Ukuhlola Izimpawu, Imisebenzi, kanye Nezicelo ze-7,8-Dihydroxyflavone

Eminyakeni yamuva nje, umphakathi wesayensi uye wagxila kakhulu ezinzuzweni zezempilo ezingaba khona zezinhlanganisela zemvelo ezihlukahlukene, ikakhulukazi ama-flavonoid. Phakathi kwalokhu, i-7,8-dihydroxyflavone (7,8-DHF) ivele njengenhlanganisela yesithakazelo ngenxa yezici zayo eziyingqayizivele nemisebenzi ethembisayo. Lesi sihloko sicubungula izakhiwo, imisebenzi, kanye nokusetshenziswa okungenzeka kwe-7,8-dihydroxyflavone, kusikhanyisela ngokubaluleka kwayo empilweni nasempilweni.

Izici ze-7,8-Dihydroxyflavone

7,8-Dihydroxyflavoneiyi-flavonoid, ikilasi lezinhlanganisela ze-polyphenolic ezisatshalaliswa kabanzi embusweni wezitshalo. Itholakala ngokuyinhloko ezithelweni ezihlukahlukene, imifino, namakhambi, okunikela emibalabala egqamile kanye nezinzuzo zezempilo ezihlobene nalokhu kudla. Isakhiwo samakhemikhali se-7,8-DHF siqukethe umgogodla we-flavone onamaqembu e-hydroxyl ezindaweni ezingu-7 kanye ne-8, ezibalulekile emsebenzini wayo webhayoloji.

Esinye sezici eziphawuleka kakhulu ze-7,8-DHF ukuncibilika kwayo. I-crystalline powder ephuzi encibilika kuzincibilikisi zemvelo njenge-dimethyl sulfoxide (DMSO) ne-ethanol, kodwa inokunyibilika okulinganiselwe emanzini. Lesi sakhiwo sibalulekile ekwakhekeni kwayo ezinhlelweni ezahlukahlukene, kufaka phakathi izithasiselo zokudla kanye nemikhiqizo yemithi.

I-compound iyaziwa ngokuzinza kwayo ngaphansi kwezimo ezijwayelekile, okwenza ifanele ukwakheka okuhlukahlukene. Kodwa-ke, njengama-flavonoid amaningi, ingazwela ekukhanyeni nasekushiseni, okungase kuthinte ukusebenza kwayo. Ngakho-ke, ukugcinwa okufanele nokuphatha kubalulekile ukuze kugcinwe izici zayo ezizuzisayo.

Imisebenzi ye-7,8-Dihydroxyflavone

Imisebenzi yebhayoloji ye-7,8-dihydroxyflavone ibe yisihloko socwaningo olunzulu, eveza uhla lwezinzuzo zezempilo ezingaba khona. Omunye wemisebenzi ebaluleke kakhulu eyenziwa yile flavonoid umphumela wayo we-neuroprotective. Ucwaningo luye lwabonisa ukuthi i-7,8-DHF ingakhuthaza ukusinda kwama-neurons futhi ithuthukise ukusebenza kwengqondo. Lokhu kubaluleke kakhulu kumongo wezifo ze-neurodeergenerative ezifana ne-Alzheimer's kanye ne-Parkinson, lapho ukucindezeleka okwenziwe nge-oxidative nokuvuvukala kudlala indima ebalulekile ekuqhubekeleni phambili kwesifo.

I-7,8-DHF kukholakala ukuthi isebenzisa imiphumela yayo ye-neuroprotective ngokusebenzisa izindlela ezimbalwa. Kuye kwaboniswa ukwenza kusebenze indlela yokusayina ye-tropomyosin receptor kinase B (TrkB), ebaluleke kakhulu ekusindeni kwe-neuronal nokuhlukaniswa. Ngokuvula le ndlela, i-7,8-DHF ingathuthukisa i-neurogenesis ne-synaptic plasticity, okuholela ekusebenzeni okuthuthukisiwe kwengqondo kanye nenkumbulo.

Ngaphezu kwezakhiwo zayo ze-neuroprotective, i-7,8-DHF ibonisa imisebenzi yokulwa nokuvuvukala kanye ne-antioxidant. Lezi zakhiwo zibalulekile ekulweni nokucindezeleka okwenziwe nge-oxidative, okuxhunyaniswa nezifo ezihlukahlukene ezingapheli, kuhlanganise nezifo zenhliziyo, isifo sikashukela, nomdlavuza. Ngokukhipha ama-radicals mahhala kanye nokunciphisa ukuvuvukala, i-7,8-DHF ingasiza ekwehliseni ubungozi balezi zimo.

