Ukuguga kuyinqubo yemvelo engenakugwenywa yezinto eziphilayo, ebonakala ngokuncipha kancane kancane kwesakhiwo somzimba nokusebenza ngokuhamba kwesikhathi. Le nqubo iyinkimbinkimbi futhi isengozini yokuthola imithelela ecashile evela ezicini ezihlukahlukene zangaphandle njengendawo ezungezile. Ukuze babambe ngokunembile ijubane lokuguga, ososayensi baye bayishiya indlela evamile yokulinganisa enzima yeminyaka noma izinsuku futhi esikhundleni salokho bagxila esilinganisweni sesikhathi esintekenteke kakhulu, balwela ukuthola ukuqonda okucashile ngenqubo yokuguga.
Kulokhu kuhlola, ososayensi benze uchungechunge lwama-biomarker aguga ngobuhlakani, phakathi kwawo amaphethini e-DNA methylation aheha kakhulu amehlo. Njengendlela eyinhloko yokulawula i-epigenetic, amaphethini e-DNA methylation angakwazi ukwenza imephu ngokunembile iphrofayili yomuntu yokuguga yamanje, ingavezi nje kuphela izinguquko eziguquguqukayo zolwazi lofuzo enqubweni yokuguga, kodwa futhi ibe semqoka ocwaningweni lwesayensi lokuguga. ukunemba amathuluzi. Ngokuhlaziywa okujulile kwalezi zimpawu ze-biomarker, ososayensi bangathola amazwibela ezinqubo zamangqamuzana abangela ukuguga, bavule izindlela ezintsha zokubambezela ukuguga nokukhuthaza ukuguga okunempilo.
Esibhakabhakeni esikhulu esinezinkanyezi zesayensi yokulwa nokuguga, i-NMN (nicotinamide mononucleotide) yake yadabula njenge-meteor ecwebezelayo. Ubunikazi bayo njengomanduleli we-NAD+ (nicotinamide adenine dinucleotide) bugqugquzele ososayensi abangenakubalwa. umdlandla wocwaningo. Nokho, ngokuhamba kwesikhathi, enye inkanyezi egqamile, i-AKG (alpha-ketoglutarate), yavela kancane kancane futhi yazuza ukuqashelwa kabanzi emkhakheni wokulwa nokuguga ngokuthakazelisa kwayo okuyingqayizivele nesisekelo sesayensi. .
Ocwaningweni olwanyatheliswa kumagazini i-Nature Metabolism, ososayensi bachaza kabanzi ngendlela ye-AKG ekusetshenzisweni kwamandla, ukusebenza kwe-mitochondrial kanye nokulwa nokuguga. Ucwaningo luveze ukuthi i-AKG ingawukhuthaza ngokuqondile umjikelezo we-tricarboxylic acid futhi ikhulise ukuphuma kwamandla kumaseli, ngaleyo ndlela ithuthukise ubungqabavu bamaseli. Ngaphezu kwalokho, iphephabhuku elithi “Cell Metabolism” liphinde lashicilela imiphumela yocwaningo ngekhono le-AKG lokukhuthaza ukwakheka kwe-collagen nokuthuthukisa ukunwebeka kwesikhumba, iphinde iqinisekise amandla ayo emkhakheni wokulwa nokuguga.
Ukubuyisela emuva iminonjana yesikhathi
Ucwaningo lomtholampilo oluvela eJapane lusinika isibonelo esicacile. Owesifazane oneminyaka ephakathi obelokhu enaka ukulwa nokuguga isikhathi eside, ngemva kokuthatha izithako ze-AKG isigamu sonyaka, hhayi nje kuphela isimo sesikhumba sakhe esathuthukiswa kakhulu, siqina futhi sinwebeka, kodwa ukuqina komzimba wonke. kanye nesimo sengqondo sathuthukiswa kakhulu. Ngokuqhathanisa izinkomba zomzimba ngaphambi nangemva kokuhlolwa, abacwaningi bathola ukuthi ukusebenza kwe-mitochondrial yowesifazane kwathuthukiswa kakhulu, okuhlobene eduze nendima ye-AKG ekukhuthazeni umzimba we-energy metabolism.
