Umkhiqizi wempuphu ye-7,8-Dihydroxyflavone (7,8-DHF) Inombolo ye-CAS: 38183-03-8 Ubumsulwa obungu-98.0% obuncane bezithako ezengeziwe
Ividiyo Yomkhiqizo
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-7,8-Dihydroxyflavone |
| Elinye igama | I-7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4-benzopyrone; I-DIHYDROXYFLAVONE, 7,8-(RG); i-hydrate engu-7,8-Dihydroxyflavone; 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one |
| Inombolo ye-CAS | 38183-03-8 |
| Ifomula yama-molecule | C15H10O4 |
| Isisindo sama-molecule | 254.24 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impuphu ephuzi |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-7,8-Dihydroxyflavone, eyaziwa nangokuthi i-7,8-DHF, iyi-flavonoid eyenzeka ngokwemvelo etholakala ezitshalweni ezahlukahlukene, kufaka phakathi i-Tridacna tridacna. Eyaziwa ngezakhiwo zayo zokulwa ne-antioxidant kanye ne-neurotrophic, esinye sezici ezithakazelisa kakhulu ze-7,8-dihydroxyflavone amandla ayo okusekela impilo yobuchopho nokuthuthukisa ukusebenza kwengqondo. Ucwaningo lubonisa ukuthi le nhlanganisela isebenza njenge-neurotrophin enamandla, ivuselela ukukhula nokusinda kwama-neurons ebuchosheni. Izifundo ezilwaneni zaselabhorethri zibonise ukuthi i-7,8-DHF ithuthukisa kakhulu amakhono okukhumbula nokufunda. Ngokukhuthaza ukwakheka kokuxhumana okusha kwe-synaptic nokuthuthukisa ukuxhumana phakathi kwamangqamuzana obuchopho, le nhlanganisela ithembisa ukuvula amandla ethu okuqonda. Ngaphezu kwalokho, i-7,8-dihydroxyflavone ixhumana nama-receptor e-serotonin ebuchosheni, ahilelekile ekulawulweni kwemizwa. Ngokuguqula la ma-receptor, ingakwazi ukunciphisa izimpawu zokukhathazeka nokucindezeleka.
Isici
(1) Ubumsulwa obuphezulu: I-7,8-Dihydroxyflavone ingathola imikhiqizo yobumsulwa obuphezulu ngokukhipha kwemvelo kanye nenqubo yokukhiqiza kahle. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: I-7,8-Dihydroxyflavone iwumkhiqizo wemvelo oye wafakazelwa ukuthi uphephile kubantu. Ngaphakathi kobubanzi bomthamo, ayinabo ubuthi noma imiphumela emibi.
(3) Ukuzinza: I-7,8-Dihydroxyflavone inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zemvelo nezokugcina.
(4) Kulula ukumunca: I-7,8-Dihydroxyflavone ingamuncwa ngokushesha ngumzimba womuntu, ingene ekujikelezeni kwegazi ngomgudu wamathumbu, bese isatshalaliswa ezicutshini nasezithweni ezahlukene.
Izicelo
I-7, 8-DHF, njengesiqalisi se-molecule encane esisebenzayo se-TrkB receptor, ingadlala indima yokuvikela ama-neuron, ukuvuselelwa kwama-neuron, ukulawulwa kwe-synaptic plasticity, njll. ngokulingisa ukubopha okuthile kwe-BDNF ku-TrkB nokwenza kusebenze izindlela zesignali ezingezansi, ukuze kuthuthukiswe kakhulu izimpawu zokufunda ngokomzwelo kanye nokwehla kwenkumbulo yendawo, ukwehla kwamandla okuqonda, ukwehla kokusebenza kwemisipha kanye nezinye izimpawu zesifo sesistimu yezinzwa njengesifo i-Alzheimer's noma amamodeli ezilwane asebekhulile, Futhi kuncishiswe izinhlobo ezihlobene zesifo sengqondo nezilwane ezikhuluphele. Okwamanje, kuze kube manje, akukho miphumela emibi ebalulekile ye-7,8-DHF etholakele ezilwaneni ezivivinywayo. I-7,8-DHF inamandla amakhulu kanye nenani ekuvimbeleni nasekwelapheni izinkinga ezihlobene ne-BDNF/TrkB.
