Ezweni lanamuhla elisheshayo, kubalulekile ukubeka kuqala impilo nenhlalakahle yethu. Njengoba kunezinhlelo ezimatasa nezindlela zokuphila ezimatasa, kungaba inselele ukuqinisekisa ukuthi sinikeza imizimba yethu imisoco eyidingayo ukuze isebenze kahle. Yilapho kungena khona izithako ze-spermidine. I-Spermidine iyinhlanganisela ye-polyamine etholakala kuwo wonke amangqamuzana aphilayo futhi idlala indima ebalulekile ekugcineni ukusebenza kwamangqamuzana nempilo. Ukwengeza nge-spermidine kungasiza ukusekela ukuvuselelwa kwamangqamuzana, ukuthuthukisa impilo yenhliziyo nemithambo yegazi, futhi kusize nokusebenza kwengqondo, okwenza le nhlanganisela yemvelo ibe isengezo esibalulekile empilweni yakho yansuku zonke.
I-Spermidine iyi-polyamine eyenzeka ngokwemvelo etholakala kuwo wonke amangqamuzana aphilayo, kuhlanganise nezitshalo nezilwane. Idlala indima ebalulekile emisebenzini ehlukahlukene yamangqamuzana, okuhlanganisa ukukhula kwamangqamuzana, ukwanda nokuguga, futhi njengoba sikhula, amazinga e-spermidine emizimbeni yethu ayancipha.
Ngokuyisisekelo, i-autophagy iyindlela yokugcina indlu yamaselula evumela umzimba ukuthi usule ama-organelles agugile, amaprotheni aphihliwe, nezinye izibi zamaselula. Ngokwenza kanjalo, kusiza ukugcina ubuqotho bamangqamuzana nezicubu zethu, ukuqinisekisa umsebenzi wabo ophelele. Kodwa-ke, izinzuzo ze-autophagy zidlulela ngalé kokunakekelwa, njengoba le nqubo iboniswe ukuthi idlala indima yokuvikela ezifundeni zezifo ezihlukahlukene. Isibonelo, ucwaningo luphakamisa ukuthi i-autophagy ethuthukisiwe ingasiza ekwehliseni ukuqhubekela phambili kwezifo ze-neurodegenerative njenge-Alzheimer's kanye nesifo sika-Parkinson ngokususa amaphrotheni anobuthi aggregate abangela ukulimala kwezinzwa.
Ngaphezu kwalokho, i-autophagy ihlobene nokulawulwa kwe-metabolism yamandla omuntu, ikakhulukazi ngezikhathi zokuntuleka kokudla okunomsoco noma ukucindezeleka kwe-metabolic. Uma kungabikho izakhi ezanele, amaseli angathembela ku-autophagy ukuze aphule izingxenye zawo futhi akhiqize uphethiloli odingekayo ukuze kugcinwe imisebenzi eyisisekelo yamaselula. Le mpendulo eguquguqukayo ivumela umzimba ukuthi ubhekane nezikhathi zokuzila ukudla noma ukukhawulelwa kwekhalori, futhi ingase ibe nomthelela ezinzuzweni zezempilo ezibonwa ngokuzila ukudla okunesikhashana noma ukudla okune-ketogenic, okuboniswe ukuthi kukhuthaza i-Autophagy.
Ucwaningo lubonisa ukuthi i-spermidine ingasiza ekusekeleni inqubo yemvelo ye-autophagy yomzimba, inqubo yeselula esusa amangqamuzana awonakele noma amadala ukuze kuvuleke amasha. Ngokukhuthaza i-autophagy, izithako ze-spermidine zingasiza ukusekela ukuguga okunempilo nokuphila isikhathi eside.
Ukwengeza, izithako ze-spermidine ziye zaboniswa ukuthi zinezinzuzo ezingase zibe nempilo yenhliziyo. Ucwaningo lubonisa ukuthi i-spermidine ingasiza ukugcina umfutho wegazi onempilo, amazinga e-cholesterol kanye nempilo yonke yenhliziyo. Ukwengeza, i-spermidine itholakale inezakhiwo ze-antioxidant ezingasiza ukuvikela umzimba ekucindezelekeni kwe-oxidative nokuvuvukala.