Umnakekeli wempilo yezinzwa
Olunye ucwaningo oluvela e-United States lugxile endimeni ye-neuroprotective ye-AKG. Ngemva kokuthola ukwelashwa kwe-AKG, indoda endala enokukhubazeka okuncane kwengqondo yabonisa ukuthuthuka okukhulu emandleni ayo okuqonda, okuhlanganisa inkumbulo ethuthukisiwe nokugxilisa ingqondo. Abacwaningi baqaphele ngobuchwepheshe be-imaging yobuchopho ukuthi ukusebenza kwe-neuron mitochondrial yesiguli kwabuyiselwa, okunikeza ukwesekwa okuqinile kwe-AKG ekuvimbeleni nasekwelapheni izifo ze-neurodegenerative.
Izinzuzo eziyingqayizivele ze-AKG
1. Umphumela wokulwa nokuguga onezinhlangothi eziningi
Ngokungafani ne-NMN, elwa kakhulu nokuguga ngokwandisa amazinga e-NAD+, i-AKG idlala indima ebanzi ekulweni nokuguga. Akukwazi nje ukukhuthaza amandla e-metabolism futhi kuthuthukise ukusebenza kwe-mitochondrial, kodwa futhi kuthuthukise isimo sokuguga komzimba kusuka ezingxenyeni eziningi ngokuthinta i-amino acid metabolism kanye nokukhuthaza ukuhlanganiswa kwe-collagen.
2. I-biocompatibility ephakeme nokuphepha
Njengemetabolite eyenzeka ngokwemvelo yomzimba womuntu, i-AKG inokuvumelana okuhle kakhulu kwe-biocompatibility nokuphepha. Ingamuncwa ngokuqondile futhi isetshenziswe umzimba womuntu ngaphandle kokudlula enqubweni yokuguqula eyinkimbinkimbi, enciphisa ubungozi bokusabela okubi okungaba khona. Lokhu kwenza ukusetshenziswa kwe-AKG emkhakheni wokulwa nokuguga kuphephe futhi kuthembeke kakhudlwana.
3. Uhlu olubanzi lwezinzuzo zezempilo
Ngaphezu kokulwa nokuguga, i-AKG iphinde ibonise izinhlobonhlobo zezinzuzo zezempilo ekukhuthazeni impilo yezinzwa kanye nokuthuthukisa amasosha omzimba. Lezi zinzuzo zezempilo ezengeziwe zenza i-AKG ikhange nakakhulu ezinhlelweni zokulwa nokuguga.
Ngokujula okuqhubekayo kocwaningo lwesayensi kanye nokuthuthuka okuqhubekayo kobuchwepheshe, amathemba okusetshenziswa kwe-AKG emkhakheni wokulwa nokuguga azoba banzi. Sibheke phambili ocwaningweni lwekhwalithi ephezulu esikhathini esizayo ukuze siveze izimfihlakalo ezengeziwe ze-AKG, futhi sibheke ngabomvu ikhono layo lokuhlanganiswa namanye amasu okulwa nokuguga njenge-NMN ukuze sihlanganyele ngokuhlanganyela ukuhlakanipha namandla okwengeziwe empilweni yomuntu nokuphila isikhathi eside. . Kulo mjaho wokulwa nesikhathi, i-AKG ngokungangabazeki ibonise ukuncintisana okuqinile namathuba angenamkhawulo.
Imisebenzi esemqoka yilezi:
I-Anti-Aging: Ingakwazi ukubambezela ngokuphawulekayo inqubo yokuguga kwamaselula ngokulawula indlela yokubonisa i-mTOR, ukukhuthaza ukutholakala kwe-autophagy, ukuthuthukisa ukuphazamiseka kwe-protein metabolism, nokulawula i-epigenetics. Ngaphezu kwalokho, ingakhuthaza ukuhlanganiswa kwe-collagen, isekele ukuxoshwa kweseli, isize ukubuyisela amazinga ajwayelekile e-calcium egazini, isheshise ukuphulukiswa kwesilonda, ikhuthaze ukulungiswa kwezicubu zemisipha, njll.
