Ingabe i-Alpha GPC Ingakuthuthukisa Ukugxila Kwakho? Nakhu Okufanele Ukwazi

Uma kuziwa ekuthuthukiseni inkumbulo nokufunda, ucwaningo lwakamuva luphakamisa ukuthi i-alpha GPC ingaba yinzuzo kakhulu. Lokhu kungenxa yokuthi i-A-GPC ihambisa i-choline ebuchosheni, ivuselela i-neurotransmitter ebalulekile ekhuthaza impilo yengqondo.

Ucwaningo lukhombisa ukuthi i-alpha GPC ingesinye sezithako ezingcono kakhulu zobuchopho be-nootropic emakethe. Kuyi-molecule yokuthuthukisa ubuchopho ekhonjiswe ukuthi iphephile futhi ibekezelelwa kahle iziguli ezindala ezifuna ukuthuthukisa izimpawu zokuwohloka komqondo, kanye nabagijimi abasha abafuna ukuthuthukisa ukukhuthazela kwabo ngokomzimba namandla.
Ngokufanayo nemiphumela yokuthuthukisa ubuchopho ye-phosphatidylserine, i-a-GPC ingase isebenze njengokwelashwa kwemvelo kwesifo se-Alzheimer futhi ingase ibambezele ukwehla kwengqondo okuhlobene neminyaka.

Iyini i-Alpha GPC?

I-Alpha GPC noma i-alpha glycerylphosphorylcholine iyi-molecule esebenza njengomthombo we-choline. Kuyi-acid enamafutha atholakala ku-soy lecithin nezinye izitshalo futhi isetshenziswa ezithasiselweni zempilo yengqondo kanye nokwakha amandla emisipha.
I-Alpha GPC, eyaziwa nangokuthi i-choline alfoscerate, yaziswa ngekhono layo lokuhambisa i-choline ebuchosheni futhi isize umzimba ukukhiqiza i-neurotransmitter acetylcholine, enesibopho sezinzuzo eziningi zezempilo ze-choline. I-acetylcholine ihlotshaniswa nokufunda kanye nenkumbulo, futhi ingenye yama-neurotransmitters abaluleke kakhulu ekufinyezeni kwemisipha.
Ngokungafani ne-choline bitartrate, esinye isengezo se-choline esidumile emakethe, i-A-GPC iyakwazi ukuwela umgoqo wegazi-ubuchopho. Yingakho inemiphumela ethembisayo ebuchosheni futhi kungani isetshenziselwa ukwelapha ukuwohloka komqondo, okuhlanganisa nesifo i-Alzheimer's.

Izinzuzo nokusetshenziswa kwe-Alpha GPC

1. Thuthukisa ukonakala kwenkumbulo

I-Alpha GPC isetshenziselwa ukuthuthukisa inkumbulo, amakhono okufunda nokucabanga. Lokhu ikwenza ngokwandisa i-acetylcholine ebuchosheni, ikhemikhali edlala indima ebalulekile emisebenzini yenkumbulo nokufunda. Abacwaningi baqaphele ukuthi i-alpha GPC inamandla okuthuthukisa izimpawu zokuqonda ezihambisana nesifo se-Alzheimer kanye nokuwohloka komqondo.
Uhlolo oluyimpumputhe kabili, olungahleliwe, olulawulwa yi-placebo olwanyatheliswa ku-Clinical Therapeutics ngo-2003 lwahlola ukusebenza kahle nokubekezelelana kwe-alpha GPC ekwelapheni ukukhubazeka kwengqondo okubangelwa isifo i-Alzheimer's esithambile kuya kokulinganisela.
Iziguli zathatha ama-capsules angu-400 mg a-GPC noma amaphilisi e-placebo kathathu ngosuku izinsuku ezingu-180. Zonke iziguli zahlolwa ekuqaleni kocwaningo, ngemva kwezinsuku ezingama-90 zokwelashwa, futhi ekupheleni kokuhlolwa kwezinsuku eziyi-180 kamuva.
Eqenjini le-alpha GPC, wonke amapharamitha ahloliwe, okuhlanganisa ne-Alzheimer's Disease Assessment Scale kanye ne-Mini-Mental State Examination, aqhubekile nokuba ngcono ngemva kwezinsuku ezingama-90 neziyi-180 zokwelashwa, kanti eqenjini le-placebo ahlala angashintshile. ukushintsha noma kubi.
Abacwaningi baphethe ngokuthi i-a-GPC iwusizo ngokomtholampilo futhi ibekezelelwa kahle ekwelapheni izimpawu zokuwohloka komqondo futhi inamandla njengokwelashwa kwemvelo kwesifo i-Alzheimer's.

