I-Urolithin A iyi-molecule ethokozisayo emkhakheni wocwaningo lokulwa nokuguga. Ikhono layo lokubuyisela ukusebenza kwamaselula kanye nokwenza ngcono impilo belilokhu lithembisa ezifundweni zezilwane. Nokho, ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukusebenza kahle kwalo kubantu.Nakuba kungenzeka ukuthi asikawutholi umthombo wobusha, i-Urolithin A isisondeza ekuqondeni izimfihlo zokuguga kanye nokuvula ukhiye wempilo ende, enempilo.
I-Urolithin A iyinhlanganisela yemvelo eye yathola ukunakwa okuningi eminyakeni yamuva nje ngenxa yezinzuzo zayo zezempilo ezingaba khona. Ucwaningo olusafufusa luveza ukuthi ingase ibe nezinto zokulwa nokuvuvukala, ezilwa nomdlavuza kanye nokuguga.
●I-Urolithin A iyi-metabolite ekhiqizwa ukuwohloka kwe-ellagitannins, isakhi se-polyphenolic esitholakala ezithelweni ezithile namantongomane. Ukuguqulwa kwe-ellagitannins ku-urolithin A kwenzeka ngokuyinhloko emathunjini ngenxa yesenzo samagciwane athile amathumbu.
●Ipomegranati ingenye yemithombo ecebile kakhulu ye-ellagitannins futhi ngaleyo ndlela i-urolithin A. Ama-arils abomvu agqamile, noma imbewu, yamahalananda aqukethe ukugxila okuphezulu kwama-ellagitannins, aguqulelwa ku-urolithin A ngesikhathi sokugaya. Ijusi yepomegranate kanye nezingcaphuno nazo ziyimithombo emihle ye-urolithin A.
●Esinye isithelo esiqukethe i-urolithin A ama-raspberries. Njengamapomegranati, ama-raspberries acebile ngama-ellagitannins, ikakhulukazi embewu yawo. Ukusetshenziswa njalo kwama-raspberries amasha noma afriziwe kungase kwenyuse amazinga e-urolithin A emzimbeni.
●Amantongomane athile, njengama-walnuts nama-pistachios, nawo aqukethe amanani omkhondo we-urolithin A. Nakuba i-urolithin A itholakala ngamanani aphansi uma kuqhathaniswa nezithelo ezifana namapomegranati, okuhlanganisa lamantongomane ekudleni kwakho kungasiza ekukhuliseni umthamo wakho wonke we-urolithin A.
Nakuba izithelo ezintsha namantongomane kuyimithombo emihle kakhulu yokudla ye-urolithin A, kufanelekile ukusho ukuthi izithasiselo ze-urolithin A ziyatholakala. Lezi zithako zingakunikeza indlela elula yokwandisa umthamo wakho we-urolithin A.
I-Urolithin A iyinhlanganisela etholakala entweni yemvelo ebizwa ngokuthi i-ellagitannin, etholakala ezithelweni ezithile ezifana namapomegranati namajikijolo. Lapho sidla lezi zithelo, amagciwane ethu amathumbu ephula ama-ellagitannins abe yi-urolithin A, okuvumela imizimba yethu ukuthi izuze kule nhlanganisela emangalisayo.
Okunye okutholwe okujabulisa kakhulu nge-urolithin A yikhono layo lokuvuselela i-mitochondria, izikhungo zamandla zamaseli ethu. Njengoba sikhula, i-mitochondria yethu iyancipha ukusebenza kahle, okuholela ekwehleni kokukhiqizwa kwamandla amaselula. Ucwaningo luye lwabonisa ukuthi i-urolithin A ingenza kusebenze inqubo ebizwa ngokuthi i-mitophagy, esusa i-mitochondria engasebenzi futhi ikhuthaze ukukhiqizwa kwezintsha ezinempilo. Le nqubo iholela ekuthuthukisweni kokukhiqizwa kwamandla kanye nomsebenzi jikelele wamaselula.
Ukwengeza, i-urolithin A itholakele ukuthuthukisa impilo yemisipha namandla. Njengoba sikhula, sivame ukulahlekelwa isisindo semisipha, okuholela ebuthakathakeni nokunciphisa ukuhamba. Kodwa-ke, ucwaningo ezilwaneni ezindala luye lwabonisa ukuthi ukwengezwa nge-urolithin A kukhuthaza ukukhula kwemisipha futhi kuvimbela ukuwohloka kwemisipha.
Enye inzuzo emangalisayo ye-Urolithin A ukuvikela kwayo ezifweni ze-neurodegenerative ezifana ne-Alzheimer's kanye ne-Parkinson. Lezi zifo zibonakala ngokunqwabelana kwamaprotheni anobuthi ebuchosheni, okuholela ekwehleni komqondo kanye nokuphazamiseka kokunyakaza. Ucwaningo lwakamuva lubonise ukuthi i-urolithin A ingasiza ekususeni la maprotheni ayingozi, inciphise ubungozi kanye nokuqhubekela phambili kwalezi zifo ze-neurodegenerative.
