Uma kuziwa ekugcineni indlela yokuphila enempilo, kubalulekile ukucabangela zonke izici zempilo nokondleka. Ukufaka isengezo se-evodiamine ohlelweni lwakho lwezempilo nokudla kungaba yindlela enhle yokusekela impilo yakho yonke kanye nokuphila kahle. Kungakhathaliseki ukuthi ufuna ukulawula isisindo sakho, ukusekela ukugaya okunempilo, noma ukuqinisa ukusebenza kwenhliziyo nemithambo yegazi, i-evodiamine ingasiza. I-Evodiamine iyinhlanganisela yemvelo etholakala esithelweni sesihlahla se-Evodia. Isetshenziswe emithini yendabuko yamaShayina amakhulu eminyaka futhi yaziwa ngezinzuzo zayo zezempilo ezingaba khona.
I-Evodiamine ihlukaniswa njenge-alkaloid ye-bioactive futhi itholakala ezithelweni zesitshalo se-Evodiamine. Lokhu kusho ukuthi inamandla okuxhumana nezinqubo ezahlukahlukene zebhayoloji emzimbeni. Le nhlanganisela iye yafundelwa imiphumela yayo engaba khona kumetabolism, ukuphathwa kwesisindo, kanye nempilo yonke. Emithini yendabuko yamaShayina, i-evodiamine isetshenziselwa ukusekela ukugaya, ukukhulula ubuhlungu, nokukhuthaza ibhalansi yamandla. Ocwaningweni lwanamuhla, i-evodiamine iye yafundelwa amandla ayo njenge-thermogenic, okusho ukuthi ingaba namandla okwandisa ukukhiqizwa komzimba kokushisa namandla.
Olunye ucwaningo lubonisa ukuthi i-evodiamine ingase ibe namandla okwandisa izinga lokugayeka kokudla emzimbeni, okuholela ekusetshenzisweni okukhulu kwekhalori kanye nokuncipha kwesisindo okungase kube khona. Ukwengeza, i-evodiamine iye yafundelwa amandla ayo okukhuthaza ukugqama kwezicubu ezimhlophe ze-adipose, okungase kube nomthelela ekuthuthukiseni impilo ye-metabolic kanye nokunciphisa ingozi yezifo ezihlobene nokukhuluphala.
Kuyaziwa ukuthi ukuvuvukala nokucindezeleka okwenziwe nge-oxidative kudlala indima ekuthuthukiseni izifo ezihlukahlukene ezingapheli, ngakho-ke izinhlanganisela ezikwazi ukulwa nalezi zinqubo zinesithakazelo esikhulu kubacwaningi nabasebenzi bezempilo. Olunye ucwaningo lubonisa ukuthi i-evodiamine ingase ibe nekhono lokunciphisa ukuvuvukala nokuvikela emonakalweni we-oxidative, okungase kube nomthelela ekusekeleni impilo yonke kanye nokuphila kahle.
Njengamanje, i-evodiamine itholakala kakhulu njengesengezo sokudla, esinochungechunge lwezinzuzo zezempilo emzimbeni womuntu.
I-Evodiamine itholakale isebenzisa imiphumela yayo ngokusebenzisa izindlela eziningi zamangqamuzana. Enye yezindlela eziyinhloko zesenzo se-evodiamine yikhono layo lokwenza kusebenze iziteshi ze-receptor ezingaba khona ze-vanilloid 1 (TRPV1) ezingaba khona. I-TRPV1 iyi-receptor ehilelekile ebuhlungu kanye nokuzwa ukushisa, futhi ukusebenza kwayo nge-evodiamine kuboniswe ukuthi kubangele i-thermogenesis nokwandisa izindleko zamandla. Lo mphumela we-thermogenic we-evodiamine ungase ube nomthelela ezenzweni zayo zokulwa nokukhuluphala, okwenza kube okuhloswe ngakho ukuthuthukiswa kokungenelela kokulahlekelwa kwesisindo.
