Iyini i-Beta-Hydroxybutyrate (BHB) & Nakhu Okufanele Ukwazi

I-Beta-hydroxybutyrate (BHB) ingenye yemizimba emithathu emikhulu ye-ketone ekhiqizwa isibindi phakathi nezikhathi zokudla okuphansi kwe-carbohydrate, ukuzila ukudla, noma ukuvivinya umzimba isikhathi eside. Eminye imizimba emibili ye-ketone yi-acetoacetate ne-acetone. I-BHB ingumzimba we-ketone ogcwele kakhulu futhi osebenza kahle, owuvumela ukuthi ubambe iqhaza elibalulekile ekusetshenzisweni kwamandla emzimbeni, ikakhulukazi lapho i-glucose iyindlala. I-Beta-hydroxybutyrate (BHB) ingumzimba we-ketone onamandla odlala indima ebalulekile ekusetshenzisweni kwamandla, ikakhulukazi ngesikhathi se-ketosis. Izinzuzo zayo zidlulela ngalé kokukhiqizwa kwamandla ukuze inikeze ukuqonda, ukulawula isisindo, kanye nezinzuzo zokulwa nokuvuvukala. Kungakhathaliseki ukuthi ulandela ukudla kwe-ketogenic noma ubheke ukuthuthukisa impilo yakho ye-metabolic, kubalulekile ukuqonda i-BHB nemisebenzi yayo.

Iyini i-beta-hydroxybutyrate (BHB)?

I-Beta-hydroxybutyrate (BHB) ingenye yemizimba emithathu ye-ketone ekhiqizwa isibindi lapho kuntuleka ama-carbohydrates. (Yaziwa nangokuthi yi-3-hydroxybutyrate noma i-3-hydroxybutyric acid noma i-3HB.)

Nansi ukubuka okufushane kwemizimba ye-ketone isibindi esikwazi ukuyikhiqiza:

I-Beta-Hydroxybutyrate (BHB). Lena i-ketone eningi kakhulu emzimbeni, ngokuvamile ebalelwa cishe ku-78% wama-ketones egazini. I-BHB ingumkhiqizo wokugcina we-ketosis.

I-acetoacetate. Lolu hlobo lomzimba we-ketone lubalelwa ku-20% wemizimba ye-ketone egazini. I-BHB ikhiqizwa kusuka ku-acetoacetate futhi ayikwazi ukukhiqizwa ngumzimba nganoma iyiphi enye indlela. Kubalulekile ukuqaphela ukuthi i-acetoacetate izinzile kancane kune-BHB, ngakho-ke i-acetoacetate ingakwazi ukuguqula ngokuzenzekelayo ku-acetone ngaphambi kokusabela okuguqula i-acetoacetate ku-BHB kwenzeke.

i-acetone. Okuncane kakhulu kwama-ketones; ibala cishe u-2% wama-ketones egazini. Ayisetshenziselwa amandla futhi ikhishwa emzimbeni cishe ngokushesha.

Kokubili i-BHB ne-acetone zitholakala ku-acetoacetate, noma kunjalo, i-BHB iyi-ketone eyinhloko esetshenziselwa amandla ngoba izinzile kakhulu futhi iningi, kuyilapho i-acetone ilahlekile ngokuphefumula nokujuluka.

Konke odinga ukukwazi nge-BHB

Ngesikhathi se-ketosis, izinhlobo ezintathu eziyinhloko zemizimba ye-ketone zingatholwa egazini:

●acetoacetate

●β-Hydroxybutyrate (BHB)

●I-acetone

I-BHB iyi-ketone esebenza kahle kakhulu, esebenza kahle kakhulu kuneglucose. Akugcini nje ukunikeza amandla angaphezu kukashukela, futhi ilwa nomonakalo we-oxidative, inciphisa ukuvuvukala, futhi ithuthukise umsebenzi wezitho, ikakhulukazi ubuchopho.

Uma ufuna ukunciphisa umzimba, uthuthukise ukusebenza kwengqondo, futhi wandise impilo yakho, i-BHB iyindlela yakho engcono kakhulu.

Indlela elula yokwandisa amazinga e-BHB ukuthatha ama-ketone angaphandle namafutha e-MCT. Kodwa-ke, lezi zithako zingakhuphula kuphela amazinga akho e-ketone kuze kube yilapho umzimba wakho uzisebenzise.

