Ekuphishekeleni impilo ephelele nokuphila kahle, imvelo ibilokhu isinika inqolobane yezinhlanganisela ezinamandla ezinezinzuzo ezihlukahlukene. Enye inhlanganisela eye yanakwa eminyakeni yamuva i-dehydrozingerone. Itholakala ku-ginger, i-dehydrozingerone iyinhlanganisela ye-bioactive enamandla amakhulu okukhuthaza impilo yonke kanye nokuphila kahle. Inezinzuzo ezihlukahlukene, kuhlanganise ne-anti-inflammatory, izakhiwo ze-antioxidant, okwenza kube isengezo esibalulekile ku-arsenal yethu yezinhlanganisela zemvelo ezikhuthaza impilo. Ngokuvula amandla e-dehydrozingerone, singathatha isinyathelo esibheke ekuzuzeni impilo ephezulu namandla.
I-Dehydrozingeroneiyinhlanganisela eyenzeka ngokwemvelo ku-ginger, isinongo esidumile kanye nekhambi elisetshenziswe ezinhlelweni zemithi yendabuko amakhulu eminyaka. Ingokwesigaba sezinhlanganisela ezibizwa ngokuthi ama-gingerols, anesibopho sezinzuzo eziningi zezempilo ezihlobene nejinja. I-Dehydrozingerone ifana ngokwesakhiwo ne-curcumin, kodwa i-bioavailability yayo iphakeme kakhulu ngenxa yekhono layo lokuhlangana namanzi. I-Dehydrozingerone yakhiwa ngokuncipha kwamanzi kwenye inhlanganisela ye-gingerol (6-gingerol) futhi inokwakheka kwamakhemikhali okuyingqayizivele kanye nomsebenzi webhayoloji.
I-Dehydrozingerone inamakhono alandelayo:
●Thuthukisa ukulawula ushukela wegazi
●Umsebenzi onamandla we-antioxidant, ikakhulukazi ngokumelene nokudla okugayiwe/amafutha
●Izakhiwo zokulwa nokuvuvukala
●Umphumela we-anti-proliferative wokukhula kwamaseli okungenampilo
●Isimo semizwa sesisonke sibe ngcono
I-Dehydrocyanin yenza i-AMP-activated protein kinase (AMPK), esiza ukuthuthukisa ukusebenza kwe-metabolic kanye nokuthathwa kwe-glucose okungcono. Kuhlanganiswe ndawonye, lokhu kubangela imiphumela enamandla yokulwa nokuguga kanye nokuncipha kwesisindo futhi kungase kuthembise kakhulu kune-curcumin ngokwayo.
I-Dehydrozingeroneiyinhlanganisela eyingxenye yesigaba se-phenolic organic compound. Iphuma ku-zingerone, isakhi semvelo esitholakala ku-ginger.
Isakhiwo se-dehydrozingerone siqukethe indandatho ye-phenolic eneqembu le-ketone kanye nesibopho esiphindwe kabili. Ifomula yamakhemikhali ye-dehydrozingerone yi-C11H12O3, futhi isisindo sayo samangqamuzana ngu-192.21 g/mol. Isakhiwo samangqamuzana e-dehydrozingerone sibonakala ngokuba khona kwendandatho enamalungu ayisithupha enephunga elimnandi eneqembu le-hydroxyl (OH) elinamathiselwe. Ngaphezu kwalokho, kuneqembu le-ketone (C = O) kanye nesibopho esiphindwe kabili (C = C) esakhiweni.
Ukuba khona kwendandatho ye-phenolic ku-dehydrozingerone kunquma izakhiwo zayo ze-antioxidant. Ama-phenolic compounds aziwa ngokukwazi kwawo ukukhipha ama-radicals mahhala futhi avikele amaseli emonakalweni we-oxidative. Lokhu kwenza i-dehydrozingerone ibe nenzuzo ekulweni nokucindezeleka kwe-oxidative nokunciphisa ingozi yezifo ezingapheli ezihlobene nomonakalo wama-radical wamahhala.
