonke.
I-NACET iwuhlobo lwe-ethyl ester ye-N-acetyl L-cysteine (NAC) futhi isebenza emzimbeni ngendlela eyingqayizivele yokusebenza, egxile endimeni yayo njengesandulela se-glutathione namandla ayo aphezulu uma kuqhathaniswa ne-NAC evamile ye-bioavailability.
Iguqulelwe ku-N-Acetyl Cysteine (NAC): Uma isingenile, i-NACET ingena egazini. Ngenxa yeqembu le-ethyl ester, ine-lipophilic (i-fat soluble) futhi ingamuncwa kangcono ngolwelwesi lwe-lipid lwamaseli. Emzimbeni, i-NACET iguqulelwa ku-N-acetylcysteine (NAC).
Khulisa amazinga e-glutathione: I-NAC iyisandulela se-glutathione, enye yama-antioxidants abaluleke kakhulu emzimbeni. I-Glutathione idlala indima ebalulekile ekunciphiseni ama-radicals mahhala, ekwehliseni ingcindezi ye-oxidative futhi isekele izinqubo zokususa ubuthi esibindini. Ngokwandisa amazinga e-glutathione, i-NACET isiza ukuvikela amaseli emonakalweni we-oxidative, okubalulekile ekugcineni impilo yamangqamuzana nokuvimbela umonakalo ohlobene neminyaka.
Ukulawulwa Komsebenzi We-Neurotransmitter Nokuvuvukala: I-NACET, ngokuguqulwa kwayo ku-NAC, ingase ithinte amazinga e-glutamate ebuchosheni. I-Glutamate iyi-neurotransmitter ebalulekile ehilelekile ekufundeni nasekukhumbuleni. Iphinde ibe nezindawo zokulwa nokuvuvukala. I-NAC ikhonjiswe ukuthi ilawula ukukhiqizwa kwama-cytokines athile, okungama-molecule abonisayo alamula futhi alawule ukuzivikela komzimba, ukuvuvukala, kanye ne-hematopoiesis.
Isenzo se-Mucolytic: I-NAC, ifomu elisebenzayo elitholakala ku-NACET, isebenza njenge-ejenti ye-mucolytic ngokuphula izibopho ze-disulfide ku-mucus, iyenze ingabonakali futhi kulula ukuyikhipha. Lokhu kusho ukuthi kusiza ukuphuka kanye namafinyila amancane, okwenza kube lula ukusula emgudwini wokuphefumula. Lokhu kunenzuzo ikakhulukazi kubantu abanezimo zokuphefumula ezifana ne-bronchitis engapheli, isifuba somoya, noma i-cystic fibrosis.
I-N-acetyl-L-cysteine ethyl ester,eyaziwa nangokuthi i-NACET, iwuhlobo lwe-antioxidant olwaziwayo noluguquliwe lwe-N-acetyl-L-cysteine (NAC). I-NACET kukholakala ukuthi inokutholakala okuphezulu kwe-bioavailability kanye nokuzinza kunezithako zendabuko ze-NAC. Lokhu kusho ukuthi ingamuncwa kalula ngumzimba futhi ibe nemiphumela ehlala isikhathi eside. Kungenzeka ukuthi uzwile nge-NAC ngoba iyisandulela se-antioxidant glutathione enamandla.
I-NACET yehluke ngokuphelele ku-NAC yendabuko. I-NACET inguqulo eqinisekisiwe ye-NAC eshintshiwe ukuze kwakhiwe i-NACET okulula ukuyithatha futhi okunzima ukuyikhomba. Akukhona nje kuphela ukuthi inguqulo ye-ethyl ester itholakala kakhulu kune-NAC, kodwa iyakwazi nokungena esibindini nasezinso futhi yeqe umgoqo wegazi nobuchopho. Ukwengeza, i-NACET inekhono eliyingqayizivele lokuvikela emonakalweni we-oxidative lapho ilethwa kuwo wonke umzimba ngamaseli abomvu egazi.
Ucwaningo olulodwa lubonise ukuthi i-NACET ingena ngokushesha kumaseli futhi ithathwe ukuze ikhiqize i-NAC ne-cysteine. I-NACET itholakala kumaseli ezicubu ezihlukene, okuhlanganisa nobuchopho, ngenxa yekhono layo lokuwela umgoqo wegazi nobuchopho. Olunye ucwaningo luye lwabonisa ukuthi i-NAC ingaphinda iwele umgoqo wegazi nobuchopho, kodwa ngamanani amancane, futhi izinga lokumunca ngomlomo licishe libe ngu-3-6%. Izinga lokumunca le-NACET lingase lidlule ku-60%, futhi lingena kumaseli kunokuba lingaphandle kwawo, futhi lingene kakhulu ebuchosheni. Uma i-NACET ingena kumaseli, iguqulelwa ku-NAC, i-cysteine, futhi ekugcineni i-glutathione. Khona-ke, i-antioxidant glutathione isiza ukuqeda ubuthi futhi ilawule ukusebenza komzimba okuvamile, isiza ekulungiseni amangqamuzana, futhi isekele umsebenzi wokulwa nokuguga nokusebenza kwengqondo.
