Njengoba sikhula, imizimba yethu ngokwemvelo ibhekana nezinguquko ezihlukahlukene ezingathinta impilo yethu yonke kanye nokuphila kahle. Esinye sezibonakaliso zokuguga ezibonakala kakhulu ukukhula kwemibimbi, imigqa emihle, nesikhumba esintengayo. Nakuba ingekho indlela yokunqanda inqubo yokuguga, abacwaningi bebesebenza ngokuzikhandla ukuze bathole izinhlanganisela ezingase zibambezele noma zihlehlise eminye yemiphumela yokuguga. I-Urolithin A ingenye yezinhlanganisela ezibonisa isithembiso esikhulu kulokhu. Ucwaningo lwakamuva lubonisa ukuthi i-urolithin A ingathuthukisa ukusebenza kwemisipha nokukhuthazela, ithuthukise ukusebenza kwe-mitochondrial, futhi ikhuthaze nokususwa kwezingxenye zamangqamuzana ezilimele ngenqubo ebizwa ngokuthi i-autophagy. Le miphumela yenza i-urolithin A ibe yikhandidethi elithembisayo lokuthuthukiswa kwezindlela zokwelapha zokulwa nokuguga. Ngaphezu kwemiphumela yayo yokulwa nokuguga, i-urolithin A iye yacwaningwa ngendima yayo engaba khona ekukhuthazeni ukuphila isikhathi eside.
Ngaphambi kokuba sihlole imiphumela engase ibe khona yokulwa nokuguga ye-urolithin A, ake siqale siqonde ukuthi kuyini ukuguga. Ukuguga kuyinqubo eyinkimbinkimbi ehilela ukwehla kancane kancane kokusebenza kwamaselula kanye nokunqwabelana kokulimala kwamaselula ngokuhamba kwesikhathi. Le nqubo ithonywa yizinto ezahlukahlukene ezihlanganisa ufuzo, indlela yokuphila, nokuchayeka kwemvelo. Ukuthola izindlela zokunciphisa noma zokuhlehlisa le nqubo kube umgomo wesikhathi eside ocwaningweni lokuguga.
I-Urolithin A ikhonjiswe ukuthi yenza kusebenze indlela yeselula ebizwa ngokuthi i-mitophagy, enesibopho sokusula nokuvuselela i-mitochondria eyonakele (indlu yamandla yeseli). I-Mitochondria idlala indima ebalulekile ekukhiqizweni kwamandla futhi iwumthombo omkhulu wezinhlobo ze-oxygen esebenzayo (ROS), engalimaza izingxenye zamaselula futhi isheshise ukuguga. Ngokukhuthaza i-mitophagy, i-urolithin A isiza ukugcina ukusebenza kahle kwe-mitochondrial futhi kunciphise ukucindezeleka okwenziwe nge-oxidative, okucatshangwa ukuthi kunomthelela ekugugeni.
Ucwaningo oluningana lunikeze imiphumela ethembisayo mayelana nemiphumela ye-urolithin A ekugugeni. Olunye ucwaningo lwama-nematodes lwathola ukuthi i-urolithin A yelula isikhathi sokuphila se-nematode kufika ku-45%. Imiphumela efanayo yabonwa ocwaningweni lwamagundane, lapho ukwengezwa nge-urolithin A kwandisa ubude bawo bokuphila futhi kwathuthukisa impilo yawo yonke. Lokhu okutholakele kusikisela ukuthi i-urolithin A inamandla okunciphisa inqubo yokuguga nokwandisa isikhathi sokuphila.
Ngaphezu kwemiphumela yayo esikhathini sokuphila, i-urolithin A nayo inemiphumela emangalisayo empilweni yemisipha. Ukuguga kuvame ukuhlotshaniswa nokulahlekelwa kwemisipha nokuncipha kwamandla, isimo esaziwa ngokuthi i-sarcopenia. Abacwaningi bathole ukuthi i-urolithin A ingakhuthaza ukukhula kwemisipha futhi yandise amandla emisipha. Esivivinyweni somtholampilo esihilela abantu abadala asebekhulile, ukwesekwa kwe-urolithin A kwandisa kakhulu imisipha nokusebenza komzimba okuthuthukisiwe. Lokhu okutholakele kusikisela ukuthi i-urolithin A ayinayo kuphela imiphumela yokuguga kodwa futhi inezinzuzo ezingase zibe nempilo yemisipha, ikakhulukazi kubantu asebekhulile.
