I-Lithium orotateIzithako zokudla zitholé ukuthandwa eminyakeni yamuva ngenxa yezinzuzo zazo ezingaba khona kwezempilo. Kodwa-ke, kusenokudideka okuningi kanye nolwazi olungalungile oluphathelene nale minerali kanye nokusetshenziswa kwayo ngendlela yezithako zokudla. Kulo mhlahlandlela ophelele, sizomboza konke okudingeka ukwazi mayelana nezithako zokudla ze-lithium orotate. Okokuqala nokubaluleke kakhulu, kubalulekile ukuqonda ukuthi i-lithium orotate iyiminerali yemvelo esetshenziselwa ukusekela impilo yengqondo kanye nenhlalakahle iyonke. Luhlobo lwe-lithium oluhlanganiswe ne-orotic acid, olusiza iminerali ukuthi ingene emangqamuzaneni eseli ngempumelelo enkulu. Lokhu kusho ukuthi imithamo ephansi ye-lithium orotate ingasetshenziswa uma kuqhathaniswa nezinye izinhlobo ze-lithium, okunciphisa ingozi yemiphumela emibi.
Yiziphi izinzuzo ze-lithium ebuchosheni?
I-Lithium orotate iyi-salt eyakhiwe yi-orotic acid kanye ne-lithium. Igama layo eligcwele yi-lithium orotate monohydrate (i-Orotic acid lithium salt monohydrate), kanti ifomula yayo yama-molecule yi-C5H3LIN2O4H2O. Ama-ion e-lithium kanye ne-orotic acid awaboshiwe ndawonye kodwa angahlukana esixazululweni ukuze akhiqize ama-ion e-lithium yamahhala. Ucwaningo lubonisa ukuthi i-lithium orotate itholakala kalula nge-bioactive kunemithi kadokotela i-lithium carbonate noma i-lithium citrate (imithi evunyelwe yi-US FDA).
I-Lithium umuthi ovame ukusetshenziswa kwezokwelapha ukwelapha ukucindezeleka, ukuphazamiseka kwengqondo, kanye nezinye izifo zengqondo. Kodwa-ke, izinga lokumuncwa kwe-lithium carbonate noma i-lithium citrate liphansi, futhi kudingeka imithamo ephezulu ukuze kuvezwe imiphumela yokwelapha. Ngakho-ke, zinemiphumela emibi emikhulu futhi zinobuthi. Kodwa-ke, i-lithium orotate ephansi inemiphumela yokwelapha efanayo futhi inemiphumela emibi embalwa.
Ngasekuqaleni kwawo-1970, i-lithium orotate yayithengiswa njengesengezo sokudla sezifo ezithile zengqondo, njengotshwala kanye nesifo i-Alzheimer's.
Ingxenye yobufakazi ilandelayo:
Isifo sika-Alzheimer: Ucwaningo lubonisa ukuthi i-lithium orotate inokutholakala okuphezulu kwe-bioavailability futhi ingasebenza ngqo kuma-mitochondria kanye nama-glial cell membranes ukuhlinzeka ukwesekwa nokuvikelwa kwama-neurons kanye nokubambezela noma ukuthuthukisa izifo ze-neurodegenerative ezifana nesifo sika-Alzheimer.
Ukuvikelwa kwemizwa kanye nokuthuthukiswa kwenkumbulo: Ucwaningo lwakamuva kwezokwelapha zaseMelika luthole ukuthi i-lithium ayikwazi nje ukusiza ekuvikeleni amangqamuzana obuchopho ekufeni ngaphambi kwesikhathi, kodwa ingase ikhuthaze nokuvuselelwa kwamangqamuzana obuchopho. Ngakho-ke, i-lithium ingavikela i-hippocampus ekulimaleni futhi igcine noma ithuthukise ukusebenza kwenkumbulo.
Iziqinisi zemizwa: I-Lithium (i-lithium carbonate noma i-lithium citrate) isetshenziswa kwezokwelapha ukwelapha ukucindezeleka kanye nesifo sokuphazamiseka kwengqondo. Ngokufanayo, i-lithium orotate inalo mphumela. Ngenxa yokuthi umthamo osetshenzisiwe mncane kakhulu uma uqhathaniswa nesikhathi esifanayo ngonyaka odlule, ibekezelelwa kahle futhi inemiphumela emibi embalwa.
Iyini i-lithium orotate enhle?
