Iyini i-Squalene futhi Kungani Kufanele Unakekele?

Njengoba abantu bekhathazeka kakhulu ngempilo yabo, i-Squalene ithola ukuduma ngenxa yezakhiwo zayo ezinhle kakhulu zokuthambisa kanye ne-antioxidant. Njengenhlanganisela eyenzeka ngokwemvelo, i-squalene isetshenziswa kakhulu emikhiqizweni yokunakekelwa kwesikhumba, izimonyo kanye nezithako zokudla. Njengoba isidingo sabathengi sezithako zemvelo siqhubeka nokwanda, kanjalo nesidingo sekhwalithi ephezulu ye-Squalene powder emakethe.

I-Squalene (I-CAS: 111-02-4) iwuketshezi olunamafutha angenambala. Kuyinhlanganisela ye-all-trans triterpene enesakhiwo se-isoprene futhi iyingxenye ebalulekile endleleni ye-cholesterol yomuntu. Ukhiye ophakathi nendawo, ama-terpenoids avame ukutholakala kuma-nutraceuticals nezimonyo. I-squalene kukholakala ukuthi inezinzuzo eziningi emzimbeni womuntu, okuhlanganisa ukwehlisa i-lipids yegazi, i-antioxidant, anti-inflammatory kanye nemiphumela ethuthukisa ukuzivikela komzimba. I-squalene ingabamba iqhaza kumetabolism njengesandulela se-steroid synthesis, futhi idlala indima ebalulekile ezindleleni zokuhlanganiswa kwe-β-carotene, i-coenzyme Q10, i-vitamin D, i-vitamin E kanye ne-vitamin K1.

I-squalene itholakala kakhulu ezilwaneni, ezitshalweni nasezintweni ezincane. Ihlanganiswa ku-endoplasmic reticulum futhi igcinwe kuma-vesicles noma idluliselwe kulwelwesi lweseli ngama-vesicle. Ngenxa yomsebenzi wayo oqinile wezinto eziphilayo, isetshenziswa kakhulu ekudleni nasezimonyoni. Izindawo zezimboni. I-squalene itholakala ekudleni okuningi, phakathi kwawo amafutha esibindi sikashaka aqukethe amazinga aphezulu kakhulu, futhi amafutha ambalwa emifino njengamafutha omnqumo namafutha e-rice bran nawo aqukethe amazinga aphezulu e-squalene.

I-Squalene inemiphumela eminingi ye-bioactive, okuhlanganisa ukuthuthukisa ukubekezelelana kwe-hypoxia, ukuvimbela ukukhula kwamagciwane, i-antibacterial and anti-inflammatory, kanye nokulawula i-cholesterol metabolism. Ngaphezu kwalokho, inamandla okucima i-oksijeni ye-singlet, ivikela ngokuphumelelayo isikhumba ku-lipid peroxidation nokuvikela amangqamuzana emonakalweni we-oxidative ku-DNA. Le nto futhi ikhombisa imisebenzi ehlukahlukene ebalulekile yomzimba njengokuvimbela isifo senhliziyo nemithambo yegazi kanye nokuthuthukisa amasosha omzimba womuntu.

Isingeniso semisebenzi ye-squalene

1. Umsebenzi we-Antioxidant

I-squalene ingavimbela ngempumelelo ukusabela kwama-radicals mahhala emzimbeni womuntu futhi idlale indima ye-antioxidant. I-molecule ye-squalene yakhiwe ngamabhondi ayi-6 angenayo i-conjugated unsaturated double futhi inezindawo eziqinile zokulwa ne-antioxidant.

