Eminyakeni yamuva nje, kuye kwaba nesithakazelo esikhulayo kumakhompiyutha emvelo angathuthukisa impilo yonke kanye nokuphila kahle. I-Urolithin A ne-urolithin B yizinhlanganisela ezimbili zemvelo ezitholakala kuma-ellagitannins atholakala ezithelweni ezithile namantongomane. Izakhiwo zabo zokulwa nokuvuvukala, i-antioxidant, neyokwakha imisipha zizenza izinhlanganisela ezithakazelisayo zokuthuthukisa impilo yonke. Nakuba i-urolithin A ne-urolithin B zinezakhiwo ezihlobene, ziphinde zibe nomehluko othile obalulekile.
I-Urolithin A no-B ama-metabolites akhiqizwa ngokwemvelo emzimbeni womuntu ngenxa yokugaya izingxenye ezithile zokudla, ikakhulukazi i-ellagitannins. Ama-Ellagitannins akhona ezithelweni namantongomane ahlukahlukene, kufaka phakathi amahalananda, ama-strawberries, ama-raspberries, amajikijolo amnyama nama-walnuts. Kodwa-ke, iphesenti elincane kuphela labantu elinamagciwane amathumbu akwazi ukuguqula ama-ellagitannins abe yi-urolithin, okwenza amazinga e-urolithin kubantu ahluke kakhulu.
Kulabo abanenkinga yokuhlangabezana nezidingo zabo ze-magnesium ngokudla kuphela, izithasiselo ze-magnesium zingazuzisa impilo ngezindlela eziningi futhi zize ngamafomu afana ne-magnesium oxide, i-magnesium threonate, i-magnesium taurate, ne-magnesium glycinate. Kodwa-ke, kunconywa ukuthi uthintane nochwepheshe bezokunakekelwa kwezempilo ngaphambi kokuqala noma yiluphi uhlobo lwemithi yokwengeza ukuze ugweme ukusebenzisana okungenzeka noma izinkinga.
I-Urolithin A iyi-molecule eningi kakhulu emndenini we-urolithin, futhi izakhiwo zayo ze-antioxidant ne-anti-inflammatory ziye zafundwa kahle. Ucwaningo luye lwabonisa ukuthi i-urolithin A ingathuthukisa umsebenzi we-mitochondrial futhi ivimbele ukulimala kwemisipha. Ngaphezu kwalokho, ucwaningo luye lwabonisa ukuthi i-urolithin A ingavimbela ukwanda kwamangqamuzana futhi ibangele ukufa kwamangqamuzana emigqeni yamangqamuzana omdlavuza.
I-Urolithin B idonse ukunaka kwabacwaningi ngekhono layo lokuthuthukisa impilo yamathumbu nokunciphisa ukuvuvukala. Ucwaningo lukhombisa ukuthi i-urolithin B ingathuthukisa ukuhlukahluka kwamagciwane emathunjini futhi yehlise ama-cytokines abangela ukuvuvukala njenge-interleukin-6 kanye ne-tumor necrosis factor alpha. Ngaphezu kwalokho, i-urolithin B itholakale inezindawo ezingaba yi-neuroprotective, ngocwaningo olubonisa ukuthi ingasiza ekuvimbeleni izifo ze-neurodegenerative ezifana ne-Parkinson kanye ne-Alzheimer's.
Nakuba i-urolithin A ne-urolithin B inezakhiwo ezihlobene, inomehluko othile obalulekile. Isibonelo, i-urolithin A iboniswe ukuthi iphumelela kakhulu njenge-anti-inflammatory and antioxidant kune-urolithin B. I-Urolithin B, ngakolunye uhlangothi, itholakale iphumelela kakhulu ekuvimbeleni izinkinga ezihlobene nokukhuluphala, njengokumelana ne-insulin kanye ne-adipocyte. umehluko.
Izinqubo zesenzo se-urolithin A ne-urolithin B nazo zihlukile. I-Urolithin A yenza kusebenze i-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) indlela, edlala indima ku-mitochondrial biogenesis, kuyilapho i-urolithin B ithuthukisa indlela ye-AMP-activated protein kinase (AMPK), ebandakanyeka ku-homeostasis yamandla. Lezi zindlela zifaka isandla emiphumeleni yezempilo enenzuzo yalezi zinhlanganisela.
