I-Urolithin A (UA) iyinhlanganisela ekhiqizwa yi-metabolism yezitshalo zamathumbu ekudleni okucebile kuma-ellagitannins (njengepomegranate, ama-raspberries, njll.). Ibhekwa njenge-anti-inflammatory, anti-aging, antioxidant, induction of mitophagy neminye imiphumela, futhi ingawela umgoqo wegazi-ubuchopho. Ucwaningo oluningi luye lwaqinisekisa ukuthi i-urolithin A ingabambezela ukuguga, futhi izifundo zomtholampilo nazo zibonise imiphumela emihle.
I-Urolithins ayitholakali ekudleni; noma kunjalo, ama-polyphenols awo angaphambili akhona. Ama-polyphenols agcwele izithelo nemifino eminingi. Uma idliwe, amanye ama-polyphenol amuncwa ngqo amathumbu amancane, kanti amanye wonakaliswa amagciwane okugaya abe kwezinye izinhlanganisela, ezinye zazo ezizuzisayo. Isibonelo, izinhlobo ezithile zamabhaktheriya amathumbu ziphula i-ellagic acid ne-ellagitannins zibe i-urolithin, okungenzeka kube ngcono impilo yabantu.
Urolithin Aiyi-metabolite ye-ellagitannin (ET) yezitshalo zamathumbu. Njengesandulela se-metabolic ye-Uro-A, imithombo yokudla eyinhloko ye-ET amahalananda, ama-strawberry, ama-raspberries, ama-walnuts newayini elibomvu. I-UA ingumkhiqizo we-ETs owenziwe nge-metabolized microorganisms zamathumbu.
I-Urolithin-A ayikho esimweni semvelo, kodwa ikhiqizwa uchungechunge lwezinguquko ze-ET ngezitshalo zamathumbu. I-UA ingumkhiqizo we-ETs owenziwe nge-metabolized microorganisms zamathumbu. Ukudla okucebile ku-ET kudlula esiswini namathumbu amancane emzimbeni womuntu, futhi ekugcineni kugaywe ngokuyinhloko ku-Uro-A kukholoni. Inani elincane le-Uro-A lingatholwa futhi emathunjini amancane angaphansi.
Njengezinhlanganisela zemvelo ze-polyphenolic, ama-ET adonse ukunakwa okukhulu ngenxa yemisebenzi yawo yezinto eziphilayo ezifana ne-antioxidant, anti-inflammatory, anti-allergic and anti-viral. Ngaphezu kokutholakala ekudleni okufana namahalananda, ama-strawberries, ama-walnuts, ama-raspberries, nama-alimondi, ama-ET atholakala emithini yendabuko yamaShayina njengama-gallnut, ama-pomegranate peels, i-Uncaria, i-Sanguisorba, i-Phyllanthus emblica, ne-agrimony. Iqembu le-hydroxyl esakhiweni samangqamuzana e-ETs li-polar ngokuqhathaniswa, elingahambisani nokumuncwa kwezindonga zamathumbu emathunjini, futhi i-bioavailability yayo iphansi kakhulu.
Ucwaningo oluningi luye lwathola ukuthi ngemva kokuba ama-ET efakwe emzimbeni womuntu, ahlanganiswa yizitshalo zamathumbu emathunjini futhi aguqulwe abe yi-urolithin ngaphambi kokumuncwa. I-ETs i-hydrolyzed ibe yi-ellagic acid (EA) endaweni engenhla ye-gastrointestinal tract, futhi i-EA idlula emathunjini. Izitshalo zebhaktheriya ziqhubeka nokusebenza futhi zilahlekelwe indandatho ye-lactone futhi zibhekana nokusabela kwe-dehydroxylation okuqhubekayo ukuze kukhiqizwe i-urolithin. Kunemibiko yokuthi i-urolithin ingaba yisisekelo sezinto eziphilayo ze-ETs emzimbeni.
