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Ukusebenzisa Amandla E-Berberine: Thuthukisa Impilo Yakho Iphelele

Imvelo isinikeza amagugu angenakubalwa uma kuziwa ekugcineni impilo, ngayinye inezici zayo nezinzuzo ezihlukile. Itshe eliyigugu elinjalo elifihliwe i-berberine, isakhi esitholakala ezinhlobonhlobo zezitshalo ezaziwa ngezici zayo ezimangalisayo ezikhuthaza impilo.

Yini iBerberine 

 I-Berberine iyi-alkaloid ephuzi eyenzeka ngokwemvelo ezinhlobonhlobo zezitshalo, okuhlanganisa izimpande, ama-rhizomes, iziqu, namagxolo. Eminye imithombo evamile ye-berberine ihlanganisa amakhambi afana ne-Oregon grape, goldenseal, ne-skullcap. Imithi yendabuko yamaShayina kanye ne-Ayurvedic isebenzise amandla alezi zitshalo ukwelapha izifo ezihlukahlukene amakhulu eminyaka, futhi i-berberine ivame ukubhekwa njengesithako esiyinhloko sokuphulukisa.

Yini iBerberine

Futhi iyisithako esiyinhloko esisebenzayo emakhambi amabili emithi yemvelo adumile: i-coptis ne-phellodendron.

I-Berberine inezinhlobonhlobo zezinzuzo zezempilo. Kusukela ekulawuleni amazinga kashukela egazini kanye ne-cholesterol kuya ekuboniseni izakhiwo ze-antioxidant, antibacterial kanye ne-anti-inflammatory, i-berberine iyisipho semvelo esingavamile ngempela. Kungakhathaliseki ukuthi isetshenziswa njengokwelashwa okuhambisanayo noma njengendlela yokuvimbela, amandla e-berberine makhulu futhi angasiza ekudaleni impilo enempilo, impilo enamandla.

Izinzuzo Zezempilo ze-Berberine

Iqhaza Le-Berberine Ekulawuleni Isifo Sikashukela

Isifo sikashukela yisifo esingelapheki esihlasela izigidi zabantu emhlabeni jikelele. Ibonakala ngokunyuka kukashukela egazini ngenxa yokuntuleka komzimba kokukhiqizwa kwe-insulin noma ukungakwazi kwawo ukusebenzisa i-insulin ngendlela efanele.

Ukumelana ne-insulin kuwuphawu lwesifo sikashukela sohlobo 2, lapho impendulo yomzimba emiphumeleni ye-insulin iyancipha. Ucwaningo luthole ukuthi i-berberine ingathuthukisa ukutholwa kwamaselula kweglucose, ngaleyo ndlela isize ukulawula amazinga kashukela egazini. Iphinde yehlise ukukhiqizwa kwe-glucose esibindini, iphinde isize ekuthuthukiseni ukulawula ushukela wegazi.

Ukwengeza, i-berberine ikhonjiswe ukuthi ivimbela ukukhiqizwa kwezimpawu zokuvuvukala, ukunciphisa ukuvuvukala, futhi okungenzeka kuvimbele izinkinga zesifo sikashukela ezifana nesifo senhliziyo kanye nokulimala kwezinso.

Ngaphezu kwemiphumela yayo ekuzweleni kwe-insulin nokuvuvukala, i-berberine ibonise amandla okuthuthukisa iphrofayili ye-lipid. Isifo sikashukela sandisa ingozi ye-dyslipidemia, ebonakala ngokukhuphuka kwe-cholesterol namazinga e-triglyceride. Ucwaningo luthole ukuthi i-berberine inganciphisa i-cholesterol ephelele, i-cholesterol ye-LDL, namazinga e-triglyceride ngenkathi ikhulisa i-cholesterol ye-HDL, ngaleyo ndlela inikeze iphrofayili ye-lipid evumayo.

