Eminyakeni yamuva nje, kube nesithakazelo esikhulayo kumakhemikhali emvelo angathuthukisa impilo kanye nenhlalakahle iyonke. I-Urolithin A kanye ne-urolithin B kumakhemikhali amabili emvelo atholakala kuma-ellagitannins atholakala ezithelweni ezithile nakumantongomane. Izakhiwo zawo zokulwa nokuvuvukala, i-antioxidant, kanye nokwakha imisipha zenza kube amakhemikhali athakazelisayo okukhuthaza impilo iyonke. Nakuba i-urolithin A kanye ne-urolithin B zinezakhiwo ezihlobene, nazo zinomehluko obalulekile.
Ama-Urolithin A kanye no-B angama-metabolites akhiqizwa ngokwemvelo emzimbeni womuntu ngenxa yokugaywa kwezingxenye ezithile zokudla, ikakhulukazi ama-ellagitannins. Ama-Ellagitannins akhona ezithelweni nasemantongomane ahlukahlukene, okuhlanganisa amapomegranate, ama-strawberry, ama-raspberry, ama-blackberry, kanye nama-walnuts. Kodwa-ke, amaphesenti amancane kuphela abantu anamabhaktheriya asemathunjini akwazi ukuguqula ama-ellagitannins abe ama-urolithin, okwenza amazinga e-urolithin kubantu ngabanye ahluke kakhulu.
Kulabo abanobunzima bokuhlangabezana nezidingo zabo ze-magnesium ngokudla kuphela, izithasiselo ze-magnesium zingazuzisa impilo ngezindlela eziningana futhi ziza ngezindlela ezifana ne-magnesium oxide, i-magnesium threonate, i-magnesium taurate, kanye ne-magnesium glycinate. Kodwa-ke, kunconywa ukubonisana nochwepheshe wezempilo ngaphambi kokuqala noma yiluphi uhlobo lokwelashwa ukuze ugweme ukusebenzisana noma izinkinga ezingaba khona.
I-Urolithin A iyi-molecule eningi kakhulu emndenini we-urolithin, futhi izakhiwo zayo zokulwa ne-antioxidant kanye nokulwa nokuvuvukala ziye zafundwa kahle. Izifundo zibonise ukuthi i-urolithin A ingathuthukisa ukusebenza kwe-mitochondrial futhi ivimbele ukulimala kwemisipha. Ngaphezu kwalokho, izifundo zibonise ukuthi i-urolithin A ingavimbela ukwanda kwamangqamuzana futhi ibangele ukufa kwamangqamuzana emigqeni ehlukahlukene yamangqamuzana omdlavuza.
I-Urolithin B idonsele ukunaka kwabacwaningi ngekhono layo lokuthuthukisa impilo yamathumbu nokunciphisa ukuvuvukala. Ucwaningo lubonisa ukuthi i-urolithin B ingathuthukisa ukuhlukahluka kwamagciwane amathumbu futhi inciphise ama-cytokine abangela ukuvuvukala njenge-interleukin-6 kanye ne-tumor necrosis factor alpha. Ngaphezu kwalokho, i-urolithin B itholakale inezakhiwo ezingaba khona zokuvikela izinzwa, kanti izifundo zibonisa ukuthi ingasiza ekuvimbeleni izifo eziwohlokayo zezinzwa njenge-Parkinson's kanye ne-Alzheimer's.
Nakuba i-urolithin A kanye ne-urolithin B zinezakhiwo ezihlobene, zinomehluko obalulekile. Isibonelo, i-urolithin A iboniswe isebenza kangcono njenge-anti-inflammatory kanye ne-antioxidant kune-urolithin B. I-Urolithin B, ngakolunye uhlangothi, itholakale isebenza kangcono ekuvimbeleni izinkinga ezihlobene nokukhuluphala, njengokumelana ne-insulin kanye nokwehlukaniswa kwamafutha.
Izindlela zokusebenza kwe-urolithin A kanye ne-urolithin B nazo zihlukile. I-Urolithin A isebenzisa indlela ye-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), edlala indima ku-mitochondrial biogenesis, kuyilapho i-urolithin B ithuthukisa indlela ye-AMP-activated protein kinase (AMPK), ehilelekile ku-energy homeostasis. Lezi zindlela zinegalelo emiphumeleni yezempilo enenzuzo yalezi zinhlanganisela.