Isifo i-Alzheimer's isifo esiwohlozayo sesimiso sezinzwa. Ngokwezokwelapha, iziguli zizobhekana nezimpawu ezifana nokukhubazeka kokukhumbula, ukukhohlwa, kanye nokungasebenzi kahle kwamalungu omzimba. Imbangela eyinhloko yalesi sifo ayikatholakali. Phakathi kwazo, isifo i-Alzheimer's sibizwa nangokuthi isifo i-Alzheimer's. Iningi leziguli liba nalesi sifo ngaphambi kweminyaka engu-65. Leli yiqembu lezifo ezingafani ezibangelwa izici ezahlukahlukene. Ngaphezu kwalokho, iningi leziguli liba nalesi sifo ngemva kweminyaka engu-50. Lesi sifo sibonakala kalula futhi sikhula kancane lapho lesi sifo siqala ukukhula. Ezimpawini zokuqala, kuzoba nokukhohlwa okubi kakhulu.
Esigabeni sokuqala, ikhono lesiguli lokukhumbula lizoncipha kancane kancane, isibonelo, uzokhohlwa ngokushesha lokho asanda kukusho noma lokho akwenzile, kanye nekhono lesiguli lokuhlaziya ukucabanga kanye nekhono lokwahlulela nalo lizoncipha, kodwa ngesikhathi esifanayo, ezinye izinto azifundile ngaphambili nazo zizoncipha. Isiguli sizobe sisenezinkumbulo zomsebenzi noma ikhono. Ngemva kokuba isifo sibhebhethekile, izimpawu zesigaba sokuqala sesiguli zizoba ukukhubazeka kokuqonda okusobala kokubona nendawo, futhi kuzoba nzima ukugqoka.
Ngokukhethekile, ukusetshenziswa kwe-lithium kwakuhlotshaniswa nengozi ephansi ngo-44% yesifo sokulahlekelwa yingqondo, ingozi ephansi ngo-45% yesifo i-Alzheimer's (AD), kanye nengozi ephansi ngo-64% yesifo sokulahlekelwa yingqondo semithambo yegazi (VD).
Lokhu kusho ukuthi usawoti we-lithium ungaba yindlela yokuvimbela i-dementia efana ne-AD.
I-dementia ibhekisela ekuphazamisekeni okukhulu nokuqhubekayo kwengqondo. Ngokwezokwelapha, ibonakala ngokuncipha kwengqondo okuhamba kancane, okuhambisana namazinga ahlukahlukene okushintsha kobuntu, kodwa akukho ukuphazamiseka kwengqondo. Kuyiqembu lezifo zemitholampilo kunokuba kube yisifo esizimele. Kunezimbangela eziningi ze-dementia, kodwa iningi le-dementia livame ukubangelwa ukulimala kobuchopho noma izilonda zobuchopho, njengesifo i-Alzheimer's, isifo i-Parkinson's, ukulimala kobuchopho okubuhlungu, njll.
Umphumela wokuvikela izinzwa we-lithium salts
Ukubuyekezwa kwemiphumela ye-lithium ebuchosheni nasegazini (Ukubuyekezwa kwemiphumela ye-lithium ebuchosheni nasegazini) Lokhu kubuyekezwa kuthi: “Ezilwaneni, i-lithium ikhulisa ama-neurotrophin, okuhlanganisa i-neurotrophic factor (BDNF) etholakala ebuchosheni, i-nerve growth factor, i-nerve Trophin 3 (NT3), kanye nama-receptor alezi zici zokukhula ebuchosheni.
I-Lithium iphinde ikhuthaze ukwanda kwamaseli okuqala, okuhlanganisa umongo wamathambo namaseli okuqala ezinzwa endaweni engaphansi kwe-ventricular, i-striatum, kanye nobuchopho obungaphambili. Ukukhuthazwa kwamaseli okuqala ezinzwa ezingaphakathi kungase kuchaze ukuthi kungani i-lithium ikhulisa ubuningi bamaseli obuchopho kanye nevolumu ezigulini ezine-bipolar disorder.
Ngaphezu kwemiphumela engenhla, i-lithium ingathuthukisa nokusebenza komzimba kokuzivikela komzimba, ilawule umsebenzi wesistimu yezinzwa ephakathi, inikeze isizotha, ukuthula, ukuvikela imizwa, futhi ilawule izifo zezinzwa. Ukuhlaziywa okubili kwe-meta kanye nokuhlolwa okulawulwa ngokungahleliwe kuvule iminyango emisha ekwelashweni kwe-anti-dementia, okubonisa ukuthi i-lithium inomthelela omuhle ekusebenzeni kwengqondo ezigulini ezine-cognitive impairment encane (MCI) kanye ne-AD.
Ngubani okungafanele athathe i-lithium orotate?
