Ezweni lanamuhla elisheshayo, ukulondoloza indlela yokuphila enempilo kungaba inselele. Njengoba kunezithako eziningi ezihlukene kanye namavithamini emakethe, kungaba yinto emangalisayo ukwazi ukuthi yiziphi ezibaluleke ngempela empilweni ephelele. Kodwa-ke, isithasiselo esisodwa esithola ukunakwa ngezinzuzo zaso zezempilo ezingaba khona i-Deazaflavin. Izithako ze-Deazaflavin zinezinhlobonhlobo zezinzuzo zezempilo ezingaba khona, kusukela ekusekeleni ukukhiqizwa kwamandla nokuzivikela okulwa ne-antioxidant kuya ekukhuthazeni ukuguga okunempilo kanye nokuphila kahle. Uma ubheke ukuthuthukisa impilo yakho futhi usekele izinqubo zemvelo zomzimba wakho, cabanga ukwengeza isithasiselo se-deazaflavin ohlelweni lwakho lwansuku zonke.
Uke wezwa nge-5-deazaflavin? Uma kungenjalo, awuwedwa. Le molekyuli engaziwa kangako idlala indima ebalulekile ezinqubweni zebhayoloji ezinhlobonhlobo zezinto eziphilayo, kodwa abantu abaningi abazi ngobukhona bayo nokubaluleka kwayo.
Ngakho-ke, iyini ngempela i-5-desazoflavin? I-5-deazaflavin iwuhlobo olulungisiwe lwe-molecule ye-flavin eyaziwa kakhulu, evame ukutholakala emvelweni futhi ibamba iqhaza ezinqubweni ezihlukahlukene zebhayoloji. Ngokukhethekile, i-5-deazaflavin ayinayo i-athomu ye-nitrogen endaweni yesi-5 yesakhiwo sendandatho, okwenza ihluke kunomlingani wayo ojwayelekile. Lo mehluko ocashile unikeza i-5-deazaflavin izakhiwo zayo eziyingqayizivele nemisebenzi, iyenza ihluke kwamanye ama-molecule e-flavin.
Ama-Flavin ayikilasi lezinhlanganisela eziphilayo ezidlala indima ebalulekile ezinqubweni ezihlukahlukene zezinto eziphilayo. Ziyizingxenye ezibalulekile ze-flavoprotein, ama-enzyme abandakanyeka ekuphenduleni okuningi kwe-metabolic ezintweni eziphilayo. Ama-flavin aziwa kakhulu ngendima yawo njengama-coenzymes ekuphenduleni kwe-redox, lapho enza lula ukudluliswa kwama-electron.
I-5-Deazaflavin inguqulo eguquliwe ye-riboflavin ehlanganisiwe yemvelo (uvithamini B2). Ibizwa nge-5-deazaflavin ngenxa yokuthi ayinayo i-athomu ye-nitrogen endaweni engu-5 yeringi ye-isoalloxazine, okuyisici se-riboflavin. Lokhu kuguqulwa kunikeza i-5-deazaflavin izakhiwo zayo eziyingqayizivele.
Ngaphezu kwendima yayo ku-quinoline biosynthesis, i-5-deazaflavin iphinde ihileleke kwezinye izinqubo zebhayoloji, ezifana ne-metabolism yama-purines kanye nokukhishwa kwezinhlanganisela eziyingozi. 5-Ukuguquguquka nokubaluleka kwe-Deazaflavin ekusebenzeni kwamaselula kuyenza i-molecule enentshisekelo enkulu kulabo abafuna ukuqonda izindlela eziyinkimbinkimbi ze-biochemical.
Ngaphezu kokwenzeka kwayo kwemvelo, i-5-deazaflavin inentshisekelo ngezicelo zayo ezingase zibe khona kwezokwelapha kanye ne-biotechnology. Ukwakheka nokusebenza kwayo okuyingqayizivele kuyenza ibe inhloso ekhangayo ekuthuthukisweni kwezidakamizwa, ikakhulukazi ekwelapheni izifo ezibangelwa amagciwane e-pathogenic athembele ku-quinoside biosynthesis ukuze aphile.
