I-Taurine iyi-micronutrient ebalulekile futhi i-aminosulfonic acid eningi. Isatshalaliswa kabanzi ezicutshini nasezithweni ezahlukahlukene emzimbeni. Itholakala kakhulu esimweni samahhala ku-interstitial fluid kanye noketshezi lwangaphakathi kweseli. Ngoba yaqala ukuba khona ku-Bile. I-Taurine yengezwa eziphuzweni ezisebenzayo ezivamile ukuze igcwalise amandla futhi ithuthukise ukukhathala.
Muva nje, ucwaningo nge-taurine lushicilelwe emaphephandabeni amathathu aphezulu i-Science, Cell, and Nature. Lezi zifundo zembule imisebenzi emisha ye-taurine - ukulwa nokuguga, ukuthuthukisa umphumela wokwelashwa komdlavuza, kanye nokulwa nokukhuluphala ngokweqile.
NgoJuni 2023, abacwaningi abavela kwiNational Institute of Immunology eNdiya, eColumbia University e-United States, nakwezinye izikhungo bashicilele amaphepha ephephabhukwini lezemfundo eliphezulu lamazwe ngamazwe iScience. Ucwaningo luphakamisa ukuthi ukuntuleka kwe-taurine kuyimbangela yokuguga. Ukwengeza i-taurine kunganciphisa ukuguga kwama-nematode, amagundane, nezinkawu, futhi kungandisa ngisho nokuphila okunempilo kwamagundane aneminyaka ephakathi ngo-12%. Imininingwane: Isayensi: Amandla angaphezu komcabango wakho! I-Taurine ingaphinde iguqule ukuguga futhi yandise ukuphila?
Ngo-Ephreli 2024, uSolwazi Zhao Xiaodi, uSolwazi ohlangene uLu Yuanyuan, uSolwazi Nie Yongzhan, kanye noSolwazi Wang Xin baseSibhedlela iXijing saseFourth Military Medical University bashicilele amaphepha ephephabhukwini lezemfundo eliphezulu lamazwe ngamazwe i-Cell. Lolu cwaningo luthole ukuthi amangqamuzana esimila ancintisana namaseli e-CD8+ T ukuze athole i-taurine ngokukhuphula kakhulu i-taurine transporter i-SLC6A6, ebangela ukufa kwamaseli e-T kanye nokukhathala, okuholela ekubalekeni kwamasosha omzimba wesimila, ngaleyo ndlela kukhuthaze ukuqhubeka kwesimila kanye nokuphindaphinda kwaso, kuyilapho ukwengeza i-Taurine kungavuselela amaseli e-CD8+ T aphelelwe amandla futhi kuthuthukise ukusebenza kahle kokwelashwa komdlavuza.
Ngo-Agasti 7, 2024, ithimba likaJonathan Z. Long waseStanford University (uDkt. Wei Wei ungumbhali wokuqala) lashicilela iphepha locwaningo elinesihloko esithi: I-PTER iyi-N-acetyl taurine hydrolase elawula ukudla kanye nokukhuluphala ephephabhukwini lezemfundo eliphezulu lamazwe ngamazwe i-Nature.
Lolu cwaningo luthole i-N-acetyl taurine hydrolase yokuqala ezincelisayo, i-PTER, futhi lwaqinisekisa indima ebalulekile ye-N-acetyl taurine ekunciphiseni ukudla kanye nokulwa nokukhuluphala. Esikhathini esizayo, kungenzeka ukuthuthukisa izithibi ze-PTER ezinamandla nezikhethayo zokwelapha ukukhuluphala.
I-Taurine itholakala kabanzi ezicutshini zezilwane ezincelisayo kanye nokudla okuningi futhi itholakala ekugxilweni okuphezulu kakhulu ezicutshini ezivuselelwa njengenhliziyo, amehlo, ubuchopho kanye nemisipha. I-Taurine ichazwe njengenemisebenzi yamaseli e-pleiotropic kanye neyomzimba, ikakhulukazi kumongo we-metabolic homeostasis. Ukwehla kwezakhi zofuzo emazingeni e-taurine kuholela ekuwohlokeni kwemisipha, ukwehla kwamandla okuzivocavoca, kanye nokungasebenzi kahle kwe-mitochondrial ezicutshini eziningi. Ukwengezwa kwe-Taurine kunciphisa ukucindezeleka kwe-mitochondrial redox, kuthuthukisa amandla okuzivocavoca, futhi kunciphisa isisindo somzimba.