Abesifazane Abakhulelwe Nabancelisayo
Abesifazane abakhulelwe nabancelisayo kufanele bagweme ukuthatha i-lithium orotate. Ukusetshenziswa kwe-lithium orotate ngesikhathi sokukhulelwa nokuncelisa akukafundwa kabanzi, futhi kunolwazi olulinganiselwe olutholakalayo ngokuphepha kwayo kulaba bantu. Kubalulekile ukuthi abesifazane abakhulelwe noma abancelisayo babonisane nomhlinzeki wabo wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo, okuhlanganisa ne-lithium orotate, ukuqinisekisa ukuphepha komama nomntwana.
Abantu abanesifo sezinso
I-Lithium ikhishwa kakhulu ngezinso, futhi abantu abanesifo sezinso bangase babe sengozini enkulu yokuqongelela i-lithium emzimbeni. Lokhu kungaholela ebuthi be-lithium, okungaba yingozi empilweni. Ngakho-ke, abantu abanesifo sezinso kufanele bagweme ukuthatha i-lithium orotate ngaphandle kokuthi bengaphansi kokuqashwa okuseduze komhlinzeki wezempilo ongaqapha ukusebenza kwezinso zabo futhi alungise umthamo ngokufanele.
Abantu abanezinkinga zenhliziyo
Kubikwe ukuthi i-lithium orotate inemiphumela engaba khona ohlelweni lwezinhliziyo, okuhlanganisa nezinguquko ekushayeni kwenhliziyo kanye nesigqi. Abantu abanezimo zenhliziyo ezikhona kakade, njenge-arrhythmias noma isifo senhliziyo, kufanele baqaphele lapho becabangela ukusebenzisa i-lithium orotate. Abantu abanezimo zenhliziyo kudingeka babonisane nomhlinzeki wezempilo ngaphambi kokusebenzisa i-lithium orotate ukuze bahlole izingozi nezinzuzo ezingaba khona ngokusekelwe emlandweni wabo wezokwelapha othize.
Izingane kanye Nentsha
Ukuphepha nokusebenza kahle kwe-lithium orotate ezinganeni nasebancane akukaqinisekiswa kahle. Ngenxa yalokho, ngokuvamile kunconywa ukuthi abantu abangaphansi kweminyaka eyi-18 bagweme ukusebenzisa i-lithium orotate ngaphandle kokuthi ngaphansi kwesiqondiso somhlinzeki wezempilo ongahlola ukufaneleka kokusetshenziswa kwayo ezimweni ezithile. Izingane nentsha zinezicabango ezihlukile zomzimba nezentuthuko okudingeka zicatshangelwe lapho kucatshangelwa ukusetshenziswa kwanoma yisiphi isithasiselo, okuhlanganisa ne-lithium orotate.
Abantu abanezinkinga ze-thyroid
I-Lithium yaziwa ngokuphazamisa ukusebenza kwe-thyroid, futhi abantu abanezinkinga ze-thyroid, njenge-hypothyroidism noma i-hyperthyroidism, kufanele baqaphele lapho becabangela ukusebenzisa i-lithium orotate. Imiphumela ye-lithium ekusebenzeni kwe-thyroid ingahluka kumuntu nomuntu, futhi abantu abanezinkinga ze-thyroid kudingeka basebenzisane eduze nomhlinzeki wabo wezempilo ukuze baqaphe ukusebenza kwe-thyroid uma becabangela ukusebenzisa i-lithium orotate.
Indlela Yokwengeza I-Lithium
Ngakho-ke, kungabonakala engxoxweni engenhla ukuthi usawoti we-lithium unomthelela wokuvikela kumaseli ezinzwa kokubili ngaphakathi nangaphandle. Ungathulisa futhi uzinzise imizwa, ulawule izifo zezinzwa, futhi ungasetshenziswa ukuvimbela isifo i-Alzheimer's, isifo sikaHuntington, ischemia yobuchopho, njll. Isifo se-cerebrovascular. Ngesikhathi esifanayo, ungathuthukisa nokusebenza kwe-hematopoietic futhi uthuthukise ukusebenza komzimba womuntu.
I-Lithium iyisakhi semvelo esitholakala emvelweni, ikakhulukazi esitholakala kokusanhlamvu nemifino. Ngaphezu kwalokho, amanzi okuphuza kwezinye izindawo anokuqukethwe okuphezulu kwe-lithium, okungaphinde kunikeze ukungenisa okwengeziwe kwe-lithium.
Ngaphezu kokuthola inani elincane le-lithium ekudleni kwakho kwansuku zonke, ungalithola nasezithasiselo.
I-Suzhou Myland Pharm & Nutrition Inc. ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.
Isikhathi sokuthunyelwe: Agasti-01-2024