●Izakhiwo Zokulwa Nokuvuvukala
Ukuvuvukala okungapheli kwaziwa ukuthi kunegalelo ezifweni eziningana. I-Urolithin A iboniswe inezakhiwo ezinamandla zokulwa nokuvuvukala, inciphisa ukukhiqizwa kwama-molecule okuvuvukala. Ngokucindezela ukuvuvukala, ingasiza ekuphatheni izimo ezahlukahlukene ezingamahlalakhona njenge-arthritis, isifo senhliziyo, kanye nezinhlobo ezithile zomdlavuza.
●Impilo Yemisipha Namandla
Njengoba sikhula, ukulahlekelwa yimisipha yamathambo kuba yinto ekhathazayo kakhulu. I-Urolithin A itholakale ikhuthaza ukukhula kwamaseli emisipha futhi ithuthukise ukusebenza kwemisipha, ikhuthaza impilo namandla emisipha. Lokhu kunesithembiso kubantu abafuna ukulondoloza ubunzima bemisipha nokulwa nokwehla kwemisipha okuhlobene nokuguga.
●Impilo ye-Mitochondrial kanye nobude besikhathi eside
I-Urolithin A ibonisa imiphumela eqinile ku-mitochondria, evame ukubizwa ngokuthi yizindawo zamandla zamaseli ethu. Iqala inqubo ebizwa ngokuthi i-mitophagy, ehilela ukususwa okukhethekile kwe-mitochondria eyonakele. Ngokukhuthaza ukusebenza kahle kwe-mitochondria, i-urolithin A ingasiza ekuphileni isikhathi eside futhi ivikele ezimweni ezihlobene nokuguga njengezifo eziwohlokayo zemizwa.
●Umsebenzi Wokulwa Nokushaqeka Kwe-Antioxidant
I-Urolithin B iyi-antioxidant enamandla esiza ekunciphiseni ama-free radical ayingozi emzimbeni. Ama-free radicals angama-molecule asabela kakhulu angabangela umonakalo wamangqamuzana kanye nokucindezeleka kwe-oxidative, okubandakanyeka ezifweni ezahlukahlukene. Umsebenzi we-Urolithin B we-antioxidant usiza ukuvikela amangqamuzana ethu ekulimaleni okunjalo futhi unganciphisa ingozi yezifo ezingamahlalakhona.
●Impilo Yamathumbu kanye Nokuguqulwa Kwama-Microbiome
Amathumbu ethu adlala indima ebalulekile empilweni yethu iyonke, futhi i-urolithin B ivele njengomdlali obalulekile ekugcineni i-microbiome yamathumbu enempilo. Ikhuthaza ukukhula kwezinzuzoivimbela ukukhula kwamagciwane ayingozi, ngaleyo ndlela ikhuthaze indawo elinganiselayo yamagciwane. I-microbiome yamathumbu enhle ihlotshaniswa nokugaya ukudla okuthuthukisiwe, ukusebenza kahle kwamasosha omzimba kanye nenhlalakahle yengqondo.
●Khuthaza impilo yemisipha
I-Urolithin B iboniswe ukuthi ikhuthaza i-mitochondrial autophagy, inqubo yamaseli esiza ekususeni i-mitochondria eyonakele emaseli. Le nqubo isiza ekuthuthukiseni impilo nokusebenza kwemisipha iyonke, okwenza kube isengezo esingaba khona kulabo abafuna ukuthuthukisa ukusebenza ngokomzimba. Ucwaningo olulodwa luthole ukuthi i-urolithin B ithuthukise ukusebenza kwemisipha kanye namandla emagundwini nakubantu.
Ama-Urolithin akhiqizwa emizimbeni yethu ngemva kokudla ukudla okuthile okuqukethe ama-ellagitannins. Imithombo emikhulu yokudla yama-ellagitannins ihlanganisa:
a) Amapomegranati
Amapomegranati angomunye wemithombo yokudla ecebile kakhulu yama-ellagitannins, aguqulwa abe yi-urolithin A kanye ne-urolithin B ngamagciwane asemathunjini. Ukudla izithelo zepomegranati, ujusi, noma izingcezu kungakhulisa ukudla kwakho la makhemikhali anamandla, kuthuthukise impilo yamaseli futhi kube nemiphumela yokulwa nokuvuvukala.