Ukwengeza, kufanelekile ukusho ukuthi i-urolithin A itholakala kumahalananda, kodwa inani le-urolithin A emikhiqizweni yamahalananda lingahluka kakhulu. Ngakho-ke, izinhlanganisela zokwenziwa ziba inketho enhle futhi zimsulwa futhi kulula ukuzithola.
I-Urolithin A itholakala ku-ellagitannins, evame ukutholakala ezithelweni ezithile namantongomane. Lawa ma-ellagitannins ashintshwa amagciwane amathumbu ukuze akhiqize i-urolithin A namanye ama-metabolites. Uma usumuncwa, i-urolithin A ithinta umzimba ezingeni lamaselula.
Enye yezinzuzo eziphawuleka kakhulu ze-urolithin A yikhono layo lokuvuselela i-mitophagy, inqubo ebalulekile empilweni yamaselula. I-Mitochondria ivame ukubizwa ngokuthi yizindlu zamandla zeseli futhi idlala indima ebalulekile ekukhiqizweni kwamandla. Kodwa-ke, njengoba sikhula, ukusebenza kahle kwe-mitochondrial kuncipha, okuholela ekungasebenzini kahle kwamaselula futhi okungenzeka kube nokuthuthukiswa kwezifo ezahlukahlukene ezihlobene nobudala.
I-Mitophagy iyindlela ebalulekile yokususa i-mitochondria eyonakele futhi engasebenzi, okuvumela i-mitochondria entsha, enempilo ukuthi ithathe indawo yayo. I-Urolithin A ikhonjiswe ukuthi yenza le nqubo ibe lula, ikhuthaze inzuzo ye-mitochondrial futhi ithuthukise impilo yamaselula. Ngokuqeda i-mitochondria engasebenzi, i-urolithin A ibambezela inqubo yokuguga futhi inciphisa ingozi yezifo ezihlobene nobudala.
Ngaphezu kwemiphumela yayo ku-mitophagy, i-urolithin A nayo inezindawo zokulwa nokuvuvukala. Ukuvuvukala okungapheli kungumshayeli omkhulu wezimo eziningi zempilo, okubandakanya isifo senhliziyo, ukukhuluphala, kanye nezifo ze-neurodeergenerative. Ucwaningo luthole ukuthi i-urolithin A icindezela izimpawu zokuvuvukala futhi ivimbele ukukhiqizwa kwezinhlanganisela ezikhuthaza ukuvuvukala, ngaleyo ndlela yehlise ingozi yokuvuvukala okungapheli kanye nezifo ezihlobene.
Ngaphezu kwalokho, i-urolithin A ibonise amandla ayo njenge-antioxidant enamandla. Ukucindezeleka kwe-oxidative kubangelwa ukungalingani phakathi kokukhiqizwa kwama-radicals mahhala kanye nekhono lomzimba lokuwanciphisa, futhi kudlala indima ebalulekile enqubweni yokuguga kanye nokuthuthukiswa kwezifo ezihlukahlukene. I-Urolithin A ingasusa ama-radicals mahhala ayingozi, ithuthukise amandla omzimba okuvikela i-antioxidant, ivikele amangqamuzana emonakalweni we-oxidative, futhi ingase ibambezele inqubo yokuguga.
Ucwaningo luphinde luveze izinzuzo ezingaba khona ze-urolithin A empilweni yemisipha nokusebenza kwezemidlalo. Ukuguga kuvame ukuhambisana nokuncipha kwesisindo somzimba namandla, okuholela engozini eyengeziwe yokuwa, ukuphuka, nokulahlekelwa ukuzimela. I-Urolithin A iye yaboniswa ukwandisa ukuhlanganiswa kwe-muscle fiber futhi ithuthukise ukusebenza kwemisipha, okungase kunciphise ukulahlekelwa kwemisipha okuhlobene nobudala.