Ngokungeziwe emiphumeleni yayo ku-TRPV1, i-evodiamine itholakale ishintsha ezinye izinto ezihlosiwe zamangqamuzana, okuhlanganisa i-adenosine monophosphate-activated protein kinase (AMPK) kanye ne-peroxisome proliferator-activated receptor gamma (PPARγ). I-AMPK iyisilawuli esiyinhloko se-homeostasis yamandla eselula, futhi ukusebenza kwayo nge-evodiamine kukhuthaza ukumuncwa kwe-glucose kanye ne-oxidation ye-fatty acid, ngaleyo ndlela ithuthukise ukuzwela kwe-insulin nempilo ye-metabolic. Ngakolunye uhlangothi, ukusebenza kwe-PPARγ nge-evodiamine kungalawula ukuvezwa kwezakhi zofuzo ezihilelekile ku-lipid metabolism kanye ne-adipogenesis, okuqhubeka kube nomthelela ekulweni nokukhuluphala.
Ukwengeza, i-evodiamine iboniswe ukuthi ibonise izakhiwo zokulwa nokuvuvukala ngokuvimbela ukusayina kwe-nuclear factor kappa B (NF-κB). I-NF-κB iyisilawuli esiyinhloko sezimpendulo ezivuthayo, futhi ukuhlukunyezwa kwayo kuhlotshaniswa nezifo ezihlukahlukene ezivuthayo ezingapheli. Ngokuvimbela ukusebenza kwe-NF-κB, i-evodiamine inganciphisa ukukhiqizwa kwabalamuli abathintekayo futhi inciphise inqubo yokuvuvukala, iphakamisa indima yayo yokwelapha engaba khona ekwelapheni izifo ezivuthayo.
Ngaphezu kwalokho, imiphumela ye-anticancer ye-evodiamine ibangelwa amandla ayo okudala i-apoptosis futhi ivimbele ukwanda kwemigqa yamaseli omdlavuza. Lokhu kucatshangwa ukuthi kwenzeka ngokulawulwa kwezindlela eziningi zokubonisa ezihilelekile ekusindeni kweseli nasekukhuleni, okuhlanganisa i-mitogen-activated protein kinase (MAPK) kanye ne-phosphoinositide 3-kinase (PI3K)/Akt pathways. Ngaphezu kwalokho, i-evodiamine iboniswe ukuthi ivimbela ukubonakaliswa kwe-matrix metalloproteinases (MMPs), ama-enzyme ahilelekile ekuhlaselweni kwe-tumor kanye ne-metastasis.
I-1.Isiza ekunciphiseni isisindo kanye nokunciphisa umzimba
Isihluthulelo sokusiza i-evodiamine ngokunciphisa umzimba ukwandisa i-thermogenesis emzimbeni. I-Thermogenesis inqubo lapho umzimba ukhiqiza ukushisa futhi ushise ama-calories. Ngokuvuselela i-thermogenesis, i-evodiamine ingasiza ukukhulisa umzimba futhi ikhuthaze ukushiswa kwamafutha. Lokhu kusho ukuthi ushisa ama-calories engeziwe usuku lonke, ngisho nalapho uphumule, okuholela ekwehleni okwengeziwe kwesisindo ngokuhamba kwesikhathi.
Ngaphezu kwemiphumela yayo ku-thermogenesis, i-evodiamine ingase ibe nemiphumela ku-fat metabolism. Ucwaningo lubonisa ukuthi i-evodiamine ingasiza ekwandiseni ukuwohloka kwamafutha futhi ivimbele ukwakheka kwamangqamuzana amafutha amasha. Lokhu kusho ukuthi akusizi nje kuphela ukuthi ushise izitolo zamafutha ezikhona, futhi kuvimbela ukuqoqwa kwamafutha amasha, okwenza kube lula ukugcina ukulahlekelwa isisindo ngokuhamba kwesikhathi.