I-Mitochondria yimithombo yamandla yamaseli ethu, anesibopho sokukhiqiza amandla nokugcina imisebenzi yamaselula. Njengoba sikhula, umsebenzi we-mitochondrial uyancipha, okuholela ezinkingeni zezempilo ezihlukahlukene. Ucwaningo luthole ukuthi i-urolithin A ingavuselela futhi ithuthukise ukusebenza kwe-mitochondrial, okungenzeka ibambezele inqubo yokuguga futhi ikhuthaze impilo namandla ayo yonke.
I-Urolithin A ingatholakala kuphela ekudleni njengezinto ezingavuthiwe ze-UA, futhi akusho ukuthi ukudla ukudla okuningi okuqukethe izandulela ze-UA kuzoholela ekuhlanganisweni kwe-urolithin A. Kubuye kuncike ekubunjweni kwezitshalo zamathumbu.
Urolithin A i-metabolite ekhiqizwa i-gut microbiota ngemva kokudla ukudla okuthile, njengamahalananda, amajikijolo, namantongomane. Le nhlanganisela ithole ukunakwa ngekhono layo lokwenza kusebenze i-mitophagy, inqubo esusa i-mitochondria eyonakele kumaseli, ngaleyo ndlela ikhuthaze ukuvuselelwa kwamaseli kanye nempilo yonke. Ngokuvamile okubizwa ngokuthi i-powerhouse yeseli, i-mitochondria idlala indima ebalulekile ekukhiqizweni kwamandla kanye nokusebenza kwamaselula. Njengoba sikhula, ukusebenza kahle kwe-mitochondrial kuncipha, okuholela ezinkingeni zezempilo ezihlobene nobudala. I-Urolithin A ikhonjiswe ukuthi isekela impilo nokusebenza kwe-mitochondrial, engase inciphise imiphumela yokuguga ekukhiqizeni amandla eselula kanye nobungqabavu buphelele.
Anti-ukuguga
I-radical theory yamahhala yokuguga ikholelwa ukuthi izinhlobo ze-oksijeni ezisebenzayo ezikhiqizwa ku-metabolism ye-mitochondrial zibangela ukucindezeleka kwe-oxidative emzimbeni futhi kuholele ekugugeni, futhi i-mitophagy idlala indima ebalulekile ekugcineni impilo ye-mitochondrial nobuqotho. Kuye kwabikwa ukuthi i-UA ingalawula i-mitophagy futhi ngaleyo ndlela ibonise amandla okubambezela ukuguga. Ucwaningo luye lwathola ukuthi i-UA inciphisa ukungasebenzi kahle kwe-mitochondrial futhi yandisa isikhathi sokuphila ku-Caenorhabditis elegans ngokufaka i-mitophagy; kumagundane, i-UA ingahlehlisa ukwehla kokusebenza kwemisipha okuhlobene nobudala, okubonisa ukuthi i-UA ithuthukisa ikhwalithi yemisipha ngokuthuthukisa ukusebenza kwe-mitochondrial. Futhi andise impilo yomzimba.
I-Urolithin A yenza kusebenze i-mitophagy
Enye yalezi i-mitophagy, ebhekisela ekukhishweni nasekusetshenzisweni kabusha kwe-mitochondria endala noma elahliwe.
Ngokukhula kanye nezinye izifo ezihlobene nobudala, i-mitophagy izokwehla noma imile, futhi ukusebenza kwezitho kuzokwehla kancane kancane. Ukuvikelwa kwe-urolithin A ekulahlekelweni kwemisipha kusanda kutholwa, futhi ucwaningo lwangaphambilini ngakho lwalugxile ku-mitochondria, ikakhulukazi i-mitophagy. (I-Mitophagy ibhekisela ekususweni okukhethekile kwe-mitochondria eyonakele ngama-autophagosomes) I-UA ingenza kusebenze i-mitophagy ngokusebenzisa izindlela eziningi, ezifana nokusebenzisa ama-enzyme akhuthaza i-mitophagy, noma ukulawula indlela ye-mitophagy, kanye nokuthuthukisa ama-autophagosomes. Ukwakheka njll.
