I-Lithium orotateizithasiselo ziye zazuza ukuduma eminyakeni yamuva ngezinzuzo zazo zezempilo ezingaba khona. Kodwa-ke, kusekuningi ukudideka nolwazi olungaqondile oluzungeze le minerali kanye nokusetshenziswa kwayo efomini lokungezelela. Kulo mhlahlandlela ophelele, sizofaka konke okudingeka ukwazi mayelana ne-lithium orotate supplements.Okokuqala futhi okubaluleke kakhulu, kubalulekile ukuqonda ukuthi i-lithium orotate iyimaminerali yemvelo esetshenziselwa ukusekela impilo yengqondo kanye nokuphila kahle. Kuwuhlobo lwe-lithium oluhlanganiswe ne-orotic acid, esiza amaminerali ukuthi angene kuma-cell membranes ngempumelelo. Lokhu kusho ukuthi imithamo ephansi ye-lithium orotate ingasetshenziswa uma kuqhathaniswa nezinye izinhlobo ze-lithium, ukunciphisa ingozi yemiphumela emibi.
Yiziphi izinzuzo ze-lithium ebuchosheni?
I-Lithium orotate ingusawoti owenziwe i-orotic acid ne-lithium. Igama layo eligcwele lithi i-lithium orotate monohydrate (i-Orotic acid lithium usawoti monohydrate), futhi ifomula yayo yamangqamuzana ithi C5H3LIN2O4H2O. I-Lithium ne-orotic acid ion ayiboshiwe ngokuhlanganyela kodwa ingahlukana nesixazululo ukukhiqiza ama-ion e-lithium mahhala. Ucwaningo lubonisa ukuthi i-lithium orotate itholakala kakhulu kunemithi kadokotela i-lithium carbonate noma i-lithium citrate (izidakamizwa ezigunyazwe yi-US FDA).
I-Lithium iyisidakamizwa esivame ukusetshenziswa kwezokwelapha ukwelapha ukudangala, ukuphazamiseka kwengqondo okuguquguqukayo, nezinye izifo zengqondo. Kodwa-ke, izinga lokumuncwa kwe-lithium carbonate noma i-lithium citrate liphansi, futhi imithamo ephezulu iyadingeka ukukhiqiza imiphumela yokwelapha. Ngakho-ke, banemiphumela emibi emikhulu futhi inobuthi. Kodwa-ke, umthamo ophansi we-lithium orotate unemiphumela ehambisanayo yokwelapha futhi unemiphumela emibi embalwa.
Kudala ngeminyaka yawo-1970, i-lithium orotate yathengiswa njengesengezo sokudla sezifo ezithile zengqondo, ezinjengotshwala nesifo i-Alzheimer's.
Ingxenye yobufakazi imi kanje:
Isifo i-Alzheimer's: Ucwaningo lubonisa ukuthi i-lithium orotate inokutholakala okuphezulu kwe-bioavailability futhi ingasebenza ngokuqondile ku-mitochondria kanye nolwelwesi lwamaseli we-glial ukuze lunikeze ukwesekwa nokuvikelwa kwama-neuron kanye nokubambezeleka noma ukuthuthukisa izifo ze-neurodegenerative ezifana nesifo i-Alzheimer's.
I-Neuroprotection kanye nokuthuthukiswa kwenkumbulo: Ucwaningo lwakamuva kwezokwelapha zaseMelika luthole ukuthi i-lithium ayikwazi nje ukusiza ukuvikela amangqamuzana obuchopho ekufeni ngaphambi kwesikhathi, ingase ikhuthaze nokuvuselelwa kwamangqamuzana obuchopho. Ngakho-ke, i-lithium ingavikela i-hippocampus ekulimaleni futhi igcine noma ithuthukise ukusebenza kwenkumbulo.
Iziqinisi zemizwelo: I-lithium (i-lithium carbonate noma i-lithium citrate) isetshenziselwa ukwelapha ukwelapha ukucindezeleka kanye nesifo sokuphazamiseka kwengqondo. Ngokufanayo, i-lithium orotate inalo mphumela. Ngenxa yokuthi isilinganiso esisetshenzisiwe sincane kakhulu uma siqhathaniswa nesikhathi esifanayo ngonyaka odlule, sibekezelelwa kahle futhi sinemiphumela emibi embalwa.
Ilungele yini i-lithium orotate?