Ngaphezu kwalokho, ikhono le-5-deazaflavin lokubamba iqhaza ekuphenduleni kwe-redox kanye ne-enzymatic catalysis kuyenza ibe ithuluzi elibalulekile ezinhlelweni zokusebenza ze-biotechnological, njengokukhiqizwa kwama-biofuels kanye nemithi.
I-compound deazaflavin yaziwa ngombala wayo ophuzi ogqamile, okwenza kube lula ukuhlukanisa endaweni yaselabhorethri. Ngaphezu kwalokho, i-deazaflavin inephuzu eliphezulu lokuncibilika futhi incibilika kalula kuzincibilikisi zemvelo. Lezi zakhiwo zomzimba zenza i-flavin e-deconjugated ibe inhlanganisela eguquguqukayo engasetshenziswa kalula futhi isetshenziswe ekuphenduleni kwamakhemikhali okuhlukene.
Ngokuphawulekayo, le nhlanganisela inomsebenzi we-redox. Lokhu kusho ukuthi ingakwazi ukwenza ukusabela kwe-reduction-oxidation, ikwenze kube yingxenye ebalulekile yenqubo yokudlulisa ama-electron. Ngaphezu kwalokho, i-deazaflavin ingakha izakhiwo ezizinzile ezinama-ion ensimbi ahlukahlukene. Lesi sakhiwo sihlinzeka ngamathuba okusetshenziswa kwama-deazaflavin kukhemikhali yokuxhumanisa insimbi nanjengama-catalysts ekuphenduleni kwensimbi.
Enye impahla yamakhemikhali ethakazelisayo ye-deazaflavin yikhono layo lokusebenza njenge-photosensitizer. Lokhu kusho ukuthi ingakwazi ukumunca amandla okukhanya futhi iwadlulisele kwamanye ama-molecule, okubangela ukusabela kwe-photochemical. Lesi sakhiwo sivuse intshisekelo yokusebenzisa i-deazaflavin ekwelashweni kwe-photodynamic, ukwelashwa okusebenzisa izinhlanganisela ezicushwe ukukhanya ukuze kuqondiswe futhi kucekelwe phansi amaseli omdlavuza.
Sekukonke, izakhiwo ezingokomzimba namakhemikhali e-deazaflavin ziyenza ibe inhlanganisela ehehayo enezinhlobonhlobo zezinhlelo zokusebenza ezingase zibe khona. Umbala wayo oyingqayizivele, ukuncibilika, umsebenzi we-redox, ukuhlanganiswa kwe-ion yensimbi, ikhono le-photosensitizing, kanye ne-fluorescence kuyenza ibe ithuluzi elibalulekile ocwaningweni lwamakhemikhali nasembonini.
I-Deazaflavin, eyaziwa nangokuthi ama-riboflavin analogues, iyisigaba sama-molecule anesakhiwo esifanayo ne-riboflavin (uvithamini B2). Lezi zinhlanganisela ziye zafundelwa amandla azo okuthuthukisa ukusebenza kwe-mitochondrial nokusekela impilo yonke yamaselula. I-NMN, ngakolunye uhlangothi, iphuma ku-niacin (uvithamini B3) kanye nesandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme eyinhloko ehilelekile ezinqubweni ezihlukahlukene zamaselula, okuhlanganisa ukukhiqizwa kwamandla kanye nokulungiswa kwe-DNA. .