Umphumela we-Antioxidant
Njengamanje, kuye kwenziwa izifundo eziningi ngomphumela we-antioxidant we-urolithin. Phakathi kwawo wonke ama-metabolites e-urolithin, i-Uro-A inomsebenzi oqinile we-antioxidant. Amandla okumunca i-oxygen free radical plasma yamavolontiya anempilo ahlolwe futhi kwatholakala ukuthi amandla e-antioxidant akhuphuke ngo-32% ngemuva kokungenwa kwejusi yehalananda ngamahora angu-0.5, kodwa umsebenzi Alukho ushintsho olubalulekile kumazinga komoyampilo, kodwa ukuhlolwa kwe-vitro kumaseli we-Neuro-2a, i-Uro-A yatholwa ukunciphisa izinga lezinhlobo ze-oxygen esebenzayo kumaseli. Izithako ezine-metabolite eyinhloko esebenzayo i-Uro-A zinganciphisa amazinga e-oxidative oxidative ezigulini, ngaleyo ndlela zithuthukise isimo seziguli, ukukhathala nokuqwasha. Le miphumela ikhombisa ukuthi i-Uro-A inemiphumela enamandla ye-antioxidant.
Umphumela wokulwa nokuvuvukala
Umthelela ojwayelekile phakathi kwawo wonke amamodeli omtholampilo we-UA ukuncishiswa kwempendulo yokuvuvukala.
Lo mphumela watholwa okokuqala kumagundane ngokuhlolwa kwe-enteritis, lapho kokubili amazinga we-mRNA namaprotheni we-inflammatory marker cyclooxygenase 2 ancishiswa. Ngocwaningo olwengeziwe, kutholwe ukuthi ezinye izimpawu zokuvuvukala, njengezici ze-pro-inflammatory kanye nezici ze-tumor necrosis, nazo zehliswa ngamazinga ahlukahlukene. Umthelela wokulwa nokuvuvukala we-UA unezici eziningi. Okokuqala, likhona ngamanani amakhulu emathunjini, ngakho-ke iningi Okusebenzayo yisifo samathumbu esivuvukalayo. Okwesibili, i-UA ayivikeli nje kuphela ukuvuvukala kwamathumbu ngoba inciphisa amazinga e-serum ewonke ezici zokuvuvukala. Ngokwethiyori, i-UA ingasebenza ezifweni ezibangelwa ukuvuvukala.
Kuningi, njenge-arthritis, i-intervertebral disc degeneration nezinye izifo ezihlangene ezivame kakhulu kubantu asebekhulile; ngaphezu kwalokho, ukuvuvukala okulimaza izinzwa kuyimbangela yezifo eziningi ze-neurodeergenerative. Ngakho-ke, lapho i-UA isebenzisa umphumela wokulwa nokuvuvukala ebuchosheni, Ingathuthukisa izifo eziningi ze-neurodegenerative, okuhlanganisa nesifo i-Alzheimer's (AD), ukukhubazeka kwenkumbulo, kanye nesifo sohlangothi.
I-Urolithin A kanye nezifo zenhliziyo ne-cerebrovascular
I-UA kubikwe ukuthi inemiphumela enamandla yokulwa nokuvuvukala kanye ne-antioxidant, futhi izifundo ezifanele ziqinisekisile ukuthi i-UA ingadlala indima enenzuzo ku-CVD. Ucwaningo lwe-In vivo luthole ukuthi i-UA inganciphisa impendulo yokuqala yokuvuvukala kwezicubu ze-myocardial ku-hyperglycemia futhi ithuthukise i-myocardial microenvironment, ikhuthaze ukutholwa kwe-cardiomyocyte contractility kanye ne-calcium dynamics, okubonisa ukuthi i-UA ingasetshenziswa njengomuthi osizayo ukulawula isifo senhliziyo nokuvimbela isifo sikashukela. yona. inkinga. I-UA ingathuthukisa ukusebenza kwe-mitochondrial kanye nokusebenza kwemisipha ngokufaka i-mitophagy. I-Mitochondria yenhliziyo yizitho zomzimba ezibalulekile ezinomthwalo wemfanelo wokukhiqiza i-ATP enothe ngamandla. Ukungasebenzi kahle kwe-Mitochondrial kuyimbangela eyinhloko yokuhluleka kwenhliziyo. Ukungasebenzi kahle kwe-Mitochondrial okwamanje kuthathwa njengokuhloswe kokwelapha okungaba khona. Ngakho-ke, i-UA isiphinde yaba yikhandidethi elisha lokwelashwa kwe-CVD.