●Izakhiwo zokulwa nokuvuvukala
Ukuvuvukala okungapheli kuyaziwa ukuthi kunomthelela ezifweni eziningana. I-Urolithin A ikhonjiswe ukuthi inezinto ezinamandla zokulwa nokuvuvukala, inciphisa ukukhiqizwa kwama-molecule avuthayo. Ngokucindezela ukuvuvukala, kungasiza ekulawuleni izimo ezihlukahlukene ezingapheli ezifana nesifo samathambo, isifo senhliziyo, nezinhlobo ezithile zomdlavuza.
●Impilo Yemisipha Namandla
Njengoba sikhula, ukulahlekelwa kwemisipha yamathambo kuba ukukhathazeka okuphawulekayo. I-Urolithin A itholwe ukuze ikhuthaze ukukhula kwamangqamuzana emisipha futhi ithuthukise ukusebenza kwemisipha, ikhuthaze impilo yemisipha namandla. Lokhu kunesithembiso kubantu abafuna ukulondoloza imisipha kanye nokulwa nokwehla kwemisipha okuhlobene neminyaka.
●Impilo ye-Mitochondrial kanye Nokuphila Okude
I-Urolithin A ibonisa imiphumela eqinile ku-mitochondria, evame ukubizwa ngokuthi izikhungo zamandla zamaseli ethu. Iqala inqubo ebizwa ngokuthi i-mitophagy, ehilela ukususwa okukhethiwe kwe-mitochondria eyonakele. Ngokuphromotha ukusebenza okunempilo kwe-mitochondrial, i-urolithin A ingase ibe nomthelela ekuphileni isikhathi eside futhi ivikele ezimeni ezihlobene nobudala njengezifo ze-neurodegenerative.
●Umsebenzi we-Antioxidant
I-Urolithin B iyi-antioxidant enamandla esiza ukunciphisa ama-radicals ayingozi emzimbeni. Ama-radicals wamahhala angama-molecule asebenzayo kakhulu angaba nomthelela ekulimaleni kwamangqamuzana kanye nengcindezi ye-oxidative, ebandakanyeka ezifweni ezahlukahlukene. Umsebenzi we-antioxidant we-urolithin B usiza ukuvikela amangqamuzana ethu emonakalweni onjalo futhi ungase unciphise ingozi yezifo ezingamahlalakhona.
●I-Gut Health kanye ne-Microbiome Modulation
Amathumbu ethu adlala indima ebalulekile empilweni yethu yonke, futhi i-urolithin B iye yavela njengengxenye ebalulekile ekugcineni i-gut microbiome enempilo. Ikhuthaza ukukhula kwe-benefiamabhaktheriya e-cial futhi avimbele ukukhula kwamabhaktheriya ayingozi, ngaleyo ndlela kukhuthaze indawo ezungezile ye-microbial. I-microbiome ye-gut elungile ihlotshaniswa nokugaya ukudla okuthuthukisiwe, ukusebenza kahle kwamasosha omzimba, nokuphila kahle kwengqondo.
●Thuthukisa impilo yemisipha
I-Urolithin B iboniswe ukuthi ivuse i-mitochondrial autophagy, inqubo yeselula esiza ukuqeda i-mitochondria eyonakele kumaseli. Le nqubo isiza ukuthuthukisa impilo nokusebenza kwemisipha jikelele, okwenza kube isengezo esingaba khona kulabo abafuna ukuthuthukisa ukusebenza komzimba. Ucwaningo olulodwa lwathola ukuthi i-urolithin B ithuthukisa ukusebenza kwemisipha namandla kumagundane nakubantu.
Ama-Urolithin akhiqizwa emizimbeni yethu ngemva kokudla ukudla okuthile okuqukethe i-ellagitannins.Imithombo yokudla emikhulu ye-ellagitannins ihlanganisa:
a)Amapomegranati
Amapomegranati angomunye wemithombo ecebile yokudla ye-ellagitannins, eguqulwa ibe i-urolithin A kanye ne-urolithin B ngamabhaktheriya amathumbu. Ukudla isithelo sepomegranate, ijusi, noma okukhishwe kungakhuphula ukudla kwakho kwalezi zinhlanganisela ezinamandla, kuthuthukise impilo yamaselula futhi kube nemiphumela elwa nokuvuvukala.