I-Spermidine iyinhlanganisela yemvelo etholakala ekudleni okufana nobhontshisi wesoya, amakhowe, noshizi osekhulile. Ngenxa yemiphumela engaba khona yokulwa nokuguga. Ucwaningo lubonisa ukuthi i-spermidine ingasiza ekukhuthazeni ukuvuselelwa kwamangqamuzana nezicubu, okubalulekile ekugcineni ukubukeka kwentsha kanye nempilo yonke.
Enye yezindlela eziyinhloko i-spermidine enciphisa inqubo yokuguga iwukwenza inqubo ye-autophagy. I-Autophagy yindlela yomzimba yokukhipha amaseli awonakele noma amadala futhi esikhundleni sawo kufakwe amaseli amasha, anempilo. Njengoba sikhula, inqubo yemvelo ye-autophagy yomzimba wethu iyancipha, okuholela ekuqoqweni kwamaseli nezicubu ezilimele. I-Spermidine iboniswe ukuthuthukisa i-autophagy, engasiza ekuvimbeleni ukwehla okuhlobene neminyaka ekusebenzeni kweseli.
Ngaphezu kokukhuthaza i-autophagy, i-spermidine iboniswe ukuthi inezindawo zokulwa nokuvuvukala kanye ne-antioxidant. Ukuvuvukala okungapheli kanye nokucindezeleka okwenziwe nge-oxidative yizici ezimbili ezinkulu enqubweni yokuguga, futhi ikhono le-spermidine lokubhekana nale miphumela lingase lisize ukuguga kancane ezingeni lamaselula.
1. Umphumela wokuguga
I-Spermidine iyinhlanganisela ye-polyamine etholakala ekudleni okuhlukahlukene, njengegciwane likakolweni, ubhontshisi wesoya, nezinhlobo ezithile zamakhowe. Idlala indima ebalulekile ekukhuleni kwamangqamuzana nasekuhlukaneni nasekugcinweni kokusebenza kwamaseli. Njengoba sikhula, imizimba yethu ngokwemvelo ikhiqiza i-spermidine encane, engaholela ekwehleni kwempilo nokusebenza kwamaseli.
Ucwaningo lubonisa ukuthi ukwesekwa kwe-spermidine kungase kube nemiphumela yokulwa nokuguga ezitho nezinhlelo ezihlukahlukene emzimbeni. Ucwaningo olushicilelwe kumagazini i-Nature Medicine lwathola ukuthi ukwesekwa kwe-spermidine kwakuhlotshaniswa nokuphila okunwetshiwe kanye nempilo yenhliziyo ethuthukisiwe kumagundane. Ukwengeza, i-spermidine ikhonjiswe ukuthi ikhuthaza i-autophagy, indlela yemvelo yomzimba yokususa amangqamuzana alimele futhi ivuselele amasha. Ngokukhuthaza le nqubo, i-spermidine ingasiza ekubambezeleni inqubo yokuguga, okubalulekile ekugcineni amangqamuzana amancane, anempilo.
2. Thuthukisa impilo yenhliziyo nemithambo yegazi
Ucwaningo oluningana luphenye ukuxhumana okungaba khona phakathi kwe-spermidine nempilo yenhliziyo, kube nemiphumela ekhuthazayo. Ucwaningo olushicilelwe kumagazini i-Nature Medicine luthole ukuthi amagundane adla ukudla okuphezulu kwe-spermidine athuthukise ukusebenza kwenhliziyo futhi aphila isikhathi eside ngama-25%. Olunye ucwaningo olwanyatheliswa kuyi-Journal of the American Heart Association lwathola ukuthi amazinga aphezulu e-spermidine okudla ahlotshaniswa nengozi ephansi yokuhluleka kwenhliziyo kubantu.