Ukuze ukhuthaze ukukhiqizwa kwe-BHB okuhlala isikhathi eside ngendlela enempilo, kufanele ulandele ukudla kwe-ketogenic.

Njengoba usebenzisa ukudla, ungasebenzisa amasu ahlukahlukene ukuze uthuthukise ukukhiqizwa kwe-ketone, okuhlanganisa:

● Nciphisa ukudla okune-carbohydrate ibe ngaphansi kuka-15 amagremu ngosuku evikini lokuqala.

● Susa izitolo ze-glycogen ngokuzivocavoca okunamandla.

●Sebenzisa ukuzivocavoca okuphansi ukuya kokumaphakathi ukuze ukhulise ukushiswa kwamafutha kanye nokukhiqizwa kwe-ketone.

●Landela uhlelo lokuzila ukudla kwesikhashana.

Uma udinga ukukhushulwa kwamandla, thatha i-MCT Oil supplement kanye/noma i-BHB Keto Salts

Kungani umzimba wakho udinga i-BHB? ngokombono wokuziphendukela kwemvelo

Ingabe umzimba wakho awuzwa sengathi wenza umzamo omkhulu wokukhiqiza nokusebenzisa ngisho nenani elincane lama-ketone? Ayishisi amafutha? Yebo, yebo futhi cha.

Ama-acids anamafutha angasetshenziswa njengophethiloli kumaseli amaningi, kodwa ebuchosheni, ayanensa kakhulu. Ubuchopho budinga imithombo yamandla esebenza ngokushesha, hhayi izibaseli ezihamba kancane ezifana namafutha.

Ngenxa yalokho, isibindi sathuthukisa ikhono lokuguqula ama-asidi anamafutha abe yimizimba ye-ketone—umthombo wamandla ohlukile wobuchopho lapho ushukela unganele. Nina zihlakaniphi zesayensi lapho ningase nicabange: “Asikwazi yini ukusebenzisa i-gluconeogenesis ukuze sinikeze ushukela ebuchosheni?”

Yebo, singakwazi—kodwa lapho ama-carbs ephansi, kufanele sephule cishe amagremu angu-200 (cishe amakhilogremu angu-0.5) emisipha ngosuku futhi siyiguqule ibe ushukela ukuze iqhube ubuchopho bethu.

Ngokushisa ama-ketone ukuze uthole uphethiloli, sigcina isisindo semisipha, sinikeze umsoco ebuchosheni, futhi sandise ukuphila lapho ukudla kuyindlala. Eqinisweni, i-ketosis ingasiza ekunciphiseni ukulahlekelwa kwesisindo somzimba ngesikhathi sokuzila ukudla izikhathi ezi-5.

Ngamanye amazwi, ukusebenzisa ama-ketones kuphethiloli kunciphisa isidingo sethu sokushisa imisipha kusuka ku-200 amagremu kuya ku-40 amagremu ngosuku lapho ukudla kuyindlala. Kodwa-ke, uma ulandela ukudla kwe-ketogenic ukuze ulahlekelwe isisindo, uzolahlekelwa ngisho nangaphansi kwamagremu angu-40 wemisipha ngosuku ngoba uzobe uhlinzeka umzimba wakho ngezakhi zokulondoloza imisipha ezifana namaprotheni.

Emavikini kuya ezinyangeni ze-ketosis yokudla okunempilo (lapho amazinga akho e-ketone ephakathi kuka-0.5 no-3 mmol/L), ama-ketones azohlangabezana nezidingo zakho zamandla ayisisekelo afika ku-50% kanye no-70% wezidingo zakho zamandla obuchopho. Lokhu kusho ukuthi uzogcina imisipha eminingi ngenkathi uthola zonke izinzuzo zokushiswa kwe-ketone:

Thuthukisa ukusebenza kwengqondo nokucaca kwengqondo

●Ushukela wegazi uzinzile

●Amandla engeziwe

●Ukulahlekelwa amafutha ngokuqhubekayo

●Ukusebenza kangcono kwezemidlalo

Kungani umzimba wakho udinga i-BHB? ngokubuka kwemishini

I-BHB ayigcini nje ngokusisiza ukuvimbela i-muscle atrophy, kodwa futhi inikeza uphethiloli ngokuphumelelayo kunoshukela ngezindlela ezimbili:

●Ikhiqiza ama-radicals mahhala ambalwa.