Isifo i-Alzheimer's yisifo esiwohlokayo sesimiso sezinzwa. Ngokomtholampilo, iziguli zizoba nezimpawu ezinjengokukhubazeka kwenkumbulo, i-amnesia, nokungasebenzi kahle emsebenzini. Imbangela enkulu yalesi sifo ayikatholakali. Phakathi kwazo, isifo i-Alzheimer's sibizwa nangokuthi isifo i-Alzheimer's. Iziguli eziningi ziba nalesi sifo ngaphambi kweminyaka engu-65. Leli yiqembu lezifo ezihlukahlukene ezibangelwa izici ezihlukahlukene. Ngaphezu kwalokho, iziguli eziningi ziba nalesi sifo ngemva kweminyaka engu-50. Lesi sifo asicashile futhi sikhula kancane lapho isifo siqala ukuvela. Ezimpawu zakuqala, kuzoba nokukhohlwa okubi kakhulu.
Esigabeni sokuqala, ikhono lesiguli lokukhumbula liyowohloka kancane kancane, ngokwesibonelo, ngokushesha sizokukhohlwa esisanda kukusho noma esikwenzile, futhi ikhono lesiguli lokuhlaziya ukucabanga nekhono lokwahlulela nakho kuyokwehla, kodwa ngesikhathi esifanayo, ezinye izinto. afunde ngaphambili futhi uzokwehla. Isiguli sisazoba nezinkumbulo zomsebenzi noma ikhono. Ngemva kokuba lesi sifo siba sibi kakhulu, izimpawu zesigaba sokuqala zesiguli ziyoba ukukhubazeka okusobala kokubona kwendawo, futhi kuyoba nzima ukugqoka.
Ngokukhethekile, ukusetshenziswa kwe-lithium kwakuhlotshaniswa nengozi ephansi engama-44% yokuwohloka komqondo, ingozi ephansi engama-45% yesifo i-Alzheimer's (AD), kanye nengozi ephansi engama-64% yokuwohloka komqondo kwemithambo (VD).
Lokhu kusho ukuthi usawoti we-lithium ungase ube yindlela yokuvimbela ukuwohloka komqondo njenge-AD.
Ukuwohloka komqondo kubhekisela ekukhubazekeni kwengqondo okunzima nokuqhubekayo. Ngokomtholampilo, kubonakala ngokuwohloka komqondo okuhamba kancane, okuhambisana namazinga ahlukahlukene okushintsha ubuntu, kodwa akukho ukonakala kokwazi. Kuyiqembu lama-syndromes emtholampilo esikhundleni sesifo esizimele. Ziningi izimbangela zokuwohloka komqondo, kodwa ukuwohloka komqondo okuningi kuvame ukubangelwa ukulimala kobuchopho noma izilonda zobuchopho, njengesifo i-Alzheimer's, isifo sikaParkinson, ukulimala kobuchopho okubuhlungu, njll.
Umphumela we-neuroprotective we-lithium usawoti
Ukubuyekezwa kwemiphumela ye-lithium ebuchosheni nasegazini (Ukubuyekezwa kwemiphumela ye-lithium ebuchosheni nasegazini) Lokhu kubuyekezwa kuthi: "Ezilwaneni, i-lithium ilawula ama-neurotrophin, kuhlanganise ne-brain-derived neurotrophic factor (BDNF), factor growth factor, nerve Trophin 3 (NT3) , kanye nama-receptors alezi zici zokukhula ebuchosheni.
I-Lithium iphinde ikhuthaze ukwanda kwamaseli e-stem, okuhlanganisa umnkantsha kanye namaseli e-neural stem endaweni engaphansi, i-striatum, ne-forebrain. Ukukhuthazwa kwamangqamuzana e-neural stem kungase kuchaze ukuthi kungani i-lithium ikhulisa ukuminyana kwamangqamuzana obuchopho kanye nevolumu ezigulini ezine-bipolar disorder. “
Ngokungeziwe kule miphumela engenhla, i-lithium ingaphinde ithuthukise ukusebenza komzimba wokuzivikela komzimba, ilawule umsebenzi wesimiso sezinzwa esimaphakathi, isebenzise ukuthulisa, ukuzola, i-neuroprotection, nokulawula ukuphazamiseka kwezinzwa. Ukuhlaziywa kwe-meta okubili kanye nokuhlolwa okulawulwa ngokungahleliwe kuvule iminyango emisha ekwelashweni okulwa nokuwohloka komqondo, okubonisa ukuthi i-lithium inomthelela omuhle ekusebenzeni kwengqondo ezigulini ezinokukhubazeka okuncane kokuqonda (MCI) kanye ne-AD.
Ubani okungafanele athathe i-lithium orotate?