Ngaphezu kwalokho, iqembu le-ketone esakhiweni se-dehydrozingerone linomthelela ekusebenzeni kabusha kwalo kanye nomsebenzi ongase ube khona wezinto eziphilayo. Ama-Ketones angamaqembu asebenzayo anemisebenzi eminingi angabamba iqhaza ekuphenduleni kwamakhemikhali okuhlukahlukene, okwenza i-dehydrozingerone ibe i-molecule enentshisekelo kukhemikhali yezokwelapha nokutholakala kwezidakamizwa.
Amabhondi aphindwe kabili esakhiweni se-dehydrozingerone nawo andisa ukusebenza kwawo kwamakhemikhali futhi angase adlale indima emsebenzini wayo webhayoloji. Amabhondi aphindwe kabili angabhekana nokusabela kokwengezwa, futhi ukuba khona kwawo kumakhompiyutha ezinto eziphilayo kuvame ukuthikameza izakhiwo zawo zomzimba namakhemikhali.
Ngokuphathelene nemiphumela yayo yezinto eziphilayo, i-dehydrozingerone iye yafundelwa izakhiwo zayo zokulwa nokuvuvukala. Ukuvuvukala kuwukusabela kwemvelo kwamasosha omzimba ekulimaleni noma ekuthelelekeni, kodwa ukuvuvukala okungapheli kungaholela ekuthuthukisweni kwezifo ezihlukahlukene. I-Dehydrozingerone ibonise amandla okuguqula izindlela zokuvuvukala futhi inciphise ukukhiqizwa kwama-molecule e-pro-inflammatory kumaseli.
Isakhiwo se-dehydrozingerone siphinde siyenze ibe umuntu ozongenela ucwaningo olwengeziwe emikhakheni yemvelo yomkhiqizo wamakhemikhali nokuthuthukiswa kwezidakamizwa. Ukuqonda izici zabo zamakhemikhali nokusebenza kabusha kungasiza ekwakhiweni kokuphuma kokunye okuthuthukisiwe kwebhayoloji noma izici ezithuthukisiwe ze-pharmacokinetic.
1. Izakhiwo zayo zokulwa nokuvuvukala
Ukuvuvukala kuwukusabela kwemvelo komzimba ekulimaleni noma ekuthelelekeni, kodwa lapho kuba okungamahlalakhona, kungaba nomthelela ekwakhekeni kwezifo ezihlukahlukene, okuhlanganisa isifo samathambo, isifo senhliziyo nemithambo yegazi, kanye nomdlavuza. I-Dehydrozingerone iboniswe ukuthi ivimbela ukukhiqizwa kwabalamuli abavuthayo futhi inciphise ukubonakaliswa kwezakhi zofuzo ezivuthayo, okwenza kube umuntu ongase abe yikhandidethi yokuthuthukiswa kwezidakamizwa ezilwa nokuvuvukala.
2.Antioxidant izakhiwo
Ukucindezeleka kwe-oxidative kwenzeka lapho kunokungalingani phakathi kokukhiqizwa kwama-radicals mahhala kanye nekhono lomzimba lokuwanciphisa, futhi kuxhumene nokuthuthukiswa kwezifo ezihlukahlukene, okuhlanganisa izifo ze-neurodeergenerative, isifo senhliziyo, nomdlavuza. I-Dehydrozingerone ikhonjiswe ukuthi isusa ama-radicals mahhala futhi ivikele amaseli emonakalweni we-oxidative, okuphakamisa ukuthi ingaba namandla njenge-antioxidant yemvelo.
3. Izakhiwo ezingaba khona zokulwa nomdlavuza
Umdlavuza uyisifo esiyinkimbinkimbi futhi esinezici eziningi, futhi ukuthola ukwelashwa okuphumelelayo kuseyinselele enkulu. Ucwaningo lubonisa ukuthi i-dehydrozingerone ingavimbela ukukhula nokwanda kwamangqamuzana omdlavuza, yenze i-apoptosis (ukufa kweseli elihleliwe) kumaseli omdlavuza, futhi ivimbele ukwakheka kwemithambo yegazi emisha edingekayo ekukhuleni kwesimila. Lokhu okutholakele kusikisela ukuthi i-dehydrozingerone ingase ibe namandla njenge-ejenti elwa nomdlavuza, kungaba iyodwa noma ihlanganiswe nezinye izidakamizwa ezilwa nomdlavuza.
