I-N-acetyl-L-cysteine ethyl ester (NACET) iwuhlobo olushintshiwe lwe-amino acid cysteine futhi ine-antioxidant enamandla, i-hepatoprotective, neuroprotective kanye nezindawo zokulwa nokuvuvukala. Ikhono layo lokwandisa ukukhiqizwa kwe-glutathione, ukuvikela isibindi, ukulawula ama-neurotransmitters nokunciphisa ukuvuvukala kwenza kube isakhi esithembisayo empilweni nasemthini. I-NACET, ngakolunye uhlangothi, iwukuphuma kwe-ethyl ester ye-NAC, okucatshangwa ukuthi yandisa i-bioavailability kanye nokusebenza kahle okuphelele kwe-NAC njengesithuthukisi sokuqonda. Sekukonke i-N-acetyl-L-cysteine ethyl ester ibonisa isithembiso esihle ekukhuthazeni impilo yonke kanye nokubhekana nezimo ezihlukahlukene zempilo.
I-N-Acetyl-L-cysteine ethyl ester, evame ukwaziwa nge-NACET noma i-N-acetylcysteine ethyl ester, iwuhlobo olulungisiwe lwe-amino acid L-cysteine. Itholakala ku-N-acetylcysteine (NAC) ngokungeza iqembu le-ethyl ester. I-L-cysteine ivela ngokwemvelo ekudleni okufana namaqanda, izinkukhu, nemikhiqizo yobisi. I-NACET yaziwa ngezici zayo ezinamandla zokulwa ne-antioxidant futhi isetshenziswa njengesengezo sokudla ukusekela impilo nempilo yonke.
I-NACET yaziwa kabanzi ngekhono layo lokukhulisa amazinga e-glutathione emzimbeni. I-Glutathione iyi-antioxidant enkulu futhi i-molecule ebalulekile yezinqubo ezihlukahlukene zamaselula. Isiza ukuqeda amandla ama-radicals mahhala futhi ivikele amangqamuzana ethu ekucindezelekeni kwe-oxidative. Ngokwandisa amazinga e-glutathione, i-NACET iluqinisa ngempumelelo uhlelo lokuzivikela lokulwa ne-antioxidant lomzimba.
I-NACET inyusa amazinga e-glutathione, isekela impilo yesibindi, futhi ibonise amandla okuthuthukisa ukusebenza kwengqondo. Ngokuthuthuka kwayo kwe-bioavailability, i-NACET inikeza inketho ephumelelayo kubantu abafuna ukusekela impilo nokuphila kahle iyonke.
Ukucindezeleka kwe-oxidative kwenzeka lapho kunokungalingani phakathi kwama-radicals mahhala nama-antioxidants emzimbeni. Ama-radicals wamahhala angama-molecule asebenza kakhulu angalimaza amangqamuzana futhi abe nomthelela ekwakhiweni kwezifo ezahlukahlukene, kubandakanya nesifo senhliziyo kanye nezifo ze-neurodegenerative. I-NACET isiza ukuvikela umzimba ekucindezelekeni kwe-oxidative.
I-Glutathione ingelinye lama-antioxidants anamandla akhiqizwa ngokwemvelo ngumzimba. Idlala indima ebalulekile enqubweni yokukhipha ubuthi kanye nokusebenza kwamasosha omzimba. I-NACET ikhuthaza impilo nokuphila kahle isiyonke ngokwandisa amazinga e-glutathione futhi ithuthukise ukukhiqizwa kwe-glutathione ukusiza umzimba ukhiphe ubuthi nezinto eziyingozi ngendlela ephumelelayo.
I-NACET ingasiza ukulawula amazinga ama-neurotransmitters ebuchosheni, njenge-dopamine ne-glutamate, adlala indima ebalulekile ekulawulweni kwemizwelo nasekuluthweni.
