I-Evodiamine iyinhlanganisela yemvelo etholakala esithelweni sesitshalo se-Evodiamine, esizalelwa e-China nakwamanye amazwe ase-Asia. Isetshenziswe emithini yendabuko yamaShayina amakhulu eminyaka ngenxa yezinzuzo zayo zezempilo ezingaba khona. Phakathi kwazo, i-evodiamine inamandla amakhulu okulawula ukuvuvukala nokusiza ukulahlekelwa isisindo. Izakhiwo zayo zokulwa nokuvuvukala zenza kube ikhandidethi elibalulekile ekwelapheni izifo ezihlukahlukene ezivuthayo, kuyilapho amandla ayo okwandisa i-thermogenesis nokukhuthaza i-lipolysis kungasiza ekulawuleni isisindo.
Wake wahlangabezana negama elithi "evodiamine" futhi wazibuza ukuthi lisho ukuthini ngempela? I-Evodiamine, etholakala esitshalweni i-Evodiamine, iyinhlanganisela yemvelo etholakala e-China nakwamanye amazwe ase-Asia. I-Evodiamine ingeyesigaba sama-alkaloid aziwa ngokuthi "i-quinazole alkaloids," izinhlanganisela ezikhishwe ezithelweni ezingavuthiwe zesitshalo futhi ezaziwa ngezakhiwo zazo zokwelapha. Sekungamakhulu eminyaka, imithi yaseShayina yendabuko isebenzise amandla e-evodiamine ukukhulula izifo ezihlukahlukene.
I-Evodiamine yaziwa ngezakhiwo zayo ze-thermogenic, inqubo lapho umzimba ukhiqiza ukushisa, okungathuthukisa izinga lokugaya futhi kukhuthaze ukushiswa kwama-calories. Ngokwandisa i-thermogenesis, i-evodiamine ingasiza ukushisa amafutha nokulawula isisindo.
Ukuvuvukala kuwukusabela kwemvelo komzimba ekulimaleni noma ekuthelelekeni. Nokho, ukuvuvukala okungapheli kungaholela ezifweni ezihlukahlukene. Ngokunciphisa ukuvuvukala, i-evodiamine ingasiza ekuthuthukiseni impilo yonke futhi inciphise ingozi yezifo ezithile.
I-Evodiamine yaziwa ngezakhiwo zayo ze-thermogenic. I-Thermogenesis ibhekisela kunqubo yokukhiqiza ukushisa emzimbeni. Ngakho-ke i-evodiamine ikhiqiza kanjani ukushisa ngokuqondile?
Enye yezindlela i-evodiamine eyenza ngayo imiphumela ye-thermogenic iwukwenza kusebenze iphrotheni ebizwa ngokuthi i-transient receptor potential vanilloid subtype 1 (TRPV1). I-TRPV1 iyi-receptor etholakala ngokuyinhloko ohlelweni lwezinzwa futhi ihileleke ekulawuleni izinga lokushisa lomzimba kanye ne-metabolism. Uma i-evodiamine ibophezela ku-TRPV1, iqala uchungechunge lwezimpendulo ze-physiological, okuhlanganisa izindleko ezikhulayo zamandla kanye ne-thermogenesis.
I-Evodiamine itholakale ishukumisa izindlala ze-adrenal ukuthi zikhulule ama-catecholamine afana ne-epinephrine ne-norepinephrine. I-catecholamines idlala indima ebalulekile ekwandiseni i-lipolysis, ukuqhekeka kwamafutha agciniwe abe ama-fatty acids mahhala angasetshenziswa njengomthombo wamandla. Le nqubo iphinde ikhuthaze imiphumela ye-thermogenic ye-evodiamine.
Ngaphezu kwalokho, i-evodiamine iboniswe ukuvimbela umsebenzi wama-enzyme athile ahilelekile ekwakhiweni nasekugcinweni kwamaseli amafutha. Isibonelo, ivimbela ukubonakaliswa kwe-peroxisome proliferator-activated receptor gamma (PPARγ), isici sokuloba esikhuthaza ukuqoqwa kwamafutha kuma-adipocyte. Ngokuvimbela umsebenzi we-PPARγ, i-evodiamine ingasiza ekuvimbeleni ukwakheka kwamangqamuzana amafutha amasha futhi inciphise ukugcinwa kwamafutha.
