Isengezo sokudla - Into entsha yokuphila isikhathi eside kanye nokulwa nokuguga: I-Calcium Alpha-ketoglutarate

I-Calcium Alpha ketoglutarate (AKG) iyi-metabolite ephakathi yomjikelezo we-tricarboxylic acid futhi ihlanganyela ekwakhiweni kwama-amino acid, amavithamini, nama-organic acid kanye ne-metabolism yamandla. Ingasetshenziswa njengesengezo sokudla futhi inamathuba amaningi okusetshenziswa. Ngaphezu kwemisebenzi yayo yezinto eziphilayo emzimbeni womuntu, i-calcium alpha-ketoglutarate nayo isetshenziswa kabanzi emkhakheni wezokwelapha futhi isibe yingxenye ebalulekile yemikhiqizo eminingi yezempilo kanye nezixazululo zezokwelapha.

Indlela i-calcium alpha-ketoglutarate esebenza ngayo

Okokuqala,ci-alcium alpha-ketoglutarateidlala indima ebalulekile ekusetshenzisweni kwamandla. Njengomkhiqizo ophakathi komjikelezo we-tricarboxylic acid (umjikelezo we-TCA), i-calcium α-ketoglutarate ihlanganyela enkambisweni yokukhiqizwa kwamandla angaphakathi kwamangqamuzana. Ngomjikelezo we-TCA, izakhamzimba ezifana nama-carbohydrate, amafutha, namaprotheni ziyaxutshwa futhi zibole ukuze kukhiqizwe i-ATP (adenosine triphosphate) ukuze kuhlinzekwe amandla amaseli. Njengomsebenzi ophakathi obalulekile emjikelezweni we-TCA, i-calcium α-ketoglutarate ingakhuthaza ukusetshenziswa kwamandla amaseli, inyuse izinga lamandla omzimba, isize ekuthuthukiseni amandla omzimba kanye nokukhuthazela, futhi ithuthukise ukukhathala ngokomzimba.

Okwesibili, i-calcium α-ketoglutarate idlala indima ebalulekile ekusetshenzisweni kwe-amino acid. Ama-amino acid ayiyunithi eyisisekelo yamaprotheni, kanti i-calcium α-ketoglutarate ihilelekile ekuguqulweni nasekusetshenzisweni kwe-amino acid. Enqubweni yokuguqula ama-amino acid abe amanye ama-metabolites, i-calcium α-ketoglutarate ishintshana ngama-amino acid ukuze ikhiqize ama-amino acid amasha noma ama-α-keto acid, ngaleyo ndlela ilawula ibhalansi nokusetshenziswa kwama-amino acid. Ngaphezu kwalokho, i-calcium α-ketoglutarate ingasebenza futhi njenge-substrate ye-oxidation yama-amino acid, ihlanganyele ekusetshenzisweni kwe-oxidative kwama-amino acid, futhi ikhiqize amandla kanye ne-carbon dioxide. Ngakho-ke, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni i-homeostasis yama-amino acid kanye nokusetshenziswa kwe-protein emzimbeni.

Ngaphezu kwalokho, i-calcium alpha-ketoglutarate isebenza njenge-antioxidant esusa ama-free radical futhi ivikele amaseli ekulimaleni kwe-oxidative. Ngesikhathi esifanayo, i-calcium α-ketoglutarate ingalawula nokusebenza kwesistimu yomzimba, ikhuthaze ukusebenza nokwanda kwamaseli omzimba, futhi ithuthukise ukumelana komzimba nezifo kanye nokutheleleka. Ngakho-ke, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni ibhalansi yomzimba yomzimba kanye nokumelana nezifo.

Ucwaningo ngemiphumela yokuguga

Ukuguga kuyasithinta sonke futhi kuyisici esiyingozi sezifo eziningi, futhi ngokusho kwezibalo zabantu embonini ye-Medicare, amathuba okuthola isifo ayanda njengoba iminyaka ikhula. Ukuze kuncishiswe ukuguga futhi kuncishiswe ngempumelelo ingozi yesifo, ucwaningo luthole into ephephile nesebenzayo engathinta ukuguga - i-calcium alpha-ketoglutarate.

I-calcium alpha-ketoglutarate iyi-metabolite ebalulekile emzimbeni wethu, eyaziwa ngendima yeseli emjikelezweni we-Krebs, umjikelezo obalulekile ekufakweni kwe-oxidation kwama-fatty acid nama-amino acid, okuvumela i-mitochondria ukuthi ikhiqize i-ATP (i-ATP ingumthombo wamandla wamaseli).

Lokhu kuhilela ukulayishwa kwenqubo ye-calcium alpha-ketoglutarate, ngakho-ke i-calcium alpha-ketoglutarate ingaguqulwa ibe yi-glutamate bese iba yi-glutamine, engasiza ekukhuthazeni ukwakheka kweprotheni ne-collagen (i-collagen iyiprotheni ene-fibrous eyakha ingxenye eyodwa kwezintathu yazo zonke iphrotheni emzimbeni futhi esiza ekusekeleni impilo yamathambo, isikhumba kanye nemisipha).

I-Ponce De Leon Health, Inc., inkampani yocwaningo lwempilo ende egxile ekuguquleni ukuguga kwezakhi zofuzo, yenze ucwaningo olulawulwa iminyaka eminingi lwe-calcium alpha-ketoglutarate kumagundane aneminyaka ephakathi nendawo futhi yathola ukuthi isikhathi sokuphila samagundane eqenjini lokuhlola sanda ngo-12%. Okubaluleke kakhulu, ubuthakathaka bancishiswa ngo-46% kanti isikhathi sokuphila esinempilo sanda ngo-41%. Ubufakazi bubonisa ukuthi ukwengezwa kwe-alpha-ketoglutarate kungase kungagcini nje ngokwandisa isikhathi sokuphila kodwa futhi kwandise isikhathi sempilo kabanzi.

I-calcium α-ketoglutarate, njengesengezo sokudla esisebenza ngezindlela eziningi, inamathuba amaningi okusetshenziswa emikhiqizweni yokunakekelwa kwempilo. Imisebenzi yayo ehlukahlukene yezinto eziphilayo njenge-antioxidant, i-anti-aging, i-immune regulation kanye ne-amino acid metabolism yenza kube ithuluzi elinamandla lokuthuthukisa impilo yabantu. Njengoba ulwazi olukhulayo ngokunakekelwa kwempilo kanye nokujula kocwaningo lwesayensi, kukholelwa ukuthi ukusetshenziswa kwe-calcium ye-α-ketoglutarate emkhakheni wemikhiqizo yokunakekelwa kwempilo kuzothola ukunakwa okwengeziwe kanye nentuthuko.