Eminyakeni yamuva nje, abantu baye baphila izimpilo ezikhathalela kakhulu impilo, futhi ekufuneni impilo engcono nokuphila kahle, sivame ukubheka izixazululo zemvelo zezifo ezihlukahlukene. Isengezo esisodwa esithembisayo esithole ukunakwa eminyakeni yamuva i-palmitoylethanolamide (PEA). Iyaziwa ngezinzuzo zayo zokwelapha ezingase zibe khona, i-PEA ifundwe kabanzi ngekhono layo lokunciphisa ubuhlungu, ukuvuvukala, kanye nokuthuthukisa impilo yonke.
I-Palmitoylethanolamide (PEA) iyi-asidi enamafutha eyenzeka ngokwemvelo ekhiqizwa imizimba yethu ukuphendula ukuvuvukala nobuhlungu. Kungokwesigaba sezinhlanganisela ezaziwa ngokuthi i-N-acylethanolamines (NAE), esebenza njengama-amide e-endogenous fatty acid, ama-molecule e-lipid ahilelekile ekulawuleni izinqubo ezihlukahlukene zomzimba. Yaqala ukutholwa ngawo-1950, kodwa izakhiwo zayo zokuphulukisa azizange zitholakale kwaze kwaba kamuva kakhulu.
I-PEA ikhona ezinhlobonhlobo zezicubu zomuntu futhi kutholakale ukuthi idlala indima ebalulekile ekuguquleni nasekulungiseni ukusabela nokuvuvukala komzimba.
Kuyaziwa ukusebenzisana nama-receptors athile emzimbeni, okuhlanganisa i-peroxisome proliferator-activated receptor-alpha (PPAR-α), ehilelekile ekulawuleni ukuvuvukala. Ngokuvula i-PPAR-α, i-PEA isiza ukuvimbela ukukhiqizwa kwama-molecule abangela ukuvuvukala, ithuthukise izindlela ezingokwemvelo zokulwa nokuvuvukala komzimba.
I-PEA isebenza ngokuvimbela ukusebenza kwamaseli akhethekile abizwa ngokuthi ama-mast cell, akhulula abalamuli abavuvukalayo futhi abangele ubuhlungu nokungezwani komzimba nezinto ezithile. Ngokunciphisa ukusebenza kwe-mast cell, i-PEA isiza ukunciphisa ubuhlungu futhi ithuthukise ikhwalithi yokuphila yonke.
Ucwaningo luye lwabonisa ukuthi i-PEA ingase idlale indima yokuvikela ezifweni ezihlukahlukene zezinzwa ngokuvimbela ukulimala kwe-neuronal nokukhuthaza ukukhula nokusinda kwamangqamuzana ezinzwa.
I-PEA isebenza ngokukhomba futhi ibophe isamukeli esithile esibizwa nge-peroxisome proliferator-activated receptor-alpha (PPAR-α). Le receptor idlala indima ebalulekile ekulawuleni ukuvuvukala nokubona ubuhlungu. Ngokuvula ama-receptors e-PPAR-alpha, i-PEA isiza ukunciphisa ukuvuvukala futhi ikhulule ubuhlungu.
I-Palmitoylethanolamide (PEA) Izinzuzo Nokusetshenziswa:
●Ukuphathwa kobuhlungu: I-PEA ibonise imiphumela ethembisayo ekwelapheni izinhlobo ezihlukahlukene zobuhlungu, kuhlanganise nobuhlungu obungapheli, ubuhlungu be-neuropathic, nobuhlungu obuvuthayo. Isebenza ngokunciphisa ukuvuvukala nokuguqula izimpawu zobuhlungu, inikeze impumuzo kubantu abanobuhlungu obuqhubekayo.
●I-Neuroprotective: I-PEA itholakale inezakhiwo ze-neuroprotective, okusho ukuthi isiza ukuvikela nokusekela impilo yamangqamuzana ezinzwa. Lokhu kwenza kube nenzuzo ezifweni ezifana ne-multiple sclerosis, i-Alzheimer's kanye nesifo sikaParkinson, lapho ukulimala kwamangqamuzana ezinzwa nokuvuvukala kudlala indima ebalulekile.
●Umphumela wokulwa nokuvuvukala: I-PEA inomphumela onamandla wokulwa nokuvuvukala futhi inenzuzo ezinhlobonhlobo zezifo ezivuthayo, njenge-arthritis, i-irritable bowel syndrome (IBS) ne-asthma. Kuyasiza ukunciphisa ukukhiqizwa kwama-molecule e-pro-inflammatory, ngaleyo ndlela kunciphise ukuvuvukala kanye nezimpawu zayo ezihambisanayo.