Ukwengeza, i-urolithin A itholakale ithuthukisa ukusebenza kokuzivocavoca ngokugqugquzela ukukhiqizwa kwamaprotheni ahilelekile ekukhuleni nasekulungiseni imisipha. Ngokusekela impilo yemisipha nokusebenza kwezemidlalo, i-urolithin A ingase isize ukugcina indlela yokuphila esebenzayo nezimele njengoba sikhula.
● Thuthukisa impilo yamathumbu
Ukuze sithuthukise ngokwemvelo ukukhiqizwa kwe-Urolithin A emizimbeni yethu, ukwenza ngcono impilo yethu yamathumbu kubalulekile. I-gut microbiome ehlukahlukene futhi echumayo isiza ukuguqulwa okusebenzayo kwe-ellagitannins ibe i-urolithin A. Ukudla ukudla okunothe nge-fiber okuhlanganisa izithelo, imifino, okusanhlamvu okuphelele, nemifino kondliwa kwamagciwane atholakala emathunjini futhi kudala indawo ekahle ekukhiqizweni kwe-urolithin A.
● I-Urolithin A ekudleni
Ipomegranate ingenye yemithombo yemvelo ecebile kakhulu ye-urolithin A. Isithelo ngokwaso siqukethe i-ellagitannins eyandulelayo, eguqulwa ibe i-urolithin A ngamabhaktheriya amathumbu ngesikhathi sokugaya. Ijusi yepomegranate ikakhulukazi itholakale iqukethe ukugxila okuphezulu kwe-urolithin A futhi ithathwa njengenketho enhle kakhulu yokuthola le nhlanganisela ngokwemvelo. Ukuphuza ingilazi yejusi yegromegranate nsuku zonke noma ukufaka amahalananda amasha ekudleni kwakho kungasiza ukwandisa umthamo wakho we-urolithin A.
Esinye isithelo esiqukethe i-urolithin A ama-strawberries, acebile nge-ellagic acid. Ngokufanayo namapomegranati, ama-strawberries aqukethe i-ellagitannins, eguqulwa ibe i-urolithin A ngamabhaktheriya amathumbu. Ukwengeza ama-strawberry ekudleni kwakho, ukuwenza njengokudla okulula, noma ukuwangeza kuma-smoothie akho zonke izindlela ezimnandi zokwandisa amazinga akho e-urolithin A.
Ngaphandle kwezithelo, amanye amantongomane aqukethe i-ellagitannins, okungenzeka kube umthombo wemvelo we-urolithin A. Ama-Walnuts, ikakhulukazi, atholakale equkethe inani elikhulu lama-ellagitannins, angaguqulwa abe yi-urolithin A emathunjini. Ukwengeza idlanzana lama-walnuts ekudleni kwakho kwamantongomane kwansuku zonke akusizi nje kuphela impilo yakho yonke, kodwa futhi nasekutholeni i-urolithin A ngokwemvelo.
● Izithako zokudla okunomsoco kanye ne-urolithin A ekhishwe
Kulabo abafuna umthamo ogxile kakhulu, onokwethenjelwa we-urolithin A, izithasiselo zokudla okunomsoco nezikhishiwe kungase kube inketho. Intuthuko ocwaningweni iholele ekuthuthukisweni kwezithasiselo zekhwalithi ephezulu ezithathwe esikhishwe ihalananda eziklanywe ngokukhethekile ukuze zinikeze amanani afanele e-urolithin A. Kodwa-ke, kubalulekile ukukhetha uhlobo oluthembekile nolwaziwayo ukuze kuqinisekiswe ikhwalithi nokuphepha komkhiqizo.