●Sinikeza amandla engeziwe nge-molecule ngayinye.

Ukukhiqiza Amandla kanye nama-Radicals Amahhala: I-Glucose (Ushukela) vs. BHB

Uma sikhiqiza amandla, sidala imikhiqizo eyingozi ebizwa ngokuthi ama-radicals mahhala (noma ama-oxidant). Uma le mikhiqizo inqwabelana ngokuhamba kwesikhathi, ingalimaza amaseli kanye ne-DNA.

Phakathi nenqubo yokukhiqiza i-ATP, umoya-mpilo ne-hydrogen peroxide ziyavuza. Lawa angama-radicals wamahhala, angalwa kalula nama-antioxidants.

Kodwa-ke, futhi zinamandla okuphuma ekulawuleni futhi ziguquke zibe ama-radicals amahhala alimaza kakhulu (okungukuthi, izinhlobo ze-nitrogen ezisebenzayo kanye nama-hydroxyl radicals), okuyimbangela yomonakalo omkhulu we-oxidative emzimbeni.

Ngakho-ke, ukuze kube nempilo enhle, ukuqoqwa okungapheli kwama-radicals mahhala kufanele kuncishiswe. Ukuze senze lokhu, kumelwe sisebenzise amandla ahlanzekile lapho kungenzeka khona.

I-glucose kanye nokukhiqizwa kwama-radicals mahhala

I-glucose kufanele idlule inqubo ende kancane kune-BHB ngaphambi kokuthi ingene kumjikelezo we-Krebs ukukhiqiza i-ATP. Uma inqubo isiqediwe, kuzokhiqizwa ama-molecule angu-4 e-NADH futhi isilinganiso se-NAD+/NADH sizokwehla.

I-NAD+ ne-NADH iyaphawuleka ngoba ilawula umsebenzi we-oxidant kanye ne-antioxidant:

●I-NAD+ ivimbela ukucindezeleka kwe-oxidative, ikakhulukazi noma yiziphi izinkinga ezibangelwa enye yama-oxidants okukhulunywe ngawo ngaphambili: i-hydrogen peroxide. Iphinde ithuthukise i-autophagy (inqubo yokuhlanza nokuvuselela izingxenye zamaseli ezilimele). Ngaphansi kwesenzo sezinqubo ezihlukahlukene ze-metabolic, i-NAD+ iba yi-NADH, esebenza njenge-electron shuttle yokukhiqiza amandla.

●I-NADH nayo iyadingeka ngoba inikeza ama-electron okukhiqizwa kwe-ATP. Kodwa-ke, ayivikeli emonakalweni wama-radical wamahhala. Uma kune-NADH eningi kune-NAD+, kuzokhiqizwa ama-radicals amahhala futhi ama-enzyme avikelayo azovinjelwa.

Ngamanye amazwi, ezimweni eziningi, isilinganiso se-NAD+/NADH sigcinwa siphezulu kakhulu. Amazinga aphansi e-NAD+ angabangela ukulimala okukhulu kwe-oxidative kumaseli.

Njengoba i-glucose metabolism idla ama-molecule e-NAD+ angu-4, okuqukethwe kwe-NADH kuzoba phezulu, futhi i-NADH ibangela umonakalo owengeziwe we-oxidative. Ngamafuphi: I-glucose ayishiswa ngokuphelele-ikakhulukazi uma iqhathaniswa ne-BHB.

I-BHB kanye nokukhiqizwa kwama-radical mahhala

I-BHB ayitholi i-glycolysis. Imane ishintshe ibuyele ku-acetyl-CoA ngaphambi kokungena kumjikelezo we-Krebs. Sekukonke, le nqubo idla kuphela ama-molecule e-NAD+ angu-2, okwenza isebenze kahle ngokuphindwe kabili njenge-glucose ngokombono wokukhiqizwa kwama-radical mahhala.