Iqhaza Le-Berberine Ekulawuleni Isifo Sikashukela

Kungasiza Ukusekela Impilo Yenhliziyo

Ucwaningo luthole ukuthi i-berberine inezakhiwo ezahlukahlukene ezingase zisekele impilo yenhliziyo. Inokulawula ushukela wegazi kanye nemiphumela yokwehlisa i-lipid, ebaluleke kakhulu ekugcineni impilo yenhliziyo nemithambo yegazi.

Ucwaningo luthole ukuthi i-berberine yenza kusebenze i-enzyme ebizwa ngokuthi i-adenosine monophosphate-activated protein kinase (AMPK), edlala indima ebalulekile ekuboniseni i-insulin kanye ne-glucose metabolism. Ngokuthuthukisa ukuzwela kwe-insulin, i-berberine ingasiza ekulawuleni amazinga kashukela egazini futhi inciphise ingozi yokuphazamiseka kwe-metabolic, okungaba nomthelela omubi empilweni yenhliziyo.

Ucwaningo lubonisa ukuthi i-berberine ingathuthukisa ukusebenza kwenhliziyo ngokuthuthukisa ukuqina kwemisipha yenhliziyo nokunciphisa ukucindezeleka okwenziwe nge-oxidative. Ngokwandisa amandla nokusebenza kahle kokufinyela kwemisipha yenhliziyo, i-berberine ingase ibe nomthelela empilweni yonke yesistimu yenhliziyo.

Okwamanje, ukwamukela indlela yokuphila enempilo, okuhlanganisa ukudla okulinganiselayo, ukuvivinya umzimba njalo kanye nokuhlolwa kwezempilo okuvamile, kusabalulekile ekugcineni inhliziyo enempilo.

Kungasiza Ukusekela Impilo Yenhliziyo

I-Berberine ekusekeleni ukwehlisa i-Cholesterol

Ucwaningo lubonisa ukuthi i-berberine inganciphisa ngempumelelo i-cholesterol ephelele, i-cholesterol ye-LDL, namazinga e-triglyceride, kuyilapho ikhulisa i-HDL cholesterol. Le miphumela yokwehlisa i-lipid ye-berberine ingasiza kakhulu ekugcineni iphrofayili ye-lipid enempilo futhi inciphise ingozi yesifo senhliziyo.

I-Berberine inemiphumela yayo yokwehlisa i-cholesterol ngokuvimbela i-enzyme ebizwa nge-PCSK9. I-PCSK9 idlala indima ebalulekile ekulawuleni amazinga e-cholesterol e-LDL egazini. Uma i-PCSK9 isebenza ngokweqile, iholela emazingeni aphezulu e-cholesterol e-LDL, okuholela ekwakhekeni kwe-plaque emithanjeni futhi ekugcineni isifo senhliziyo. I-Berberine iboniswe ukuthi ivimbela ukukhiqizwa kwe-PCSK9, ngaleyo ndlela yehlisa amazinga e-cholesterol e-LDL futhi ithuthukise impilo yenhliziyo nemithambo yegazi. 

Ukwengeza, i-berberine itholakale ithinta ukwakheka kwe-cholesterol esibindini. Ivimbela i-enzyme ebizwa ngokuthi i-HMG-CoA reductase, ebhekele ukukhiqizwa kwe-cholesterol emzimbeni. Ngokuvimbela le enzyme, i-berberine yehlisa ukwakheka kwe-cholesterol futhi iholela emazingeni aphansi e-LDL cholesterol.

Ngaphezu kwemiphumela yayo ku-cholesterol, i-berberine nayo inezindawo zokulwa nokuvuvukala kanye ne-antioxidant, ezibuye zibe nomthelela ezinzuzweni zayo zenhliziyo. Ukuvuvukala okungapheli kanye nokucindezeleka okwenziwe nge-oxidative yizici ezaziwayo zengozi yesifo senhliziyo. Ucwaningo luye lwathola ukuthi i-berberine ingavimbela ukukhiqizwa kwama-molecule e-pro-inflammatory futhi ikhuthaze umsebenzi we-antioxidant enzymes, ekugcineni inciphise ingozi yezinkinga zenhliziyo.

