Amandla e-taurine angaphezu komcabango wakho !!

Muva nje, ucwaningo nge-taurine lushicilelwe kumajenali amathathu aphezulu iSayensi, iCell, neNature. Lezi zifundo zembule imisebenzi emisha ye-taurine - anti-ukuguga, ukuthuthukisa umphumela wokwelashwa komdlavuza, kanye nokulwa nokukhuluphala.

NgoJuni 2023, abacwaningi abavela ku-National Institute of Immunology in India, Columbia University e-United States, kanye nezinye izikhungo bashicilela amaphepha kujenali yezemfundo ephakeme yamazwe ngamazwe i-Science. Ucwaningo luphakamisa ukuthi ukushoda kwe-taurine kungumshayeli wokuguga. Ukwengeza i-taurine kunganciphisa ukuguga kwe-nematode, amagundane, nezinkawu, futhi kunganweba nokuphila okunempilo kwamagundane aneminyaka ephakathi ngo-12%. Imininingwane: Isayensi: Amandla angaphezu komcabango wakho! I-Taurine ingabuye ihlehlise ukuguga futhi inwebe isikhathi sokuphila?

Ngo-Ephreli 2024, uSolwazi Zhao Xiaodi, UProfesa Lu Yuanyuan, USolwazi Nie Yongzhan, kanye noSolwazi Wang Xin baseSibhedlela sase-Xijing se-Fourth Military Medical University bashicilela amaphepha ephephabhukwini lezemfundo eliphezulu lamazwe ngamazwe elithi Cell. Lolu cwaningo luthole ukuthi amaseli e-tumor ancintisana namaseli e-CD8+ T e-taurine ngokugcizelela ngokweqile isithuthi se-taurine i-SLC6A6, esidala ukufa kwe-T cell kanye nokukhathala, okuholela ekuphunyukeni kokuzivikela komzimba kwesimila, ngaleyo ndlela kugqugquzele ukuqhubekela phambili kwesimila nokuphindaphinda, kuyilapho ukwengeza i-Taurine kungaphinda kusebenze amaseli e-CD8+ T akhathele. futhi uthuthukise ukusebenza kahle kokwelashwa komdlavuza.

Ngo-Agasti 7, 2024, ithimba lika-Jonathan Z. Long wase-Stanford University (uDkt. Wei Wei ungumbhali wokuqala) lashicilela iphepha locwaningo elinesihloko esithi: I-PTER iyi-N-acetyl taurine hydrolase elawula ukondla nokukhuluphala esifundweni esiphakeme samazwe ngamazwe. iphephabhuku Imvelo.

Lolu cwaningo luthole i-N-acetyl taurine hydrolase yokuqala ezilwaneni ezincelisayo, i-PTER, futhi lwaqinisekisa indima ebalulekile ye-N-acetyl taurine ekwehliseni ukudla kanye nokulwa nokukhuluphala. Esikhathini esizayo, kungenzeka ukuthuthukisa ama-PTER inhibitors anamandla futhi akhethiwe ekwelapheni ukukhuluphala.

I-Taurine itholakala kakhulu ezicutshini ezincelisayo kanye nokudla okuningi futhi itholakala ezindaweni eziphakeme kakhulu ezicutshini ezijabulisayo njengenhliziyo, amehlo, ubuchopho nemisipha. I-Taurine ichazwe njengemisebenzi ye-pleiotropic yeselula kanye neyomzimba, ikakhulukazi kumongo we-homeostasis ye-metabolic. Ukwehliswa kofuzo emazingeni e-taurine kuholela ekuwohlokeni kwemisipha, ukunciphisa amandla okuzivocavoca, kanye nokungasebenzi kahle kwe-mitochondrial ezicutshini eziningi. Ukwengezwa kweTaurine kunciphisa ukucindezeleka kwe-mitochondrial redox, kuthuthukisa umthamo wokuzivocavoca, futhi kucindezela isisindo somzimba.