Ukwengeza, i-evodiamine ikhonjiswe ukuthi inemiphumela engaba khona yokucindezela ukudla. Ngokunciphisa indlala nokwandisa imizwa yokugcwala, i-evodiamine ingakusiza ukuthi udle amakholori ambalwa, okwenza kube lula ukunamathela ekudleni kwakho futhi ufinyelele imigomo yakho yokulahlekelwa isisindo. Ukwengeza, olunye ucwaningo lubonisa ukuthi i-evodiamine ingase ibe nezindawo zokulwa nokuvuvukala kanye ne-antioxidant, engasiza impilo yonke kanye nokuphila kahle ngesikhathi sokulahlekelwa isisindo.
2.Isiza ukunciphisa ukuvuvukala
I-Evodiamine isuselwa esithelweni sesitshalo i-Evodia rutaecarpa, esisetshenziswe emithini yendabuko yamaShayina ukwelapha izifo ezahlukahlukene amakhulu eminyaka. Ucwaningo nge-evodiamine lubonisa ukuthi luvimbela ukukhiqizwa kwama-molecule avuthayo emzimbeni, njengama-cytokines nama-prostaglandin. Lokhu kusiza ukunciphisa amazinga okuvuvukala emzimbeni, ngaleyo ndlela kunciphise ubuhlungu nezinye izimpawu ezihlobene nokuvuvukala okungapheli.
Ucwaningo olushicilelwe ku-Journal of Ethnopharmacology lwathola ukuthi i-evodiamine yayinemiphumela ebalulekile yokulwa nokuvuvukala kumagundane anokuvuvukala okubangelwa. Abacwaningi baphethe ngokuthi i-evodiamine ingase ibe ukwelashwa okungokwemvelo okuwusizo kwezifo ezivuthayo. Olunye ucwaningo kujenali i-Phytomedicine luthole ukuthi i-evodiamine inemiphumela enamandla yokulwa nokuvuvukala emasikweni amaseli, okuphakamisa ukuthi ingase futhi ibe ukwelashwa okuphumelelayo kokuvuvukala kubantu.
3.Isiza impilo yenhliziyo nemithambo yegazi
I-Evodiamine iboniswe ukuthi inezici ze-vasodilatory, okusho ukuthi ingasiza ukuphumula nokwandisa imithambo yegazi, ngaleyo ndlela ithuthukise ukugeleza kwegazi. Lokhu kunenzuzo ikakhulukazi kubantu abanomfutho wegazi ophakeme, njengoba kungasiza ekunciphiseni umsebenzi wenhliziyo futhi kunciphise ingozi yezinkinga ezinjengohlangothi noma isifo senhliziyo.
Ukwengeza, i-evodiamine iye yacwaningwa ngekhono layo elinamandla lokunciphisa ukuvuvukala nokucindezeleka okwenziwe nge-oxidative, kokubili okuhlobene kakhulu nokuthuthukiswa kwesifo senhliziyo. Ngokunciphisa lezi zingozi, i-evodiamine ingasiza ukuvikela inhliziyo nemithambo yegazi ekulimaleni nasekungasebenzini kahle. I-Evodiamine itholwe inemiphumela ye-antiplatelet ne-antithrombotic, okusho ukuthi ingasiza ekuvimbeleni amahlule egazi ukuthi akheke. Amahlule egazi angaphazamisa ukugeleza kwegazi futhi aholele ezenzakalweni ezimbi kakhulu zenhliziyo nemithambo yegazi, ngakho ikhono le-evodiamine lokuvimbela ukwakheka kwehlule lingaba nomthelela omkhulu empilweni yenhliziyo nemithambo yegazi.