● Isikhathi nezici zomuntu siqu
Okuqaphelekayo, ukuguqulwa kwe-ellagitannins ku-urolithin A kuyahlukahluka phakathi kwabantu, kuye ngokuthi i-gut microbiota yabo ibunjwe kanjani kanye nokwakheka kofuzo. Ngakho-ke, isikhathi esidingekayo ukuze ubone inzuzo ebalulekile ekusetshenzisweni kwe-urolithin A singahluka. Ukubekezela nokungaguquguquki kubalulekile lapho ufaka ukudla okucebile nge-urolithin A noma izithasiselo ohlelweni lwakho lwansuku zonke. Ukunikeza umzimba wakho isikhathi sokuzivumelanisa nokuthola ibhalansi kuzokusiza uthole imivuzo yale nhlanganisela emangalisayo.
I-Myland iyisengezo sesayensi yempilo emisha, inkampani ehlanganisa ngokwezifiso kanye nezinsizakalo zokukhiqiza ekhiqiza futhi ithole izinhlobonhlobo zezithako zokudla okunomsoco ezinekhwalithi engaguquki nokukhula okuqhubekayo kwempilo yabantu. Izithako ze-Urolithin A ezikhiqizwa yi-myland:
(1) Ukuhlanzeka okuphezulu: I-Urolithin A ingaba umkhiqizo ohlanzekile ngokusebenzisa isizinda semvelo kanye nezinqubo zokukhiqiza zokucwenga. Ukuhlanzeka okuphezulu kusho i-bioavailability engcono kanye nokusabela okungekuhle okumbalwa.
(2) Ukuphepha: I-Urolithin A iwumkhiqizo wemvelo ofakazelwe ukuthi uphephile emzimbeni womuntu. Phakathi kwebanga lomthamo, ayikho imiphumela emibi enobuthi.
(3) Ukuzinza: I-Urolithin A inokuzinza okuhle futhi ingagcina umsebenzi wayo nomthelela ngaphansi kwezindawo ezihlukene nezimo zokugcina.
(4) Kulula ukumunca: I-Urolithin A ingamuncwa ngokushesha umzimba womuntu, ingene ekujikelezeni kwegazi emathunjini, futhi isakazwe ezicutshini nasezithweni ezihlukahlukene.
1. Thuthukisa impilo yemisipha
I-Urolithin A inamandla amakhulu emkhakheni wezempilo yemisipha. Ucwaningo lubonisa ukuthi liyisisebenzi esinamandla se-mitophagy, inqubo yemvelo esusa i-mitochondria engasebenzi kumaseli. Ngokugqugquzela i-mitophagy, i-urolithin A isiza ekuvuseleleni nasekuvuseleleni izicubu zemisipha, ngaleyo ndlela ithuthukise ukusebenza kwemisipha kanye nokunciphisa i-muscle atrophy ehlobene neminyaka. Leli khono elithakazelisayo le-urolithin A livula indlela yokungenelela kokwelapha ukuze kudambise isifo semisipha futhi kuthuthukiswe amandla omzimba wonke.
2. Izakhiwo zokulwa nokuvuvukala
Ukuvuvukala kudlala indima ebalulekile ekuthuthukiseni izifo ezihlukahlukene ezingapheli, njengezifo zenhliziyo, izifo ze-neurodeergenerative, ngisho nezinhlobo ezithile zomdlavuza. I-Urolithin A itholakale inezinto ezinamandla zokulwa nokuvuvukala ezisiza ukulwa nokuvuvukala ezingeni lamaselula. Ngokunciphisa amazinga ama-molecule abangela ukuvuvukala, i-urolithin A isiza ukugcina impendulo yokuvuvukala elinganiselayo, ebalulekile ekuvimbeleni nasekulawuleni izifo ezingamahlalakhona.