Thuthukisa izifo ezingelapheki: Ukuhlolwa komtholampilo kubonise ukuthi kunomphumela ongcono kakhulu wentuthuko ezifweni ezihlukahlukene ezingapheli, okuhlanganisa kodwa kungagcini nje nge-osteoporosis, izifo ze-neurodeergenerative (njenge-Parkinson's disease), izifo zenhliziyo, isifo sikashukela, nomdlavuza. Ixazulula ngokuyisisekelo izimbangela zezifo ezingamahlalakhona ngokwenza kusebenze amaprotheni okuphila isikhathi eside emzimbeni kanye nokulungisa i-DNA eyonakele.
Thuthukisa amasosha omzimba: Ingathuthukisa umsebenzi nenani lamaseli omzimba, ithuthukise ukuvikeleka komzimba wonke, futhi ngaleyo ndlela isize umzimba ukuthi umelane kangcono nezifo nezifo.
Thuthukisa impilo: Lo mkhiqizo futhi unezinzuzo ezinjengokukhuthaza ukuguqulwa kweshukela egazini namafutha emzimbeni kanye nokusekela ukusebenza kwengqondo okunempilo kobuchopho, ukusiza ukugcina impilo yonke yomzimba womuntu.
Imiphumela yokulwa nokuguga isekelwa ucwaningo lwesayensi. Isibonelo, ngo-2014, iphephabhuku eliphezulu elithi "Nature" libike okokuqala ukuthi ukuguga kungabambezeleka ngokuvimbela umsebenzi we-mTOR; ucwaningo lwamangqamuzana e-osteosarcoma yomuntu luphinde lwafakazela ukuthi lungakhuthaza i-autophagy; ngaphezu kwalokho, ingabamba iqhaza ekuhlanganiseni ama-amino acid futhi inciphise amaprotheni umzimba. Okungavamile kwenzeka futhi kuhileleke ezinqubweni zokulawula i-epigenetic ezifana ne-DNA demethylation.
Izivivinyo zemitholampilo ziphinde zaqinisekisa ukuphepha nokusebenza kwayo. Isibonelo, umbiko wokuhlolwa komtholampilo womuntu weSigaba I okhishwe yiSibhedlela saseNewMed eCalifornia ukhombisa ukuthi unomthelela omkhulu ekwelapheni okuhlukahlukene kwezimpawu zezifo ezingamahlalakhona njengokuqwasha, ukulahlekelwa inkumbulo, ukwehluleka kwezinso, i-stroke sequelae, futhi ungelapha ukushoda ukuphefumula, ukukhathala, nezinye izimpawu ezibangelwa i-coronavirus entsha. Iphinde ibe nomthelela omuhle kakhulu wokwenza isimo kuma-sequelae anjengokukhwehlela.
Ngokusebenza kwayo okumangalisayo nokuphepha, isizuze ukunakwa nodumo olusabalele emakethe. Abasebenzisi abaningi baye babika ukuthuthukiswa okuphawulekayo esimweni sabo somzimba ngemva kokuyithatha, njengamandla engeziwe, isikhumba esiqinile futhi esinwebekayo, njll. Ngesikhathi esifanayo, lo mkhiqizo uye waqashelwa futhi wasekelwa izikhungo eziningi ezigunyaziwe kanye nochwepheshe.
Ukufingqa, i-Calcium Alpha ketoglutarate ingumkhiqizo wesayensi, ophephile futhi osebenzayo wokulwa nokuguga. Ifinyelela imiphumela yokulwa nokuguga futhi ithuthukise izimpawu zezifo ezihlukahlukene ezingapheli ngezindlela eziningi. Kuyisinqumo esihle kubantu abaphishekela impilo nempilo ende.
Isikhathi sokuthumela: Jul-08-2024