1. Yidla ukudla okucebile ngama-ellagitannins: Ukwandisa amazinga e-urolithin ngokwemvelo, ukudla ukudla okucebile ngama-ellagitannins kuyisihluthulelo. Amapomegranati, ama-strawberry, ama-raspberries, nama-blackberries ayimithombo emihle kakhulu ye-ellagitannins. Ukufaka lezi zithelo ekudleni kwakho kungakhuphula ukukhiqizwa kwe-urolithin emathunjini akho.
2. Ukuthuthukisa Impilo Yamathumbu: Ukuba ne-gut microbiota enempilo kubalulekile ekukhiqizeni i-urolithin. Ukuze usekele i-microbiome yamathumbu ehlukahlukene futhi elinganiselayo, faka ukudla okubilile okufana neyogathi, i-kefir, i-sauerkraut, ne-kimchi ekudleni kwakho. Lokhu kudla kwethula amagciwane amahle emathunjini akho, athuthukisa ukukhiqizwa kwe-urolithin.
3. Thatha izithasiselo ze-urolithin: Ngaphezu kwemithombo yokudla, izithasiselo ze-urolithin nazo ziyatholakala emakethe. Lezi zithako zihlinzeka ngemithamo egxilile ye-urolithin, engaba yinzuzo kulabo abanobunzima bokudla amanani anele okudla okunothe nge-ellagitannin njalo noma abanezinkinga zempilo yamathumbu.
4. Hlanganisa ama-ellagitannins nemithombo yamafutha: I-Ellagitannins imuncwa kalula ngumzimba uma idliwa ngemithombo yamafutha enempilo. Cabanga ngokungeza amantongomane, imbewu, noma amafutha omnqumo amancane esithelweni ukuze uthuthukise ukumuncwa kwe-ellagitannins futhi ukwandise ukukhiqizwa kwe-urolithin.
Isikhathi esisithathayo ukuze i-urolithin A isebenze siyahlukahluka kunezici ezimbalwa. Isici esibaluleke kakhulu umzimba womuntu siqu. Umzimba wawo wonke umuntu ucubungula izinto ngendlela ehlukile, okuphinde kuthinte ukuthi umzimba uthatha ngokushesha futhi usebenzise kanjani i-urolithin A. Ngaphezu kwalokho, umthamo kanye nefomu lapho i-urolithin A esetshenziswa khona kungase kuthinte isikhathi sokuqala kwesenzo sayo.
Ucwaningo luye lwabonisa ukuthi ukusebenzisa izinhlobo zemvelo ze-urolithin A, njengejusi yehalananda noma amajikijolo athile, kungakhiqiza amazinga atholakalayo wenhlanganisela egazini phakathi namahora. Nokho, imiphumela ye-urolithin A ingase ingabonakali ngokushesha, njengoba izenzo zenhlanganisela zigxile kakhulu ezinzuzweni zezempilo zesikhathi eside.
Kubalulekile ukuqaphela ukuthi i-urolithin A ayilona ikhambi elisheshayo lanoma yisiphi isimo sezempilo esithile. Esikhundleni salokho, kucatshangwa ukuthi iveza imiphumela yayo ngokwenza kusebenze inqubo yokuvuselela amangqamuzana omzimba ebizwa ngokuthi i-autophagy. Le nqubo ihilela ukudiliza nokukhipha amangqamuzana namaprotheni awonakele, okungaba nemiphumela yesikhathi eside empilweni nasenhlalakahleni yonke. Ucwaningo lusaqhubeka mayelana nokuthi kuzothatha isikhathi esingakanani ukuthola izinzuzo ezingaba khona ze-urolithin A.
Ucwaningo ngemiphumela engemihle ye-urolithin A lusalinganiselwe, njengoba luwumkhakha wocwaningo olusha. Ucwaningo oluningi olwenziwe kuze kube manje lugxile emiphumeleni yako emihle kunanoma yimiphi imiphumela emibi. Noma kunjalo, kubalulekile ukuqhubeka ngokuqapha futhi uqonde izingozi ezingaba khona.
Inkinga engenzeka ngokusetshenziswa kwe-urolithin A ukuthi ingase ihlangane nemithi ethile. Njengesengezo sokudla, kungase kuhlanganyele nezidakamizwa ezigaywe ama-enzyme esibindi afanayo. Lokhu kungase kushintshe ukuthi le mithi isebenza noma iphephe kangakanani. Ngakho-ke, kubalulekile ukubonana nochwepheshe bezempilo ngaphambi kokuthatha i-urolithin A uma uthatha noma yimiphi eminye imithi.
Esinye isici okufanele sicatshangelwe umthamo we-urolithin A. Njengamanje, azikho izidakamizwa ezinconyiwe zansuku zonke noma iziqondiso ezithile zomthamo wale nhlanganisela. Ngakho-ke, kunzima ukunquma ukuthi ingabe kukhona umthamo olungile, noma uma kukhona imiphumela engemihle engaba khona ehambisana nemithamo ephezulu. Kunconywa ukuthi ulandele izikhombisi-ndlela ezikulebula yomkhiqizo noma uxhumane nomhlinzeki wezokunakekelwa kwempilo ukuze uthole umthamo ofanele.
Isikhathi sokuthumela: Jun-21-2023