Ucwaningo luphinde lubonise ukuthi i-BHB ayikwazi ukugcina isilinganiso se-NAD +/NADH kuphela, kodwa futhi siyithuthukise. Lokhu kusho ukuthi i-BHB ingakwazi:

● Vimbela ukucindezeleka kwe-oxidative nama-oxidants akhiqizwa ngesikhathi sokubola kwe-ketone

● Isekela umsebenzi we-mitochondrial nokukhiqiza kabusha

●Ihlinzeka ngemiphumela yokulwa nokuguga nokuphila isikhathi eside

I-BHB futhi isebenza njenge-antioxidant ngokwenza kusebenze amaprotheni avikelayo:

● I-UCP: Le phrotheni inganciphisa ama-radicals mahhala avuza ngesikhathi sokumetabolism futhi ivimbele ukulimala kwe-oxidative kumaseli.

●SIRT3: Lapho umzimba wakho ushintsha usuka ku-glucose uye emafutheni, iphrotheni ebizwa ngokuthi i-Sirtuin 3 (SIRT3) iyanda. Ivula ama-antioxidants anamandla agcina amazinga e-radical mahhala ephansi ngesikhathi sokukhiqizwa kwamandla. Iphinde iqinise isakhi sofuzo se-FOXO futhi ivimbele i-oxidation.

● I-HCA2: I-BHB ingakwazi futhi ukusebenzisa le phrotheni ye-receptor. Ucwaningo oluningi luye lwabonisa ukuthi lokhu kungase kuchaze imiphumela ye-neuroprotective ye-BHB.

Izinzuzo eziyi-10 ze-Beta-Hydroxybutyric Acid (BHB) zokuthuthukisa Impilo Yakho

1. I-BHB ikhuthaza ukuvezwa kwezakhi zofuzo ezihlukahlukene ezikhuthaza impilo.

I-BHB "i-metabolite ebonisa izimpawu" evuselela izinguquko ezihlukahlukene ze-epigenetic kuwo wonke umzimba. Eqinisweni, izinzuzo eziningi ze-BHB zivela ekhonweni layo lokuthuthukisa ukubonakaliswa kofuzo. Isibonelo, i-BHB ivimbela ama-molecule athulisa amaprotheni anamandla. Lokhu kuvumela ukuvezwa kofuzo oluzuzisayo njenge-FOXO ne-MTL1.

Ukusebenza kwe-FOXO kusivumela ukuthi silawule ngempumelelo ukumelana nengcindezi ye-oxidative, i-metabolism, umjikelezo wamaseli kanye ne-apoptosis, okunomthelela omuhle esikhathini sethu sokuphila namandla. Ngaphezu kwalokho, i-MLT1 inomthelela ekwehliseni ubuthi ngemuva kokugqugquzelwa kwenkulumo yayo nge-BHB.

Lezi yizibonelo ezimbili nje zemiphumela yofuzo ye-BHB kumaseli ethu. Ososayensi basahlola izindima ezengeziwe zala ma-molecule amangalisayo.

2. I-BHB inciphisa ukuvuvukala.

I-BHB ivimbela iphrotheni evuthayo ebizwa ngokuthi i-NLRP3 inflammasome. I-NLRP3 ikhipha ama-molecule avuvukalayo aklanyelwe ukusiza umzimba ukuba ululame, kodwa lapho ecasulwa isikhathi eside angaba nomthelela kumdlavuza, ukumelana ne-insulin, isifo samathambo, isifo i-Alzheimer's, izifo zesikhumba, i-metabolic syndrome, uhlobo lwe-2 sikashukela kanye ne-gout .

Ucwaningo oluningi luye lwathola ukuthi i-BHB ingasiza ekuvimbeleni izifo ezibangelwa noma ezimbi kakhulu ukuvuvukala ngokunciphisa ukuvuvukala okuhambisana nalezi zimo.

Isibonelo, i-BHB (kanye nokudla kwe-ketogenic) ingasiza ukwelapha i-gout futhi ivimbele ukuhlaselwa kwe-gout ngokuvimbela i-NLRP3.

3. I-BHB ivikela ukucindezeleka okwenziwe nge-oxidative.

Ukucindezeleka kwe-oxidative kuhlotshaniswa nokuguga okusheshayo kanye nezinkinga ezihlukahlukene zempilo ezingapheli. Enye indlela yokunciphisa lezi zinkinga ukusebenzisa umthombo wamafutha osebenza kahle njenge-BHB.

