Isengezo sokudla-Into entsha yokuphila isikhathi eside nokulwa nokuguga: I-Calcium Alpha-ketoglutarate

I-Calcium Alpha ketoglutarate (I-AKG) iyi-metabolite emaphakathi yomjikelezo we-tricarboxylic acid futhi ibamba iqhaza ekuhlanganiseni ama-amino acid, amavithamini, nama-acids ephilayo kanye namandla okumetabolism. Ingasetshenziswa njengesengezo sokudla futhi inamathuba amaningi okusebenza. Ngaphezu kwemisebenzi yayo yezinto eziphilayo emzimbeni womuntu, i-calcium alpha-ketoglutarate nayo isetshenziswa kabanzi emkhakheni wezokwelapha futhi isibe yingxenye ebalulekile yemikhiqizo eminingi yezempilo nezixazululo zezokwelapha.

Isebenza kanjani i-calcium alpha-ketoglutarate

Okokuqala,ci-alcium alpha-ketoglutarateidlala indima ebalulekile kumetabolism yamandla. Njengomkhiqizo omaphakathi womjikelezo we-tricarboxylic acid (umjikelezo we-TCA), i-calcium α-ketoglutarate ibamba iqhaza kunqubo yokukhiqiza amandla e-intracellular. Ngomjikelezo we-TCA, izakhi ezinjengama-carbohydrate, amafutha, namaprotheni afakwa i-oxidized futhi abola ukuze akhiqize i-ATP (i-adenosine triphosphate) ukuze inikeze amandla kumaseli. Njengesiphakathi esibalulekile emjikelezweni we-TCA, i-calcium α-ketoglutarate ingakhuthaza i-cell metabolism, ikhulise izinga lamandla omzimba, isize ukuthuthukisa amandla omzimba nokukhuthazela, futhi ithuthukise ukukhathala ngokomzimba.

Okwesibili, i-calcium α-ketoglutarate idlala indima ebalulekile ku-amino acid metabolism. Ama-amino acid angamayunithi ayisisekelo amaprotheni, futhi i-calcium α-ketoglutarate ihilelekile ekuguquleni nasekusetshenzisweni kwama-amino acid. Enqubweni yokuguqula ama-amino acid abe amanye ama-metabolite, i-calcium α-ketoglutarate idlulisa ngama-amino acid ukuze ikhiqize ama-amino acid amasha noma ama-α-keto acid, ngaleyo ndlela ilawule ibhalansi nokusetshenziswa kwama-amino acid. Ngaphezu kwalokho, i-calcium α-ketoglutarate ingase futhi isebenze njenge-oxidation substrate yama-amino acid, ibambe iqhaza ekusetshenzisweni kwe-oxidative yama-amino acids, futhi ikhiqize amandla ne-carbon dioxide. Ngakho-ke, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni i-homeostasis yama-amino acid kanye ne-protein metabolism emzimbeni.

Ngaphezu kwalokho, i-calcium alpha-ketoglutarate isebenza njenge-antioxidant ekhipha ama-radicals mahhala futhi ivikele amaseli emonakalweni we-oxidative. Ngesikhathi esifanayo, i-calcium α-ketoglutarate ingaphinde ilawule ukusebenza kwamasosha omzimba, ikhuthaze ukusebenza nokwanda kwamangqamuzana omzimba omzimba, futhi ithuthukise ukumelana komzimba nezifo nokutheleleka. Ngakho-ke, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni ibhalansi yamasosha omzimba kanye nokumelana nezifo.

Ucwaningo ngemiphumela yokuguga

Ukuguga kusithinta sonke futhi kuyisici esiyingozi sezifo eziningi, futhi ngokusho kwezibalo zemboni ye-Medicare, amathuba okuba nezifo ayanda ngokuya ngeminyaka. Ukuze kuncishiswe ukuguga nokunciphisa ngempumelelo ingozi yesifo, ucwaningo luye lwathola into ephephile futhi esebenzayo engathinta ukuguga - i-calcium alpha-ketoglutarate.

I-calcium alpha-ketoglutarate iyi-metabolite ebalulekile emzimbeni wethu, eyaziwa ngendima yeseli kumjikelezo we-Krebs, umjikelezo obalulekile ekwenziweni kwe-oxidation yama-fatty acids nama-amino acid, okuvumela i-mitochondria ukuthi ikhiqize i-ATP (i-ATP iwumthombo wamandla wamaseli).

Lokhu kuhilela ukulayishwa kwenqubo ye-calcium alpha-ketoglutarate, ngakho-ke i-calcium alpha-ketoglutarate ingabuye iguqulwe ibe i-glutamate bese iba yi-glutamine, engasiza ukugqugquzela ukwakheka kwamaprotheni kanye ne-collagen (i-collagen iyiphrotheni ene-fibrous eyenza i-1/3 wonke amaprotheni emzimbeni futhi asiza ukusekela impilo yamathambo, isikhumba nemisipha).

I-Ponce De Leon Health, Inc., inkampani yocwaningo lwesikhathi eside egxile ekubuyiseleni ukuguga kwezakhi zofuzo, yenza ucwaningo olulawulwa iminyaka eminingi lwe-calcium alpha-ketoglutarate kumagundane aneminyaka ephakathi futhi yathola ukuthi isikhathi sokuphila samagundane eqenjini lokuhlola sanda ngo. 12%. Okubaluleke nakakhulu, Ngaphezu kwalokho, ubuthakathaka behliswa ngo-46% futhi impilo enempilo inyuke ngo-41%. Ubufakazi bubonisa ukuthi ukwesekwa kwe-alpha-ketoglutarate kungase kungagcini nje ngokunweba ubude bokuphila kodwa futhi kwandise isikhathi sempilo ngokubanzi.

I-Calcium α-ketoglutarate, njengesithasiselo sokudla okunomsoco esisebenza ngezindlela eziningi, inamathuba amaningi okusebenza emikhiqizweni yokunakekelwa kwezempilo. Imisebenzi yayo ehlukahlukene yezinto eziphilayo ezifana ne-antioxidant, anti-aging, regulation immune system kanye ne-amino acid metabolism iyenza ibe ithuluzi elinamandla lokuthuthukisa impilo yabantu. Ngokuqwashisa okwandayo kokunakekelwa kwezempilo kanye nokujula kocwaningo lwesayensi, kukholakala ukuthi ukusetshenziswa kwe-α-ketoglutarate calcium emkhakheni wemikhiqizo yokunakekelwa kwezempilo kuzothola ukunakwa nokuthuthukiswa okwengeziwe.