Enye into esebenzayo ye-NACET amandla ayo okudlula isisu futhi ingamuncwa amathumbu. Umzimba wakho uyalibona inani le-cysteine ku-NAC futhi ulidonsa esiswini, isibindi, noma izinso-ugcina i-cysteine kumangqamuzana e-epithelial (amangqamuzana ahlanganisa imigodi yomzimba nezitho ezingenalutho) esikhundleni sokuyiyeka Ingena ebuchosheni nezinye. izindawo ezidingekayo! Ngenxa ye-ethyl ester eyengeziwe, i-NACET ayaziwa njenge-NAC, eyivumela ukuthi ihambe emgudwini wegazi iye kuwo wonke umfantu womzimba iye endaweni yayo yokugcina oyifunayo.
I-NACET iwuhlobo lokwengeza lwe-cysteine. Ukuthola i-NACET eyanele kubalulekile ngezizathu ezehlukene zempilo:
1. Ukwesekwa kwe-Antioxidant: Ukuqoqwa kanye ne-oxidation yama-radicals mahhala emzimbeni kuyimbangela enkulu yezifo eziningi nokuphazamiseka kwengqondo. Ukungakwazi komzimba wethu ukususa lobu buthi kubangelwa izici zofuzo (i-methylation engalungile), ukudla okungenamsoco, ukucindezeleka, kanye nobuthi bemvelo. I-NACET ibonakala ihlinzeka umzimba ngendlela esebenza ngempumelelo ukusiza ukubuyisela impilo yethu engokomzimba neyengqondo. Ngokuqeda ama-molecule ayingozi, i-NACET ingasiza ekwehliseni ubungozi besifo esingelapheki futhi isekele impilo yamaselula iyonke.
2. Impilo Yesibindi: I-NACET iboniswe ukuthi isekela ukusebenza kwesibindi ngokukhuthaza ukukhiqizwa kwe-glutathione, okuyisihluthulelo sokwakha nokulungisa izicubu. Njenge-antioxidant enamandla, i-glutathione ivimbela ukulimala kwe-oxidative futhi isekela impilo ephelele yamaselula yobuchopho, inhliziyo, amaphaphu, nazo zonke ezinye izitho nezicubu. I-Glutathione idlala indima ebalulekile ekukhipheni ubuthi emzimbeni, okuzuzisa kakhulu abantu abangase bachayeke ebuthini bemvelo noma abanomlando wezinkinga zesibindi.
3. Impilo Yokuphefumula: I-NACET iye yacwaningelwa amandla ayo okusekela impilo yokuphefumula, ikakhulukazi kubantu abanezimo ezifana ne-bronchitis engapheli, isifuba somoya, nesifo se-chronic obstructive pulmonary. Izici zayo ze-mucolytic zingasiza ukuphula amafinyila futhi kuthuthukise ukuphefumula.
4. Impilo yengqondo: I-NACET iye yaxhunyaniswa nempilo yengqondo ethuthukisiwe, nocwaningo olubonisa ukuthi inamandla okusekela ukulinganisela ngokomzwelo nokunciphisa izimpawu zokukhathazeka nokudangala. Ikhono layo lokulawula amazinga e-glutamate ebuchosheni lingase libe nomthelela emiphumeleni yalo emihle empilweni yengqondo.
5. Ukusekelwa Kwamasosha omzimba: I-NACET iboniswe ukuthuthukisa ukusebenza komzimba ngokusekela ukukhiqizwa kwe-glutathione kanye nokukhuthaza impendulo enempilo yokuvuvukala. Lokhu kungasiza umzimba ukuthi uvikeleke kangcono ekuthelelekeni futhi ugcine impilo yonke yokuzivikela komzimba.
6. Ukusebenza Kokuzivocavoca: Abasubathi nabathandi bokufaneleka bangase bazuze ekwengezeni i-NACET ngenxa yamandla ayo okunciphisa ukucindezeleka okwenziwe nge-oxidative okubangelwa ukuvivinya umzimba kanye nokusekela ukululama kwemisipha. Kungase futhi kusize ukuthuthukisa ukukhuthazela nokusebenza komdlalo jikelele.
7. Impilo Yesikhumba: Izakhi zokuvikela ze-NACET nazo zizuzisa impilo yesikhumba, zisiza ukuvimbela ukulimala kwama-radical mahhala futhi okungenzeka kunciphise izimpawu zokuguga.
1. Ikhwalithi Nobumsulwa: Lapho ukhetha isithasiselo se-NACET, kubalulekile ukubeka phambili ikhwalithi nobumsulwa. Bheka imikhiqizo eyenziwe ezindaweni eziqinisekiswe i-GMP kanye nenkampani yangaphandle ehlolelwe ubumsulwa namandla. Lokhu kuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ngaphandle kokungcola noma ukungcola.