Ngaphezu kwalokho, i-7,8-DHF iphenywe ngendima yayo engaba khona empilweni ye-metabolic. Ucwaningo lokuqala luphakamisa ukuthi lungathuthukisa ukuzwela kwe-insulin kanye ne-glucose metabolism, ikwenze kube ikhandidethi lokuphatha izimo ezifana nesifo sikashukela sohlobo 2. Ikhono le-compound lokushintsha izindlela ze-metabolic lingaba nomthelela omkhulu ekulawuleni isisindo kanye nempilo yonke ye-metabolic.

Izicelo ze-7,8-Dihydroxyflavone

Uma kubhekwa imisebenzi yayo eyahlukene, i-7,8-dihydroxyflavone izuze ukunakwa emikhakheni eyahlukene, okuhlanganisa ukudla okunomsoco, imithi, kanye nezimonyo. Izicelo zayo ezingase zibe khona ziningi, futhi ucwaningo oluqhubekayo luyaqhubeka nokuveza amathuba amasha.

1. Izithasiselo Zokudla: Ukusetshenziswa okuvame kakhulu kwe-7,8-DHF kusezithasiselweni zokudla okuhloswe ngazo ukuthuthukisa ukusebenza kwengqondo kanye nempilo iyonke. Njengenhlanganisela yemvelo enezici ze-neuroprotective, ivame ukudayiswa njenge-nootropic, ekhangayo kubantu abafuna ukuthuthukisa inkumbulo, ukugxila, nokucaca kwengqondo. Izithasiselo eziqukethe i-7,8-DHF zivame ukutholakala ngempushana noma ifomu le-capsule, okuvumela ukufakwa kalula ezindleleni zansuku zonke.

2. Ukuthuthukiswa Kwemithi: Imboni yezemithi ihlola amandla e-7,8-DHF njenge-ejenti yokwelapha izifo ze-neurodegenerative. Izivivinyo zemitholampilo ziyaqhubeka ukuhlola ukusebenza kahle nokuphepha kwayo ekwelapheni izimo ezifana nesifo i-Alzheimer's. Uma kuphumelele, i-7,8-DHF ingavula indlela yezinketho zokwelashwa ezintsha eziqondise izindlela eziyisisekelo zalezi zifo.

3. Imikhiqizo yezimonyo: I-antioxidant ne-anti-inflammatory properties ye-7,8-DHF iyenza ibe isithako esikhangayo ekwakhiweni kwezimonyo. Ihlanganiswa emikhiqizweni ye-skincare okuhloswe ngayo ukunciphisa izimpawu zokuguga, ukuvikela ekucindezelekeni kwemvelo, nokuthuthukisa impilo yesikhumba. Ikhono layo lokuthuthukisa ukusebenza kwamangqamuzana lingase libe negalelo ekuthuthukiseni ukuthungwa nokubukeka kwesikhumba.

4. Ukudla Okusebenzayo: Njengoba abathengi beqaphela kakhulu impilo, kuba nesithakazelo esikhulayo ekudleni okusebenzayo okunikeza izinzuzo ezengeziwe zezempilo. I-7,8-DHF ingafakwa emikhiqizweni ehlukahlukene yokudla, njengeziphuzo, ukudla okulula, kanye nezithasiselo, ukuze kuthuthukiswe iphrofayili yazo yokudla okunomsoco. Lo mkhuba uhambisana nesidingo esikhulayo sezithako zemvelo ezisekela inhlalakahle jikelele.

Isiphetho

I-7,8-Dihydroxyflavone iyi-flavonoid ephawulekayo enohlu lwezimpawu nemisebenzi eyenza ibe inhlanganisela ebalulekile empilweni nasempilweni. Izakhiwo zayo ze-neuroprotective, anti-inflammatory, kanye ne-antioxidant ziyibeka njenge-ejenti yokwelapha engaba khona ezimweni zezempilo ezihlukahlukene, ikakhulukazi izifo ze-neurodegenerative kanye nokuphazamiseka kwe-metabolic.

Njengoba ucwaningo luqhubeka nokwembula inqwaba yezinzuzo ezihlotshaniswa ne-7,8-DHF, ukusetshenziswa kwayo ezithasiselweni zokudla, imithi, izimonyo, nokudla okusebenzayo kungenzeka kwande. Nokho, kubalulekile kubathengi ukuthi basondele kule mikhiqizo ngokuqapha, njengoba ukusebenza kahle nokuphepha kwe-7,8-DHF kungahluka kuye ngokwakhiwe kanye nezimo zempilo ngazinye.

Kafushane, i-7,8-dihydroxyflavone imelela indawo ethembisayo yocwaningo ngaphakathi kwendawo yezinhlanganisela zemvelo, enikeza ithemba lemiphumela yezempilo ethuthukisiwe kanye nezinga lempilo elithuthukisiwe. Njengoba siqhubeka nokuhlola amandla ale flavonoid, kubalulekile ukusekela ucwaningo oluqhubekayo nentuthuko ukuze siqonde ngokugcwele amakhono ayo kanye nokusetshenziswa kwayo emikhubeni yezempilo yesimanje.