Akukhona nje ukuthi i-BHB iphumelela kakhulu kunoshukela, izifundo zithole ukuthi ingavimbela futhi ihlehlise umonakalo we-oxidative kuwo wonke ubuchopho nomzimba:

● I-BHB ivikela ubuqotho bokuxhumana kwe-neuronal ku-hippocampus, ingxenye yobuchopho elawula ukuma kwenhliziyo, inkumbulo yesikhathi eside, nokuzulazula kwendawo, ekulimaleni kwe-oxidative.

●Ku-cerebral cortex, indawo yobuchopho enesibopho semisebenzi esezingeni eliphezulu efana nokuqonda, ukucabanga kwendawo, ulimi, nokubona kwezinzwa, i-BHB ivikela amaseli ezinzwa kuma-radicals mahhala kanye ne-oxidation.

●Kumaseli e-endothelial (amangqamuzana ahlanganisa imithambo yegazi), ama-ketone enza kusebenze amasistimu okuvikela e-antioxidant avikela isimiso senhliziyo nemithambo yegazi.

● Kubasubathi, imizimba ye-ketone itholwe inciphisa ukucindezeleka okwenziwe nge-oxidative.

4. I-BHB inganweba isikhathi sokuphila.

Ngokuthola izinzuzo ezimbili esizifunde ngaphambili (ukuvuvukala okuncishisiwe kanye nokubonakaliswa kwezakhi zofuzo), i-BHB inganweba impilo yakho futhi yenze ukuphila kwakho kucebe.

Nansi indlela i-BHB engena ngayo ezakhini zofuzo ezilwa nokuguga:

●Vimba i-insulin-like growth factor (IGF-1) gene receptor. Lesi sakhi sofuzo sikhuthaza ukukhula nokwanda kwamangqamuzana, kodwa ukwanda kuye kwahlotshaniswa nezifo, umdlavuza, nokufa ngaphambi kwesikhathi. Umsebenzi ophansi we-IGF-1 ubambezela ukuguga futhi unwebe isikhathi sokuphila.

●Sebenzisa isakhi sofuzo se-FOXO. Isakhi sofuzo esisodwa se-FOXO, i-FOXO3a, siye saxhunyaniswa nokwanda kwesikhathi sokuphila kwabantu ngoba sikhuthaza ukukhiqizwa kwama-antioxidants.

 

5. I-BHB ithuthukisa ukusebenza kwengqondo.

Sixoxile ngaphambi kokuthi i-BHB iwumthombo wamafutha obalulekile wobuchopho lapho ushukela uphansi. Lokhu kungenxa yokuthi ikwazi ukweqa kalula umgoqo wegazi nobuchopho futhi inikeze ngaphezu kwe-70% yezidingo zamandla zobuchopho.

Nokho, izinzuzo zobuchopho be-BHB azigcini lapho. I-BHB ingase futhi ithuthukise ukusebenza kwengqondo ngoku:

● Isebenza njenge-antioxidant ye-neuroprotective.

● Thuthukisa ukusebenza kahle kwe-mitochondrial namandla okuzala.

● Thuthukisa ibhalansi phakathi kwama-neurotransmitters avimbelayo kanye ne-excitatory.

●Thuthukisa ukukhula nokuhlukaniswa kwama-neuron amasha nokuxhuma kwe-neuronal.

●Vimbela i-atrophy yobuchopho nokunqwabelana koqweqwe lwawo.

Uma ufuna ukufunda kabanzi mayelana nokuthi i-BHB izuzisa kanjani ubuchopho kanye nocwaningo olungemuva kwayo, hlola isihloko sethu mayelana nama-ketones nobuchopho.

6. I-BHB ingasiza ukulwa nokuvimbela umdlavuza.

I-BHB inciphisa ukukhula kwezicubu ezihlukahlukene ngoba amangqamuzana amaningi omdlavuza awakwazi ukusebenzisa ngokugcwele imizimba ye-ketone ukuze ikhule futhi isakazeke. Lokhu kuvame ukubangelwa ukungasebenzi kahle kwemetabolism yamangqamuzana omdlavuza, okuwenza athembele ikakhulukazi kushukela.

