Ingabe i-Alpha GPC ingakuthuthukisa ukugxila kwakho? Nakhu okudingeka ukwazi

Uma kukhulunywa ngokuthuthukisa inkumbulo nokufunda, ucwaningo lwakamuva luphakamisa ukuthi i-alpha GPC ingaba wusizo kakhulu. Lokhu kungenxa yokuthi i-A-GPC ithutha i-choline iye ebuchosheni, ivuselele i-neurotransmitter ebalulekile ekhuthaza impilo yokuqonda.

Ucwaningo lubonisa ukuthi i-alpha GPC ingenye yezithako zobuchopho ze-nootropic ezinhle kakhulu emakethe. Iyi-molecule ekhuthaza ubuchopho ekhonjiswe ukuthi iphephile futhi ibekezelelwa kahle yiziguli ezindala ezifuna ukuthuthukisa izimpawu ze-dementia, kanye nabadlali abasebasha abafuna ukuthuthukisa ukukhuthazela kwabo ngokomzimba namandla.
Ngokufanayo nemiphumela yokukhulisa ubuchopho ye-phosphatidylserine, i-a-GPC ingasebenza njengokwelashwa kwemvelo kwesifo i-Alzheimer futhi ingase inciphise ukwehla kwengqondo okuhlobene nokuguga.

Kuyini i-Alpha GPC?

I-Alpha GPC noma i-alpha glycerylphosphorylcholine iyi-molecule esebenza njengomthombo we-choline. Iyi-fatty acid etholakala ku-soy lecithin nakwezinye izitshalo futhi isetshenziswa ezithasiselweni zempilo yengqondo kanye nokwakha amandla emisipha.
I-Alpha GPC, eyaziwa nangokuthi i-choline alfoscerate, iyaziswa ngekhono layo lokuhambisa i-choline ebuchosheni futhi isize umzimba ukuthi ukhiqize i-neurotransmitter acetylcholine acetylcholine, okuyiyona enesibopho sezinzuzo eziningi zezempilo ze-choline. I-Acetylcholine ihlotshaniswa nokufunda kanye nenkumbulo, futhi ingenye yama-neurotransmitter abaluleke kakhulu ekuncipheni kwemisipha.
Ngokungafani ne-choline bitartrate, esinye isithasiselo se-choline esidumile emakethe, i-A-GPC iyakwazi ukuwela umgoqo wegazi nobuchopho. Yingakho inemiphumela ethembisayo ebuchosheni nokuthi kungani isetshenziselwa ukwelapha i-dementia, okuhlanganisa nesifo i-Alzheimer's.

Izinzuzo kanye nokusetshenziswa kwe-Alpha GPC

1. Thuthukisa ukukhubazeka kwenkumbulo

I-Alpha GPC isetshenziselwa ukuthuthukisa amakhono okukhumbula, ukufunda nokucabanga. Lokhu ikwenza ngokwandisa i-acetylcholine ebuchosheni, ikhemikhali edlala indima ebalulekile emisebenzini yenkumbulo nokufunda. Abacwaningi baphawule ukuthi i-alpha GPC inamandla okuthuthukisa izimpawu zokuqonda ezihlobene nesifo i-Alzheimer's kanye ne-dementia.
Isivivinyo esingaboni kahle, esingahleliwe, esilawulwa yi-placebo esanyatheliswa kuyi-Clinical Therapeutics ngo-2003 sahlola ukusebenza kahle nokubekezeleleka kwe-alpha GPC ekwelapheni ukukhubazeka kwengqondo okubangelwa yisifo se-Alzheimer esingesibi kakhulu kuya kwesiphakathi.
Iziguli zathatha ama-capsule angu-400 mg e-a-GPC noma ama-capsule e-placebo kathathu ngosuku izinsuku ezingu-180. Zonke iziguli zahlolwa ekuqaleni kwesivivinyo, ngemva kwezinsuku ezingu-90 zokwelashwa, kanye nasekupheleni kwesivivinyo ngemva kwezinsuku ezingu-180.
Eqenjini le-alpha GPC, zonke izilinganiso ezihlolwe, okuhlanganisa i-cognitive and behavioral Alzheimer's Disease Assessment Scale kanye ne-Mini-Mental State Examination, zaqhubeka nokuthuthuka ngemva kwezinsuku ezingu-90 kanye nezingu-180 zokwelashwa, kanti eqenjini le-placebo zahlala zingashintshi.
Abacwaningi baphetha ngokuthi i-a-GPC iwusizo emtholampilo futhi ibekezelelwa kahle ekwelapheni izimpawu zomqondo ezibangelwa yi-dementia futhi inamandla okwelapha isifo se-Alzheimer's ngokwemvelo.