1. Ukuphatha isisindo
Enye yezinzuzo ezaziwa kakhulu ze-evodiamine amandla ayo njengosizo lokulawula isisindo semvelo. Ucwaningo lubonisa ukuthi i-evodiamine ingashukumisa ama-receptor "okushisa" emizimbeni yethu, aziwa ngokuthi ama-transient receptor angaba khona i-vanilloid 1 (TRPV1) receptors. Ngokuvula la ma-receptors, i-evodiamine ingasiza ekwandiseni i-thermogenesis kanye ne-oxidation yamafutha, ngaleyo ndlela ikhulise imetabolism kanye nokuncipha kwesisindo okungaba khona. Ukwengeza, ivimbela ukukhula kwamangqamuzana amafutha amasha, iqhubeke nokusekela izakhiwo zayo zokulawula isisindo.
2. Izakhiwo zokulwa nokuvuvukala
Ukuvuvukala okungapheli kuhlotshaniswa nezinkinga zempilo ezahlukahlukene, okubandakanya isifo senhliziyo, isifo sikashukela, nokunye. I-Evodiamine ibhekwa njenge-ejenti ephikisana nokuvuvukala ngenxa yekhono layo lokuvimbela ukukhiqizwa kwama-molecule e-pro-inflammatory. Ucwaningo oluningana lubonise ukuthi i-evodiamine ingavimbela umsebenzi we-nuclear factor-κB (NF-κB), isici esiyinhloko sokuloba esilawula ukubonakaliswa kwezakhi zofuzo ezivuthayo. Ngokuvimbela i-NF-κB, i-evodiamine inciphisa ukuvuvukala ngokunciphisa ukukhiqizwa kwama-cytokines avuthayo njenge-interleukin-1β (IL-1β) kanye ne-tumor necrosis factor-α (TNF-α).
3. Izakhiwo ze-analgesic kanye ne-analgesic
Ubuhlungu, obuvame ukuhlotshaniswa nokuvuvukala, bungolunye uphawu olubalulekile olungathinta kakhulu izinga lokuphila. Izakhiwo ze-analgesic ze-evodiamine ziye zacwaningwa kabanzi, kwaba nemiphumela ekhuthazayo. Ucwaningo lubonisa ukuthi i-evodiamine ingakwazi ukwenza kusebenze isiteshi se-receptor esingaba khona se-vanilloid 1 (TRPV1), esihilelekile ekudlulisweni kwezimpawu zobuhlungu. Ngokusebenzisa lezi ziteshi, i-evodiamine ingavimbela ukuzwa ubuhlungu futhi inikeze ukukhululeka kubantu abanazo zonke izinhlobo zobuhlungu, kuhlanganise nobuhlungu be-neuropathic nokuvuvukala.
4. Impilo yenhliziyo nemithambo yegazi
Ukugcina uhlelo lwenhliziyo olunempilo kubalulekile empilweni yonke. I-Evodiamine ikhonjiswe ukuthi inemiphumela emihle yenhliziyo, njengokunciphisa umfutho wegazi ophakeme kanye nokuvimbela ukuhlangana kweplatelet. Ngokuphumuza imithambo yegazi nokuvimbela amahlule egazi ukuthi akheke, i-evodiamine ingasiza ekuthuthukiseni ukujikeleza kwegazi futhi inciphise ingozi yesifo senhliziyo nemithambo yegazi, okuhlanganisa ukuhlasela kwenhliziyo nesifo sohlangothi.
5. Impilo Yamathumbu
I-Evodiamine ingase ibe nomthelela omuhle empilweni yamathumbu ngokukhuthaza umsebenzi wokugaya ukudla kanye nokunciphisa ukuphazamiseka kwamathumbu. Ucwaningo lubonisa ukuthi i-evodiamine ingashukumisa ukukhiqizwa kwama-enzyme okugaya futhi ithuthukise ukuhamba kwamathumbu, ekugcineni isize ukugaya futhi ikhulule ukungakhululeki kokugaya. Ukwengeza, izinto ze-evodiamine ezingaba khona ezilwa namagciwane zingasiza ukulwa namagciwane ayingozi futhi zikhuthaze i-gut microbiome enempilo.