b) Amajikijolo
Amajikijolo ahlukahlukene afana nama-strawberry, ama-raspberries, nama-blackberries aqukethe amazinga aphezulu e-ellagitannins. Ucwaningo luye lwabonisa ukuthi ukudla lezi zithelo ezinempilo kukhuthaza ukukhiqizwa kwe-urolithin A ne-urolithin B emathunjini. Ukwengeza amajikijolo ekudleni kwakho akugcini nje ngokuthuthukisa ukunambitheka kodwa futhi kunikeza izinzuzo ezingaba khona zezempilo zesikhathi eside.
c) Amantongomane
Amantongomane, ikakhulukazi ama-walnuts nama-pecans, ayimithombo ecebile ye-ellagitannins. Ukwengeza, zigcwele amafutha anempilo, i-fiber, nezinye izakhi ezibalulekile. Ukufaka amantongomane ekudleni kwakho kwansuku zonke akunikezeli nje kuphela i-urolithin A no-B kodwa futhi kunikeza izinzuzo eziningi zezempilo zenhliziyo, ubuchopho, kanye nenhlalakahle yonke.
d) Iwayini elidala i-Oak
Nakuba kungase kusimangaze, ukusetshenziswa okusesilinganisweni kwewayini elibomvu le-oki nakho kungaba nomthelela ekukhiqizweni kwe-urolithin. Izinhlanganisela ezikhona emiphongolweni ye-oki esetshenziselwa ukuguga kwewayini zingakhishwa ngesikhathi sokuguga, kufakwe iwayini nge-ellagitannins. Nokho, kubalulekile ukukhumbula ukuthi ukuphuza ngokweqile kunemiphumela emibi empilweni, ngakho ukulinganisela kubalulekile.
e) Izitshalo ezinothe nge-Ellagitannin
Eceleni kwamapomegranati, izitshalo ezithile ezifana negxolo le-oki, ama-strawberry, namaqabunga e-oki ziningi ngokwemvelo kuma-ellagitannins. Ukufaka lezi zitshalo ekudleni kwakho kungasiza ekwandiseni amazinga e-urolithin A ne-urolithin B emzimbeni wakho, okusekela impilo yamaselula kanye nokwenza ngcono impilo yonke.
Ukufakaurolithin A kanye no-B endleleni yakho yokuphila, indlela eyodwa elula iwukudla ukudla okunothe ngama-ellagitannins. Amapomegranati, ama-strawberries, ama-raspberries, nama-walnuts ayimithombo emihle kakhulu.
Kodwa-ke, kubalulekile ukuqaphela ukuthi okuqukethwe kwe-ellagitannin kuyahlukahluka ngaphakathi kwesithelo ngasinye, futhi akuwona wonke umuntu one-gut microbiota efanayo ekwazi ukuguqula i-ellagitannins ibe i-urolithins. Ngakho-ke, abanye abantu bangase bangakwazi ukukhiqiza ama-urolithin kule mithombo yokudla. izithasiselo kungenye inketho yokuqinisekisa ukuthathwa okwanele kwe-urolithin A no-B.
Q: I-Urolithin A ne-Urolithin B ikhuthaza kanjani impilo ye-mitochondrial?
A: I-Urolithin A ne-Urolithin B yenza kusebenze indlela yeselula ebizwa ngokuthi i-mitophagy, enesibopho sokususa i-mitochondria eyonakele kumaseli. Ngokuthuthukisa i-mitophagy, lezi zinhlanganisela zisiza ukugcina inani labantu elinempilo le-mitochondrial, elibalulekile ekukhiqizweni kwamandla kanye nokusebenza jikelele kwamaselula.
Q: Ingabe i-Urolithin A ne-Urolithin B ingatholakala ngezithako zokudla?
A: Yebo, izithasiselo ze-Urolithin A ne-Urolithin B ziyatholakala emakethe. Nokho, kubalulekile ukuqaphela ukuthi ukusebenza kahle nokuphepha kwalezi zithako kungase kwehluke. Kunconywa ukuthi ubonane nochwepheshe bezempilo ngaphambi kokuqala noma yiziphi izithasiselo zokudla ezintsha.
Umshwana wokuzihlangula: Lesi sihloko senzelwe izinjongo zokwaziswa kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukushintsha uhlobo lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Sep-13-2023