Omunye umehluko omkhulu phakathi kwe-deazaflavin ne-NMN indlela yabo yokusebenza. Kukholakala ukuthi i-deazaflavin isekela ukusebenza kwe-mitochondrial ngokusebenza njenge-cofactor yama-enzyme abandakanyeka kumetabolism yamandla. Lokhu kungasiza ukuthuthukisa ukukhiqizwa kwamandla eselula kanye nempilo yonke ye-mitochondrial. Ngokuphambene, i-NMN iguqulelwa ku-NAD+ emzimbeni futhi idlala indima ebalulekile ekukhiqizweni kwamandla amaselula kanye nokulungisa i-DNA. Ngokwandisa amazinga e-NAD+, i-NMN ingase isize ukusekela izinqubo ezihlukahlukene zamaselula futhi ikhuthaze impilo yonke yamaselula.
Mayelana nezinzuzo ezingaba khona, kokubili i-deazaflavin ne-NMN kukholakala ukuthi zinezakhiwo zokulwa nokuguga. Ngokusekela umsebenzi we-mitochondrial nokwandisa amazinga e-NAD+, lezi zinhlanganisela zingasiza ukulwa nemiphumela yokuguga futhi zikhuthaze impilo yonke yamaselula. Ukwengeza, i-NMN iye yafundelwa amandla ayo okuthuthukisa ukusebenza kwe-metabolic, ukuthuthukisa ukusebenza kwezemidlalo, nokusekela impilo yenhliziyo nemithambo yegazi.
Mayelana nokuphepha nokubekezelelana, i-deazaflavin ne-NMN ngokuvamile ibhekwa njengephephile kubantu abaningi uma isetshenziswa njengoba kuyalelwe. Kodwa-ke, kubalulekile ngaso sonke isikhathi ukubonana nochwepheshe bezempilo ngaphambi kokuqala noma yiluphi uhlobo lomuthi olusha lwezithako, ikakhulukazi uma unezimo zempilo ezicashile noma uphuza imithi.
I-Deazaflavin iyinhlanganisela etholakala ku-riboflavin, eyaziwa nangokuthi uvithamini B2. Icutshungulwe ngezindawo zayo zokulwa nokuguga ezingase zibe khona, ikakhulukazi amandla ayo okulwa nezifo nezimo ezihlobene nobudala. Ezinye zezinzuzo ezingaba khona ze-defazoflavin njengesithako esilwa nokuguga zihlanganisa ukuthuthukisa impilo yesikhumba, ukunciphisa ukubukeka kwemibimbi, nokukhuthaza impilo yonke.
Esinye sezizathu eziyinhloko zokuthi kungani i-deazaflavin kucatshangwa ukuthi iyasebenza ngokumelene nezimpawu zokuguga amandla ayo okuthuthukisa ukusebenza kwe-mitochondrial. I-Mitochondria yimithombo yamandla yeseli, enesibopho sokukhiqiza amandla. Njengoba sikhula, umsebenzi we-mitochondrial uyancipha, okuholela ekunciphiseni ukukhiqizwa kwamandla kanye nokulimala kwe-oxidative. I-deazaflavin ikhonjiswe ukuthi isekela ukusebenza kwe-mitochondrial, engase isize ukubambezela inqubo yokuguga.
I-Desoflavin iyinhlanganisela ekhonjiswe ukuthi ine-antioxidant, okusho ukuthi ingasiza ukuvikela amangqamuzana ethu emonakalweni obangelwa ama-radicals mahhala. Ama-radicals wamahhala angama-molecule angazinzile adala umonakalo kumangqamuzana ethu, anomthelela ekugugeni futhi andise ingozi yezifo ezinjengomdlavuza nesifo senhliziyo. Ngokuqeda la ma-radicals mahhala, i-deazaflavin ingasiza ekubambezeleni inqubo yokuguga futhi inciphise ingozi yezifo ezihlobene nobudala.
Ngaphezu kwezakhiwo zayo zokulwa ne-antioxidant, i-deazaflavin nayo iboniswe ukuthi inemiphumela elwa nokuvuvukala. Ukuvuvukala okungapheli kuhlotshaniswa nezifo eziningi ezihlobene nobudala, ngakho ukunciphisa ukuvuvukala emzimbeni kungasiza ekuthuthukiseni impilo yonke futhi kungase kubambezele inqubo yokuguga.
