Njengoba sikhula, kungokwemvelo ngathi ukuthi siqale ukucabanga ngokuthi singahlala kanjani sinempilo futhi sikhuthele isikhathi eside ngangokunokwenzeka. Enye indlela enhle i-urolithin A, eboniswe ukuthi yenza kusebenze inqubo ebizwa ngokuthi i-mitophagy, esiza ukusula i-mitochondria eyonakele futhi ikhuthaze ukudalwa kwe-mitochondria entsha, enempilo. Ngokusekela impilo ye-mitochondrial, i-urolithin A ingase isize ukubambezela inqubo yokuguga ezingeni lamaselula. Ucwaningo luphinde luveze ukuthi i-urolithin A ingase ibe nezinye izinzuzo, njengokusekela impilo nokusebenza kwemisipha futhi ingase inciphise ngisho nokuvuvukala emzimbeni.
Ama-microbiomes wamathumbu abantu ayahlukahluka. Izinto ezifana nokudla, ubudala, kanye nezakhi zofuzo zonke zihilelekile futhi ziholela ekuhlukeni ekukhiqizeni amazinga ahlukene e-urolithin A. Abantu abangenawo amagciwane emathunjini abo abakwazi ukukhiqiza i-UA. Ngisho nalabo abakwazi ukwenza i-urolithin A abakwazi ukwenza i-urolithin A eyanele. Kungashiwo ukuthi ingxenye eyodwa kwezintathu kuphela yabantu ine-urolithin A eyanele.
Ngakho-ke, yimiphi imithombo engcono kakhulu ye-urolithin A?
Ihalananda: Ipomegranate ingenye yemithombo yemvelo ecebile kakhuluurolithin A.Lesi sithelo siqukethe i-ellagitannins, eguqulwa ibe yi-urolithin A yi-microbiota yamathumbu. Ukusebenzisa ijusi yehalananda noma imbewu yegromegranate yonke kunikeza inani elikhulu le-urolithin A, okwenza kube umthombo omuhle kakhulu wokudla wale nhlanganisela.
I-Ellagic acid supplements: I-Ellagic acid supplements ingenye inketho yokuthola i-urolithin A. Ngemva kokusetshenziswa, i-ellagic acid iguqulwa ibe i-urolithin A nge-intestinal microbiota. Lezi zithako zinenzuzo ikakhulukazi kubantu abangakudli njalo ukudla okunothe nge-urolithin A.
Amajikijolo: Amajikijolo athile, anjengama-raspberries, ama-strawberry, namajikijolo amnyama, aqukethe i-ellagic acid, engase ibe nomthelela ekukhiqizweni kwe-urolithin A emzimbeni. Ukufaka amajikijolo ahlukahlukene ekudleni kungasiza ekwandiseni ukuthathwa kwe-ellagic acid futhi kungase kwenyuse amazinga e-urolithin A.
Izithako zokudla okunomsoco: Ezinye izithasiselo zokudla okunomsoco zakhiwe ngokukhethekile ukuze zinikeze i-urolithin A ngokuqondile. Lezi zithako zivame ukuqukatha okukhishwe kwemvelo okucebile nge-urolithin A, okuhlinzeka ngendlela egxile kakhulu futhi elula yokwandisa umthamo wakho we-urolithin A.
I-Gut Microbiota: Ukwakheka kwe-gut microbiota kudlala indima ebalulekile ekukhiqizweni kwe-urolithin A. Izinhlobo ezithile zebhaktheriya emathunjini zinesibopho sokuguqula i-ellagitannins ne-ellagic acid ibe i-urolithin A. Isekela i-gut microbiota enempilo nehlukahlukene ngokusebenzisa ama-probiotics, ama-prebiotics , kanye ne-fiber yokudla ingathuthukisa ukukhiqizwa kwe-urolithin A emzimbeni.
Qaphela, i-bioavailability nokusebenza kwe-urolithin A kungase kwehluke kuye ngomthombo kanye nezici ngazinye. Nakuba imithombo yemvelo efana namapomegranati namajikijolo inikeza izinzuzo ezengeziwe zokudla okunomsoco, izithasiselo zinganikeza umthamo othembeke kakhulu, ogxilile we-urolithin A.
