I-Science Behind Palmitoylethanolamide (PEA) Powder: Okufanele Ukwazi

Palmitoylethanolamide  i-endogenous fatty acid amide engeyesigaba se-nuclear factor agonists. Ingenye yezinto ezibaluleke kakhulu ze-endogenous analgesic and anti-inflammatory compounds eziye zaboniswa ukuthi zisebenza kahle hhayi kuphela ebuhlungu obukhulu kodwa futhi obungapheli. Njengesidambisi sobuhlungu bemvelo, kuyindlela ehlukile yemithi yendabuko engabangela imiphumela emibi.

I-PEA iboniswe ukuthi ine-anti-inflammatory, antinociceptive, neuroprotective, ne-anticonvulsant properties. I-PEA ibilokhu ihlola abantu abanezimo ezihlukahlukene zobuhlungu, ukuvuvukala nama-syndromes ezinhlungu ezivivinyweni ezahlukene zomtholampilo. Izicelo: I-Palmitoylethanolamide iyi-organic synthesis ephakathi nendawo yemithi, engasetshenziswa ekucwaningweni kwelabhorethri nezinqubo zokuthuthukiswa kanye nezinqubo zokucwaninga zamakhemikhali nezemithi kanye nentuthuko.

Ocwaningweni lwanamuhla lwesayensi nezimboni, i-Palmitoylethanolamide, njengento ebalulekile yamakhemikhali aluhlaza, ithole ukunakwa okubanzi kwezakhiwo zayo zamakhemikhali eziyingqayizivele kanye namathemba okufaka isicelo abanzi.

1. Ukulungiswa kwePalmitoylethanolamide

Ukulungiswa kwePalmitoylethanolamide kuvame ukubandakanya ukusabela kwe-esterification. Ngesikhathi senqubo yokulungiselela, i-palmitadecanoic acid ne-ethanol zithola ukusabela kwe-esterification ngaphansi kwesenzo se-catalyst ukukhiqiza i-palmitadecanamide ethanol. Phakathi nenqubo yokulungiselela, izici ezifana nezinga lokushisa lokusabela, uhlobo lwe-catalyst kanye nomthamo, nesikhathi sokusabela kunomthelela obalulekile kwikhwalithi kanye nesivuno somkhiqizo. Ngakho-ke, ukwenza kahle inqubo yokulungiselela kuyisihluthulelo sokuthuthukisa ikhwalithi yomkhiqizo kanye nokunciphisa izindleko.

2. Izakhiwo zePalmitoylethanolamide

I-Palmitoylethanolamide iqinile ngokumhlophe kuya kokuphuzi ngokuncibilika okuhle nokuzinza. Iqinile ekamelweni lokushisa, kodwa i-soluble ezinhlobonhlobo ze-solvents eziphilayo ekushiseni okuthile, njenge-ethanol, i-acetone, njll Ngaphezu kwalokho, i-Palmitoylethanolamide ibuye ibe nokuzinza okuhle kwe-thermal kanye namakhemikhali, okuvumela ukuba igcine isakhiwo sayo kanye nezakhiwo ngaphansi. amazinga okushisa aphezulu kanye nezindawo eziyinkimbinkimbi.

3. Ukusetshenziswa kwePalmitoylethanolamide

1. Ucwaningo nokuthuthukiswa kwezemithi nelabhorethri:

● I-PEA iyindawo ebalulekile yemithi, esetshenziswa ocwaningweni lwaselabhorethri nasezinqubweni zokuthuthukiswa kanye nezinqubo zocwaningo lwekhemikhali nentuthuko.

●Kuye kwaboniswa ukuthi kunezinto ezilwa nokuvuvukala, ezidambisa ubuhlungu, i-neuroprotective kanye ne-anticonvulsant futhi ifaneleka ekwelapheni ubuhlungu obungapheli, isithuthwane, i-cerebral ischemia kanye ne-stroke.

2. Imboni yezimonyo:

● I-PEA inemisebenzi ye-surfactant ne-foam accelerator futhi isetshenziswa ekwenzeni izimonyo ezifana nezinto zokuthambisa kanye nama-shampoos.

●Ingathuthukisa ukuvumelana nokuzinza komkhiqizo, kuyilapho ithuthukisa umphumela wokuswakama kanye nokuswakama komkhiqizo.

3. Imboni yezindwangu:

● I-PEA isetshenziswa njengesithambisa, i-ejenti ye-antistatic kanye nokothambisa ukuze kuthuthukiswe ukuthamba nokucwebezela kwezindwangu kanye nokunciphisa i-coefficient yokungqubuzana kanye nemiphumela ye-electrostatic.

