Ukuhlola i-Urolithin A kanye no-B: Ikusasa Lokuncipha Kwesisindo Nezengezo Zezempilo

Eminyakeni yamuva nje, ukugqama sekuphenduke ama-urolithin, ikakhulukazi i-urolithin A no-B, njengezinhlanganisela ezithembisayo ezitholakala kumetabolism yama-polyphenols atholakala kumahalananda nezinye izithelo. Lawa ma-metabolites athole ukunakwa ngezinzuzo zawo zezempilo ezingaba khona, okuhlanganisa ukuncipha kwesisindo, izakhiwo zokulwa nokuguga, kanye nempilo enhle iyonke.

Ukuqonda i-Urolithins: A no-B

Ama-Urolithin ama-metabolites akhiqizwa amagciwane amathumbu lapho ephula i-ellagitannins, uhlobo lwe-polyphenol olutholakala ezithelweni ezihlukahlukene, ikakhulukazi amahalananda. Phakathi kwezinhlobo ezahlukene ze-urolithins, i-urolithin A (UA) kanyei-urolithin B (UB) yizona ezifundwe kakhulu.

I-Urolithin A ixhunyaniswe nezinzuzo zezempilo eziningana, okuhlanganisa ukusebenza okuthuthukisiwe kwe-mitochondrial, impilo yemisipha ethuthukisiwe, kanye nemiphumela engase ibe khona yokulwa nokuvuvukala. Ucwaningo lusikisela ukuthi i-UA ingase ibambe iqhaza ekukhuthazeni i-autophagy, inqubo esiza umzimba ukuthi ukhiphe amaseli alimele futhi ukhiqize kabusha amasha. Leli khono lokuvuselela lithandeka ikakhulukazi kulabo abafuna ukugcina isisindo semisipha kanye nempilo yonke njengoba bekhula.

Ngakolunye uhlangothi, i-Urolithin B iye yafundwa kancane kakhulu kodwa kukholakala ukuthi inesethi yayo yezinzuzo zezempilo. Ezinye izifundo zibonisa ukuthi i-UB ingase futhi isekele umsebenzi we-mitochondrial futhi ibonise izakhiwo ze-antioxidant, nakuba imiphumela yayo ingabhaliwe kahle njengaleyo ye-UA.

I-Urolithin A kanye Nokuncipha Kwesisindo

Enye yezindawo ezithakazelisa kakhulu zocwaningo ezizungeze i-urolithin A indima yayo engaba khona ekunciphiseni isisindo. Ucwaningo oluningana luphakamise ukuthi i-UA ingasiza ekulawuleni i-metabolism futhi ikhuthaze ukulahleka kwamafutha. Isibonelo, ucwaningo olushicilelwe kujenali *Nature* luthole lokhourolithin Akungathuthukisa amandla omzimba okushisa amafutha ngokuthuthukisa umsebenzi we-mitochondrial. Lokhu kubaluleke kakhulu njengoba impilo ye-mitochondrial ibalulekile ekukhiqizeni amandla kanye ne-metabolism.

Ngaphezu kwalokho, i-urolithin A ikhonjiswe ukuthi inethonya elihle ku-gut microbiome. I-gut microbiome enempilo ibalulekile ekugayeni ukudla okusebenzayo kanye ne-metabolism, futhi ingadlala indima ebalulekile ekulawulweni kwesisindo. Ngokuphromotha indawo elinganiselayo yamathumbu, i-UA ingase isize abantu ngabanye ukufeza izinhloso zabo zokulahlekelwa isisindo ngempumelelo kakhudlwana.

Izithasiselo ze-Urolithin A ezihlanzekile

Ngentshisekelo ekhulayo ye-urolithin A, izinkampani eziningi seziqalile ukunikeza izithasiselo ze-urolithin A emsulwa. Lezi zithako zithengiswa njengendlela yokusebenzisa izinzuzo zalesi sithako ngaphandle kokudinga ukudla okuningi kwehalananda noma okunye ukudla okunothe nge-ellagitannin.

Uma ucubungula isithasiselo se-urolithin A emsulwa, kubalulekile ukubheka imikhiqizo esekelwa ucwaningo lwesayensi futhi eye yahlolwa kanzima ukuhlanzeka nokusebenza kwayo. Izithasiselo zekhwalithi ephezulu kufanele ziqukathe umthamo ojwayelekile we-urolithin A ukuze kuqinisekiswe ukuthi abasebenzisi bathola izinzuzo ezihlosiwe.

Izithasiselo ezihamba phambili ze-Urolithin A Emakethe

Njengoba isidingo sezithasiselo ze-urolithin A sikhula, kuvele izinhlobo ezimbalwa njengabaholi emakethe. Nazi ezinye izithasiselo ezihamba phambili ze-urolithin A ezitholakalayo njengamanje:

1. I-Pomegranate Extract ene-Urolithin A: Ezinye izinhlobo zinikeza izithasiselo zokukhishwa kwehalananda ezihlanganisa i-urolithin A njengesithako esiyinhloko. Le mikhiqizo inikeza izinzuzo zombili izithelo nama-metabolites aso.

2. I-Myland Nutraceuticals Urolithin A: Lo mkhiqizo unikeza isithasiselo se-urolithin A esihlanzekile esingenazo izithasiselo nama-fillers, okwenza kube ukukhetha okuhle kulabo abafuna indlela eqondile yokwengeza.

Isiphetho

I-Urolithin A no-B imelela indawo yocwaningo ethakazelisayo enemithelela ebalulekile empilweni nempilo. Nakuba i-urolithin A ibonisa isithembiso ekusekeleni ukuncipha kwesisindo nempilo iyonke, i-urolithin B ingase ibe nomthelela kulezi zinzuzo, nakuba ngokwezinga elincane. Njengoba isayensi ezungeze lezi zinhlanganisela iqhubeka nokuvela, kanjalo nezinketho ezitholakalayo kubathengi abafuna ukuthuthukisa impilo yabo ngokufaka izithasiselo.

Kulabo abathanda ukuhlola izinzuzo ezingaba khona ze-urolithin A, kubalulekile ukukhetha izithasiselo zekhwalithi ephezulu ezisekelwa ucwaningo. Njengenjwayelo, abantu kufanele baxhumane nochwepheshe bezokunakekelwa kwempilo ngaphambi kokuqala noma yiluphi uhlobo lomuthi olusha lokwengeza, ikakhulukazi uma benezimo zempilo ezingaphansi noma bephuza eminye imithi.

Ngamafuphi, i-urolithin A no-B ingaphezu nje kwama-buzzwords embonini yezengezo zezempilo; bamelela umngcele omusha ekuqondeni kwethu ukuthi izinhlanganisela zemvelo zingasekela kanjani ukulahlekelwa isisindo, impilo yamaselula, kanye nokuphila kahle. Njengoba ucwaningo luqhubeka nokuvela, singathola izinhlelo zokusebenza ezijabulisa kakhulu zalawa ma-metabolites anamandla eminyakeni ezayo.