2. Khuthaza ukufunda nokugxila

Kukhona ucwaningo oluningi olusekela izinzuzo ze-alpha GPC kubantu abanokukhubazeka kokuqonda, kodwa isebenza kangakanani kubantu abangenayo i-dementia? Ucwaningo lubonisa ukuthi i-Alpha GPC ingathuthukisa nokunaka, inkumbulo kanye namakhono okufunda kubantu abadala abasebasha abanempilo enhle.
I-American Journal of Clinical Nutrition yashicilela ucwaningo lweqembu elihilela abahlanganyeli abangenayo i-dementia futhi yathola ukuthi ukudla i-choline ephezulu kuhlotshaniswa nokusebenza kahle kwengqondo. Izindawo zokuqonda ezihlolwe zifaka phakathi inkumbulo yomlomo, inkumbulo ebonakalayo, ukufunda ngomlomo, kanye nomsebenzi wokuphatha.
Ucwaningo olwanyatheliswa kuyi-Journal of the International Society of Sports Nutrition luthole ukuthi lapho abantu abadala abasebasha besebenzisa izithasiselo ze-alpha GPC, kwakuzuzisa emisebenzini ethile yokusebenza ngokomzimba nangokwengqondo. Labo abathole ama-400 mg e-a-GPC bathole ama-18% ngokushesha esivivinyweni sokukhipha esilandelanayo kunalabo abathole ama-200 mg e-caffeine. Ngaphezu kwalokho, iqembu elidla i-caffeine lathola ama-neuroticism aphezulu kakhulu uma kuqhathaniswa neqembu le-alpha GPC.

3. Thuthukisa ukusebenza kwezemidlalo

Ucwaningo lusekela izakhiwo ezihambisanayo ze-alpha GPC. Ngenxa yalesi sizathu, abasubathi banesithakazelo esikhulu ku-a-GPC ngenxa yamandla ayo okuthuthukisa ukukhuthazela, ukukhishwa kwamandla, kanye namandla emisipha. Ukwengeza nge-a-GPC kwaziwa ukuthi kusiza ukwandisa amandla omzimba, ukukhuthaza ukwakhiwa kwemisipha eqinile, kanye nokunciphisa isikhathi sokululama ngemva kokujima.
Ucwaningo lubonisa ukuthi i-alpha GPC ikhulisa i-hormone yokukhula komuntu, edlala indima ekuvuseleleni amaseli, ekukhuleni nasekugcinweni kwezicubu zomuntu ezinempilo. I-hormone yokukhula yaziwa ngekhono layo lokuthuthukisa ikhono lomzimba kanye nokusebenza kahle kwezemidlalo.
Kube nezifundo eziningi ezihlola ukusebenza kahle kwe-alpha GPC ekukhuthazeleni ngokomzimba kanye namandla. Ucwaningo lwe-crossover olwenziwe ngo-2008 olulawulwa yi-placebo oluhilela amadoda ayisikhombisa anolwazi lokuqeqeshwa kokumelana lubonise ukuthi i-a-GPC iyawathinta amazinga e-growth hormone. Abahlanganyeli eqenjini lokuhlola banikezwa u-600 mg we-alpha GPC imizuzu engama-90 ngaphambi kokuzivocavoca kokumelana.
Abacwaningi bathole ukuthi uma kuqhathaniswa nesisekelo, amazinga e-hormone yokukhula okuphezulu akhuphuke ngokuphindwe ka-44 nge-alpha GPC kanye nokuphindwe ka-2.6 nge-placebo. Ukusetshenziswa kwe-A-GPC nakho kwandisa amandla omzimba, lapho amandla okucindezela ebhentshini aphezulu enyuka ngo-14% uma kuqhathaniswa ne-placebo.
Ngaphezu kokwandisa amandla emisipha kanye nokuqina, i-hormone yokukhula ingakhuthaza ukwehla kwesisindo, iqinise amathambo, ithuthukise imizwa, futhi ithuthukise ikhwalithi yokulala.