2. Thuthukisa ukufunda nokugxilisa ingqondo

Kunocwaningo oluningi olusekela izinzuzo ze-alpha GPC kubantu abanokukhubazeka kwengqondo, kodwa lusebenza kangakanani kubantu abangenawo ukuwohloka komqondo? Ucwaningo lubonisa ukuthi i-Alpha GPC ingaphinde ithuthukise ukunaka, inkumbulo namakhono okufunda kubantu abadala abasebasha abanempilo.
I-American Journal of Clinical Nutrition ishicilele ucwaningo lweqembu olubandakanya ababambiqhaza abangenawo ukuwohloka komqondo futhi yathola ukuthi ukuthathwa kwe-choline ephakeme kwakuhlotshaniswa nokusebenza kwengqondo okungcono. Izizinda zengqondo ezihlolwayo zifaka inkumbulo yomlomo, inkumbulo ebonakalayo, ukufunda ngomlomo, kanye nomsebenzi wokuphatha.
Ucwaningo olwanyatheliswa ku-Journal of the International Society of Sports Nutrition lwathola ukuthi lapho abantu abadala abasebasha basebenzisa izithasiselo ze-alpha GPC, kwakunenzuzo emisebenzini ethile yokusebenza ngokomzimba nangokwengqondo. Labo abathole i-400 mg ye-a-GPC bathole i-18% ngokushesha ekuhlolweni kokukhipha i-serial kunalabo abathole i-200 mg ye-caffeine. Ukwengeza, iqembu elisebenzisa i-caffeine lithole amaphuzu aphezulu kakhulu ku-neuroticism uma liqhathaniswa neqembu le-alpha GPC.

3. Thuthukisa ukusebenza kwezemidlalo

Ucwaningo lusekela izakhiwo ze-synergistic ze-alpha GPC. Ngalesi sizathu, abasubathi baya ngokuya bethakasela i-a-GPC ngenxa yamandla ayo okuthuthukisa ukukhuthazela, ukuphuma kwamandla, namandla emisipha. Ukwengeza nge-a-GPC kwaziwa ukusiza ukukhulisa amandla omzimba, ukukhuthaza ukwakhiwa kwesisindo somzimba esithambile, kanye nokunciphisa isikhathi sokululama ngemva kokujima.
Ucwaningo lubonisa ukuthi i-alpha GPC ikhulisa i-hormone yokukhula komuntu, edlala indima ekuvuselelweni kweseli, ukukhula nokugcinwa kwezicubu zomuntu ezinempilo. I-hormone yokukhula iyaziwa ngamandla ayo okuthuthukisa ikhono lomzimba nokusebenza kwezemidlalo.
Kube khona izifundo eziningi ezihlola ukusebenza kahle kwe-alpha GPC ekukhuthazeleni ngokomzimba namandla. Ucwaningo lwango-2008 olungahleliwe, olulawulwa yi-placebo, oluhlanganisa amadoda ayisikhombisa anesipiliyoni sokuqeqeshwa kokumelana lubonise ukuthi i-a-GPC iyawathinta amazinga e-hormone yokukhula. Abahlanganyeli eqenjini lokuhlola banikezwe i-600 mg ye-alpha GPC imizuzu engu-90 ngaphambi kokuzivocavoca kokumelana.
Abacwaningi bathola ukuthi uma kuqhathaniswa nesisekelo, amazinga e-hormone okukhula aphezulu anda i-44-fold nge-alpha GPC kanye ne-2.6-fold nge-placebo. Ukusetshenziswa kwe-A-GPC kuphinde kwenyuse amandla omzimba, amandla okucindezela ebhentshini eliphakeme akhuphuka ngo-14% uma kuqhathaniswa ne-placebo.
Ngaphezu kokwandisa amandla emisipha namandla, i-hormone yokukhula ingakhuthaza ukwehla kwesisindo, iqinise amathambo, ithuthukise isimo sengqondo, futhi ithuthukise izinga lokulala.