I-biochemistry kanye ne-enzyme ye-taurine metabolism kudonsele isithakazelo esikhulu socwaningo. Endleleni ye-endogenous taurine biosynthetic, i-cysteine iguqulwa yi-cysteine dioxygenase (CDO) kanye ne-cysteine sulfinate decarboxylase (CSAD) ukuze kukhiqizwe i-hypotaurine, okuthi kamuva i-Oxidation yi-flavin monooxygenase 1 (FMO1) ikhiqize i-taurine. Ngaphezu kwalokho, i-cysteine ingakhiqiza i-hypotaurine ngendlela ehlukile ye-cysteamine kanye ne-cysteamine dioxygenase (ADO). Ngaphansi kwe-taurine ngokwayo kunezinhlobo eziningana ze-taurine metabolites, kufaka phakathi i-taurocholate, i-tauramidine, kanye ne-N-acetyl taurine. I-enzyme kuphela eyaziwa ngokubangela lezi zindlela ezingezansi yi-BAAT, ehlanganisa i-taurine ne-bile acyl-CoA ukukhiqiza i-taurocholate kanye nezinye i-bile salts. Ngaphezu kwe-BAAT, ubunikazi bama-molecule bamanye ama-enzyme alawula i-secondary taurine metabolism abukakaqinisekiswa.
I-N-acetyltaurine (i-N-acetyl taurine) iyi-metabolite yesibili ye-taurine ethakazelisa kakhulu kodwa engafundwanga kahle. Amazinga e-N-acetyl taurine kuketshezi lwebhayoloji alawulwa ngokuguquguqukayo yiziphazamiso eziningi zomzimba ezandisa i-taurine kanye/noma i-acetate flux, okuhlanganisa ukuzivocavoca okukhuthazela, ukusetshenziswa kotshwala, kanye nokwengezwa kwe-taurine okunomsoco. Ngaphezu kwalokho, i-N-acetyltaurine inokufana kwesakhiwo samakhemikhali nama-molecule okubonisa izimpawu okuhlanganisa i-neurotransmitter acetylcholine kanye ne-N-fatty acyltaurine ende elawula ushukela wegazi, okuphakamisa ukuthi ingasebenza futhi njenge-metabolite yesignali. Umkhiqizo uyasebenza. Kodwa-ke, i-biosynthesis, ukuwohloka, kanye nemisebenzi engaba khona ye-N-acetyl taurine akukacaci.
Kulolu cwaningo lwakamuva, ithimba locwaningo lithole i-PTER, i-enzyme engasebenzi kahle engaziwa, njenge-N-acetyl taurine hydrolase enkulu yezilwane ezincelisayo. E-vitro, i-PTER ephindayo ibonise ububanzi obuncane be-substrate kanye nemikhawulo emikhulu. Ku-N-acetyl taurine, i-hydrolyzed ibe yi-taurine kanye ne-acetate.
Ukukhipha i-Pter gene emagundwini kuholela ekulahlekelweni ngokuphelele komsebenzi we-N-acetyl taurine hydrolytic ezicutshini kanye nokwanda okuhlelekile kokuqukethwe kwe-N-acetyl taurine ezicutshini ezahlukahlukene.
Indawo ye-PTER yomuntu ihlotshaniswa ne-body mass index (BMI). Ithimba locwaningo liphinde lathola ukuthi ngemva kokukhuthazwa ngamazinga e-taurine akhuphukile, amagundane e-Pter knockout abonise ukwehla kokudla futhi ayemelana nokukhuluphala okubangelwa ukudla. kanye ne-glucose homeostasis ethuthukisiwe. Ukwengezwa kwe-N-acetyl taurine kumagundane angohlobo lwezilwane zasendle akhuluphele nakho kunciphisa ukudla kanye nesisindo somzimba ngendlela encike ku-GFRAL.
Le datha ibeka i-PTER endaweni eyinhloko ye-enzyme ye-taurine secondary metabolism futhi yembula izindima ze-PTER kanye ne-N-acetyl taurine ekulawuleni isisindo kanye nokulinganisela kwamandla.
Sekukonke, lolu cwaningo luthole i-acetyl taurine hydrolase yokuqala ezincelisayo, i-PTER, futhi lwaqinisekisa indima ebalulekile ye-acetyl taurine ekunciphiseni ukudla kanye nokulwa nokukhuluphala. Esikhathini esizayo, kulindeleke ukuthi kuzokwakhiwa izithibi ze-PTER ezinamandla nezikhethayo zokwelapha ukukhuluphala.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Agasti-12-2024