4. Imiphumela ohlelweni lwenhliziyo nemithambo yegazi
Isifo senhliziyo, okuhlanganisa nesifo sohlangothi, yisona sizathu esihamba phambili sokufa emhlabeni wonke. I-Dehydrozingerone iboniswe ukuthi inemiphumela ye-vasodilatory, okusho ukuthi ikhulula futhi ikhulise imithambo yegazi, engasiza ukwehlisa umfutho wegazi futhi ithuthukise ukugeleza kwegazi. Ukwengeza, kutholakale ukuthi kuvimbela ukwakheka kwamahlule egazi, imbangela ehamba phambili yokuhlaselwa yinhliziyo nokushaywa unhlangothi. Lokhu okutholakele kusikisela ukuthi i-dehydrozingerone ingase ibe namandla okuvimbela nokwelapha isifo senhliziyo nemithambo yegazi.
Ngaphezu kwezakhiwo zayo zemithi, i-dehydrozingerone nayo iye yafundelwa ukusetshenziswa kwayo okungaba khona ezimbonini zokudla nezimonyo. Njengenhlanganisela yemvelo ene-antioxidant kanye ne-anti-inflammatory properties, isetshenziswa njengesilondolozi sokudla noma isithasiselo kanye nemikhiqizo yokunakekelwa kwesikhumba. Ikhono layo lokususa ama-radicals mahhala futhi linciphise ukuvuvukala lingase liyenze ibe isithako esibalulekile ekuthuthukisweni kokudla okusebenzayo kanye nemikhiqizo yokunakekelwa kwesikhumba yemvelo.
1. Ikhwalithi nobumsulwa
Lapho ukhetha isengezo se-dehydrozingerone, kubalulekile ukubeka phambili ikhwalithi nokuhlanzeka. Bheka imikhiqizo eyenziwe izinkampani ezinedumela elihle futhi ihlolwe ngokuqinile ubumsulwa namandla. Khetha izithasiselo ezingenazo izithasiselo, izigcwalisi, nezithako zokwenziwa. Ukwengeza, cabanga ukukhetha imikhiqizo eqinisekisiwe ye-organic ukuqinisekisa ukuthi uthola isithasiselo semvelo esiphezulu.
2. I-Bioavailability
I-Bioavailability isho ikhono lomzimba lokumunca nokusebenzisa into ethile. Lapho ukhetha isithasiselo se-dehydrozingerone, khetha umkhiqizo one-bioavailability engcono kakhulu. Ngokukhetha isengezo esine-bioavailability ephezulu, ungaqinisekisa ukuthi umzimba wakho ungasebenzisa ngempumelelo i-dehydrozingerone ukuze uthole izinzuzo eziphezulu.
3. Iresiphi
Cabangela ukwakheka kwesengezo se-dehydrozingerone. Eminye imikhiqizo ingaqukatha ezinye izithako ezihambisana nemiphumela ye-dehydrozingerone, njenge-turmeric noma amanye ama-antioxidants. Lezi zithako ze-synergistic zithuthukisa ukusebenza kahle okuphelele kwesengezo. Ukwengeza, cabangela uhlobo lwesithasiselo, kungakhathaliseki ukuthi i-capsule, impushana, noma uketshezi, bese ukhetha evumelana kangcono nezintandokazi zakho nendlela yokuphila.
4. Idumela lomkhiqizo
Lapho ukhetha isithasiselo se-dehydrozingerone, cabangela isithunzi somkhiqizo. Bheka inkampani enomlando wokukhiqiza izithasiselo zekhwalithi ephezulu, ezisebenzayo. Cwaninga izinqubo zokukhiqiza zomkhiqizo, ukuthola isithako, nokuzibophezela kwikhwalithi. Ukufunda izibuyekezo zekhasimende nokufuna iseluleko kochwepheshe bezokunakekelwa kwempilo nakho kungakunikeza imininingwane ebalulekile ngesithunzi somkhiqizo wakho.
