Kusukela Ekukhululekeni Kokucindezeleka Kuya Ekuthuthukisweni Kokuqonda: Ukuhlola Ukuguquguquka Kwe-Salidroside

I-Rhodiola rosea iyimpande nesiqu esomile se-Rhodiola rosea, isitshalo sohlobo lwe-Sedum lomndeni wakwaCrassuaceae. Luhlobo lomuthi wendabuko waseTibet. Lukhula ezindaweni eziphakeme nasezindaweni ezinemisebe enamandla ye-ultraviolet. Ngenxa yokuzivumelanisa kwayo isikhathi eside ne-hypoxia, imimoya enamandla, ukoma, kanye nokubanda okukhulu. Indawo enjalo yokukhula kwemvelo enzima idale amandla ayo aqinile kanye nokuzivumelanisa nezimo okubanzi kwemvelo, futhi inemisebenzi ekhethekile yomzimba.

I-Salidroside, njengomkhiqizo wemvelo, inemiphumela engaba khona yokuvikela ngemisebe. Ngokuvikela nokuthuthukisa umsebenzi wama-EPC, i-salidroside inganciphisa umonakalo wemisebe ezicutshini zabantu. Ucwaningo olwengeziwe luzosiza ekwembuleni indlela yokuvikela ngemisebe ye-salidroside futhi lukhuthaze ukusetshenziswa kwayo emtholampilo.

Izifundo zithole ukuthi i-salidroside inamandla okuvikela ngemisebe kumaseli e-endothelial progenitor (EPCs). Ama-EPC angamaseli andulela amaseli e-vascular endothelial futhi adlala indima ebalulekile ekuvuseleleni nasekulungiseni i-vascular endothelium kanye nokwakheka kwemithambo yegazi emisha ezicutshini ezonakele. I-Salidroside ingavikela ama-EPC ekulimaleni ngemisebe, ithuthukise ukusebenza kwawo, ukunamathela kanye nokukwazi kwawo ukufuduka, futhi inciphise i-apoptosis ebangelwa yimisebe.

Ngaphezu kwalokho, i-salidroside ingathuthukisa nomphumela wokuvikela ngemisebe we-EPCs ngokusebenzisa indlela yokubonisana ye-PI3K/Akt. Lokhu kutholwa kunikeza isisekelo sokusetshenziswa kwe-salidroside njengesivikelo ngemisebe.

I-Salidroside ayibonisi nje kuphela amandla okuvikela imisebe kodwa futhi ineminye imisebenzi eminingi yebhayoloji. Kutholakale ukuthi inengcindezi yokulwa ne-oxidative, elwa nokuvuvukala, elwa nokukhathala, elwa nokuguga kanye nemiphumela yokuvikela imizwa. Le miphumela ingase ihlobane nokulawulwa kwe-metabolism yamandla eseli, ukucindezeleka kwe-oxidative kanye nempendulo yokuvuvukala yi-salidroside.

1. Ukulwa nokuvuvukala

UYang Zelin nabanye basungule imodeli yokulimala kwe-BV2 microglial okubangelwa yi-LPS (lipopolysaccharide). Ngemva kokwelashwa ngamanani ahlukene e-salidroside, bathola ukuvezwa kwama-cytokines IL-6, IL-1β, kanye ne-TNF-αmRNA ukuze babone umphumela wokulwa nokuvuvukala.

2. I-Antioxidant

I-Rhodiola rosea ingathuthukisa ikhono lomzimba lokukhipha ama-free radical ngokwandisa umsebenzi wama-enzyme ahlobene ne-antioxidant (i-SOD, i-GSH-Px kanye ne-CAT), ukunciphisa umsebenzi we-acid phosphatase kanye nokuqukethwe komkhiqizo wokubola kokugcina kwe-lipid peroxide (LPO) kanye ne-MDA. , ukunciphisa izinga lokubola kwama-biofilms futhi kuvikele amangqamuzana omzimba nezicubu ekulimaleni kwama-free radical.