2. Imiphumela elwa namagciwane kanye ne-anti-inflammatory

I-squalene ine-antibacterial, anti-inflammatory kanye ne-bactericidal effect futhi ingasetshenziselwa izifo eziphezulu zokuphefumula kanye nezifo zesikhumba ezibangelwa amagciwane, kanye nokusha, izilonda zesikhumba kanye nezifo ze-aphthous. Ucwaningo lubonisa ukuthi i-squalene ingasheshisa inqubo yokuphola kwamanxeba nokusikeka. Izakhiwo zayo zokulwa nokuvuvukala kanye ne-antioxidant zisiza ekululameni ngokushesha, okwenza kube isengezo esibalulekile kunoma iyiphi ikhithi yosizo lokuqala

3. Free radical kadoti, ngcono amasosha omzimba

I-squalene inekhono eliqinile lokukhipha ama-radical mahhala futhi idlala indima ebalulekile ekukhuthazeni umzimba womuntu. Ngokuvula imetabolism, i-squalene isiza ukuthuthukisa ukumuncwa komzimba nokusebenzisa kahle izakhi, ngaleyo ndlela ikhuthaze ukugcinwa kwezempilo. Njengesengezo sokudla esisebenzayo, i-squalene isetshenziswa emikhiqizweni ehlukahlukene yezempilo, njengezithako zokudla okunomsoco, ukudla okunempilo, neziphuzo ezisebenzayo. Ucwaningo kanye nokusetshenziswa kwe-squalene nakho kuyanda njalo, kuhlinzeka abantu ngamathuba amaningi okuthola izinzuzo zezempilo ngokudla.

4. Umswakama kanye ne-antioxidant

I-squalene inezinzuzo eziningi zezempilo zesikhumba, okuhlanganisa ukuvikelwa emisebeni ye-UV kanye ne-antioxidant. Ithuthukisa ukuthungwa kwesikhumba, inciphisa izimbotshana nemibimbi, futhi ithambisa isikhumba ngaphandle kokubangela ukucasuka. Ukuhlolwa kwabesifazane abaneminyaka engaphezu kwengu-50 ubudala kubonise ukuthi ukuphuza i-squalene kunganciphisa kakhulu imibimbi yobuso futhi kuthuthukise ukuqubuka kobuso nokushintsha umbala. Ngaphezu kwalokho, i-squalene ingakhuphula umsebenzi we-enzyme ye-antioxidant yesikhumba, futhi umphumela ungcono kakhulu kune-vitamin E. Ngenxa yemiphumela yayo emihle kakhulu ye-emollient, ezinye izinhlobo zezimonyo ezaziwayo ziye zayisebenzisa emikhiqizweni yokunakekelwa kwesikhumba nezinwele njengama-serum hydrating nokunakekelwa kwesikhumba. amafutha.

3. Isicelo semboni ye-Squalene

1). I-Squalene kanye nemikhiqizo yayo ye-hydrogenated ithandwa ngezinhlobonhlobo zabo zokusetshenziswa kwezimonyo. I-squalene inezinzuzo eziningi zezempilo zesikhumba, okuhlanganisa ukuvikelwa emisebeni ye-UV kanye ne-antioxidant. Ithuthukisa ukuthungwa kwesikhumba, inciphisa izimbotshana nemibimbi, futhi ithambisa isikhumba ngaphandle kokubangela ukucasuka.

2). Njengowoyela wemvelo, i-squalene isetshenziswa kabanzi njengesithwali sezidakamizwa esisebenza nge-biocompatible ukuze kukhishwe izidakamizwa okuqhubekayo. Izidakamizwa ze-emulsion eziqukethe i-squalene zinganweba isigamu sempilo yomuthi.

3). I-Squalene ibonise amandla amaningi okufaka isicelo ocwaningweni lwezokwelapha: kumaseli we-HepG2, ihlola indlela yokwehlisa i-cholesterol ngokuvimbela ukwanda kwamangqamuzana nokwandisa inkulumo ye-LDLR; okwesibili, izifundo ze-molecular docking zibonisa ukuthi i-squalene ingaba nendima ekwelapheni umdlavuza wesikhumba ukuze idlale indima; ekugcineni, ngokufakwa ku-PLGA NPs, ukusebenza kahle kokuthathwa kwamaselula emafutheni omnqumo kuyathuthukiswa, futhi kunamandla okugcina impilo yamaseli nokumelana nokucindezeleka okwenziwe nge-oxidative.