4.Ukusekela Impilo Yamathumbu
Ucwaningo lubonisa ukuthi i-evodiamine ingase ibe nemiphumela eminingana enenzuzo ohlelweni lwamathumbu. Inezindawo zokulwa nokuvuvukala kanye ne-antioxidant ezisiza ukuvikela isisu nolwelwesi lwamathumbu ekulimaleni okubangelwa ama-radicals mahhala kanye nokuvuvukala. Ngaphezu kwalokho, i-evodiamine iboniswe ukuthi inemiphumela elwa namagciwane futhi ingasiza ekukhuthazeni ibhalansi enempilo yama-bacteria amathumbu futhi inciphise ingozi yokutheleleka kwesisu.
Ngaphezu kwalokho, i-evodiamine itholakale inezindawo zokulwa nezilonda, isiza ukunciphisa ingozi yezilonda zesisu nezinye izifo zesisu. Ngokukhuthaza ubuqotho bolwelwesi lwe-mucosal nokuvimbela ukukhishwa kwe-asidi ngokweqile, i-evodiamine ingasiza ukuvikela isisu namathumbu emonakalweni nokucasuka.
5.Ezinye izinzuzo zezempilo
I-Evodiamine inamandla okulawula amazinga kashukela egazini. Amazinga aphezulu kashukela egazini angaholela ezinhlobonhlobo zezinkinga zempilo, kuhlanganise nesifo sikashukela nesifo senhliziyo. Ucwaningo lubonisa ukuthi i-evodiamine ingasiza ekuthuthukiseni ukuzwela kwe-insulin futhi ilawule amazinga kashukela egazini, iyenze ibe ithuluzi elibalulekile kunoma ubani ofuna ukugcina amazinga kashukela egazi enempilo.
Ngaphezu kwekhono layo lokulawula amazinga kashukela egazini, i-evodiamine nayo itholakale inciphisa amazinga e-cholesterol. Amazinga aphezulu e-cholesterol anyusa ingozi yesifo senhliziyo nesifo sohlangothi, ngakho-ke ukuthola izindlela zemvelo zokwehlisa amazinga e-cholesterol kubalulekile ekugcineni impilo yakho yonke. I-Evodiamine ikhonjiswe ukunciphisa amazinga e-LDL cholesterol ("cholesterol embi") ngenkathi ikhulisa amazinga e-HDL cholesterol (ebizwa nangokuthi "enhle" cholesterol).
Ukwengeza, i-evodiamine itholakele ukwandisa amazinga wamandla jikelele. Ezweni lanamuhla elisheshayo, abantu abaningi bahlushwa amandla amancane nokukhathala. I-Evodiamine ikhonjiswe ukuthi yandisa i-metabolism kanye nezindleko zamandla, ngaleyo ndlela ikhulise amazinga wamandla ngokwemvelo. Lokhu kunenzuzo ikakhulukazi kubasubathi nanoma ubani ofuna ukuthuthukisa amandla abo kanye namandla.
Uma uqhathanisa izithako ze-evodiamine, into yokuqala okufanele uyicabangele umthombo we-evodiamine. Kubalulekile ukukhetha isengezo esisebenzisa ikhwalithi ephezulu, i-evodiamine ehlanzekile ekhishwe emthonjeni onedumela elihle. Bheka imikhiqizo ehloliwe evela eceleni futhi inesitifiketi sokuhlaziya ukuze uqinisekise ubumsulwa namandla.
Esinye isici esibalulekile okufanele sicatshangelwe umthamo we-evodiamine esengezo. Umthamo onconyiwe we-evodiamine ungahluka kuye ngomuntu kanye nemigomo yakhe yezempilo ethile. Ezinye izithasiselo zingaqukatha ukugxila okuphezulu noma okuphansi kwe-evodiamine, ngakho-ke kubalulekile ukukhetha ehlangabezana nezidingo zakho nokuncamelayo.
Ngokungeziwe kokuqukethwe kwe-evodiamine, kubalulekile ukucabangela ezinye izithako ezisesengezo sakho. Ezinye izithako ze-evodiamine zingaqukatha ezinye izithako, ezifana ne-black pepper extract noma i-green tea extract.