4. Imboni yePlastiki:

● Njenge-plasticizer, i-lubricant ne-dispersant, i-PEA ithuthukisa ukuthamba nokuqina kwamapulasitiki futhi yehlisa izinga lokushisa lokucubungula kanye nokusetshenziswa kwamandla.

5. Iqeda ukuvuvukala kanye ne-analgesic:

● I-PEA inciphisa izimpawu zokuvuvukala ngokushintsha izakhi zofuzo, inemiphumela eqeda ukuvuvukala ne-analgesic, futhi ifanelekela ukwelapha izimo ezihlukahlukene zobuhlungu nezifo ezivuvukalayo.

6. Ezinye izinhlelo zokusebenza ezingaba khona:

● Emkhakheni wamandla amasha, i-PEA ingasetshenziselwa ukwenza izinto ezintsha zamandla njengamaseli elanga namabhethri e-lithium-ion.

● Emkhakheni wokuvikelwa kwemvelo, ingasetshenziswa ukwenza amapulasitiki angaboli, ama-coatings ahambisana nemvelo kanye neminye imikhiqizo ehambisana nemvelo.

● Emkhakheni wokwenza imithi, ingasetshenziswa ukwenza izinto zokwenza imithi njengabathwali bemithi kanye nama-ejenti akhishwa isikhathi eside.

Lokhu kusetshenziswa kubonisa ukusetshenziswa okubanzi kanye nenani elingaba khona le-palmitamide ethanol ezimbonini eziningi.

4. Amathrendi entuthuko yesikhathi esizayo ye-Palmitoylethanolamide

Ngokuthuthuka okuqhubekayo kwesayensi nobuchwepheshe kanye nokuthuthukiswa okusheshayo kwezimboni, izinkambu zokufaka isicelo zePalmitoylethanolamide zizoqhubeka zanda. Esikhathini esizayo, ukusetshenziswa kwePalmitoylethanolamide emandleni amasha, ukuvikelwa kwemvelo, imithi kanye neminye imikhakha kuzokhula kancane kancane. Isibonelo, emkhakheni wamandla amasha, i-Palmitoylethanolamide ingasetshenziswa ukwenza izinto ezintsha zamandla njengamaseli elanga namabhethri e-lithium-ion; emkhakheni wokuvikelwa kwemvelo, ingasetshenziswa ukwenza imikhiqizo evumelana nemvelo njengamapulasitiki abolayo kanye nezigqoko ezihambisana nemvelo; emkhakheni wezokwelapha, ingasetshenziswa Ukwenziwa kwezinto zokwenza imithi njengabathwali bezidakamizwa kanye nama-ejenti akhishwa ngokuqhubekayo.

Ngaphezu kwalokho, njengoba ukuqwashisa kwabantu ngempilo nokuvikelwa kwemvelo kuqhubeka nokwanda, izidingo zekhwalithi nokusebenza kwePalmitoylethanolamide nazo zizoba phezulu kakhulu. Ngakho-ke, ucwaningo lwesikhathi esizayo nokuthuthukiswa kanye nokukhiqizwa kwePalmitoylethanolamide kuzonaka kakhulu ukuvikelwa kwemvelo, ukuphepha nokusimama. Ngesikhathi esifanayo, ukuze kuhlangatshezwane nezidingo zemikhakha ehlukene, ucwaningo nokuthuthukiswa kokuphuma okusha kwePalmitoylethanolamide nakho kuzoba isiqondiso esibalulekile esikhathini esizayo.

I-PEA iyi-endogenous fatty acid amide engeyesigaba sama-agonists we-nuclear factor agonists. I-PEA iboniswe ukuthi ibophezela kuma-receptors ku-nucleus (i-nuclear receptors) futhi yenza imisebenzi eminingi yezinto eziphilayo ezihlobene nobuhlungu obungapheli nokuvuvukala. Okuhlosiwe okuyinhloko kucatshangwa ukuthi i-peroxisome proliferator-activated receptor alpha (PPAR-alpha).　

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-Oleoylethanolamide (OEA) yekhwalithi ephezulu nephezulu.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-Oleoylethanolamide (OEA) yethu powder ihlolelwa ngokuqinile ubumsulwa namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongayethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukukhulisa amasosha akho omzimba noma uthuthukise impilo yonke, i-Oleoylethanolamide (OEA) powder yethu iyisinqumo esiphelele.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.