5. Ukungafihli nokuhlola
Khetha izithasiselo ze-dehydrozingerone ezinkampanini ezinomthombo osobala nezinqubo zokuhlola. Bheka imikhiqizo ehlolwe amalebhu ezinkampani zangaphandle ukuze uthole ubumsulwa, amandla, nokuphepha. Ukungafihli enqubweni yokukhiqiza nokuhlola kubonisa ukuzibophezela kwikhwalithi futhi kuqinisekisa ubuqotho besengezo.
6. Imigomo yezempilo
Lapho ukhetha isithasiselo se-dehydrozingerone, cabangela imigomo yakho ethile yezempilo nempilo. Kungakhathaliseki ukuthi ufuna ukusekela impilo ehlanganyelwe, ukunciphisa ukuvuvukala, noma ukuthuthukisa impilo yonke, khetha isithasiselo esifanelana nezidingo zakho zomuntu ngamunye. Eminye imikhiqizo ingase yakhelwe izinjongo ezithile, njengokusekela ukusebenza kwengqondo noma ukukhuthaza impilo yokugaya ukudla, ngakho-ke kubalulekile ukukhetha isithasiselo esifanelana nemigomo yakho.
7. Xhumana nochwepheshe bezempilo
Ngaphambi kokwengeza noma yiziphi izithasiselo ezintsha esimisweni sakho sezempilo, kutuswa ukuthi uthintane nochwepheshe bezempilo, ikakhulukazi uma unanoma yiziphi izimo zempilo ezicashile noma uphuza imithi. Uchwepheshe wezokunakekelwa kwempilo angakunikeza izeluleko eziqondene nawe ngokusekelwe esimweni sakho sezempilo futhi akusize unqume ukuthi yisiphi isithasiselo se-dehydrozingerone esilungele izidingo zakho.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP. .
Q: Iyini i-Dehydrozingerone futhi inomthelela kanjani empilweni ephelele?
A: I-Dehydrozingerone iyinhlanganisela yemvelo etholakala ku-ginger eye yafundelwa izinzuzo zayo zezempilo ezingase zibe khona, kuhlanganise ne-anti-inflammatory, izakhiwo ze-antioxidant, ezifaka isandla empilweni ephelele.
Q: I-Dehydrozingerone ingafakwa kanjani ohlelweni lwezempilo oluphelele?
A: I-Dehydrozingerone ingafakwa ohlelweni lwezempilo oluphelele ngemithombo yokudla efana nempande yejinja, kanye nezithasiselo kanye nezicelo zezihloko zemiphumela engaba khona yokuthuthukisa impilo.
Q: I-Dehydrozingerone ingawusekela kanjani umsebenzi wokuzivikela komzimba kanye nokuphila kahle?
A: Izakhiwo ze-Dehydrozingerone ezilwa nokuvuvukala kanye ne-antioxidant zingase zisekele umsebenzi wokuzivikela komzimba kanye nokuphila kahle ngokusiza ukunciphisa ukucindezeleka okwenziwe nge-oxidative nokuvuvukala emzimbeni.
Q: Yiziphi izinhlobo iDehydrozingerone etholakalayo ukuze isetshenziswe noma isetshenziswe?
A: I-Dehydrozingerone itholakala ngezindlela zokudla ezifana nezimpande zejinja, kanye namafomu agxilile njengezithako ezingeziwe, okukhishwe, kanye namalungiselelo ezihloko zezinhlelo zokusebenza zezempilo ezihlukahlukene.
Q: I-Dehydrozingerone iqhathaniswa kanjani nezinye izinhlanganisela zemvelo ekukhuthazeni impilo ephelele?
A: I-Dehydrozingerone yabelana ngokufana nezinye izinhlanganisela zemvelo ezifana ne-curcumin ne-resveratrol emandleni ayo okusekela impilo ephelele ngokusebenzisa izakhiwo zayo zokulwa nokuvuvukala kanye ne-antioxidant.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Apr-09-2024