Ukwengeza, uhlobo lwesengezo lungenye into ebalulekile yokucatshangelwa. Izithasiselo ze-Evodiamine zitholakala ngezindlela ezehlukene, okuhlanganisa amaphilisi, izimpushana, nezithako zokuthambisa. Khetha ifomethi elula nelula ukuyifaka empilweni yakho yansuku zonke. Isibonelo, uma unenkinga yokugwinya amaphilisi, impushana ingaba inketho engcono kuwe.
Kubalulekile futhi ukucabangela ikhwalithi lapho ukhetha isithasiselo se-evodiamine. Bheka umkhiqizi osesidlangalaleni onomlando wokukhiqiza izithasiselo zekhwalithi ephezulu kanye nokubuyekezwa okuhle kwamakhasimende. Cwaninga izinqubo zokukhiqiza zomkhiqizo kanye nezinyathelo zokulawula ikhwalithi ukuze uqinisekise ukuthi uthola umkhiqizo ophephile nothembekile.
Okokugcina, lapho ukhetha isithasiselo se-evodiamine, cabanga ngezinhloso zakho zezempilo kanye nanoma yikuphi ukukhathazeka okuthile kwezempilo. Abanye abantu bangase babe nesithakazelo ku-evodiamine yokulawula isisindo, kuyilapho abanye bangase bafune ukusekela impilo yokugaya ukudla noma impilo yonke. Futhi, thintana nochwepheshe bezokunakekelwa kwempilo ngaphambi kokuqala noma yiluphi uhlobo lwemithi yokwengeza, ikakhulukazi uma unesimo sezempilo esikhona noma uthatha imithi.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Umbuzo: Iyini i-evodiamine?
A: I-Evodiamine iyinhlanganisela yemvelo etholakala esithelweni sesitshalo se-Evodia rutaecarpa, Sekungamakhulu eminyaka isetshenziswa emithini yendabuko yamaShayina futhi yaziwa ngezinzuzo zayo zezempilo ezingaba khona.
Q: Yiziphi izinzuzo ezingaba khona ze-evodiamine supplements?
A: Izithako ze-Evodiamine kukholakala ukuthi zinezinhlobonhlobo zezinzuzo zezempilo ezingaba khona, okuhlanganisa ukusekelwa kokulawulwa kwesisindo, umzimba, kanye nokuphila kahle jikelele. Ukwengeza, bangase babe ne-anti-inflammatory kanye ne-antioxidant.
Q: Kufanele ngizihlanganise kanjani izithasiselo ze-evodiamine ohlelweni lwami lwezempilo kanye nokudla?
IMP: Ngaphambi kokufaka noma yisiphi isithasiselo esisha ohlelweni lwakho lwezempilo kanye nokudla, kubalulekile ukubonisana nochwepheshe bezempilo. Bangakusiza ukuthi unqume umthamo ofanele futhi uhlole noma yikuphi ukusebenzelana okungaba khona neminye imithi noma izithasiselo ongase uzithathe.
Q: Ingabe ikhona imiphumela emibi engaba khona yezithako ze-evodiamine?
A: Nakuba izithako ze-evodiamine ngokuvamile zibhekwa njengeziphephile kubantu abaningi uma zithathwa ngemithamo efanelekile, abanye abantu bangase babe nemiphumela engemihle efana nokucasuka kokugaya ukudla noma ukucasuka. Kubalulekile ukulandela umthamo onconyiwe futhi uqaphe impendulo yomzimba wakho esithasiselweni.
Q: Ingabe zikhona izindlela zokuphepha okufanele uzicabangele lapho uthatha izithasiselo ze-evodiamine?
IMPENDULO: Uma ukhulelwe, umhlengikazi, noma unezimo zempilo ezicashile, kubalulekile ukukhuluma nochwepheshe bezempilo ngaphambi kokuthatha izithasiselo ze-evodiamine. Ukwengeza, kubalulekile ukuthenga izithasiselo emthonjeni onedumela elihle ukuze uqinisekise ikhwalithi nokuphepha.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Feb-02-2024