4. Thuthukisa ukululama kohlangothi

Ucwaningo lwangaphambili lubonisa ukuthi i-GPC ingase izuze iziguli eziye zaba nesifo sohlangothi noma i-ischemic yesikhashana, eyaziwa ngokuthi "i-mini-stroke." Lokhu kungenxa yekhono le-alpha GPC lokusebenza njenge-neuroprotectant futhi lisekele i-neuroplasticity ngokusebenzisa ama-receptors e-nerve factor.
Ocwaningweni lwango-1994, abacwaningi base-Italy bathola ukuthi i-alpha GPC yenza ngcono ukululama kwengqondo ezigulini ezinemivimbo eyingozi noma emincane. Ngemuva kokushaywa unhlangothi, iziguli zithole i-1,000 mg ye-alpha GPC ngomjovo wezinsuku ze-28, kulandelwa i-400 mg ngomlomo izikhathi ezintathu nsuku zonke ezinyangeni ezilandelayo ze-5.
Ekupheleni kocwaningo, ama-71% eziguli awazange abonise ukwehla kwengqondo noma amnesia, kubika abacwaningi. Ukwengeza, amaphuzu esiguli ku-Mini-Mental State Examination athuthuke kakhulu. Ngaphezu kwalokhu okutholakele, iphesenti lezenzakalo ezimbi ezilandela ukusetshenziswa kwe-alpha GPC laliphansi futhi abacwaningi baqinisekisa ukubekezelelana kwayo okuhle kakhulu.

5. Kungase kuzuze abantu abanesifo sokuwa

Ucwaningo lwezilwane olwanyatheliswa ku-Brain Research ngo-2017 lwaluhlose ukuhlola umthelela wokwelashwa kwe-alpha GPC ekukhubazekeni kwengqondo ngemva kokuquleka. Abacwaningi bathola ukuthi lapho amagundane ejovwe nge-a-GPC emasontweni amathathu ngemva kokubanjwa, inhlanganisela yathuthukisa ukusebenza kwengqondo futhi yanda i-neurogenesis, ukukhula kwezicubu zezinzwa.
Lolu cwaningo luphakamisa ukuthi i-alpha GPC ingaba wusizo ezigulini ezinesifo sokuwa ngenxa yemiphumela yayo ye-neuroprotective futhi ingase ithuthukise ukukhubazeka kwengqondo okubangelwa isithuthwane kanye nokulimala kwe-neuronal.

I-Alpha GPC ne-Choline

I-Choline iyi-micronutrient ebalulekile edingekayo ezinqubweni eziningi zomzimba, ikakhulukazi ukusebenza kobuchopho. Kudingeka ukuze kusebenze kahle i-neurotransmitter eyinhloko i-acetylcholine, esebenza njenge-neurotransmitter elwa nokuguga futhi isiza izinzwa zethu ukuxhumana.
Nakuba umzimba wenza amanani amancane e-choline ngokwawo, kufanele sithole umsoco ekudleni. Okunye ukudla okuphezulu kwe-choline kufaka isibindi senkomo, i-salmon, ama-chickpeas, amaqanda, nesifuba senkukhu. Kodwa-ke, eminye imibiko iphakamisa ukuthi i-choline emithonjeni yokudla ayithathwanga kahle ngumzimba, yingakho abanye abantu behlupheka ngenxa yokuntuleka kwe-choline. Lokhu kungenxa yokuthi i-choline icutshungulwa ngokwengxenye esibindini, futhi abantu abanokukhubazeka kwesibindi ngeke bakwazi ukumunca.
Yilapho izithasiselo ze-alpha GPC ziqala ukusebenza khona. Abanye ochwepheshe batusa ukusebenzisa izithako ze-choline, njenge-a-GPC, ukuthuthukisa ukusebenza kobuchopho nokusiza ukugcinwa kwenkumbulo. I-Alpha GPC ne-CDP choline kucatshangwa ukuthi inenzuzo kakhulu emzimbeni ngoba ifana kakhulu nendlela i-choline eyenzeka ngayo ngokwemvelo ekudleni. Njenge-choline emuncwa ngokwemvelo ekudleni esikudlayo, i-alpha GPC yaziwa ngekhono layo lokuwela umgoqo wegazi-ubuchopho lapho idliwe, isiza umzimba ukuguqula i-choline ibe yi-neurotransmitter acetylcholine ebaluleke kakhulu.
I-Alpha GPC iwuhlobo olunamandla lwe-choline. Umthamo we-1,000 mg we-a-GPC ulingana cishe ne-400 mg ye-choline yokudla. Noma, ngamanye amazwi, i-alpha GPC cishe i-40% ye-choline ngesisindo.