Amathuba e-Berberine Okunciphisa Isisindo

I-Berberine ikhonjiswe ukuthi ithuthukisa i-glucose metabolism, ngaleyo ndlela isiza ukulawula amazinga kashukela egazini. Ngokuthuthukisa ukuzwela kwe-insulin, i-berberine isiza umzimba ukuthi usebenzise i-glucose ngokuphumelelayo futhi ivimbele i-glucose eyeqile ukuthi ingaguqulwa ibe isitoreji samafutha. 

Ukwengeza, i-berberine inamandla okukhuthaza i-lipolysis ngokuvula i-enzyme ebizwa ngokuthi i-adenosine monophosphate-activated protein kinase (AMPK). Le enzyme yaziwa ngokuthi "i-metabolic master switch" ngoba idlala indima ebalulekile ekulawuleni ukugaywa kwamandla kanye nokusiza ukwehla kwesisindo. Ngokuvula i-AMPK, i-berberine ingasiza ekukhuthazeni i-oxidation yamafutha futhi ivimbele ukuhlanganiswa kwamafutha, okuholela ekulahlekelweni kwesisindo.

I-Berberine itholakale ithinta i-gut microbiome, edlala indima ebalulekile ekulawuleni isisindo. Ucwaningo lubonisa ukuthi i-berberine ingashintsha ukwakheka kwe-microbiota yamathumbu, ikhuthaze ukukhula kwamabhaktheriya anenzuzo futhi ivimbele ukukhula kwamagciwane ayingozi. I-balanced gut microbiome ibalulekile ekugcineni isisindo esinempilo ngoba ithinta ukukhishwa kwamandla ekudleni futhi ilawula umzimba.

Kodwa-ke, kubalulekile ukukhumbula ukuthi ukuncipha kwesisindo kuyinqubo eyinkimbinkimbi ethonywa yizici eziningi, okuhlanganisa ukudla, ukuvivinya umzimba, nokukhetha indlela yokuphila. Ukuthatha i-berberine njengengxenye yendlela yokulawula isisindo jikelele kunganikeza ukwesekwa okwengeziwe ekuzuzeni nasekugcineni isisindo esinempilo.

Amathuba e-Berberine Okunciphisa Isisindo

Isixhumanisi Phakathi KweBerberine kanye Nempilo Yamathumbu

Ucwaningo lukhombisa ukuthi i-berberine ingasiza ukubuyisela nokugcina i-gut microbiome enempilo. Ucwaningo olushicilelwe kujenali ye-Nature Communications luthole ukuthi i-berberine inyusa ukuhlukahluka kwamagciwane amathumbu, ikhuthaza ukukhula kwezinhlobo ezinenzuzo njenge-Bifidobacterium ne-Lactobacillus. Lawa mabhaktheriya aziwa ngemiphumela yawo yokuvikela ekuvuvukeni nasekuthuthukiseni umsebenzi wokuvimbela amathumbu.

Olunye ucwaningo olushicilelwe kumagazini iFrontiers in Microbiology lwagqamisa izakhiwo ezilwa namagciwane ze-berberine. Kuye kwatholakala ukuthi kuvimbela ukukhula kwezinhlobonhlobo zamagciwane ayingozi, kuhlanganise no-E. coli ne-salmonella. Ngokunciphisa inani lama-microorganisms we-pathogenic, i-berberine ingasiza ukulinganisa kabusha i-gut microbiome futhi ikhuthaze uhlelo olunempilo lokugaya ukudla.