3. Umsebenzi onamandla we-antioxidant
Ukucindezeleka okwenziwe nge-oxidative, okubangelwa ukungalingani phakathi kwama-radicals mahhala kanye nama-antioxidants emizimbeni yethu, kungabangela ukulimala kwamangqamuzana futhi kube nomthelela ekwakhiweni kwezifo ezihlukahlukene, kuhlanganise nalezo ezihambisana nokuguga. I-Urolithin A iyi-antioxidant yemvelo enamandla eyenza ama-radicals mahhala ayingozi futhi ivikele amangqamuzana ethu emonakalweni we-oxidative. Ngokufaka i-urolithin A ekudleni kwethu noma ohlelweni lokwengeza, singase sibe namandla okuthuthukisa isimiso somzimba sokuzivikela ezifweni ze-antioxidant futhi sikhuthaze ukuguga okunempilo.
4. I-Gut Health Booster
Eminyakeni yamuva nje, i-gut microbiome ithole ukunakwa okukhulu ngomthelela wayo empilweni nasenhlalakahleni yethu iyonke. I-Urolithin A idlala indima eyingqayizivele empilweni yamathumbu ngokukhetha ngokukhetha izinhlobo ezithile zebhaktheriya emathunjini. Iguqulwa ibe ifomu elisebenzayo yilawa magciwane, ngaleyo ndlela ikhuthaze ubuqotho besithiyo samathumbu kanye nempilo yamathumbu isiyonke. Ukwengeza, ucwaningo lwakamuva lubonisa ukuthi i-urolithin A ingathuthukisa ukukhiqizwa kwe-short-chain fatty acids, enikeza amandla abalulekile kumaseli ahlanganisa ikholoni futhi asekele indawo enempilo yamathumbu.
5. Imiphumela yokulwa nokuguga ye-urolithin A
(1) Thuthukisa impilo ye-mitochondrial: I-Mitochondria iwumthombo wamandla wamaseli ethu futhi inomthwalo wemfanelo wokukhiqiza amandla. Njengoba sikhula, ukusebenza kahle kwe-mitochondrial kuncipha. I-Urolithin A ikhonjiswe ukuthi yenza kusebenze indlela ethile ye-mitochondrial ebizwa ngokuthi i-mitophagy, esusa i-mitochondria eyonakele futhi ikhuthaze ukudalwa kwe-mitochondria entsha, enempilo. Ukubuyiselwa kwempilo ye-mitochondrial kungathuthukisa ukukhiqizwa kwamandla kanye nobungqabavu buphelele.
(2) Thuthukisa i-autophagy: I-Autophagy iyinqubo yokuzihlanza iseli lapho izingxenye ezilimele noma ezingasebenzi zigaywa kabusha futhi ziqedwe. Emangqamuzaneni aguga, le nqubo ihamba kancane, okuholela ekuqongeleleni udoti oyingozi wamangqamuzana. Ucwaningo luthole ukuthi i-urolithin A ingathuthukisa i-autophagy, ngaleyo ndlela ihlanze amaseli ngempumelelo futhi ikhuthaze impilo ende yamaseli.
Umbuzo: Ingabe izithasiselo zokulwa nokuguga ziphephile?
A: Ngokuvamile, izithasiselo zokulwa nokuguga zibhekwa njengeziphephile uma zithathwa ngaphakathi kwemihlahlandlela yemithamo enconyiwe. Kodwa-ke, kubalulekile ukubonisana nochwepheshe wezokunakekelwa kwempilo ngaphambi kokwethula noma yiziphi izithasiselo ezintsha ohlelweni lwakho, ikakhulukazi uma unanoma yiziphi izimo zezokwelapha ezicashile noma uthatha imithi kadokotela.
Q: Kuthatha isikhathi esingakanani ukuthi izithasiselo zokulwa nokuguga zibonise imiphumela?
IMP: Isikhathi semiphumela ebonakalayo singahluka kuye ngomuntu kanye nesithasiselo esithile esisetshenziswayo. Nakuba abanye abantu bangase baqale ukuqaphela ukuthuthuka phakathi namaviki ambalwa, abanye bangadinga isikhathi eside sokusetshenziswa okungaguquki ngaphambi kokuba bathole izinguquko eziphawulekayo empilweni yabo yonke kanye nokubukeka kwabo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Dec-04-2023