●Ukusekelwa kwamasosha omzimba: I-PEA iboniswe njenge-immunomodulatory, okusho ukuthi isiza ukulawula kanye nokulinganisa impendulo yokuzivikela komzimba. Lokhu kungaba yinzuzo ezifweni ezizimele, njenge-rheumatoid arthritis kanye ne-lupus, lapho amasosha omzimba ehlasela izicubu zawo ngephutha.
●Imiphumela ye-Antidepressant kanye ne-anxiolytic: I-PEA itholwe inezindawo ezingaba ze-antidepressant kanye ne-anxiolytic. Kuyasiza ukulawula isimo sengqondo nokunciphisa izimpawu zokucindezeleka nokukhathazeka ngokulawula ama-neurotransmitters ahlukahlukene ahilelekile ekulawuleni isimo sengqondo, njenge-serotonin ne-dopamine.
●Impilo yesikhumba: I-PEA itholwe inezindawo zokupholisa isikhumba futhi ivimbela ukulunywa, okuyenza ibe nenzuzo ekwelapheni izimo zesikhumba ezihlukahlukene, okuhlanganisa i-eczema, i-psoriasis, ne-dermatitis. Kuyasiza ukunciphisa ukuvuvukala nokuluma, kukhuthaze isikhumba esinempilo, esikhululekile.
I-CBD, ekhishwe esitshalweni se-hemp, idume ngamandla ayo okunikeza izinzuzo ezinjengokuqeda izinhlungu, ukunciphisa ukukhathazeka kanye nokulala okuthuthukisiwe. Ngakolunye uhlangothi, i-PEA, i-amide ye-fatty acid eyenzeka ngokwemvelo, icutshungulwe kabanzi mayelana nezakhiwo zayo zokulwa nokuvuvukala kanye ne-analgesic. Zombili lezi zinhlanganisela zikhiqizwa ngokwemvelo emizimbeni yethu futhi zingatholakala nasekudleni okuthile.
Omunye umehluko omkhulu phakathi kwe-PEA ne-CBD yindlela ngayinye esebenza ngayo emzimbeni wethu. I-CBD isebenzisana ngokuyinhloko nohlelo lwethu lwe-endocannabinoid (ECS), inethiwekhi yama-receptors alawula izinqubo ezihlukahlukene zomzimba, okuhlanganisa ukubona ubuhlungu, isimo sengqondo, nokuvuvukala. I-CBD ithinta ngokungaqondile i-ECS ngokuthuthukisa ukukhiqizwa kwe-endocannabinoid noma ukuvimbela ukuwohloka kwayo.
Nokho, i-PEA isebenza ngezindlela ezahlukene. Ihlose futhi ilawula umsebenzi wezinye izinhlelo eziningi emzimbeni wethu, ikakhulukazi labo abathintekayo ekulawuleni ubuhlungu nokuvuvukala. I-PEA isebenzisana nama-receptors amaningana, njenge-peroxisome proliferator-activated receptor-α (PPAR-α), edlala indima ebalulekile ekulawuleni ubuhlungu.
Nakuba kokubili i-PEA ne-CBD zinemiphumela yokulwa nokuvuvukala, isenzo se-PEA sibonakala sisendaweni kakhudlwana, siqondise ama-molecule athile abangela ubuhlungu, kuyilapho i-CBD inomphumela obanzi ekuphenduleni okuphelele kokuvuvukala. Lo mehluko wemishini ungase uchaze ukuthi kungani i-PEA ivame ukusetshenziselwa ukubhekana nobuhlungu bendawo, kuyilapho i-CBD ivame ukusetshenziswa kabanzi ukwelapha ukuvuvukala kwesistimu.
Elinye iphuzu elihlukile yisimo esingokomthetho salezi zinhlanganisela ezimbili emazweni athile. I-CBD, etholakala ku-hemp, ingaphansi kwemikhawulo nemithethonqubo ehlukahlukene, ikakhulukazi ngenxa yokuhlangana kwayo ne-hemp. Ngokuphambene, i-PEA ihlukaniswa njengesithasiselo sokudla futhi ngokuvamile ibhekwa njengephephile futhi isemthethweni ukusetshenziswa.
Nakuba zombili izinhlanganisela zinezakhiwo zokwelapha ezingaba khona, amaphrofayili azo okuphepha ayahluka. I-CBD ifundwe kabanzi futhi ngokuvamile ibhekwa njengephephile, kunemiphumela emibi embalwa ebikiwe. Nokho, ingase ihlanganyele nemithi ethile futhi ingase ingafaneleki kuwo wonke umuntu, ikakhulukazi labo abanesifo sesibindi. I-PEA, ngakolunye uhlangothi, iyinto eyenzeka ngokwemvelo emizimbeni yethu futhi isetshenziswe ngokuphepha njengesengezo sokudla amashumi eminyaka.