4. Thuthukisa ukululama kwesifo sohlangothi

Ucwaningo lwasekuqaleni lusikisela ukuthi i-a-GPC ingasiza iziguli ezike zaba nesifo sohlangothi noma ukuhlaselwa yi-ischemic okwesikhashana, okwaziwa ngokuthi "i-mini-stroke." Lokhu kungenxa yekhono le-alpha GPC lokusebenza njenge-neuroprotective futhi lisekele i-neuroplasticity ngokusebenzisa ama-receptor e-nerve growth factor.
Esifundweni sango-1994, abacwaningi base-Italy bathole ukuthi i-alpha GPC ithuthukise ukululama kwengqondo ezigulini ezine-stroke esibi noma esincane. Ngemva kwe-stroke, iziguli zathola i-1,000 mg ye-alpha GPC ngomjovo izinsuku ezingama-28, kulandele i-400 mg ngomlomo kathathu ngosuku ezinyangeni ezi-5 ezilandelayo.
Ekupheleni kocwaningo, abacwaningi babike ukuthi iziguli ezingama-71% azizange zibonise ukwehla kwengqondo noma ukukhohlwa. Ngaphezu kwalokho, amaphuzu eziguli ku-Mini-Mental State Examination athuthuke kakhulu. Ngaphezu kwalokhu okutholakele, iphesenti lezehlakalo ezimbi ngemuva kokusetshenziswa kwe-alpha GPC laliphansi futhi abacwaningi baqinisekisile ukubekezeleleka kwayo okuhle kakhulu.

5. Kungabazuzisa abantu abanesifo sokuwa

Ucwaningo lwezilwane olwanyatheliswa kuyi-Brain Research ngo-2017 lwaluhlose ukuhlola umthelela wokwelashwa kwe-alpha GPC ekulimaleni kwengqondo ngemva kokuxhuzula kwesifo sokuwa. Abacwaningi bathole ukuthi lapho amagundane ejovwa nge-a-GPC emavikini amathathu ngemva kokuxhuzula okubangelwe yisifo sokuwa, lesi sakhi sathuthukisa ukusebenza kwengqondo kanye nokwanda kwe-neurogeneis, ukukhula kwezicubu zezinzwa.
Lolu cwaningo luphakamisa ukuthi i-alpha GPC ingaba usizo ezigulini zesifo sokuwa ngenxa yemiphumela yayo yokuvikela izinzwa futhi ingase ithuthukise ukukhubazeka kokuqonda okubangelwa yisifo sokuwa kanye nomonakalo wezinzwa.

I-Alpha GPC kanye ne-Choline

I-Choline iyisakhi esibalulekile esidingekayo ezinqubweni eziningi zomzimba, ikakhulukazi ukusebenza kobuchopho. Iyadingeka ekusebenzeni kahle kwe-neurotransmitter ebalulekile i-acetylcholine, esebenza njenge-neurotransmitter yokulwa nokuguga futhi isiza izinzwa zethu ukuthi zixhumane.
Nakuba umzimba ukhiqiza inani elincane le-choline ngokwawo, kumelwe sithole izakhamzimba ekudleni. Okunye ukudla okune-choline eningi kufaka phakathi isibindi senyama yenkomo, i-salmon, ama-chickpeas, amaqanda, kanye nesifuba senkukhu. Kodwa-ke, eminye imibiko iphakamisa ukuthi i-choline evela emithonjeni yokudla ayimuncwa kahle ngumzimba, yingakho abanye abantu behlushwa ukuntuleka kwe-choline. Lokhu kungenxa yokuthi i-choline icutshungulwa kancane esibindini, futhi abantu abanenkinga yesibindi ngeke bakwazi ukuyimunca.
Yilapho izithasiselo ze-alpha GPC zisebenza khona. Abanye ochwepheshe batusa ukusebenzisa izithasiselo ze-choline, njenge-a-GPC, ukuthuthukisa ukusebenza kobuchopho nokusiza ukugcina inkumbulo. I-Alpha GPC kanye ne-CDP choline kucatshangwa ukuthi zizuzisa kakhulu emzimbeni ngoba zifana kakhulu nendlela i-choline eyenzeka ngayo ngokwemvelo ekudleni. Njenge-choline emuncwa ngokwemvelo ekudleni esikudlayo, i-alpha GPC yaziwa ngekhono layo lokuwela isithiyo segazi nobuchopho lapho igwinywa, isiza umzimba ukuguqula i-choline ibe yi-neurotransmitter acetylcholine ebaluleke kakhulu.
I-Alpha GPC iwuhlobo olunamandla lwe-choline. Umthamo we-a-GPC ongu-1,000 mg ulingana cishe no-400 mg we-choline yokudla. Noma, ngamanye amazwi, i-alpha GPC cishe ingu-40% we-choline ngesisindo.