3. Ukulwa nokuguga

Umphumela wokulwa nokubola kwesikhumba we-Rhodiola rosea ungase ubangelwe iqiniso lokuthi ama-saponins e-Rhodiola rosea anobuhlobo obuhle futhi angena ku-stratum corneum yesikhumba, angangena ngempumelelo esikhumbeni, futhi akhululwa kancane kancane ukuze adlale indima yokulungisa. Ngaphezu kwalokho, ama-saponins nawo angakhuthaza ukuvuselelwa kwamaseli futhi akhuthaze ukukhula kwama-fibroblast, ngaleyo ndlela athuthukise ukuqina kwesikhumba, abambezele ukwenzeka kwemibimbi yesikhumba, futhi afeze injongo yokumelana nokubola kwesikhumba.

Ungayitholaphi i-salidroside powder esezingeni eliphezulu

Njengesithako esibalulekile esisebenzayo, i-salidroside ithola ukunakwa okwengeziwe. Ukuze kuhlangatshezwane nezidingo zocwaningo lwesayensi kanye nemakethe yemikhiqizo yokunakekelwa kwempilo, kubaluleke kakhulu ukukhetha i-salidroside powder esezingeni eliphezulu.

I-Suzhou Myland yinkampani egxile ocwaningweni, ekuthuthukisweni nasekukhiqizweni kwezinto zokusetshenziswa zezithako zokudla, ezizinikele ekuhlinzekeni amakhasimende ngempuphu ye-salidroside ehlanzekile kakhulu. Inombolo ye-CAS yalo mkhiqizo ingu-10338-51-9, futhi ubumsulwa bayo bufinyelela ku-98%, okuqinisekisa ukuthembeka kwayo nokusebenza kwayo ekuhlolweni nasekusetshenzisweni okuhlukahlukene.

Isici

Ukuhlanzeka okuphezulu: Ukuhlanzeka kwempuphu ye-salidroside kaSuzhou Myland kufinyelela ku-98%, okusho ukuthi abasebenzisi bangathola imiphumela yokuhlola enembile futhi ehambisanayo ngesikhathi sokusetshenziswa. Imikhiqizo ehlanzeka kakhulu inganciphisa ngempumelelo ukuphazamiseka kokungcola ekuhlolweni futhi iqinisekise ukuqina kocwaningo.

Ukuqinisekiswa Kwekhwalithi: Njengenkampani ye-biotechnology enolwazi oluningi, iSuzhou Myland ilandela ngokuqinile amazinga omhlaba wonke okukhiqiza nokulawula ikhwalithi. Iqoqo ngalinye lemikhiqizo lihlolwa ngokuqinile ukuqinisekisa ukuhambisana nezindinganiso zekhwalithi ezifanele. Amakhasimende angalisebenzisa ngokuzethemba futhi anciphise izingozi ezibangelwa izinkinga zekhwalithi yomkhiqizo.

I-salidroside powder isetshenziswa kabanzi emikhakheni eminingi:

Imikhiqizo yokunakekelwa kwempilo: Ngenxa yokuthi i-salidroside inezakhiwo zokulwa nokukhathala, ukuthuthukisa amasosha omzimba kanye nezinye, ivame ukusetshenziswa njengesithako esiyinhloko emikhiqizweni yokunakekelwa kwempilo ukusiza abantu baqinise imizimba yabo futhi bamelane nokucindezeleka kwangaphandle.

Ucwaningo lokulwa nokuguga: Njengoba ukuguga kukhuphuka, amandla omzimba okulwa nokuguga ayancipha kancane kancane. Njenge-antioxidant yemvelo, i-salidroside kucatshangwa ukuthi iyasiza ekunciphiseni inqubo yokuguga nokuthuthukisa ukusebenza kwamaseli.

Izimonyo: Ngenxa yezakhiwo zayo ezinhle ze-antioxidant, i-salidroside isetshenziswa kabanzi nasezimonyweni ukusiza ukuthuthukisa ukuthungwa kwesikhumba nokumelana nomonakalo wemvelo esikhumbeni.

Thenga iziteshi

I-Suzhou Myland inikeza iziteshi zokuthenga eziku-inthanethi ezilula. Amakhasimende angafaka ama-oda ngqo ngewebhusayithi esemthethweni futhi ajabulele izinsizakalo zokuthutha ezisheshayo. Ngaphezu kwalokho, ithimba lochwepheshe lenkampani lizophinde linikeze amakhasimende ukwesekwa kobuchwepheshe kanye nezinsizakalo zokubonisana ukusiza amakhasimende ukuqonda nokusebenzisa imikhiqizo kangcono.