I-Urolithin A kanye nesistimu yezinzwa
I-Neuroinflammation iyinqubo ebalulekile ekuveleni nasekuthuthukisweni kwezifo ze-neurodeergenerative. I-apoptosis ebangelwa ingcindezi ye-oxidative kanye nokuhlangana okungajwayelekile kwamaprotheni kuvame ukubangela i-neuroinflammation, futhi ama-cytokines abangela ukuvuvukala akhishwa yi-neuroinflammation abe esethinta ukwakheka kwe-neurodegeneration. Ucwaningo luye lwathola ukuthi i-UA ilamula umsebenzi wokulwa nokuvuvukala ngokwenza i-autophagy futhi isebenze isilawuli sesignali esithulile esingu-1 (SIRT-1) se-deacetylation mechanism, ivimbela i-neuroinflammation kanye ne-neurotoxicity, futhi ivimbele i-neurodegeneration, iphakamisa ukuthi i-UA iyi-ejenti ye-Neuroprotective esebenzayo. Ngesikhathi esifanayo, ezinye izifundo zithole ukuthi i-UA ingasebenzisa imiphumela ye-neuroprotective ngokukhipha ngokuqondile ama-radicals mahhala kanye nokuvimbela ama-oxidase. U-Ahsan et al. ithole ukuthi i-UA ivimbela ukucindezeleka kwe-endoplasmic reticulum ngokuvula i-autophagy, ngaleyo ndlela inciphise ukufa kwe-ischemic neuronal, futhi inamandla okwelapha ukushaywa yi-cerebral ischemic stroke.
Ucwaningo luthole ukuthi ijusi yehalananda ingakwazi ukwelapha amagundane e-PD enziwe yi-rotenone, futhi umphumela we-neuroprotective wejusi yehalananda ulamula kakhulu nge-UA. Ucwaningo luye lwabonisa ukuthi ijusi yegromegranate idlala indima ye-neuroprotective ngokwandisa umsebenzi we-mitochondrial aldehyde dehydrogenase, ukugcina izinga le-anti-apoptotic protein Bcl-xL, ukunciphisa ukuhlanganisa kwe-α-synuclein kanye nokulimala kwe-oxidative, futhi kuthinte umsebenzi we-neuronal nokuzinza. Ama-Urolithin compounds angama-metabolites kanye nezingxenye zomphumela we-ellagitannins emzimbeni futhi anemisebenzi yebhayoloji efana nokulwa nokuvuvukala, ukucindezelwa kwe-anti-oxidative, kanye ne-anti-apoptosis. I-Urolithin ingakwazi ukwenza umsebenzi we-neuroprotective ngokusebenzisa umgoqo wegazi nobuchopho futhi iyingqamuzana elincane elinamandla eliphazamisa ukuwohloka kwemizwa.
Siza ukunciphisa umzimba
I-Urolithin A ayikwazi ukuvikela imisipha kuphela, kodwa ucwaningo lwakamuva luthole ukuthi i-urolithin A ingathinta i-lipid metabolism yamaselula kanye ne-lipogenesis. Kunganciphisa ukuqoqwa kwe-triglyceride kanye ne-fatty acid oxidation, kanye nokuvezwa kwezakhi zofuzo ezihlobene ne-lipogenesis, kuyilapho kuvimbela ukuqoqwa kwamafutha okudla.
Kungenzeka ukuthi uke wezwa ngamafutha ansundu, okuwuhlobo oluhlukile lwamafutha. Akugcini nje ngokukwenza ukhuluphale, kungashisa namafutha. Ngakho-ke, amafutha ansundu kakhulu, angcono ukuncipha.
Ihalananda
Amapomegranati aziwa ngokuqukethwe kwawo okuphezulu kwe-ellagic acid, engaguqulwa ibe i-urolithin A ngama-microbes amathumbu. Ukuphuza ijusi yegromegranate noma ukufaka imbewu yamapomegranate ekudleni kwakho kunikeza umthombo wemvelo weurolithin A, esekela ukuvuselelwa kwamaseli kanye nempilo yonke.