I-Spermidine ine-antioxidant ne-anti-inflammatory properties, ebalulekile ekugcineni impilo yenhliziyo. Ukucindezeleka kwe-oxidative nokuvuvukala yizici ezaziwa ngokufaka isandla ekuthuthukiseni isifo senhliziyo, futhi ngokunciphisa lezi zinqubo, i-spermidine ingasiza ekuthuthukiseni impilo yenhliziyo ngokunciphisa ingozi yesifo senhliziyo nokuthuthukisa umsebenzi wenhliziyo yonke. Ucwaningo olwengeziwe lubonisa ukuthi i-spermidine ingasiza ekuvimbeleni i-atherosclerosis, isifo lapho i-plaque yakheka emithanjeni, okuholela engozini enkulu yokuhlaselwa yinhliziyo nesifo sohlangothi.
Ucwaningo olushicilelwe kumagazini i-Nature Medicine lwathola ukuthi ukufaka amagundane nge-spermidine kunciphisa ukwakheka kwe-atherosclerotic plaque futhi kwathuthukisa impilo yonke yenhliziyo. Lokhu kuwubufakazi obuthembisayo bokuthi i-spermidine inomphumela ovikelayo enhliziyweni.
Ngaphezu kwezinzuzo zayo ezingase zibe khona ekuvimbeleni i-atherosclerosis, i-spermidine nayo iboniswe ukuthi inemiphumela emihle ekusebenzeni kwenhliziyo. Ucwaningo luthole ukuthi ukwesekwa kwe-spermidine kuthuthukisa ikhono lenhliziyo lokufinyela nokuphumula, okubalulekile ekugcineni ukugeleza kwegazi okunempilo nokusebenza okuphelele kwenhliziyo.
3. Thuthukisa ukusebenza kwengqondo
Ucwaningo lubonisa ukuthi i-spermidine ingase idlale indima ebalulekile ekusekeleni umsebenzi wokuqonda. I-Spermidine inemiphumela ye-neuroprotective, kuhlanganise nokuthuthukisa ukusebenza kwengqondo nokunciphisa ingozi yokuncipha kwengqondo okuhlobene neminyaka. Lezi yizindaba ezithokozisayo ikakhulukazi kubantu asebekhulile, njengoba ukugcina ukusebenza kwengqondo njengoba sikhula kuyinto ebalulekile kubantu abaningi.
Ngaphandle kwemiphumela yayo yokuthuthukisa impilo yobuchopho, i-spermidine iboniswe ukuthi inezindawo zokulwa nokuvuvukala kanye ne-antioxidant, kokubili okubalulekile ekugcineni impilo yobuchopho. Ukuvuvukala okungapheli kanye nokucindezeleka okwenziwe nge-oxidative kucatshangwa ukuthi kunomthelela ekwehleni kwengqondo, ngakho ikhono le-spermidine lokulwa nalezi zici lingaba nomthelela omkhulu empilweni yobuchopho.
4. Amazinga aphansi kashukela egazini
Ucwaningo lubonisa ukuthi i-spermidine ingase ibambe iqhaza ekuthuthukiseni ukuzwela kwe-insulin, okubalulekile ekugcineni amazinga kashukela egazini enempilo. Ukuzwela kwe-insulin kubhekisela emandleni omzimba okusabela ku-insulin, ihomoni enomthwalo wemfanelo wokulawula ushukela osegazini. Lapho umzimba ungazwela kakhulu ku-insulin, amazinga kashukela egazini ayakhuphuka, okuholela ezinhlobonhlobo zezinkinga zempilo ezihlanganisa isifo sikashukela nesifo senhliziyo.
Ucwaningo olushicilelwe kumagazini i-Nature Communications lwathola ukuthi ukwesekwa kwe-spermidine kuthuthukisa ukuzwela kwe-insulin kubantu abadala abaneminyaka ephakathi nendawo. Abahlanganyeli abathatha i-spermidine izinyanga ezintathu bathola ukuthuthukiswa okuphawulekayo kumazinga kashukela egazini uma kuqhathaniswa nalabo abathatha indawo ye-placebo. Lokhu okutholakele kusikisela ukuthi i-spermidine ingaba yithuluzi elithembisayo lokulawula amazinga kashukela egazini, ikakhulukazi kulabo abasengozini yokuba nesifo sikashukela.