Njengoba sikhula, imizimba yethu ngokwemvelo ikhiqiza i-urolithin encane, okuholele ekwakhiweni kwezithako ze-urolithin njengendlela engase yeseke impilo yamangqamuzana nokuguga.
Enye yezinzuzo eziyinhloko ze-urolithin amandla ayo okuthuthukisa ukusebenza kwe-mitochondrial, okubalulekile ekukhiqizeni amandla kanye nempilo yonke yamaselula. I-Mitochondria yimithombo yamandla yamangqamuzana ethu, ama-organelles amancane aguqula i-glucose nomoya-mpilo ku-adenosine triphosphate (ATP) ukuze uthole amandla. Njengoba sikhula, umsebenzi wabo ungase unciphe, okuholela ezinkingeni ezihlukahlukene zempilo. Ama-Urolithin aboniswe ukusiza ukuthuthukisa ukusebenza kwe-mitochondrial, okungase kukhuphule amazinga wamandla kanye nobungqabavu buphelele.
Kubantu abanekhono lomzimba elincishisiwe, i-urolithin A ingasetshenziswa ukukhuthaza impilo ye-mitochondrial ngaphandle kwesidingo sokuzivocavoca. I-Urolithin A, engatholakala ekudleni noma, ngokuphumelelayo, ngokusebenzisa izithako zokudla, iboniswe ukukhuthaza impilo ye-mitochondrial nokukhuthazela kwemisipha. Lokhu ikwenza ngokuthuthukisa umsebenzi we-mitochondrial, ikakhulukazi ngokuvula inqubo ye-mitophagy.
Ngaphezu kwemiphumela yayo ekusebenzeni kwe-mitochondrial, i-urolithin iye yacutshungulwa ngenxa yezakhiwo zayo ezingaba khona zokulwa nokuvuvukala kanye ne-antioxidant. Ukuvuvukala okungapheli kanye nengcindezi ye-oxidative yizici eziyisisekelo ezifweni eziningi ezingalapheki, ngakho amandla e-urolithin okulwa nalezi zinkinga angaba nezinzuzo ezijulile empilweni yonke. Ezinye izifundo ziphakamisa nokuthi i-urolithin ingase ibe nomthelela omuhle empilweni yemisipha nokusebenza komzimba, okwenza kube inketho ekhangayo kubasubathi nabathanda ukuqina.
Urolithin Aiyinhlanganisela yemvelo etholakala ku-ellagic acid, etholakala ezithelweni ezithile namantongomane. Kuye kwaboniswa ukwenza kusebenze inqubo ebizwa ngokuthi i-mitophagy, indlela yemvelo yomzimba yokususa i-mitochondria eyonakele futhi ikhuthaze ukusebenza kwamangqamuzana anempilo. Le nqubo ibalulekile ekugcineni impilo yeselula iyonke futhi iye yaxhunyaniswa nokuphila isikhathi eside kanye nengozi encishisiwe yezifo ezihlobene nobudala.
I-NMN, ngakolunye uhlangothi, iyisandulela se-NAD+ (nicotinamide adenine dinucleotide), i-coenzyme edlala indima ebalulekile kumetabolism yamaselula nokukhiqizwa kwamandla. Njengoba sikhula, amazinga e-NAD+ ayancipha, okuholela ekwehleni kokusebenza kwamaseli kanye nengozi eyengeziwe yezifo ezihlobene nobudala. Ngokufaka i-NMN, sikholelwa ukuthi singakhuphula amazinga e-NAD+ futhi sisekele impilo yonke yamaselula nokuphila isikhathi eside.
Ngakho, iyiphi engcono? Iqiniso liwukuthi, akuyona impendulo elula. Kokubili i-urolithin A ne-NMN zibonise imiphumela ethembisayo ezifundweni zangaphambi komtholampilo futhi zombili zinezinqubo eziyingqayizivele zokwenza. I-Urolithin A yenza kusebenze i-mitophagy, kuyilapho i-NMN inyusa amazinga e-NAD+. Kungenzeka ngokuphelele ukuthi lezi zinhlanganisela ezimbili ziyaphelelisana futhi zinikeze izinzuzo ezinkulu nakakhulu uma zihlangene.