I-A-GPC kanye ne-CDP Choline

I-CDP Choline, eyaziwa nangokuthi i-cytidine diphosphate choline ne-citicoline, iyinhlanganisela eyakhiwe i-choline ne-cytidine. I-CDP Choline yaziwa ngamandla ayo okusiza ukuthutha i-dopamine ebuchosheni. Njenge-alpha GPC, i-Citicoline ihlonishwa ngekhono layo lokuwela umgoqo wegazi nobuchopho lapho idliwe, iwunikeze imiphumela ethuthukisa inkumbulo kanye nethuthukisa ingqondo.
Nakuba i-alpha GPC iqukethe cishe u-40% we-choline ngesisindo, i-choline ye-CDP iqukethe cishe i-choline engu-18%. Kodwa i-CDP choline iqukethe ne-cytidine, isandulela se-nucleotide uridine. Eyaziwa ngekhono layo lokwandisa ukwakheka kolwelwesi lwamangqamuzana, i-uridine nayo inezici ezithuthukisa ingqondo.
Kokubili i-a-GPC ne-CDP choline baziwa ngezinzuzo zabo zokuqonda, okuhlanganisa indima yabo ekusekeleni inkumbulo, ukusebenza kwengqondo, nokugxilisa ingqondo.

Lapho ungathola khona futhi kanjani ukusetshenziswa

Izithasiselo ze-A-GPC zivame ukusetshenziswa kakhulu ukuthuthukisa inkumbulo namakhono okuqonda. Ingase futhi isetshenziselwe ukuthuthukisa ukukhuthazela ngokomzimba nokusebenza. I-Alpha GPC iyatholakala njengesengezo sokudla somlomo. Izithasiselo ze-Alpha GPC zitholakala kalula ku-inthanethi noma kubahlinzeki. Uzoyithola kumafomu we-capsule ne-powder. Imikhiqizo eminingi equkethe i-a-GPC incoma ukuthatha isithasiselo nokudla ukuze sisebenze kakhulu.
I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-alpha GPC yekhwalithi ephezulu kanye nobumsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-alpha GPC yethu powder ihlolelwa ngokuqinile ubumsulwa namandla, iqinisekisa ukuthi uthola isithasiselo sekhwalithi ongasethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba noma ukuthuthukisa impilo yonke, i-alpha GPC yethu powder iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.
I-A-GPC yaziwa njenge-hygroscopic, okusho ukuthi idonsa umswakama emoyeni ozungezile. Ngalesi sizathu, izithasiselo kufanele zigcinwe ezitsheni ezingangeni moya futhi akufanele zivezwe emoyeni isikhathi eside.

Imicabango yokugcina

I-Alpha GPC isetshenziselwa ukuletha i-choline ebuchosheni kuwo wonke umgoqo wegazi nobuchopho. Kuyisandulela se-acetylcholine, i-neurotransmitter ekhuthaza impilo yengqondo. Izithasiselo ze-Alpha GPC zingasetshenziswa ukuze kuzuze impilo yakho yokuqonda ngokuthuthukisa inkumbulo, ukufunda, nokugxilisa ingqondo. Ucwaningo luphinde lubonise ukuthi i-a-GPC isiza ukukhulisa amandla omzimba namandla emisipha.