Ezifundweni eziningi, ososayensi basebenzise lobu buthakathaka ngokususa i-glucose, bephoqa amangqamuzana omdlavuza ukuthi athembele emizimbeni ye-ketone. Ngale ndlela, empeleni banciphisa izimila ezithweni eziningi, okuhlanganisa ubuchopho, amanyikwe kanye nekholoni, ngoba amangqamuzana ayengakwazi ukukhula nokusabalala.

Kodwa-ke, kubalulekile ukuqaphela ukuthi akuwona wonke ama-cancer aziphatha ngendlela efanayo, futhi i-BHB ngeke isize ukulwa nokuvimbela wonke umdlavuza. Uma ungathanda ukufunda okwengeziwe ngocwaningo lwe-keto, ukudla kwe-ketogenic, nomdlavuza, bheka isihloko sethu esihlokweni.

7. I-BHB ithuthukisa ukuzwela kwe-insulin.

Ama-ketone angasiza ekubuyiseleni ukumelana ne-insulin ngoba angakwazi ukulingisa eminye yemiphumela ye-insulin futhi alawule ushukela wegazi namazinga e-insulin. Lezi yizindaba ezinhle kunoma ngubani one-prediabetes noma uhlobo 2 sikashukela, nanoma ubani ofuna ukuthuthukisa impilo yakhe yonke ye-metabolic.

8. I-BHB iyiphethiloli engcono kakhulu yenhliziyo yakho.

Umthombo wamandla wenhliziyo okhethwayo ama-acids amaketanga amade. Kulungile, inhliziyo ishisa amafutha, hhayi ama-ketone, njengomthombo wayo oyinhloko wokubasa.

Kodwa-ke, njengobuchopho, inhliziyo yakho ingakwazi ukuzivumelanisa kahle ne-keto uma kuphakama isidingo.

Ucwaningo luye lwathola ukuthi uma ushisa i-BHB, impilo yakho yenhliziyo iba ngcono ngezindlela eziningi 

●Ukusebenza kahle kwenhliziyo kunganyuswa kuze kufike ku-30%

●Ukugeleza kwegazi kunganyuswa kuze kufike ku-75%.

● Ukucindezeleka kwe-oxidative kumaseli enhliziyo kuyancipha.

Uma kuhlanganiswe, lokhu kusho ukuthi i-BHB ingaba uphethiloli ongcono kakhulu wenhliziyo yakho.

9. I-BHB isheshisa ukulahlekelwa kwamafutha.

Ukushiswa kwama-ketones kuphethiloli kungakhuthaza ukulahleka kwamafutha ngezindlela ezimbili:

●Ngokwandisa amandla akho okushisa amafutha ne-ketone.

●Ngokucindezela ukudla.

Njengoba ugcina isimo se-ketosis, amandla akho okushisa ama-ketone amaningi namafutha azokhula kakhulu, akuguqule ube umshini oshisa amafutha. Ngaphezu kwalokhu, uzophinde uhlangabezane nemiphumela yokucindezela ukudla kwama-ketones.

Nakuba ucwaningo lungazange lukhombe ukuthi kungani noma kanjani ama-ketones anciphisa ukudla kwethu, siyazi ukuthi ukwanda kokushiswa kwe-ketone kubonakala kumazinga aphansi e-ghrelin, ihomoni yendlala.

Uma sihlanganisa le miphumela emibili ye-BHB ekulahlekelweni kwesisindo, sigcina sinophethiloli kokubili okukhuthaza ukushiswa kwamafutha futhi ngesikhathi esifanayo kukuvimbela ekutholeni amafutha (ngokuvimbela ukusetshenziswa kwekhalori ngokweqile).

10. I-BHB ithuthukisa ukusebenza kahle kokujima kwakho.

Kube nocwaningo oluningi mayelana nokuthi i-BHB ithinta kanjani ukusebenza kwezemidlalo, kodwa imininingwane isasetshenzwa (i-pun ihlosiwe). Ngamafuphi, izifundo zithole ukuthi ama-ketone angakwazi:

●Thuthukisa ukusebenza ngesikhathi sokuqeqeshwa kokuqina okuphansi ukuya kokumaphakathi (isb., ukuhamba ngebhayisikili, ukuqwala izintaba, ukudansa, ukubhukuda, i-yoga yamandla, ukujima, ukuhamba ibanga elide).