Kuhle ukusho ukuthi i-PEA ne-CBD akuzona izindlela ezihlukile. Eqinisweni, abanye abantu bakhetha ukusebenzisa zombili izinhlanganisela ngoba zingase zibe nemiphumela ehambisanayo. Isibonelo, imiphumela ebanzi yokulwa nokuvuvukala ye-CBD ingahlanganiswa nezakhiwo ze-PEA zokuqeda ukuvuvukala ukuze kusetshenziswe indlela ephelele yokulawula ubuhlungu.
Imihlahlandlela Yemithamo:
Uma ucubungula umthamo ophelele we-palmitoylethanolamide, kubalulekile ukukhumbula ukuthi izidingo zomuntu ngamunye zingahluka. Kuhlale kunconywa ukuthi uthintane nochwepheshe bezokunakekelwa kwempilo ngaphambi kokuqala noma yiluphi uhlobo lwemithi yokwengeza entsha. Nokho, nansi eminye imihlahlandlela yemithamo evamile ukuze uqalise:
1.Qala ngedosi ephansi: Ukuqala ngethamo eliphansi kuvimbela umzimba ukuthi ungakhungatheki futhi kuvumela ukuzivumelanisa nezimo.
2.Kancane kancane ukwanda: ngemva kwezinsuku ezimbalwa, uma kungekho ukusabela okubi okwenzekayo, kubalulekile ukuqaphela ukuthi ukubekezela nokungaguquguquki kubalulekile lapho uhlanganisa i-PEA esimisweni sakho sansuku zonke.
3.Qaphela impendulo yomuntu ngamunye: Umzimba wawo wonke umuntu uhlukile, ngakho kungase kuthathe isikhathi ukunquma umthamo ongcono kakhulu wezidingo zakho ezithile. Naka kakhulu ukuthi umzimba wakho uphendula kanjani, futhi uxhumane nochwepheshe bezempilo ukuze uthole isiqondiso endleleni yakho.
isiqondiso somsebenzisi:
Ngokungeziwe kumthamo, kubalulekile ngokufanayo ukwazi izindlela ezingcono kakhulu zokusebenzisa i-palmitoylethanolamide. Cabangela imihlahlandlela yokusebenzisa elandelayo ukuze ukwandise izinzuzo ezingaba khona ze-PEA:
1.Ukuvumelana kuyisihluthulelo: Ukuze uthole uhla olugcwele lwezinzuzo zokwelapha ze-PEA, ukusetshenziswa okungaguquki kubalulekile. Ukuthatha umthamo onconyiwe njalo isikhathi eside kusiza umzimba ukuthi uzivumelanise futhi wandise izinzuzo ze-PEA.
2.Amabhangqa anokudla okunomsoco: I-PEA isebenza ngokubambisana nokudla okunempilo. Ukwengeza ngokudla okunomsoco okunothe ngemisoco ebalulekile kungathuthukisa izinzuzo zako futhi kukhuthaze impilo yonke.
3.Faka izinguquko zendlela yokuphila: Ukwamukela indlela yokuphila enempilo, okuhlanganisa ukuzivocavoca, ukulawula ingcindezi, nokulala kwekhwalithi, kungathuthukisa imiphumela ye-PEA. Izinguquko zendlela yokuphila zihambisana nesengezo se-PEA ukuze uthole izinzuzo ezingcono zezempilo.
Q: Ingatholakala kanjani i-palmitoylethanolamide?
A: I-Palmitoylethanolamide itholakala njengesengezo sokudla ngendlela yama-capsules noma ama-powders. Ingathengwa ngaphandle kwe-counter ezitolo zokudla zezempilo, amakhemisi, noma abathengisi be-inthanethi. Nokho, kuyatuseka ukuthintana nochwepheshe bezempilo ngaphambi kokuqala ukuyisebenzisa, ikakhulukazi uma unezimo zempilo ezicashile noma uphuza imithi.
Q: Ingabe i-palmitoylethanolamide ingasetshenziswa njengendlela yokwelapha ezimele noma ihlanganiswe nezinye izindlela zokwelapha?
A: I-Palmitoylethanolamide ingasetshenziswa njengendlela yokwelapha ezimele ezimweni ezithile, ikakhulukazi ukuphathwa kobuhlungu obungapheli. Kodwa-ke, kwezinye izimo, ingase isebenze kakhulu uma isetshenziswa njengokwelashwa okuhambisanayo kanye nokwelashwa okuvamile. Ukusetshenziswa kwe-palmitoylethanolamide kufanele kuxoxwe nochwepheshe bezempilo ukuze kunqunywe indlela yokwelashwa efanelekile kakhulu yezidingo zomuntu ngamunye.
Umshwana wokuzihlangula: Lesi sihloko senzelwe izinjongo zokwaziswa kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukushintsha uhlobo lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Aug-21-2023