Berry
Amajikijolo athile, njengama-strawberry, ama-raspberries, namajikijolo amnyama, aqukethe i-ellagic acid futhi ayimithombo engaba khona ye-urolithin A. Ukwengeza lezi zithelo ezimnandi ekudleni kwakho akungezi ukunambitheka nje kuphela kodwa futhi kunikeza izinzuzo zezempilo zeselula nempilo ende ye-urolithin A.
Nut
Amanye amantongomane, okuhlanganisa ama-walnuts nama-pecans, aqukethe i-ellagic acid, engenziwa i-metabolized emathunjini ibe yi-urolithin A. Ukwengeza idlanzana lamantongomane esidlweni sakho sansuku zonke noma esidlweni kungasiza ekwandiseni ukungenisa kwe-urolithin A nokusekela ukuvuselelwa kweseli.
Amathumbu microbiota
Ngaphezu kwemithombo yokudla, ukwakheka kwe-microbiota yamathumbu nakho kudlala indima ebalulekile ekukhiqizeni i-urolithin A. Ukudla ukudla okunothe kakhulu kwe-prebiotic, njengo-anyanisi, u-garlic, nobhanana, kungasekela ukukhula kwamagciwane atholakala emathunjini. Ithuthukisa ukuguqulwa kwe-ellagic acid ibe yi-urolithin A.
Izithako ze-Urolithin A
Omunye wemithombo eyaziwa kakhulu ye-urolithin A ihalananda. Ngesikhathi sokugaya, amagciwane amathumbu aguqula ama-molecule e-ellagitannin aqukethwe kumahalananda abe yi-urolithin A.
Kodwa i-gut microbiome yethu ihluke njengoba sinjalo, futhi iyahlukahluka ngokudla, ubudala kanye nofuzo, ngakho abantu abahlukene bakhiqiza i-urolithin ngamanani ahlukene. Labo abangenawo amabhaktheriya, ikakhulukazi labo abavela emndenini wakwaClostridia noRuminococcaceae abahlala emathunjini, abakwazi ukukhiqiza noma iyiphi i-urolithin A nhlobo!
Ngisho nalabo abakwazi ukukhiqiza i-urolithin A abavamile ukukhiqiza ngokwanele. Eqinisweni, i-1/3 kuphela yabantu ikhiqiza i-urolithin A eyanele.
Nakuba kunempilo futhi kumnandi, ukudla ama-superfoods njengamapomegranati akwanele ukuthi amathumbu akho akhiqize i-urolithin A eyanele. Ngakho-ke, indlela kuphela yokuqinisekisa ukuthi uthola okwanele ukugcwalisa ngokuqondile. I-Urolithin A supplementation iyithuluzi eliphumelelayo nelifinyelelekayo lokuthuthukisa impilo nokuphila isikhathi eside kubantu abadala asebekhulile.
I-Urolithin A itholakala ku-ellagic acid, isakhi semvelo esihlotshaniswa nokusebenza okuthuthukisiwe kwe-mitochondrial kanye nokuvuselelwa kwamaselula jikelele. Nokho, nakuba abantu abaningi bengase bazuze ezithasiselweni ze-urolithin A, kubalulekile ukuqonda ukuthi amaqembu athile kufanele aqaphe noma agweme ukuthatha i-urolithin A ngokuphelele.
Abesifazane abakhulelwe nabancelisayo
Abesifazane abakhulelwe nabancelisayo kufanele baqaphele lapho becabangela ukwesekwa kwe-urolithin A. Nakuba kunocwaningo olulinganiselwe ngemiphumela ye-urolithin A kulesi sibalo, ngokuvamile kunconywa ukuthi abesifazane abakhulelwe nabancelisayo bagweme ukuthatha noma yiziphi izithasiselo ezintsha noma imishanguzo ngaphandle uma kunconywe ngokukhethekile uchwepheshe wezempilo. Imiphumela engaba khona ye-urolithin A ekukhuleni komntwana kanye nezinsana ezincelisayo ayaziwa, ngakho-ke kungcono ukuqhubeka ngokuqapha.