●Khulisa ukushiswa kwamafutha futhi ulondoloze izitolo ze-glycogen ukuze uzivocavoce ngamandla.

●Isiza ngokugcwalisa ngokungaqondile izinqolobane ze-glycogen ngemva kokuzivocavoca futhi isheshise ukululama.

●Yehlisa ukukhathala phakathi nomsebenzi futhi ithuthukisa ukusebenza kwengqondo.

Sekukonke, ucwaningo lubonisa ukuthi i-BHB ingasiza ekunciphiseni ukukhathala, ukwandisa ukukhuthazela, futhi okungenzeka ithuthukise ukusebenza kokuzivocavoca jikelele. Nokho, ngeke kuthuthukise ukusebenza kwakho emisebenzini esezingeni eliphezulu njengokugijima nokuphakamisa izinsimbi. (Ukuthola ukuthi kungani, zizwe ukhululekile ukuhlola umhlahlandlela wethu wokuzivocavoca kwe-ketogenic .)

Kunezindlela ezimbili zokukhulisa amazinga akho e-BHB: ngokuzenzakalelayo nangaphandle.

I-Endogenous BHB ikhiqizwa umzimba wakho wodwa.

Ama-ketone angaphandle angama-molecule e-BHB angaphandle angathathwa njengesengezo ukuze akhulise ngokushesha amazinga e-ketone. Lezi zivame ukuthathwa ngendlela ye-BHB usawoti noma ama-esters.

Okuwukuphela kwendlela yokwandisa ngempela nokugcina amazinga e-ketone ngokukhiqizwa okungapheli kwama-ketone. Ukwengezwa kwe-ketone yangaphandle kungasiza, kodwa akusoze kwashintsha izinzuzo ze-ketosis yokudla okunempilo.

I-Exogenous Ketosis: Konke Odinga Ukukwazi Nge-BHB Ketone Supplement

Kunezindlela ezimbili ezivamile zokuthola ama-ketones angaphandle: osawoti be-BHB nama-ketone esters.

I-Ketone esters iwuhlobo lokuqala lwe-BHB ngaphandle kwezithako ezengeziwe ezingeziwe. Ziyabiza, kunzima ukuzithola, zinambitheka kabi, futhi zingaba nemiphumela engemihle ohlelweni lwamathumbu.

Usawoti we-BHB, ngakolunye uhlangothi, uyisithasiselo esisebenza ngempumelelo okulula ukusithenga, ukusisebenzisa, nokugaya. Lezi zithako ze-ketone zivame ukwenziwa ngenhlanganisela ye-BHB nosawoti wamaminerali (okungukuthi i-potassium, i-calcium, i-sodium, noma i-magnesium).

Usawoti wamaminerali wengezwa ezithasiselweni ze-BHB zangaphandle ukuze:

●Amandla e-ketone evinjiwe

●Thuthukisa ukunambitheka

●Yehlisa izinga lezinkinga zesisu

●Yenze ixube nokudla neziphuzo

Uma uthatha usawoti we-BHB, aphulwa futhi akhishwe egazini lakho. I-BHB ibe isihamba iye ezithweni zakho lapho i-ketosis iqala khona, ikunikeze amandla.

Kuya ngokuthi uthatha malini, ungafaka isimo se-ketosis cishe ngokushesha. Kodwa-ke, ungahlala kuphela ku-ketosis inqobo nje uma le mizimba ye-ketone iqhubeka (ngaphandle uma udla ukudla kwe-ketogenic futhi usuvele ukhiqiza ama-ketone ngokungapheli).

I-Ketone Ester (R-BHB) ne-Beta-Hydroxybutyrate (BHB)

I-Beta-hydroxybutyrate (BHB) ingenye yemizimba emithathu eyinhloko ye-ketone ekhiqizwa isibindi phakathi nezikhathi zokudla okuphansi kwe-carbohydrate, ukuzila ukudla, noma ukuzivocavoca isikhathi eside. Lapho amazinga e-glucose ephansi, i-BHB isebenza njengomthombo wamandla ohlukile wokushisa ubuchopho, imisipha, nezinye izicubu. Kuyi-molecule eyenzeka ngokwemvelo edlala indima ebalulekile esimweni se-metabolic se-ketosis.