Ngakho-ke i-spermidine iwusebenzisa kanjani umphumela wayo emazingeni kashukela egazini? Enye indlela engenzeka ikhono layo lokuthuthukisa i-autophagy—inqubo yemvelo yomzimba yokubhidliza nokuvuselela amangqamuzana amadala noma alimele. I-Autophagy idlala indima ebalulekile ekugcineni impilo nokusebenza kwamaseli, futhi ukungasebenzi kahle kwale nqubo kuye kwaxhunyaniswa nokumelana ne-insulin nesifo sikashukela. I-Spermidine ikhonjiswe ukuthuthukisa i-autophagy, engathuthukisa ukuzwela kwe-insulin nokulawulwa kwe-glycemic.
5. Ukwesekwa kwamasosha omzimba
Ucwaningo luye lwathola ukuthi i-spermidine ingasekela amasosha omzimba futhi isize umzimba ukulwa nezifo nesifo. Isebenza ngokukhuthaza ukukhiqizwa nokusebenza kwamangqamuzana omzimba omzimba, kanye nokunciphisa ukuvuvukala emzimbeni. Lokhu kusiza ukuthuthukisa ukusebenza komzimba jikelele futhi kunciphise ukugula.
I-Spermidine, inhlanganisela ye-polyamine etholakala kuwo wonke amangqamuzana aphilayo, idume ngezinzuzo zayo zezempilo ezingase zibe khona, okuhlanganisa ukulwa nokuguga kanye nokuqinisa amasosha omzimba. Abantu abaningi baqala ukusebenzisa izithasiselo ze-spermidine ukuze bafake le nhlanganisela esimisweni sabo sansuku zonke. Kodwa kuthatha isikhathi esingakanani ukuthi i-spermidine isebenze?
I-Spermidine isebenza ngokwenza inqubo emangqamuzaneni ebizwa ngokuthi i-autophagy, okuyindlela yomzimba yokususa amangqamuzana alimele futhi avuselele amasha. Le nqubo ibalulekile ekugcineni impilo yamangqamuzana futhi kucatshangwa ukuthi idlala indima enqubweni yokuguga. Ngokuthuthukisa i-autophagy, i-spermidine ingasiza ekukhuthazeni ukuvuselelwa kwamangqamuzana, ithuthukise impilo yonke, futhi ibambezele inqubo yokuguga.
Uma kuziwa esikhathini sokusebenza kwe-spermidine, kubalulekile ukucabangela ukuthi izimpendulo zomuntu ngamunye zingahluka. Izinto ezinjengobudala, impilo yonke, kanye nomthamo konke kungathinta ukuthi i-spermidine ithatha isikhathi esingakanani ukusebenza. Abanye abantu bangase baqaphele imiphumela ngokushesha, kuyilapho abanye kungase kuthathe isikhathi eside ukuthola izinzuzo.
Ngokuvamile, ucwaningo lubonisa ukuthi ukwesekwa kwe-spermidine kungaveza imiphumela ebonakalayo phakathi kwamasonto kuya ezinyangeni. Ucwaningo lwango-2018 olwanyatheliswa kumagazini i-Nature Medicine lwathola ukuthi ukwesekwa kwe-spermidine kuthuthukisa ukusebenza kwenhliziyo nokwandisa isikhathi sokuphila kumagundane amadala. Nakuba lolu cwaningo lwenziwe kumagundane, luhlinzeka ngemininingwane ebalulekile emiphumeleni engaba khona ye-spermidine ezinqubweni ezihlobene nokuguga.
Ucwaningo lwabantu lwango-2018 olushicilelwe kumagazini Ukuguga luphinde lwabonisa izinzuzo zokungezelelwa kwe-spermidine. Ucwaningo luthole ukuthi abantu abathathe izithasiselo ze-spermidine izinyanga ezintathu bathole intuthuko kumfutho wegazi kanye nempilo yenhliziyo nemithambo yegazi uma kuqhathaniswa nalabo abangazange bazithathe lezi zithako.