1. Izakhiwo ezinamandla ze-antioxidant
I-NACET inamandla okulwa ne-antioxidant, futhi izakhiwo zayo ze-antioxidant ziyenza ibe isengezo esihle kakhulu kubantu abafuna ukuvimbela ukulimala kwamaseli okubangelwa ingcindezi ye-oxidative. Phakathi kwazo, ama-antioxidants anciphisa ama-radicals mahhala ayingozi emizimbeni yethu, avikele amangqamuzana ethu emonakalweni futhi anciphise ingozi yezifo ezingamahlalakhona. Ngokulwa nengcindezi ye-oxidative, i-NACET ingasiza ekukhuthazeni ukuguga okunempilo, isekele impilo yenhliziyo, futhi isize ukuqinisa amasosha omzimba.
2. Impilo yengqondo
Iqhaza le-NACET empilweni yengqondo lithola ukunakwa okukhulayo. Ucwaningo luphakamisa ukuthi le nhlanganisela ingaba nezakhiwo zokulwa nokuvuvukala ezingaba nomthelela omuhle empilweni yobuchopho. Ukwengeza, ngokukhuthaza ukuhlanganiswa kwe-glutathione, i-antioxidant ebalulekile, i-NACET isiza ukwehlisa ukulimala kwe-neuronal futhi ingasiza ukuthuthukisa ukusebenza kwengqondo. Ezinye izifundo zize ziphakamise ukuthi i-NACET ingasiza ekwelapheni ukuphazamiseka kwemizwa okufana nokudangala nokukhathazeka.
3. Ukwesekwa kwesibindi nokukhishwa ubuthi
Isibindi sethu sinesibopho sokususa ubuthi obuyingozi emzimbeni. I-NACET ibonisa isithembiso ekukhuthazeni impilo yesibindi ngokusekela izinqubo zokuqeda ubuthi nokunciphisa ukucindezeleka okwenziwe nge-oxidative esibindini. Ngokuthuthukisa ukukhiqizwa kwe-glutathione, i-NACET isiza ukuqeda ubuthi, okungenzeka ivikele isibindi ekulimaleni futhi isekele umsebenzi waso wonke.
4. Thuthukisa ukusebenza kwengqondo
Ucwaningo oluningi luphenye imiphumela ye-NACET emisebenzini yengqondo, okuhlanganisa inkumbulo, ukunaka, nemisebenzi yokuphatha. Uhlolo olulawulwa ngokungahleliwe olwenziwa ithimba labacwaningi luthole ukuthi ukwesekwa kwe-NACET kuthuthukisa kakhulu ukusebenza kwengqondo kanye nenkumbulo yokusebenza kubantu abadala abanempilo.
Kukholakala ukuthi imiphumela enenzuzo ye-NACET ekusebenzeni kwengqondo ingase ibangelwe amandla ayo okulawula amazinga e-glutamate ebuchosheni. I-Glutamate iyi-neurotransmitter ebalulekile ehilelekile ekufundeni nasekukhumbuleni izinqubo. Ngokulawula amazinga e-glutamate, i-NACET ithuthukisa ukuxhumana phakathi kwezifunda zobuchopho, ngaleyo ndlela ithuthukise ukusebenza kwengqondo.
Ukwengeza, ucwaningo luphakamisa ukuthi i-NACET ingaba nezakhiwo ze-neuroprotective ezingasiza ukuthuthukisa ukusebenza kwengqondo. Ifundelwe amandla ayo ekwelapheni izifo ze-neurodeergenerative njenge-Alzheimer's kanye nesifo sikaParkinson.
1. Imithombo yokudla
Nakuba imithombo yokudla yemvelo ingenawo amanani abalulekile e-N-acetyl-L-cysteine ethyl ester, iqukethe i-cysteine, eguqulelwa ku-NACET emzimbeni. Ukudla okucebile nge-cysteine kuhlanganisa izinkukhu, amaqanda, imikhiqizo yobisi, ubhontshisi, u-garlic, u-anyanisi, i-broccoli kanye namahlumela aseBrussels. Ukufaka lokhu kudla ekudleni kwakho kungasiza ukuqinisekisa ukutholakala okwanele kwe-cysteine, esekela ukukhiqizwa kwe-NACET emzimbeni.