I-Ketone ester (R-BHB), ngakolunye uhlangothi, kuyindlela yokwenziwa ye-BHB eboshelwe ku-molecule yotshwala. Leli fomu le-esterified litholakala kakhulu futhi lisebenza kahle ekukhuphuleni amazinga e-ketone yegazi kunosawoti we-BHB wendabuko. I-R-BHB ivame ukusetshenziswa ezithasiselweni zokuthuthukisa ukusebenza kwezemidlalo, ukusebenza kwengqondo, kanye namazinga wamandla jikelele.

Lapho umzimba ungena esimweni se-ketosis, uqala ukudiliza ama-fatty acids abe ama-ketone, kuhlanganise ne-BHB. Le nqubo iwukujwayela okungokwemvelo ezikhathini zokutholakala kwe-carbohydrate ephansi, okuvumela umzimba ukuthi ugcine ukukhiqizwa kwamandla. I-BHB ibe ihanjiswa ngegazi kuya ezicutshini ezihlukahlukene, lapho iguqulwa ibe amandla.

I-R-BHB iyindlela egxile kakhulu, enamandla kakhulu ye-BHB engakhuphula ngokushesha amazinga e-ketone yegazi. Lokhu kwenza kube inketho ekhangayo kulabo abafuna izinzuzo ze-ketosis ngaphandle kwemikhawulo eqinile yokudla. Ucwaningo lubonisa ukuthi i-R-BHB ingathuthukisa ukusebenza komzimba, ithuthukise ukusebenza kwengqondo, futhi isekele imizamo yokulahlekelwa isisindo.

Ungakukhethela kanjani usawoti we-BHB ongcono kakhulu

Uma ufuna usawoti ongcono kakhulu we-BHB, qiniseka ukuthi wenza lezi zinto ezintathu:

1. Bheka i-BHB eyengeziwe kanye nosawoti omncane

Izithako ezisezingeni eliphezulu zandisa i-BHB yangaphandle futhi zengeza kuphela amanani adingekayo kasawoti wamaminerali.

Usawoti wamaminerali osetshenziswa kakhulu emakethe yi-sodium, potassium, magnesium, ne-calcium, enezithako eziningi zisebenzisa ezintathu, nakuba ezinye zisebenzisa eyodwa noma ezimbili zazo.

Hlola ilebula ukuze uqiniseke ukuthi lingaphansi kwegremu elingu-1 losawoti wamaminerali ngamunye. Izingxube zikasawoti ze-BHB azivamile ukudinga okungaphezu kwe-1 igremu yeminerali ngayinye ukuze iphumelele

2. Qiniseka ukuthi uthola amaminerali owadingayo.

Awutholi i-potassium eyanele, i-sodium, i-calcium noma i-magnesium? Khetha imikhiqizo ye-BHB ukukunikeza amaminerali owadingayo.

3. Hlala kude nama-fillers kanye nama-carbohydrate angeziwe.

Izihlungi nezithuthukisi zokuthungwa njenge-guar gum, i-xanthan gum, ne-silica zivamile kuma-exogenous ketone salts futhi azidingeki nhlobo. Ngokuvamile azinayo imiphumela emibi yezempilo, kodwa zingakuphuca usawoti we-BHB obalulekile.

Ukuze uthole usawoti we-keto omsulwa, vele ubheke isigaba esikulebula yomsoco ethi "Ezinye Izithako" futhi uthenge umkhiqizo ngohlu olufushane kakhulu lwezithako zangempela.

Uma uthenga usawoti we-BHB keto, qiniseka ukuthi aqukethe izithako zangempela kanye nama-sweeteners aphansi we-carb. Gwema noma yiziphi izithasiselo eziqukethe ama-carbohydrate njenge-maltodextrin ne-dextrose.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka nge-Ketone Ester (R-BHB) yekhwalithi ephezulu nehlanzekile.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-Ketone Ester yethu (i-R-BHB) powder ihlolwe ngokuqinile ukuhlanzeka namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongayethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba noma uthuthukise impilo yonke, i-Ketone Ester yethu (R-BHB) iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izindawo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kuma-milligrams kuye kumathani esikalini, futhi ithobelane namazinga e-ISO 9001 kanye nokucaciswa kokukhiqiza kwe-GMP.