Isayensi ngemuva kwe-ketone ester nezinzuzo zayo iyathakazelisa. I-ketone ester ingathuthukisa ukukhuthazela, ukwandisa amandla, ukusekela ukulondolozwa kwemisipha, nokuningi, okubaluleke kakhulu banamandla amakhulu okuthuthukisa impilo yonke kanye nokuphila kahle. Ngenxa yokuthi izidingo zomuntu ngamunye nokubekezelela kungase kuhluke, kubalulekile ukuthintana nochwepheshe bezempilo ngaphambi kokufaka i-ketone ester esimisweni sakho.
I-ketone ester iyinhlanganisela equkethe i-molecule ye-ketone exhunywe eqenjini le-ester. Ama-ketones ngendlela yawo elula kakhulu amakhemikhali e-organic akhiqizwa ngokwemvelo emzimbeni lapho amazinga e-glucose ephansi, njengesikhathi sokuzila ukudla noma ukudla kwe-ketogenic. Lapho i-glucose iyindlala, i-metabolism yethu iyashintsha futhi iqala ukudiliza amafutha agciniwe ukuze kukhiqizwe ama-ketone, asebenza njengomthombo ohlukile kaphethiloli wobuchopho nemisipha. Ngenkathi imizimba ye-endogenous ketone idunyiswa, amazinga ayo avame ukukhawulelwa, ngisho nangesikhathi sokuzila ukudla isikhathi eside noma ukudla okuqinile.
I-ketone esters kanye nama-ketones angaphandle, amagama amabili avame ukusetshenziswa ngokushintshana, angase azwakale engajwayelekile kubantu abaningi, kodwa empeleni ayizinto ezihlukene ezinemiphumela ehlukene emzimbeni. Ngenkathi zombili zingaheha i-ketosis, izithako zazo, ukuthi zisetshenziswa kanjani, kanye nezinzuzo zazo ziyabahlukanisa.
Ukuze uqonde umehluko phakathi kwe-ketone esters nama-ketones angaphandle, kubalulekile ukuqonda kuqala ukuthi iyini i-ketosis. I-Ketosis yisimo se-metabolic lapho umzimba usebenzisa ama-ketones atholakala emafutheni njengomthombo wawo oyinhloko wamafutha esikhundleni se-glucose. Lesi simo sifezwa ngokulandela ukudla okune-carb ephansi, okunamafutha aphezulu e-ketogenic noma ngokungenisa ama-ketone angaphandle.
●Ama-ketone angaphandle ama-ketone avela emthonjeni ongaphandle, ngokuvamile njengesengezo. Ngokuvamile atholakala ngezindlela ezintathu: usawoti we-ketone, i-ketone esters, namafutha e-ketone. Usawoti we-ketone, uhlobo oluvame kakhulu, yinhlanganisela yama-ketone nosawoti onjenge-sodium, i-magnesium, noma i-potassium. Ngakolunye uhlangothi, i-ketone esters yizinhlanganisela zokwenziwa eziqukethe iqembu le-ketone neqembu lotshwala. Amafutha e-Ketone uhlobo lwe-ketone oluyimpuphu exutshwe namafutha othwala, njengamafutha e-MCT.
●I-ketone esters, njengoba negama liphakamisa, ihluke kuma-ketones angaphandle ngoba ahlanganisa kuphela ama-molecule e-ketone esters. Lokhu kubenza babe umthombo onamandla futhi osheshayo wama-ketone. Uma idliwe, i-ketone esters idlula isidingo somzimba sokudiliza amafutha ukuze kukhiqizwe ama-ketone ngoba asevele esesimweni se-ketone. Lokhu kubangela ukuthi amazinga e-ketone egazi anyuke ngokushesha futhi abe namandla, okuholela esimweni esisheshayo nesinzima se-ketosis.
Inzuzo ephawulekayo ye-ketone esters ukuthi ayigcini nje ukwandisa amazinga e-ketone, kodwa futhi icindezela amazinga e-glucose ne-insulin. Lesi senzo esikabili sizenza zibe yinzuzo ikakhulukazi kulabo abamelana ne-insulin, isifo sikashukela, noma labo abafuna ukuthuthukisa impilo ye-metabolic. Ukwengeza, i-ketone esters iye yaboniswa ukuthuthukisa ukusebenza kwezemidlalo nokusebenza kwengqondo, okwenza idume phakathi kwabasubathi nalabo abafuna ukusula izingqondo zabo.