Ngokungeziwe emiphumeleni yayo eqondile kuma-bacterium amathumbu, i-berberine itholakale ilawula ukukhiqizwa kwama-enzyme ahlukahlukene okugaya. Lawa ma-enzyme anesibopho sokudiliza ukudla kanye nokuqinisekisa ukumuncwa okufanele kwezakhi. Ucwaningo lubonisa ukuthi i-berberine ingathuthukisa umsebenzi wama-enzyme athile, njenge-amylase ne-lipase, ngaleyo ndlela ithuthukise ukugayeka kokudla kanye nokusetshenziswa kwezakhi.

Izithasiselo kanye Nemithamo, side Effects 

I-Berberine ingezwa empilweni yomuntu ngendlela yezithako zokudla, ezivame kakhulu i-berberine hydrochloride.

Isikali esilungile esishicilelwe:

Ukunquma isilinganiso esifanele sezithasiselo ze-berberine kungaba umsebenzi onzima. Kunezici ezimbalwa ezidlala indima ebalulekile, okuhlanganisa impilo yakho nemiphumela oyifunayo. Ngokuvamile, kunconywa ukuthi uqale nge-dose ephansi futhi kancane kancane ukwandisa umthamo ngokuhamba kwesikhathi. Ukuze uthole ukwesekwa kwezempilo okujwayelekile, izilinganiso zomthamo ezijwayelekile zingu-500 mg kuya ku-1500 mg ngosuku, zihlukaniswe ngemithamo eminingi. Kodwa-ke, kubalulekile ukuthintana nochwepheshe bezokunakekelwa kwempilo noma ulandele imihlahlandlela eqondene nomkhiqizo ngezincomo zomthamo ngamunye. 

 Qaphela imiphumela engemihle engaba khona:

Nakuba i-berberine inezinzuzo ezinhle zezempilo, kubalulekile ukucabangela imiphumela engemihle engaba khona. Njenganoma yisiphi isengezo, singase singafaneli wonke umuntu. Abanye abantu bangase babhekane nokungakhululeki kwamathumbu okufana nesifo sohudo, ukuqunjelwa, noma ubuhlungu besisu. Ukwengeza, i-berberine ingakwazi ukusebenzisana nemithi ethile, kuhlanganise naleyo eyenziwa isibindi. Ngakho-ke, kubalulekile ukubonana nochwepheshe bezempilo ngaphambi kokufaka izithasiselo ze-berberine empilweni yakho yansuku zonke.

Nakuba izithasiselo ze-berberine ziqashelwa ngezinzuzo zazo zezempilo ezingaba khona, kubalulekile ukukhumbula ukuthi impilo engcono incike kokungaphezu nje kwezithasiselo. Ukudla okulinganiselayo, ukuvivinya umzimba njalo nokulala okwanele kuyizici ezibalulekile zempilo iyonke. I-Berberine kufanele ithathwe njengesengezo sendlela yokuphila enempilo kunesixazululo esizimele sodwa.

Q: Ingabe i-berberine ingasiza ekunciphiseni isisindo?
A: Yebo, ucwaningo luye lwabonisa ukuthi i-berberine ingasiza ekwehleni kwesisindo ngokwandisa i-metabolism, ukunciphisa ukuhlangana kwamafutha, nokukhuthaza ukuwohloka kwamafutha.
Q: Ngingazithola kuphi izithasiselo ze-berberine?
A: Izithako ze-Berberine zingatholakala ezitolo zokudla zezempilo ezahlukahlukene, amakhemisi, kanye nabathengisi be-inthanethi. Bheka amabhrendi ahloniphekile ahlinzeka ngolwazi olusobala mayelana nokutholakala komkhiqizo wabo, ubumsulwa, kanye nekhwalithi.

Ukuzihlangula: Lokhu okuthunyelwe kwebhulogi kusebenza njengolwazi olujwayelekile futhi akufanele kuthathwe njengeseluleko sezokwelapha. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.

Isikhathi sokuthumela: Sep-21-2023