Ukuqhathaniswa okuqondile kwekhanda kuya kwekhanda kwe-urolithin A ne-NMN akuzange kwenziwe ezifundweni zabantu, ngakho-ke kunzima ukusho ngokucacile ukuthi iyiphi engcono. Kodwa-ke, zombili izinhlanganisela ziye zaboniswa ukuthi zinamandla okukhuthaza ukuguga okunempilo futhi zingase zibe nemiphumela ye-synergistic uma zisetshenziswa ngokuhlangene.
Kubalulekile futhi ukucabangela ukuhlukana komuntu ngamunye nokuthi umuntu ngamunye angasabela kanjani ngendlela ehlukile kulezi zinhlanganisela. Abanye abantu bangase babe nokusabela okugqame kakhudlwana ku-urolithin A, kuyilapho abanye bengazuza kakhulu ku-NMN. Izakhi zofuzo, indlela yokuphila, nezinye izici zingathonya indlela umuntu ngamunye asabela ngayo kulezi zinhlanganisela, kwenze kube nzima ukwenza ukuhlanganisa okubanzi mayelana nokuthi iyiphi inhlanganisela ephakeme.
Ekugcineni, umbuzo wokuthi i-urolithin A ingcono yini kune-NMN akulula ukuwuphendula. Zombili lezi zinhlanganisela zibonise amandla okukhuthaza ukuguga okunempilo futhi zombili zinezinqubo eziyingqayizivele zokwenza. Indlela engcono kakhulu ingase ibe ukucabangela ukuthatha zombili izithasiselo ngesikhathi esisodwa ukuze wandise izinzuzo zazo.
1. Impilo Yemisipha: Enye yezinzuzo ezibaluleke kakhulu ze-urolithin A yikhono layo lokusekela impilo yemisipha. Njengoba sikhula, imizimba yethu ngokwemvelo ithola ukwehla kwesisindo somzimba namandla. Kodwa-ke, ucwaningo lubonisa ukuthi i-urolithin A ingasiza ekulweni nale nqubo ngokuthuthukisa umsebenzi we-mitochondria, izindlu zamandla zeseli. Ngokwenza kanjalo, kungasiza ukuthuthukisa ukusebenza kwemisipha futhi kukhuthaze ukusebenza komzimba jikelele.
2. Ukuphila isikhathi eside: Esinye isizathu esicindezelayo sokucabangela ukwesekwa kwe-urolithin A amandla ayo okukhuthaza ukuphila isikhathi eside. Ucwaningo luphakamisa ukuthi le nhlanganisela ingase isebenze inqubo ebizwa ngokuthi i-mitophagy, enesibopho sokususa i-mitochondria eyonakele. Ngokususa lezi zingxenye ezingasebenzi, i-Urolithin A ingase isize ukunweba ubude bempilo futhi isekele impilo yonke enempilo.
3. Impilo Yeselula: I-Urolithin A nayo iboniswe ukuthi isekela impilo nokusebenza kwamaseli. Ngokuthuthukisa ukusebenza kwe-mitochondrial nokukhuthaza i-mitophagy, le nhlanganisela ingasiza ekuthuthukiseni impilo yonke kanye nokululama kwamaseli. Lokhu, kungase kube nomthelela omuhle kuzo zonke izici zempilo, kusukela ekukhiqizeni amandla kuya ekusebenzeni komzimba.
4. Izakhiwo Zokulwa Nokuvuvukala: Ukuvuvukala okungapheli kuyisici esivamile esiyisisekelo ezimweni eziningi zezempilo, futhi i-Urolithin A iboniswe ukuthi inezici zokulwa nokuvuvukala ezingasiza ekunciphiseni ingozi yezifo ezithile futhi isekele impilo yonke kanye nokuphila kahle.
5. Impilo yobuchopho: Ucwaningo olukhulayo luphakamisa ukuthi i-urolithin A ingase ibe nezinzuzo ezingaba khona empilweni yobuchopho. Ngokusekela umsebenzi we-mitochondrial nokukhuthaza impilo yamaselula, le nhlanganisela ingasiza ekuvimbeleni ukwehla kwengqondo okuhlobene neminyaka kanye nezifo ze-neurodegenerative.