2. Izithako zokudla
Izithasiselo zingenye indlela ethembekile yokuthola i-N-acetyl-L-cysteine ethyl ester. Ungathola izithasiselo ze-NACET ngezindlela eziningi, okuhlanganisa amaphilisi, amaphilisi, noma impushana. Kubalulekile ukuqaphela ukuthi ngaphambi kokwengeza noma yiziphi izithasiselo ezintsha esimisweni sakho sansuku zonke, kutuswa ukuthi uthintane nochwepheshe bezempilo ukuze uqinisekise ukuthi kuyahambisana nesimo sakho sezempilo samanje.
Funda nge-NAC
I-N-Acetyl Cysteine, evame ukubizwa ngokuthi i-NAC, iyi-antioxidant enamandla futhi isandulela ku-glutathione, i-antioxidant eyinhloko yomzimba. Ngamandla ayo anamandla okukhipha ama-radicals mahhala futhi asekele isibindi, i-NAC idume ngezinzuzo zayo eziningi zezempilo. Kusukela empilweni yokuphefumula kuye ekukhishweni kwesibindi, i-NAC isiphenduke isengezo kubantu abahlose ukuthuthukisa impilo yabo yonke.
Ukukhuphuka kwe-NAC ethyl ester
I-NAC ethyl ester iphuma ku-NAC futhi iyathuthukiswa njengendlela engase ibe ngcono kusukela kumanduleli wayo. Inqubo ye-esterification ishintsha ukwakheka kwamangqamuzana e-NAC, ikhulise i-bioavailability yayo futhi ikhuthaze ukungena kwezicubu okuphakeme.
I-Bioavailability kanye nokumuncwa
Isici esibalulekile ekuqhathaniseni i-NAC ne-NAC ethyl ester i-bioavailability yazo nezinga lokumunca. I-NAC ingabhekana nezinselele ekuweleni imigoqo yezinto eziphilayo futhi ifinyelele emazingeni okwelapha ukuze isuse ubuthi ngempumelelo futhi ivikele amaseli. Uma kuqhathaniswa, i-NAC ethyl ester itholakala kalula futhi ingamuncwa kangcono futhi isetshenziswe emzimbeni. Le ndlela yokulethwa ethuthukisiwe ingase iholele ezinzuzweni ezinkulu lapho iqondiswe ezinkingeni ezithile zezempilo.
I-Glutathione Recovery Efficiency
Inhloso enkulu yokwengeza i-NAC ukukhuthaza ukukhiqizwa kwe-glutathione emzimbeni. I-Glutathione idlala indima ebalulekile ekuvikeleni amaselula ekucindezelekeni kwe-oxidative futhi isekela izinqubo ezihlukahlukene zomzimba. Nakuba i-NAC iqashelwa ngamandla ayo okwandisa amazinga e-glutathione, ucwaningo lubonisa ukuthi i-NAC ethyl ester ingase idlule i-NAC kulokhu. Ukumuncwa okuthuthukisiwe kwe-NAC ethyl ester kungasiza ukubuyisela amazinga e-glutathione ngempumelelo kakhudlwana, kunikeze ukuvikeleka kweselula okuthuthukisiwe.
Umbuzo: Ingabe i-NACET ingathuthukisa ukusebenza kwengqondo?
A: Ezinye izifundo ziphakamisa ukuthi ukwesekwa kwe-NACET kungase kube nemiphumela enenzuzo ekusebenzeni kwengqondo. Ifundwe ngaphansi kwezimo ezifana nesifo i-Alzheimer's, i-Parkinson's, kanye ne-schizophrenia, ebonisa ukuthuthukiswa okungenzeka kwenkumbulo, ukunaka, nemisebenzi yokuphatha. Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukusebenza kahle kwalo kanye nesilinganiso esifanele sokuthuthukisa ingqondo.
Umbuzo: Ngingayithenga kuphi i-NACET?
IMPENDULO: I-NACET itholakala kabanzi njengesithasiselo esitholakala ezitolo ezinkulu emakhemisi, ezitolo zokudla kwezempilo, kanye nasezitolo eziku-inthanethi. Kubalulekile ukuthenga emithonjeni ehloniphekile ukuze uqinisekise ikhwalithi nokuphepha komkhiqizo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Sep-27-2023