1. Thola izinto zokusetshenziswa zekhwalithi ephezulu
Lapho ukhetha isengezo se-spermidine, kufanele uhlole ngokucophelela izithako zayo. Bheka isithasiselo esingenawo ama-fillers, imibala yokwenziwa, nama-preservatives. Ngokufanelekile, izithasiselo kufanele zenziwe ngemithombo ye-organic kanye ne-non-GMO ukuze kuqinisekiswe ubumsulwa namandla.
2. Cabangela umthombo we-spermidine
I-Spermidine ingatholakala emithonjeni yemvelo ehlukahlukene, njengegciwane likakolweni, ubhontshisi wesoya, nembewu yethanga, kanye nezinhlanganisela zokwenziwa ezibhekana nezinqubo zokucwengisiswa. Izinzuzo zomthombo ngamunye zingahluka kancane, ngakho-ke kubalulekile ukucabangela umthombo we-spermidine ku-supplement yakho. Abanye abantu bangase babe nomzimba noma bangazweli izithako ezithile, ngakho-ke kubalulekile ukukhetha isithasiselo esihlangabezana nezidingo zakho zokudla.
3. Hlola okuqukethwe kwe-spermidine
Ukusebenza kwezithako ze-spermidine kuyehluka kumkhiqizo kuye komunye. Kubalulekile ukuhlola okuqukethwe kwe-spermidine ekuphakeni ngakunye ukuze uqinisekise ukuthi uthola umthamo osebenzayo. Bheka izithasiselo ezihlinzeka ngamanani anele e-spermidine ukusekela imigomo yakho yezempilo. Futhi cabanga nge-bioavailability ye-spermidine, njengoba lokhu kuthinta ukuthi imuncwa kahle futhi isetshenziswa kanjani ngumzimba.
4. Linganisa ikhwalithi nedumela lomkhiqizo
Lapho ukhetha isengezo se-spermidine, kubalulekile ukucabangela idumela lomkhiqizi. Bheka inkampani ezibophezele kwikhwalithi, obala, nokuphepha. Cwaninga izinqubo zokukhiqiza zomkhiqizo, izitifiketi, nokubuyekezwa kwamakhasimende ukuze ukale ikhwalithi iyonke yemikhiqizo yalo.
5. Xhumana nochwepheshe bezempilo
Kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokufaka noma yiziphi izithasiselo ezintsha ohlelweni lwakho lwansuku zonke, ikakhulukazi uma unezimo zempilo ezicashile noma uphuza imithi. Bangakunikeza isiqondiso nezeluleko eziqondene nawe ngokusekelwe ezidingweni zakho ezithile zezempilo.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Umbuzo: Iyini i-spermidine futhi kungani ibalulekile empilweni?
A: I-Spermidine i-polyamine eyenzeka ngokwemvelo edlala indima ebalulekile ezinqubweni ezihlukahlukene zamaselula, okuhlanganisa i-autophagy kanye ne-protein synthesis. Kuye kwaboniswa ukuthi kunezindawo zokulwa nokuguga nezikhuthaza impilo, okwenza kube yingxenye ebalulekile yokuphila kahle okuphelele.
Q: Ngingawafaka kanjani ama-spermidine supplements esimisweni sami sansuku zonke?
A: Izithako ze-Spermidine zitholakala ngezindlela ezihlukahlukene, kuhlanganise amaphilisi, izimpushana, nemithombo yokudla efana negciwane likakolweni nobhontshisi wesoya. Ungakwazi ukuzifaka ohlelweni lwakho lwansuku zonke ngokuzithatha njengoba kuqondiswe emaphaketheni, noma ngokungeza ukudla okune-spermidine ekudleni kwakho.
Q: Kuthatha isikhathi esingakanani ukubona izinzuzo ze-spermidine supplementation?
A: Umugqa wesikhathi wokuthola izinzuzo ze-spermidine supplementation ungahluka kumuntu nomuntu. Abanye abantu bangase baqaphele ukuthuthuka empilweni yabo yonke phakathi kwamaviki ambalwa okusebenzisa njalo, kuyilapho abanye kungase kuthathe isikhathi eside ukubona imiphumela.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Jan-24-2024