I-Evodiamine iqanjwe ngegama lomunye wemithombo yayo eyinhloko yezitshalo, i-Evodia rutaecarpa, evame ukwaziwa nge-Evodia fruit noma i-Evodia rutaecarpa. Lesi sitshalo sidabuka eMpumalanga Asia futhi sekungamakhulu eminyaka sisetshenziswa emithini yendabuko yamaShayina. Izithelo ezingavuthiwe zesitshalo se-Evodia carota ziwumthombo oyinhloko we-evodiamine. Lesi simangaliso se-botanical siqukethe ama-alkaloid amaningana, kuhlanganise ne-evodiamine, abonise imiphumela enenzuzo empilweni.
Eminye imithombo yezitshalo
Ngaphezu kwe-Evodiamine, i-evodiamine itholakala kweminye imithombo eminingi yezitshalo. Lezi zihlanganisa i-Alstonia macrophylla, i-Evodia lepta ne-Euodia lepta, phakathi kwabanye. Lezi zitshalo zitholakala ezingxenyeni ezahlukene ze-Asia, kuhlanganise ne-China, Japan, ne-Thailand.
Kuyathakazelisa ukuthi le mithombo yezitshalo ayikhawulelwe ezingxenyeni ezithile zesitshalo. Nakuba izithelo ezingavuthiwe ziwumthombo oyinhloko, i-evodiamine ingabuye ikhishwe emaqabunga, iziqu, nezimpande zalezi zitshalo. Lolu hlu olubanzi lwemithombo lunikeza abacwaningi nososayensi amathuba amaningi okuhlola izinzuzo ezihlukahlukene zezempilo kanye nokusetshenziswa kwe-evodiamine.
●Umthamo ophelele: Umthamo ofanelekile we-evodiamine uncike ezintweni ezimbalwa ezifana neminyaka yomsebenzisi, impilo, nezinye izimo ezimbalwa. Khumbula ukuthi imikhiqizo yemvelo ayihlali iphephile, futhi umthamo ubalulekile. Kubalulekile ukufunda amalebula omkhiqizo ngokucophelela futhi uxhumane nochwepheshe bezempilo ukuze uthole umthamo ofanele izidingo zakho zomuntu ngamunye.
●Ukucatshangelwa Kwempilo Yomuntu Siqu: Lapho unquma ukusebenzisa noma yisiphi isithasiselo, okuhlanganisa i-evodiamine, kubalulekile ukucabangela impilo yomuntu iyonke, umlando wezokwelapha, nokubekezelela komuntu siqu. Ukwengeza, qaphela ukusebenzisana kwezidakamizwa okungenzeka futhi ucabangele izici zempilo yomuntu siqu ukuze wandise izinzuzo ze-evodiamine kuyilapho unciphisa noma yiziphi izingozi ezihlobene.
Umbuzo: I-evodiamine ikuphatha kanjani ukuvuvukala?
A: I-Evodiamine itholwe inezindawo zokulwa nokuvuvukala. Ivimbela umsebenzi wama-molecule athile avuvukalayo, njenge-nuclear factor-kappa B (NF-kB) ne-cyclooxygenase-2 (COX-2), adlala indima ebalulekile ekuvuvukeni. Ngokunciphisa ukukhiqizwa kwala ma-molecule, i-evodiamine isiza ekudambiseni ukuvuvukala emzimbeni.
Umbuzo: Ingabe i-evodiamine ingasetshenziselwa ukulahlekelwa isisindo?
A:I-Evodiamine iphenywe ngemiphumela engaba khona ekuncipheni kwesisindo. Kukholakala ukuthi yenza kusebenze inqubo ebizwa ngokuthi i-thermogenesis, enyusa izinga lokushisa eliwumgogodla womzimba kanye nezinga lokugayeka kokudla. Lokhu, kungase kukhuphule ukusetshenziswa kwekhalori futhi kusize ekunciphiseni isisindo. Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze kusungulwe ukusebenza kahle nokuphepha kwe-evodiamine ekulahlekelweni kwesisindo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Sep-26-2023