1.Izakhiwo ze-Antioxidant: Ama-Antioxidants abalulekile ekulweni nama-radicals mahhala emzimbeni, angabangela ukulimala kwamangqamuzana futhi abangele izinkinga ezihlukahlukene zempilo. Ngokudla i-deazaflavin powder, ungasiza ukuvikela umzimba wakho ekucindezelekeni okwenziwe nge-oxidative futhi unciphise ingozi yezifo ezingapheli ezifana nesifo senhliziyo, umdlavuza nesifo sikashukela.
2.Ngaphandle kwezakhiwo zayo ze-antioxidant, i-deazaflavin powder nayo yaziwa ngemiphumela yayo yokunciphisa ukuvuvukala. Ukuvuvukala kuwukusabela kwemvelo komzimba ekulimaleni noma ekuthelelekeni, kodwa ukuvuvukala okungapheli kungaholela ezinkingeni zezempilo ezihlukahlukene. Ucwaningo lubonisa ukuthi i-deazaflavin powder ingasiza ekunciphiseni ukuvuvukala futhi ikhulule izimo ezifana nesifo samathambo, i-asthma, nesifo samathumbu esivuthayo.
3.I-deazaflavin nayo ibalulekile ekusebenzeni okuvamile kwamasosha omzimba. Basiza ukwenza amangqamuzana omzimba asebenze futhi basize ukulwa nokutheleleka kanye nezifo. Ngokuthatha izithako ze-deazaflavin, ungaqinisa amasosha akho omzimba ukuze akwazi ukuvikela umzimba wakho ngempumelelo emagciwaneni ayingozi. Ngokungeza i-deazaflavin powder ekudleni kwakho, ungaqinisekisa ukuthi umzimba wakho uthola izakhi ezidingekayo ukuze usebenze kahle.
4.I-deazaflavin powder ihlotshaniswa nokusebenza okuthuthukisiwe kwengqondo nokucaca kwengqondo. Ama-antioxidants nezinye izakhi ku-deazaflavin powder zingasiza ukuvikela ubuchopho ekucindezelekeni kwe-oxidative futhi zisekele impilo yonke yobuchopho. Ezinye izifundo ziphakamisa nokuthi i-deazaflavin powder ingase ibe namandla okuvimbela izifo ze-neurodeergenerative ezifana nesifo i-Alzheimer's kanye ne-Parkinson.
5.Izakhiwo zokulwa nokuguga: i-deazaflavin iyi-antioxidant enamandla engasiza ukulwa nama-radicals mahhala emzimbeni. Ama-radicals wamahhala angama-molecule angazinzile angalimaza amaseli futhi abangele izinkinga ezihlobene nokuguga. Ngokuthatha izithako ze-deazaflavin, ungasiza ekunciphiseni imiphumela yokuguga esikhumbeni sakho, amalunga, kanye nempilo yonke.
6.Ikhuphula amandla: i-deazaflavin idlala indima ebalulekile ekukhiqizeni amandla emzimbeni ngokusebenza njenge-coenzyme. Ngokuthatha izithako ze-deazaflavin, ungasiza umzimba wakho ukukhiqiza amandla ngokuphumelelayo. Lokhu kukhulisa ukukhuthazela futhi kunciphisa ukukhathala, kukuvumela ukuthi wenze kangcono ngokomzimba nangokwengqondo.
Uma ufuna isithasiselo se-5-deazaflavin, kubalulekile ukubeka phambili ikhwalithi. Bheka amabhrendi ahloniphekile anerekhodi elihle lokukhiqiza izithasiselo zekhwalithi ephezulu. Ukufunda ukubuyekezwa kwamakhasimende kanye nokubonisana nezingcweti zezokunakekelwa kwempilo nakho kungakunikeza imininingwane ebalulekile ngesithunzi somkhiqizo wakho.