Ngakolunye uhlangothi, ama-ketone angaphandle, okuhlanganisa nosawoti we-ketone namafutha e-ketone, anezindlela ezihluke kancane zokwenza. Uma zidliwa, zihlukaniswa emzimbeni zibe imizimba ye-ketone yamahhala, ngokuyinhloko i-beta-hydroxybutyrate (BHB). Lezi zidumbu ze-ketone zibe sezisetshenziswa amaseli ukukhiqiza amandla.
Nakuba ama-ketone angaphandle angakhuphula amazinga e-ketone yegazi, angase angamuncwe ngokushesha noma ngempumelelo njenge-ketone esters. Noma kunjalo, banikeza izinzuzo ezithile, njengokukhuphuka kwamandla, ukugxila kwengqondo okuthuthukisiwe, nokuncipha kwesifiso sokudla. Labo abalandela ukudla kwe-ketogenic bavame ukusebenzisa ama-ketones angaphandle ukusiza ukugcina i-ketosis noma ukushintshela ku-ketosis kalula.
Enye yezingxenye ezibalulekile zokudla kwe-ketogenic ama-ketones, akhiqizwa lapho umzimba usesimweni se-ketosis. Nakuba i-ketone ester iwuhlobo lwama-ketones angaphandle, okusho ukuthi iwumthombo wangaphandle wama-ketones angadliwa ngendlela yokwengeza. Lapho idliwe, i-ketone esters ihlukaniswa ibe i-beta-hydroxybutyrate (BHB), i-ketone eyinhloko ekhiqizwa ngesikhathi se-ketosis. I-BHB bese isetshenziswa ngumzimba njengomthombo ohlukile wamafutha weglucose.
Ngakho-ke i-ketone esters isebenza kanjani emzimbeni?Inhloso eyinhloko yokusebenzisa i-ketone esters ukukhulisa amazinga e-ketones emzimbeni, okuholela ezingeni elijulile le-ketosis. Lapho umzimba uku-ketosis, ungena esimweni sokugayeka kokudla emzimbeni lapho usebenzisa khona ngokuyinhloko ama-ketone esikhundleni se-glucose ukuze ube namandla. Lokhu kushintshwa komthombo wamandla kunezinzuzo ezimbalwa, okuhlanganisa ukwanda kokushiswa kwamafutha, ukucaca kwengqondo okuthuthukisiwe, nokusebenza komzimba okuthuthukisiwe.
I-ketone esters isebenza ngokuhlinzeka ngomthombo oqondile wama-ketone, idlula isidingo somzimba sokukhiqiza ama-ketone ngokwawo. Ngokwenza lokhu, ingakhuphula ngokushesha amazinga e-ketone, ibangele isimo se-ketosis ngokushesha kunokudla kuphela.
Uma isidliwe, i-ketone esters ingena ngokushesha egazini, lapho ingawela khona umgoqo wegazi nobuchopho futhi isetshenziswe ubuchopho. Lokhu kuthuthukisa ukusebenza kwengqondo nokucaca kwengqondo, futhi kunikeza ubuchopho umthombo wemvelo wamandla.
Ukwengeza, izithako ze-ketone ester zingasiza ukuthuthukisa ukusebenza komzimba ngesikhathi sokuzivocavoca. Lapho umzimba uku-ketosis, usebenzisa amafutha ukuze uthole amandla ngokuphumelelayo, okwandisa ukukhuthazela futhi kunciphisa ukuthembela ezitolo ze-glycogen.
I-Autophagy iyinqubo yemvelo ye-metabolic ebhekisela endleleni yeselula enesibopho sokuphinda isetshenziswe izinto ezilimele noma ezingafuneki, okuhlanganisa amaprotheni nama-organelles, ukugcina impilo yonke kanye nokusebenza kweseli. Le nqubo ixhunyaniswe nezinzuzo zezempilo ezahlukahlukene, okubandakanya ukwelula isikhathi sokuphila, ukuvimbela izifo ze-neurodegenerative, kanye nokweseka impilo yonke yamaselula.
Manje, ingabe i-ketone esters yandisa i-autophagy? Ukuze uphendule lo mbuzo, ake siqale siqonde ukuthi i-ketone esters iyini. I-ketone esters yizinhlanganisela ezihlinzeka ngomthombo wama-ketones, uhlobo lukaphethiloli olukhiqizwa umzimba wakho lapho ugaya amafutha esikhundleni sama-carbohydrate. Lezi zinhlanganisela zithole ukuthandwa ekudleni kwe-ketogenic ngenxa yekhono labo lokudala isimo se-ketosis, lapho umzimba usebenzisa ngokuyinhloko ama-ketones esikhundleni se-glucose ukuze uthole amandla.
