Ukuhlola i-Urolithin A kanye ne-B: Ikusasa Lokwehlisa Isisindo kanye Nezithasiselo Zempilo

Eminyakeni yamuva nje, ukugqanyiswa kuye kwaphendukela kuma-urolithin, ikakhulukazi i-urolithin A no-B, njengamakhemikhali athembisayo atholakala ekugayweni kwama-polyphenol atholakala kumapomegranati nakwezinye izithelo. Lawa ma-metabolite athole ukunakwa ngezinzuzo zawo zezempilo ezingaba khona, okuhlanganisa ukwehlisa isisindo, izakhiwo zokulwa nokuguga, kanye nokuphila kahle jikelele.

Ukuqonda ama-Urolithin: A kanye no-B

Ama-Urolithin ayizinto ezikhiqizwa yibhaktheriya yamathumbu lapho ephula ama-ellagitannins, uhlobo lwe-polyphenol olutholakala ezithelweni ezahlukahlukene, ikakhulukazi amapomegranate. Phakathi kwezinhlobo ezahlukene zama-urolithin, i-urolithin A (UA) kanyei-urolithin B (UB) yizona ezifundwe kakhulu.

I-Urolithin A ihlotshaniswa nezinzuzo eziningana zezempilo, okuhlanganisa ukusebenza kwe-mitochondrial okuthuthukisiwe, impilo yemisipha ethuthukisiwe, kanye nemiphumela engaba khona yokulwa nokuvuvukala. Ucwaningo lubonisa ukuthi i-UA ingadlala indima ekukhuthazeni i-autophagy, inqubo esiza umzimba ukuthi ukhiphe amangqamuzana alimele futhi uvuselele amasha. Leli khono lokuvuselela likhanga kakhulu labo abafuna ukugcina imisipha kanye namandla abo bonke njengoba bekhula.

Ngakolunye uhlangothi, i-Urolithin B ayifundwanga kabanzi kodwa kukholakala ukuthi inezinzuzo zayo zezempilo. Ezinye izifundo zibonisa ukuthi i-UB ingase futhi isekele umsebenzi we-mitochondrial futhi ibonise izakhiwo ze-antioxidant, yize imiphumela yayo ingabhalwanga kahle njengeye-UA.

I-Urolithin A kanye nokwehlisa isisindo

Enye yezindawo ezijabulisa kakhulu zocwaningo oluphathelene ne-urolithin A yindima yayo engaba khona ekunciphiseni isisindo. Izifundo eziningana ziphakamise ukuthi i-UA ingasiza ekulawuleni i-metabolism futhi ikhuthaze ukwehla kwamafutha. Isibonelo, ucwaningo olwanyatheliswa kumagazini i-*Nature* luthole ukuthii-urolithin Akungathuthukisa ikhono lomzimba lokushisa amafutha ngokuthuthukisa ukusebenza kwe-mitochondrial. Lokhu kubaluleke kakhulu njengoba impilo ye-mitochondrial ibalulekile ekukhiqizweni kwamandla kanye nokusetshenziswa kwe-metabolism.

Ngaphezu kwalokho, i-urolithin A iboniswe ukuthi inethonya elihle kuma-microbiome amathumbu. I-microbiome enempilo yamathumbu ibalulekile ekugayweni kahle nasekugayweni kahle kwe-metabolism, futhi ingadlala indima ebalulekile ekulawuleni isisindo. Ngokukhuthaza indawo yamathumbu elinganiselayo, i-UA ingasiza abantu ukuthi bafeze imigomo yabo yokunciphisa isisindo ngempumelelo.

Izithasiselo ze-Urolithin A ezimsulwa

Njengoba isithakazelo esikhulayo ku-urolithin A sikhula, izinkampani eziningi seziqalile ukunikeza izithasiselo ze-urolithin A ezihlanzekile. Lezi zithasiselo zithengiswa njengendlela yokusebenzisa izinzuzo zalesi sakhi ngaphandle kokudinga ukudla inani elikhulu le-pomegranate noma okunye ukudla okucebile nge-ellagitannin.

Uma ucabangela isithasiselo se-urolithin A esimsulwa, kubalulekile ukufuna imikhiqizo esekelwa ucwaningo lwesayensi futhi eye yahlolwa ngokuqinile ukuze ithole ubumsulwa nokusebenza kahle. Izithasiselo ezisezingeni eliphezulu kufanele zibe nomthamo ojwayelekile we-urolithin A ukuqinisekisa ukuthi abasebenzisi bathola izinzuzo ezihlosiwe.

Izithasiselo ze-Urolithin A Ezinhle Kakhulu Emakethe

Njengoba isidingo sezithako ze-urolithin A sikhula, izinhlobo eziningana ziye zavela njengezihamba phambili emakethe. Nazi ezinye zezithako ze-urolithin A ezinhle kakhulu ezitholakalayo njengamanje:

1. I-Pomegranate Extract ene-Urolithin A: Amanye amabhrendi anikeza izithasiselo ze-pomegranate extract ezifaka i-urolithin A njengesithako esiyinhloko. Le mikhiqizo inikeza izinzuzo zesithelo kanye nama-metabolites aso.

2. I-Myland Nutraceuticals Urolithin A: Lo mkhiqizo unikeza isengezo se-urolithin A esimsulwa esingenazo izithasiselo nama-filler, okwenza kube ukukhetha okuhle kulabo abafuna indlela eqondile yokwengeza.

Isiphetho

I-Urolithin A kanye ne-B zimelela indawo ethakazelisayo yocwaningo enemiphumela ebalulekile empilweni nasekuphileni kahle. Ngenkathi i-urolithin A ikhombisa ithemba ekusekeleni ukwehla kwesisindo kanye nempilo iyonke, i-urolithin B nayo ingase ibe negalelo kulezi zinzuzo, yize ngezinga elincane. Njengoba isayensi ezungeze lezi zinhlanganisela iqhubeka nokukhula, nezinketho ezitholakalayo zizotholakala kubathengi abafuna ukuthuthukisa impilo yabo ngokunezela izithako.

Kulabo abanesifiso sokuhlola izinzuzo ezingaba khona ze-urolithin A, kubalulekile ukukhetha izithasiselo ezisezingeni eliphezulu ezisekelwa ucwaningo. Njengokujwayelekile, abantu kufanele babonisane nochwepheshe bezempilo ngaphambi kokuqala noma yiluphi uhlobo olusha lwezithasiselo, ikakhulukazi uma benezinkinga zempilo eziyisisekelo noma bethatha eminye imithi.

Ngamafuphi, i-urolithin A kanye ne-B kungaphezu nje kwamagama adumile embonini yezithasiselo zezempilo; zimelela umngcele omusha ekuqondeni kwethu ukuthi amakhemikhali emvelo angasekela kanjani ukwehla kwesisindo, impilo yamaseli, kanye nenhlalakahle iyonke. Njengoba ucwaningo luqhubeka nokuvela, singathola izinhlelo zokusebenza ezijabulisa kakhulu zala ma-metabolites anamandla eminyakeni ezayo.