b) Amajikijolo
Amajikijolo ahlukahlukene afana nama-strawberry, ama-raspberry, nama-blackberry aqukethe amazinga aphezulu e-ellagitannins. Ucwaningo luye lwabonisa ukuthi ukudla lezi zithelo eziqhakazile kukhuthaza ukukhiqizwa kwe-urolithin A kanye ne-urolithin B emathunjini. Ukwengeza amajikijolo ekudleni kwakho akugcini nje ngokuthuthukisa ukunambitheka kodwa futhi kunikeza izinzuzo zezempilo zesikhathi eside.
c) Amantongomane
Amantongomane, ikakhulukazi ama-walnut nama-pecan, ayimithombo ecebile yama-ellagitannins. Ngaphezu kwalokho, agcwele amafutha anempilo, i-fiber, nezinye izakhamzimba ezibalulekile. Ukufaka amantongomane ekudleni kwakho kwansuku zonke akugcini nje ngokunikeza i-urolithin A no-B kodwa futhi kunikeza izinzuzo eziningi zezempilo zenhliziyo, ubuchopho, kanye nenhlalakahle iyonke.
d) Amawayini asebekhulile nge-oki
Nakuba kungase kumangaze, ukusetshenziswa okulinganiselwe kwewayini elibomvu elineminyaka engu-oki nakho kungasiza ekukhiqizweni kwe-urolithin. Amakhemikhali akhona emiphongolweni ye-oki esetshenziselwa ukuguga kwewayini angakhishwa ngesikhathi senqubo yokuguga, okuhlanganisa ama-ellagitannins ewayinini. Kodwa-ke, kubalulekile ukukhumbula ukuthi ukuphuza utshwala ngokweqile kunemiphumela emibi empilweni, ngakho-ke ukulinganisela kubalulekile.
e) Izitshalo ezicebile nge-Ellagitannin
Eceleni kwamapomegranati, izitshalo ezithile ezifana negxolo le-oki, ama-strawberry, namaqabunga e-oki ziningi ngokwemvelo kuma-ellagitannins. Ukufaka lezi zitshalo ekudleni kwakho kungasiza ekwandiseni amazinga e-urolithin A kanye ne-urolithin B emzimbeni wakho, kusekele impilo yamangqamuzana futhi kuthuthukise inhlalakahle iyonke.
Ukufakai-urolithin A kanye ne-B endleleni yakho yokuphila, enye indlela elula ukudla ukudla okucebile ngama-ellagitannins. Amapomegranate, ama-strawberry, ama-raspberry, nama-walnuts ayimithombo emihle kakhulu.
Kodwa-ke, kubalulekile ukuqaphela ukuthi okuqukethwe kwe-ellagitannin kuyahlukahluka ngaphakathi kwesithelo ngasinye, futhi akuwona wonke umuntu one-microbiota efanayo yamathumbu ekwazi ukuguqula i-ellagitannin ibe yi-urolithins. Ngakho-ke, abanye abantu bangase bangakhiqizi kahle i-urolithin kule mithombo yokudla. Izithako zokudla zingenye indlela yokuqinisekisa ukuthi i-urolithin A ne-B idliwa ngokwanele.
Q: I-Urolithin A ne-Urolithin B zikhuthaza kanjani impilo ye-mitochondrial?
A: I-Urolithin A kanye ne-Urolithin B zivuselela indlela yeselula ebizwa ngokuthi i-mitophagy, enesibopho sokususa i-mitochondria eyonakele emaselini. Ngokukhuthaza i-mitophagy, lawa ma-compound asiza ukugcina inani eliphilile le-mitochondrial, elibalulekile ekukhiqizweni kwamandla kanye nokusebenza kwamaseli jikelele.
U: Ingabe i-Urolithin A kanye ne-Urolithin B zingatholakala ngezithasiselo?
A: Yebo, izithasiselo ze-Urolithin A kanye ne-Urolithin B ziyatholakala emakethe. Kodwa-ke, kubalulekile ukuqaphela ukuthi ukusebenza kahle kanye nokuphepha kwalezi zithasiselo kungahluka. Kunconywa ukubonisana nochwepheshe wezempilo ngaphambi kokuqala noma yiziphi izithasiselo zokudla ezintsha.
Isixwayiso: Lesi sihloko senzelwe ulwazi kuphela futhi akufanele sibhekwe njengeseluleko sezokwelapha. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukushintsha uhlelo lwakho lwezempilo.
Isikhathi sokuthunyelwe: Septhemba 13-2023