Abesifazane Abakhulelwe Nabancelisa Ibele
Abesifazane abakhulelwe nabancelisayo kufanele bagweme ukuthatha i-lithium orotate. Ukusetshenziswa kwe-lithium orotate ngesikhathi sokukhulelwa nokuncelisa akuzange kufundwe kabanzi, futhi kunolwazi olulinganiselwe olutholakalayo ngokuphepha kwayo kulezi zibalo. Kubalulekile ukuthi abesifazane abakhulelwe noma abancelisayo babonane nomhlinzeki wabo wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo, okuhlanganisa i-lithium orotate, ukuze kuqinisekiswe ukuphepha komama nomntwana.
Abantu Abanesifo Sezinso
I-lithium ikhishwa ngokuyinhloko ngezinso, futhi abantu abanesifo sezinso bangase babe sengozini enkulu yokunqwabelana kwe-lithium emzimbeni. Lokhu kungaholela ebuthi be-lithium, okungase kube yingozi empilweni. Ngakho-ke, abantu abanesifo sezinso kufanele bakugweme ukuthatha i-lithium orotate ngaphandle uma begadwe umhlinzeki wezokunakekelwa kwempilo ongakwazi ukuqapha ukusebenza kwezinso zabo futhi alungise umthamo ngokufanele.
Abantu Abanezimo Zenhliziyo
I-lithium orotate kubikwe ukuthi inemiphumela engaba khona ohlelweni lwenhliziyo nemithambo yegazi, okuhlanganisa izinguquko ekushayeni kwenhliziyo nesigqi. Abantu abanezimo zenhliziyo ezivele zikhona ngaphambili, njenge-arrhythmias noma isifo senhliziyo, kufanele baqaphele lapho becabangela ukusetshenziswa kwe-lithium orotate. Abantu abanezimo zenhliziyo kudingeka babonane nomhlinzeki wezokunakekelwa kwempilo ngaphambi kokusebenzisa i-lithium orotate ukuze bahlole ubungozi obungaba khona kanye nezinzuzo ngokusekelwe kumlando wabo wezokwelapha othize.
Izingane Nentsha
Ukuphepha nokusebenza ngempumelelo kwe-lithium orotate ezinganeni nasentsheni akukasungulwa kahle. Ngenxa yalokho, ngokuvamile kunconywa ukuthi abantu abangaphansi kweminyaka engu-18 bagweme ukusebenzisa i-lithium orotate ngaphandle uma ngaphansi kokuqondisa komhlinzeki wezempilo ongahlola ukufaneleka kokusetshenziswa kwayo ezimweni ezithile. Izingane kanye nentsha inokucatshangelwa okuyingqayizivele komzimba nentuthuko okudingeka kucatshangelwe lapho kucutshungulwa ukusetshenziswa kwanoma yisiphi isithasiselo, okubandakanya i-lithium orotate.
Abantu abane-Thyroid Disorders
I-lithium yaziwa ngokuthi iphazamisa ukusebenza kwegilo, futhi abantu abanezinkinga zegilo, njenge-hypothyroidism noma i-hyperthyroidism, kufanele baqaphele lapho becabangela ukusetshenziswa kwe-lithium orotate. Imiphumela ye-lithium ekusebenzeni kwe-thyroid ingahluka kumuntu nomuntu, futhi abantu abanezinkinga ze-thyroid badinga ukusebenzisana eduze nomhlinzeki wabo wezempilo ukuze baqaphe umsebenzi wabo we-thyroid uma becabangela ukusetshenziswa kwe-lithium orotate.
Indlela Yokwengeza I-Lithium
Ngakho-ke, kungabonakala engxoxweni engenhla ukuthi usawoti we-lithium unomphumela wokuvikela kumaseli wezinzwa kokubili ku-vivo kanye ne-in vitro. Ingathulisa futhi izinze imizwelo, ilawule ukuphazamiseka kwemizwa, futhi ingasetshenziswa ukuvimbela isifo i-Alzheimer's, isifo sika-Huntington, ischemia yobuchopho, njll. Isifo se-Cerebrovascular. Ngesikhathi esifanayo, ingakwazi futhi ukuthuthukisa umsebenzi we-hematopoietic futhi ithuthukise umsebenzi wokuzivikela womuntu.
I-lithium iyisici semvelo esitholakala emvelweni, ikakhulukazi etholakala kuzinhlamvu nemifino. Ngaphezu kwalokho, amanzi okuphuza kwezinye izindawo anokuqukethwe okuphezulu kwe-lithium, okungase futhi kunikeze ukungena okwengeziwe kwe-lithium.
Ngaphezu kokuthola inani elincane le-lithium ekudleni kwakho kwansuku zonke, ungayithola nasezithanjeni.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ithobelane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.
Isikhathi sokuthumela: Aug-01-2024