Okokuqala futhi okubaluleke kakhulu, kubalulekile ukuqonda ukuthi akubona bonkeizithako ze-urolithin Azidalwe zilingana. Izinga nokuhlanzeka kwe-Urolithin A kungahluka kakhulu phakathi kwemikhiqizo ehlukene, ngakho-ke kubalulekile ukwenza ucwaningo lwakho bese ukhetha isengezo kumkhiqizi onedumela elihle. Bheka izithasiselo ezihlolelwe ubumsulwa namandla ukuze uqinisekise ukuthi uthola umkhiqizo wekhwalithi ephezulu.
Ngaphezu kwekhwalithi ye-urolithin A ekhishwe, kubalulekile futhi ukucabangela uhlobo lwesithasiselo. I-Urolithin A itholakala ngezindlela ezihlukahlukene, okuhlanganisa amaphilisi, impushana, noketshezi. Cabangela okuncamelayo komuntu siqu kanye nendlela yokuphila lapho ukhetha ifomethi elungele ukuyifaka ekuphileni kwakho kwansuku zonke.
Esinye isici okufanele icatshangelwe lapho ukhetha isengezo se-urolithin A umthamo. Izithako ezihlukene zingaqukatha amanani ahlukene e-urolithin A ngokusetshenziswa ngakunye, ngakho-ke kubalulekile ukucabangela izidingo zakho zomuntu siqu kanye nemigomo lapho unquma umthamo okulungele wena. Uma ungaqiniseki ngomthamo olungele wena, thintana nochwepheshe bezokunakekelwa kwezempilo ukuze uthole isiqondiso somuntu ngamunye.
Ukwengeza, cabanga ukuthi zikhona yini ezinye izithako ezitholakala ku-urolithin A. Ezinye izithasiselo zingaqukatha izithako ezengeziwe, ezifana nama-antioxidants noma ezinye izinhlanganisela ze-bioactive, ezingathuthukisa imiphumela ye-urolithin A. Nokho, kubalulekile ukuqinisekisa ukuthi noma yiziphi ezinye izithako ziphephile futhi zinenzuzo ngezidingo zakho ezithile zempilo.
Ukwengeza, lapho ukhetha isithasiselo se-urolithin A, sicela ucabangele impilo yakho siqu nanoma yiziphi izimo zezokwelapha ezivele zikhona. Uma unanoma yiziphi izimo zempilo ezicashile noma uphuza imithi, kubalulekile ukuthi uthintane nomhlinzeki wakho wokunakekelwa kwezempilo ngaphambi kokuqala noma yiluphi uhlobo lomuthi olusha lokwengeza ukuze uqiniseke ukuthi luphephile futhi lukufanele.
Okokugcina, kubalulekile ukulawula lokho okulindele lapho uthatha izithasiselo ze-urolithin A. Nakuba i-urolithin A ibonisa isithembiso esihle ekuthuthukiseni ukusebenza kwemisipha, amazinga wamandla, kanye nempilo yonke yamaselula, imiphumela ngayinye ingase ihluke. Kubalulekile ukunikeza isengezo isikhathi esanele sokusebenza futhi uhambisane nokusebenzisa kwakho ukuze ubone imiphumela engcono kakhulu.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Umbuzo: Iyini i-urolithin A?
A: I-Urolithin A iyinhlanganisela yemvelo ekhiqizwa emzimbeni ngemva kokusetshenziswa kokudla okuthile, njengamapomegranati namajikijolo. Iyatholakala futhi njengesengezo.
Umbuzo: Isebenza kanjani i-urolithin A?
A: I-Urolithin A isebenza ngokwenza kusebenze inqubo yeselula ebizwa ngokuthi i-mitophagy, esiza ukususa i-mitochondria eyonakele kumaseli. Lokhu, futhi, kusiza ukuthuthukisa ukusebenza kwamaselula kanye nempilo yonke.
Q: Yiziphi izinzuzo ezingaba khona ze-urolithin A supplementation?
A: Ezinye izinzuzo ezingaba khona ze-urolithin A supplementation zihlanganisa ukuthuthukiswa komsebenzi wemisipha, ukukhiqizwa kwamandla okwandayo, nokuphila isikhathi eside okuthuthukisiwe. Kungase futhi kusize ukusekela impilo yonke nokuphila kahle njengoba sikhula.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Mar-06-2024