I-A-GPC kanye ne-CDP Choline

I-CDP Choline, eyaziwa nangokuthi i-cytidine diphosphate choline kanye ne-citicoline, iyinhlanganisela eyakhiwe yi-choline kanye ne-cytidine. I-CDP Choline yaziwa ngekhono layo lokusiza ukuthutha i-dopamine ebuchosheni. Njenge-alpha GPC, i-Citicoline iyaziswa ngekhono layo lokuwela isithiyo segazi nobuchopho lapho igwinywa, iyinika imiphumela yokuthuthukisa inkumbulo kanye nokuthuthukisa ingqondo.
Nakuba i-alpha GPC iqukethe cishe i-40% ye-choline ngesisindo, i-CDP choline iqukethe cishe i-18% ye-choline. Kodwa i-CDP choline iqukethe ne-cytidine, isandulela se-nucleotide uridine. Yaziwa ngekhono layo lokukhulisa ukwakheka kwe-membrane yamaseli, i-uridine nayo inezakhiwo ezithuthukisa ukuqonda.
Kokubili i-a-GPC kanye ne-CDP choline zaziwa ngezinzuzo zazo zokuqonda, okuhlanganisa nendima yazo ekusekeleni inkumbulo, ukusebenza kwengqondo, kanye nokugxila.

Kutholakala kuphi nokuthi ungayisebenzisa kanjani

Izithasiselo ze-A-GPC zivame ukusetshenziswa kakhulu ukuthuthukisa inkumbulo kanye namakhono okuqonda. Zingasetshenziswa futhi ukuthuthukisa ukukhuthazela ngokomzimba kanye nokusebenza kahle. I-Alpha GPC iyatholakala njengesengezo sokudla somlomo. Izithasiselo ze-Alpha GPC kulula ukuzithola ku-inthanethi noma kubaphakeli. Uzothola ngefomu le-capsule kanye ne-powder. Imikhiqizo eminingi equkethe i-a-GPC incoma ukuthatha isengezo nokudla ukuze sisebenze kahle kakhulu.
I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu ye-alpha GPC esezingeni eliphezulu futhi emsulwa kakhulu.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu ye-alpha GPC ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu ye-alpha GPC iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.
I-A-GPC yaziwa ngokuthi i-hygroscopic, okusho ukuthi imunca umswakama ovela emoyeni ozungezile. Ngenxa yalesi sizathu, izithako kufanele zigcinwe ezitsheni ezingangeni moya futhi akufanele zivezwe emoyeni isikhathi eside.

Imicabango yokugcina

I-Alpha GPC isetshenziselwa ukuletha i-choline ebuchosheni ngaphesheya kwesithiyo segazi nobuchopho. Iyisandulela se-acetylcholine, i-neurotransmitter ekhuthaza impilo yobuchopho. Izithasiselo ze-Alpha GPC zingasetshenziswa ukuzuzisa impilo yakho yobuchopho ngokuthuthukisa inkumbulo, ukufunda, kanye nokugxila. Ucwaningo luphinde lubonise ukuthi i-a-GPC isiza ekwandiseni amandla omzimba kanye namandla emisipha.