Ngaphezu kwekhwalithi, ifomu le-5-deazaflavin elisetshenziswe ekwengezeni kufanele licatshangelwe. Ezinye izithasiselo zingasebenzisa uhlobo lokwenziwa lwe-5-deazaflavin, kanti ezinye zisebenzisa imithombo yemvelo. Amafomu okwenziwa ngokuvamile ayathandwa ngoba kucatshangwa ukuthi ane-bioavailability ephezulu futhi amuncwa kalula futhi asetshenziswe umzimba.
Futhi, cabangela ezinye izithako esithasiselweni sakho. Bheka izithasiselo ezingenazo izigcwalisi ezingadingekile, izithasiselo, nezinto ezingezwani nomzimba. Ngokufanelekile, izithasiselo kufanele zenziwe ngezithako ezihambisanayo ezithuthukisa ukumuncwa kanye nokusetshenziswa kwe-5-deazaflavin emzimbeni.
Kubuye Kunconywe ukucabangela umthamo kanye potency of the ibhekwa. Ukuhlushwa kwe-5-deazaflavin kungase kuhluke phakathi kwemikhiqizo, ngakho-ke kubalulekile ukukhetha isengezo esihlangabezana nezidingo zakho zomuntu siqu kanye nemigomo yezempilo. Ukubonisana nochwepheshe bezokunakekelwa kwempilo kungakusiza ukuthi unqume umthamo ofanele wesimo sakho esithile.
Uma uthenga izithasiselo ze-5-deazaflavin, qaphela ukuthi uzithenga kuphi. Kungcono ukuthenga kumthengisi othembekile, kungaba kusesitolo noma ku-inthanethi, ukuze uqinisekise ukuthi uthola umkhiqizo wangempela. Qaphela izithasiselo ezinesaphulelo esikhulu noma ezinentengo engabazekayo, njengoba lezi zingase zingabi ezekhwalithi enhle.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Umbuzo: Iyini isengezo se-deazaflavin futhi singazizuzisa kanjani izinjongo zami zezempilo?
A: I-Deazaflavin iyinhlanganisela esekela imisebenzi ehlukahlukene ye-metabolic emzimbeni, okuhlanganisa ukukhiqizwa kwamandla kanye nempilo yamaselula. Ingasekela inhlalakahle iyonke futhi isize ngezinjongo ezithile zezempilo ezifana namazinga athuthukisiwe wamandla nokwesekwa kwe-antioxidant.
Q: Ngisikhetha kanjani isithasiselo se-deazaflavin esifanele ngezidingo zami?
A: Uma ukhetha isithasiselo se-deazaflavin, kubalulekile ukucabangela izici ezifana nekhwalithi, ukuhlanzeka, namandla. Bheka uhlobo oluthembekile olusebenzisa izithako zekhwalithi ephezulu futhi olunokuhlolwa okuvela eceleni ukuze uqinisekise amandla nobumsulwa. Ukwengeza, cabangela imigomo yakho yezempilo ethile futhi ubheke isengezo esakhelwe ukusekela leyo migomo.
Q: Kuthatha isikhathi esingakanani ukubona imiphumela yokuthatha isithasiselo se-deazaflavin?
IMP: Isikhathi esisithathayo ukubona imiphumela yokuthatha isithasiselo se-deazaflavin singahluka kuye ngezici ngazinye njengempilo iyonke, ukudla, nendlela yokuphila. Abanye abantu bangase baqaphele ukuthuthuka kumazinga wamandla kanye nempilo yonke ngokushesha uma kuqhathaniswa, kuyilapho abanye kungase kuthathe isikhathi eside ukuze bathole izinzuzo ezigcwele. Kubalulekile ukuhambisana nokuthatha isithasiselo njengoba kuyalelwe futhi usinikeze isikhathi sokusebenza.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Jan-19-2024