Abantu abanokungezwani komzimba okwaziwayo
Njenganoma yisiphi isithasiselo, abantu abanokungezwani komzimba ne-urolithin A noma izinhlanganisela ezihlobene kufanele bakugweme ukusetshenziswa. Ukungezwani komzimba kungase kuqale kokuncane kuye kokuqina futhi kungase kuhlanganise izimpawu ezinjengokulunywa, ukuqunjelwa, ukuvuvukala, kanye nobunzima bokuphefumula. Kubalulekile ukuhlola ngokucophelela izithako zanoma yimuphi umkhiqizo we-urolithin A futhi uthintane nomhlinzeki wakho wokunakekelwa kwezempilo uma ungaqiniseki nge-allergen engaba khona.
Abantu abanezifo ezingaphansi
Abantu abanezimo zezokwelapha ezingaphansi, ikakhulukazi lezo ezihlobene nokusebenza kwezinso noma kwesibindi, kufanele baqaphele lapho becabangela ukwesekwa kwe-urolithin A. Ngenxa yokuthi i-urolithin A igaywe esibindini futhi ikhishwa yizinso, abantu abanokukhubazeka kwesibindi noma ukusebenza kwezinso bangase babe sengcupheni enkulu yemiphumela emibi. Kubalulekile ukuthi abantu abanezimo zezokwelapha ezivele zikhona babonane nochwepheshe bezempilo ngaphambi kokuqala isithasiselo se-urolithin A.
Izingane kanye nentsha
Ngenxa yokuthi kunocwaningo olulinganiselwe ngemiphumela ye-urolithin A ezinganeni nasentsheni, ngokuvamile kunconywa ukuthi abantu abaneminyaka engaphansi kwe-18 bagweme ukufakwa kwe-urolithin A ngaphandle kwalapho kunconywe ngokukhethekile umhlinzeki wezempilo. Imizimba ekhulayo yezingane kanye nentsha ingase iphendule ngendlela ehlukile ekwengezeni, futhi imiphumela engaba khona yesikhathi eside ye-urolithin A kulesi sibalo ayaziwa.
Ukusebenzisana kwezidakamizwa
I-Urolithin A ingase ihlanganyele nezidakamizwa ezithile, ikakhulukazi lezo ezigaywe esibindini. Abantu abathatha imithi kadokotela kufanele babonane nochwepheshe bezempilo ngaphambi kokungeza i-urolithin A ohlelweni lwabo lokwelapha ukuze baqinisekise ukuthi akukho ukusebenzisana okungase kuthinte ukuphepha noma ukusebenza kahle kwemithi yabo.
1. Abathengisi bezinsiza abahloniphekile
Omunye wemithombo onokwethenjelwa kakhulu yokuthenga i-Urolithin A powder ngokusebenzisa umthengisi wezithako onedumela elihle. Laba bathengisi bavame ukuthengisa izinhlobonhlobo zezithako zokudla eziphezulu, okuhlanganisa i-urolithin A powder. Uma ukhetha umthengisi wezinsiza, bheka lawo abeka kuqala ikhwalithi yomkhiqizo, obala, nokwaneliseka kwamakhasimende. Kubalulekile ukufunda ukubuyekezwa kwamakhasimende futhi uhlole ukuhlolwa kanye nesitifiketi somuntu wesithathu ukuze uqinisekise ubuqiniso nokuhlanzeka kwempushana ye-Urolithin A.
2. Isitolo Sezempilo Esiku-inthanethi Esiqinisekisiwe
Izitolo zezempilo eziku-inthanethi eziqinisekisiwe zingenye inketho enhle yokuthenga i-Urolithin A powder. Lezi zitolo zisebenza ngokukhethekile emikhiqizweni eyehlukene yezempilo yemvelo, okuhlanganisa i-urolithin A powder. Lapho uthenga ezitolo zezempilo eziku-inthanethi eziqinisekisiwe, bheka lezo ezihlinzeka ngolwazi oluningiliziwe lomkhiqizo, okuhlanganisa nomthombo we-Urolithin A powder kanye nanoma yimiphi imiphumela yokuhlolwa evela eceleni. Ukwengeza, izitolo zezempilo eziku-inthanethi ezihloniphekile zivame ukuba nabamele isevisi yamakhasimende abanolwazi abangaphendula noma yimiphi imibuzo noma okukukhathazayo okungenzeka ube nakho ngemikhiqizo yabo.