4). Njengesengezo sokudla esisebenzayo, i-squalene idonse ukunakwa okuningi futhi ifundwe kabanzi ngendima yayo ekuvimbeleni izifo zenhliziyo, umdlavuza nezinye izifo.

Ungayithenga kuphi i-Squalene?

Izinto Ezibalulekile Ekukhetheni Umhlinzeki We-squalene

1. Ikhwalithi yomkhiqizo

Lapho ukhetha umphakeli, into yokuqala okufanele uyicabangele yikhwalithi yomkhiqizo. Ukuhlanzeka okuphezulu kwe-Squalene powder iqinisekisa umsebenzi wayo wezinto eziphilayo nokusebenza kwayo. I-Squalene powder enikezwe i-Suzhou Myland iye yahlolwa ikhwalithi eqinile ukuze kuqinisekiswe ukuthi iqoqo ngalinye lemikhiqizo lihlangabezana nezindinganiso zamazwe ngamazwe futhi linekhwalithi eqinisekisiwe.

2. Amandla okukhiqiza

Amandla okukhiqiza womkhiqizi athinta ngqo ukugcinwa kwesikhathi kanye nokuzinza kokunikezwayo. I-Suzhou Myland inemishini yokukhiqiza ethuthukisiwe nobuchwepheshe obungakwazi ukuhlangabezana nezidingo zokukhiqiza ngobuningi, ukuqinisekisa ukuthi amakhasimende angathola imikhiqizo ayidingayo ngesikhathi lapho eyidinga.

3. Amakhono e-R&D

Umphakeli omuhle kakhulu uvamise ukuba neqembu eliqinile le-R&D elingaqhubeka lithuthukisa imikhiqizo futhi lithuthukise imikhiqizo emisha. I-Suzhou Myland iqongelele ulwazi olucebile ocwaningweni nasekusetshenzisweni kwe-Squalene futhi iyakwazi ukunikeza amakhasimende ukwesekwa kobuchwepheshe nezisombululo.

4. Isevisi Yekhasimende

Isevisi yamakhasimende enhle iyisici esingenakuzitshwa lapho kukhethwa umphakeli. I-Suzhou Myland igxile ekuxhumaneni namakhasimende futhi iyakwazi ukuhlinzeka ngezinsizakalo zomuntu siqu ngokwezidingo zamakhasimende ukuze kuqinisekiswe ukuthi amakhasimende athola ulwazi olungcono kakhulu phakathi nenqubo yokuthenga.

5. Isitifiketi Nokuhambisana

Ukuqinisekisa ukuthi abahlinzeki banezitifiketi ezifanele kanye nokuthobela imithetho ebalulekile yokukhetha. I-Suzhou Myland iqinisekisiwe nge-ISO futhi ithobela izindinganiso ze-GMP (Good Manufacturing Practice), iqinisekisa ukuthi imikhiqizo yayo ilandela uhlelo oluqinile lokuphatha ikhwalithi phakathi nenqubo yokukhiqiza.

Ekuphetheni

Ukukhetha umphakeli ofanele we-Squalene kuyisihluthulelo sokuqinisekisa ikhwalithi nokuphepha komkhiqizo. I-Suzhou Myland isiphenduke inketho enokwethenjelwa embonini ngemikhiqizo yayo ehlanzekile, ukulawula okuqinile kwekhwalithi kanye nezinsizakalo zochwepheshe. Kungakhathaliseki ukuthi ungumkhiqizi womkhiqizo wokunakekelwa kwesikhumba, inkampani yezimonyo noma omunye ofuna ngenkani embonini, i-Suzhou Myland ingakunikeza ngempushana yekhwalithi ephezulu ye-Squalene ukusiza impilo yakho nokuthuthuka komsebenzi wakho. Ukuze uthole imininingwane eyengeziwe, sicela uvakashele iwebhusayithi esemthethweni ye-Suzhou Mailun Biology.