Ucwaningo luye lwabonisa ukuthi ukudla kwe-ketogenic kungashukumisa i-autophagy, iphakamisa ukuxhumana okungaba khona phakathi kwe-ketone esters kanye ne-autophagy. Kodwa-ke, ubufakazi obuqondile emiphumeleni ye-ketone esters ku-autophagy okwamanje bunqunyelwe. Kodwa-ke, amandla e-ketone esters okwandisa amazinga e-ketone emzimbeni angase athinte ngokungaqondile i-autophagy.
Ucwaningo lwamagundane lubonise ukuthi amazinga e-ketone aphakeme aholela ekwandeni kwe-autophagy ebuchosheni, okuphakamisa umphumela ongase ube ne-neuroprotective. Ngaphezu kwalokho, ucwaningo oluhlukile kumagundane lubonise ukuthi ukusebenza kwe-autophagy ngokudla kwe-ketogenic kuthuthukisa ukusebenza kobuchopho, kunciphisa i-neuroinflammation, futhi kwandise isikhathi sokuphila.
Nakuba ucwaningo olwengeziwe luyadingeka ukuze kuhlolwe imiphumela eqondile ye-ketone esters ku-autophagy, ubufakazi obutholakalayo bubonisa ukuthi i-ketosis eyenziwa yilezi zinhlanganisela ingase ibe nemiphumela emihle empilweni yeselula nokuphila isikhathi eside.
Kubalulekile ukuqaphela ukuthi i-ketone esters ayiyona i-panacea futhi akufanele ithathe indawo yokudla okulinganiselayo kwe-ketogenic. Kuthathwa kangcono njengesengezo ukusekela indlela yokuphila enempilo futhi kuthuthukise imiphumela yokudla kwe-ketogenic.
Ukwazi ukuthi yisiphi isikhathi sosuku sokuthatha i-ketone esters kubalulekile ekuqondeni kuqala ukuthi i-ketone esters isebenza kanjani.I-ketone esters iyisengezo sokudla esilingisa imiphumela ye-ketosis. Iqukethe i-compound ebizwa ngokuthi i-beta-hydroxybutyrate (BHB), ethathwa kalula ngumzimba futhi isetshenziswe njengomthombo wamandla. Lapho isetshenziswa, i-ketone esters inyusa amazinga e-ketone egazini, ikhuthaza ukusetshenziswa kwamafutha esikhundleni se-glucose njengophethiloli.
Njengoba kunikezwe indlela yayo yokusebenza, isikhathi sokuthatha i-ketone esters singathinta kakhulu ukusebenza kwayo. Kulabo abafuna ukuthuthukisa ukusebenza kwezemidlalo, i-ketone esters ngokuvamile inconywa ukuthi ithathwe cishe imizuzu engama-30 ngaphambi kokuzivocavoca. Lesi sikhathi sivumela umzimba ukuthi usebenzise ama-ketone njengomthombo wamandla phakathi nomsebenzi womzimba, okungaholela ekwandeni kokukhuthazela nokuncipha kokukhathala.
Futhi, abanye abantu bangase bazuze ngokuthatha i-ketone esters ekuseni, ikakhulukazi uma belandela ukudla kwe-ketogenic. Ngokudla i-ketone esters ekuseni, lapho izitolo ze-glycogen zomzimba ziphansi, kungasiza ukwenza kube lula ukuguqukela ku-ketosis futhi kunikeze amandla asheshayo okuqala usuku.
Ngakolunye uhlangothi, ukuthatha i-ketone esters ebusuku kungase kuphazamise amaphethini okulala ngenxa yemiphumela yawo eqabulayo. Kodwa-ke, lokhu kungase kuhluke kumuntu nomuntu, njengoba abanye abantu bangase bangatholi ukuphazamiseka kokulala. Kunconywa ukuthi uqale ngomthamo ophansi futhi uqaphe impendulo ukuze unqume ukubekezelelana nokuzwela komuntu ngamunye.
Ekugcineni, isikhathi esingcono kakhulu sokuthatha i-ketone esters sincike ezinhlosweni eziqondile zomuntu kanye nendlela yokuphila. Ukunquma isikhathi esifanele sosuku sokuthatha i-ketone esters ekugcineni kuyindaba yezimo zomuntu ngamunye futhi kufanele kuqondiswe iseluleko sochwepheshe.
Isikhathi sokuthumela: Jun-15-2023