3. Ngokuqondile kusuka kumenzi
Enye inketho ethembekile yokuthenga i-Urolithin A powder ukuyithenga ngokuqondile kumenzi. Abakhiqizi abaningi be-urolithin A powder banikela ngemikhiqizo yabo ukuze ithengiswe ku-inthanethi ngamawebhusayithi abo asemthethweni. Ukuthenga ngokuqondile kumkhiqizi kuqinisekisa ubuqiniso bomkhiqizo kanye nekhwalithi. Ngaphezu kwalokho, ikunikeza imininingwane enemininingwane mayelana nokutholakala, ukukhiqizwa nokuhlolwa kwe-Urolithin A powder, ikunikeza ukuthula kwengqondo mayelana nekhwalithi nokusebenza komkhiqizo wakho.
I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-urolithin A yekhwalithi ephezulu nehlanzekile.
KwaSuzhou Myland Pharm, sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-Urolithin A yethu powder ihlolwe ngokuqinile ukuhlanzeka namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongayethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba noma ukuthuthukisa impilo yonke, i-Urolithin A powder yethu iyisinqumo esihle kakhulu.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, iSuzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.
4. Imakethe Yezempilo Nempilo Enhle
Imakethe yezempilo nokuphila kahle iyinkundla eku-inthanethi ehlanganisa ndawonye inhlobonhlobo yemikhiqizo yokuphila kahle yemvelo evela kubathengisi abahlukene nemikhiqizo. Lezi zimakethe zivame ukunikeza i-Urolithin A powder evela kubakhiqizi abahlukene nabathengisi, okukunikeza ithuba lokuqhathanisa imikhiqizo nezintengo. Lapho uthenga emakethe yezempilo nokuphila kahle, qiniseka ukuthi uhlola izilinganiso zomthengisi kanye nempendulo yekhasimende ukuze uqinisekise ukuthi uthenga emthonjeni othembekile nothembekile.
Q: Iyini i-urolithin A powder futhi inenzuzo kanjani?
A:I-Urolithin A powder iyinhlanganisela yemvelo etholakala ku-metabolism ye-ellagitannins, etholakala ezithelweni ezifana namapomegranati namajikijolo. Kuye kwaboniswa ukuthi kunezinzuzo ezihlukahlukene zezempilo, okuhlanganisa ukukhuthaza impilo ye-mitochondrial, ukusebenza kwemisipha, nokuvuselelwa kwamaselula jikelele.
Q: Ingasetshenziswa kanjani i-urolithin A powder?
A:I-Urolithin A powder ingadliwa njengesengezo sokudla ngendlela yama-capsules noma yengezwe ekudleni naseziphuzweni. Kuyafundelwa futhi ukusetshenziswa kwayo emikhiqizweni ye-skincare ngenxa yezakhiwo zayo zokulwa nokuguga.
Q: Yiziphi izinzuzo zezempilo ezingaba khona ze-urolithin A powder?
A: Ucwaningo lubonisa ukuthi i-urolithin A powder ingasiza ekuthuthukiseni ukusebenza kwemisipha, ukukhuthaza ukuguga okunempilo, nokusekela impilo yonke yamaselula. Kuphinde kwaxhunyaniswa nezinzuzo ezingaba khona zempilo yamathumbu kanye nokunciphisa ukuvuvukala.
Q:Ingathengwa kuphi i-urolithin A powder?
A:I-Urolithin A powder ingatholakala ezitolo zokudla zezempilo, abathengisi be-inthanethi, kanye nezinkampani ezingeza ukudla. Kubalulekile ukuqinisekisa ukuthi umkhiqizo uvela emthonjeni onedumela elihle futhi ulandele imihlahlandlela yomthamo enconyiwe.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Aug-30-2024