2. I-Bioavailability: Khetha izithasiselo ze-NACET ezinokutholakala kwe-bioavailability okuthuthukisiwe. Lokhu kusho ukuthi isengezo simuncwa kalula futhi sisetshenziswe ngumzimba ukuze sisebenze kahle kakhulu.
3. Umthamo kanye Nokugxilisa ingqondo: Naka umthamo nokugxila kwe-NACET esithasiselweni sakho. Umthamo onconyiwe we-NACET ungahluka kuye ngezidingo zomuntu ngamunye kanye nemigomo yezempilo. Kubalulekile ukukhetha umthamo olungile wesithasiselo esihlangabezana nezidingo zakho ezithile. Ukwengeza, ukugxila okuphezulu kwe-NACET kungase kunikeze izinzuzo ezinamandla, ngakho-ke cabangela amandla owafisayo lapho ukhetha.
4. Ukwakhiwa: Cabangela ukwakhiwa kwesithasiselo sakho se-NACET. Eminye imikhiqizo ingase ibe nezithako ezengeziwe noma izinhlanganisela ze-synergistic ukuthuthukisa ukusebenza kahle kwe-NACET. Isibonelo, izithasiselo eziqukethe amanye ama-antioxidants noma imisoco efana ne-vitamin C noma i-selenium zinganikeza ukwesekwa okwengeziwe kwempilo iyonke.
5. Idumela Nokubuyekezwa: Cwaninga umkhiqizo futhi ufunde ukubuyekezwa kwamakhasimende ngaphambi kokuthenga izithasiselo ze-NACET. Bheka inkampani enedumela elihle elinomlando wokukhiqiza izithasiselo zekhwalithi ephezulu. Izibuyekezo zekhasimende zinganikeza imininingwane ebalulekile ekusebenzeni kahle nekhwalithi yomkhiqizo, kukusize wenze isinqumo unolwazi.
6. Inani Nenani: Nakuba intengo kungafanele kube ukuphela kwesici esinqumayo, kubalulekile ukucabangela inani eliphelele lesithasiselo. Qhathanisa izindleko ngesevisi ngayinye kanye nekhwalithi yomkhiqizo ukuze uqiniseke ukuthi uthola idili elihle. Khumbula ukuthi ukutshala imali kusithasiselo sekhwalithi ephezulu se-NACET kungase kunikeze izinzuzo ezinkulu ngokuhamba kwesikhathi.
7. Xhumana nochwepheshe bezokunakekelwa kwempilo: Ngaphambi kokuqala noma yiluphi uhlobo lwemithi yokwelapha entsha, kunconywa ukuthi uthintane nochwepheshe bezempilo, ikakhulukazi uma unezimo zempilo ezicashile noma uphuza imithi. Bangakunikeza izeluleko eziqondene nawe futhi baqinisekise ukuthi i-NACET iphephile futhi ifanele izidingo zakho zomuntu ngamunye.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izindawo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kuma-milligrams kuye kumathani esikalini, futhi ithobelane namazinga e-ISO 9001 kanye nokucaciswa kokukhiqiza kwe-GMP.
Q: Yiziphi izici okufanele zicatshangelwe lapho ukhetha isithasiselo se-N-Acetyl-L-Cysteine Ethyl Ester ngezidingo zakho?
A: Uma ukhetha isithasiselo se-N-Acetyl-L-Cysteine Ethyl Ester, cabangela izici ezifana nekhwalithi yomkhiqizo, ukuhlanzeka, izincomo zomthamo, izithako ezengeziwe, kanye nesithunzi somkhiqizo noma umkhiqizi. Kubalulekile futhi ukubonisana nochwepheshe bezempilo ngaphambi kokusebenzisa.
Q: Ngingayihlola kanjani ikhwalithi nokuhlanzeka kwesithasiselo se-N-Acetyl-L-Cysteine Ethyl Ester?
IMPENDULO: Hlola ikhwalithi nokuhlanzeka kwesithasiselo se-N-Acetyl-L-Cysteine Ethyl Ester ngokubheka imikhiqizo ehlolelwe amandla nobumsulwa benkampani yangaphandle. Ukwengeza, cabangela isithunzi somkhiqizi nokubambelela kwabo ku-Good Manufacturing Practices (GMP).
Q: Ngingasihlanganisa kanjani isithasiselo se-N-Acetyl-L-Cysteine Ethyl Ester ohlelweni lwami lwezempilo?
A: Isithasiselo se-N-Acetyl-L-Cysteine Ethyl Ester singahlanganiswa nesimiso sempilo kahle ngokulandela umthamo onconywayo onikezwe umkhiqizo. Kubalulekile ukucabangela imigomo yokuphila kahle komuntu ngamunye futhi uxhumane nochwepheshe bezempilo uma kudingeka.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Jun-17-2024