I-biochemistry kanye ne-enzymology ye-taurine metabolism ihehe intshisekelo enkulu yocwaningo. Endleleni ye-taurine biosynthetic engapheli, i-cysteine ​​​​ishintshwa yi-cysteine ​​​​dioxygenase (CDO) kanye ne-cysteine ​​​​sulfinate decarboxylase (CSAD) ukuze kukhiqizwe i-hypotaurine, kamuva okuba i-Oxidation nge-flavin monooxygenase 1 (FMO1) ikhiqiza i-taurine. Ngaphezu kwalokho, i-cysteine ​​​​ingakhiqiza i-hypotaurine ngenye indlela ye-cysteamine ne-cysteamine dioxygenase (ADO). Ezansi nomfula we-taurine ngokwawo kunama-metabolite esibili e-taurine, okuhlanganisa i-taurocholate, i-tauramidine, ne-N-acetyl taurine. Okuwukuphela kwe-enzyme eyaziwa ngokudala lezi zindlela ezansi nomfula i-BAAT, ehlanganisa i-taurine ne-bile acyl-CoA ukukhiqiza i-taurocholate namanye ama-bile salts. Ngokungeziwe ku-BAAT, ubunikazi bengqamuzana bamanye ama-enzyme alamula i-taurine metabolism yesibili awakanqunywa.

I-N-acetyltaurine (N-acetyl taurine) iyi-metabolite yesibili ethakazelisa kakhulu kodwa engafundwanga kahle ye-taurine. Amazinga e-N-acetyl taurine oketshezini lwebhayoloji alawulwa ngokuguquguqukayo yiziphazamiso eziningi zomzimba ezikhulisa i-taurine kanye/noma i-acetate flux, okuhlanganisa ukuvivinya umzimba ukukhuthazela, ukuphuza utshwala, kanye nokwengezwa kwe-taurine okunomsoco. Ukwengeza, i-N-acetyltaurine inokufana kwesakhiwo samakhemikhali kumamolekyuli okusayina okuhlanganisa i-neurotransmitter acetylcholine kanye neketango elide le-N-fatty acyltaurine elawula ushukela wegazi, okuphakamisa ukuthi ingase futhi isebenze njengesignali ye-metabolite Umkhiqizo uyasebenza. Kodwa-ke, i-biosynthesis, ukuwohloka, kanye nemisebenzi engaba khona ye-N-acetyl taurine ihlala ingacacile.

Kulolu cwaningo lwakamuva, ithimba labacwaningi lihlonze i-PTER, i-enzyme yezintandane esebenza ngokungaziwa, njengesilwane esikhulu esincelisayo i-N-acetyl taurine hydrolase. I-In vitro, i-recombinant PTER ibonise ububanzi obuncane be-substrate kanye nemikhawulo emikhulu. Ku-N-acetyl taurine, i-hydrolyzed ibe yi-taurine ne-acetate.

Ukukhipha isakhi sofuzo se-Pter kumagundane kubangela ukulahlekelwa okuphelele komsebenzi we-N-acetyl taurine hydrolytic ezicutshini kanye nokwanda okuhlelekile kokuqukethwe kwe-N-acetyl taurine ezicutshini ezihlukahlukene.

I-PTER locus yomuntu ihlotshaniswa ne-body mass index (BMI). Ithimba labacwaningi liphinde lathola ukuthi ngemva kokukhuthazwa ngamazinga e-taurine anda, amagundane e-Pter knockout abonise ukunciphisa ukudla futhi abekwazi ukumelana nokukhuluphala okubangelwa ukudla. kanye ne-glucose homeostasis ethuthukisiwe. Ukwengezwa kwe-N-acetyl taurine ekukhuluphaleni kwamagundane ohlobo lwasendle kuphinde kwehlise ukudla kanye nesisindo somzimba ngendlela encike ku-GFRAL.

Le datha ibeka i-PTER endaweni eyinhloko ye-enzyme ye-taurine yesibili metabolism futhi yembula izindima ze-PTER ne-N-acetyl taurine ekulawuleni isisindo nokulinganisela kwamandla.

Sekukonke, lolu cwaningo luthole i-acetyl taurine hydrolase yokuqala ezilwaneni ezincelisayo, i-PTER, futhi lwaqinisekisa indima ebalulekile ye-acetyl taurine ekwehliseni ukudla kanye nokulwa nokukhuluphala. Ngokuzayo, kulindelekile ukuthi ama-PTER inhibitors anamandla futhi akhethiwe azothuthukiswa ukuze kwelashwe ukukhuluphala.