I-Glycerylphosphocholine Ingawathuthukisa Kanjani Amandla Engqondo Yakho?

I-Glycerylphosphocholine (GPC, eyaziwa nangokuthi i-L-alpha-glycerylphosphorylcholine noma i-alphacholine)iwumthombo ovela ngokwemvelo we-choline otholakala ekudleni okuhlukahlukene (kuhlanganise nobisi lwebele) futhi kuwo wonke amangqamuzana omuntu Kuqukethe amanani amancane we-choline. I-GPC i-molecule encibilikayo emanzini eboniswe ukuthi iwumthombo onamandla kakhulu we-choline yomtholampilo kune-choline noma i-phosphatidylcholine (i-PC) evela ekudleni noma izithasiselo.

I-GPC elawulwa ngomlomo imunca kahle futhi iqhekeke ngaphakathi kwama-enterocyte ibe i-glycerol-1-phosphate ne-choline. Ngemva kokungenisa i-GPC, amazinga e-choline ku-plasma akhuphuka ngokushesha futhi ahlala ephakeme amahora angu-10. I-high plasma concentration gradient ye-choline ikhuthaza ukuthuthwa kwayo okuphumelelayo kuwo wonke umgoqo wegazi nobuchopho. Lokhu kwandisa izitolo ze-choline ngaphakathi kwama-neurons, lapho isetshenziselwa khona ukuhlanganisa i-PC ne-acetylcholine.

Ngokwesakhiwo, i-α-GPC iyinhlanganisela ye-choline eboshwe ku-molecule ye-glycerol ngokusebenzisa iqembu le-phosphate, futhi i-choline equkethe i-phospholipid. Okuqukethwe kwe-choline kuphezulu kakhulu, kubalwa cishe nge-40%, okusho ukuthi i-1000 mg ye-α-GPC ingakhiqiza cishe i-400 mg ye-choline yamahhala.

I-Choline isakhi esibalulekile esitholakala emikhiqizweni yobisi namaqanda esiza amaseli ukuthi agcine ulwelwesi lwawo. I-Choline ngokwayo nayo iyadingeka ukwenza i-acetylcholine. Nakuba i-alpha-GPC nezinye i-choline ezifana ne-phosphatidylcholine ne-lecithin zingakhuthaza ukukhiqizwa kwe-acetylcholine, i-alpha-GPC empeleni iphakeme ngoba i-lipids ehlinzekayo empeleni yenza kube lula ukuthi amangqamuzana amunce, Ngaphezu kwe-90% ye-phosphatidylcholine idonswa yimikhumbi ye-lymphatic. , kuyilapho i-α-GPC imuncwa kakhulu umthambo we-portal, ngakho-ke ukusebenza kahle kokumuncwa kuphakeme, ngaleyo ndlela kukhuthaze ukukhiqizwa kwe-acetylcholine ngokuphumelelayo. I-Acetylcholine iyi-neurotransmitter edlala indima ebalulekile ekulawuleni ukusebenza kobuchopho nokulawulwa kwemisipha. Nakuba singadla i-choline ngokudla, inani le-acetylcholine liyancipha ngokukhula.

Izinzuzo ze-GPC Esekelwe Ocwaningweni

Ukusebenza kobuchopho

• Ithuthukisa inkumbulo, ukugxilisa ingqondo nesikhathi sokusabela kubantu abadala nabancane
• Iphromotha ukukhiqizwa nokukhululwa kwe-acetylcholine (ACh) kuma-neurons kanye nakwamanye amaseli.
• Ingase inxephezele ukwehla kwe-ACh okubangelwa ukuguga, ukuntuleka kwe-estrogen (ukunqamuka kokuya esikhathini, kanye nokusetshenziswa okungenzeka kokuvimbela inzalo ngomlomo)
• Thuthukisa amaphethini e-EEG
• Yandisa ukukhiqizwa kwe-dopamine, i-serotonin ne-GABA18.
• Thuthukisa umsebenzi we-mitochondrial ngesikhathi sokucindezeleka kwe-ischemia/oxidative
• Iphikisana nokuncipha okuhlobene neminyaka yobudala kumaseli obuchopho nezinombolo zamamukeli we-ACh, ukusebenza kwemisipha nokukhiqizwa kwe-hormone yokukhula
• Thuthukisa ukukhiqizwa kwe-hormone yokukhula kwabancane nabadala
• Ukwandisa i-oxidation yamafutha, amandla emisipha kanye nesikhathi sokuphendula, mhlawumbe ukuthuthukisa ibhalansi, ikakhulukazi kubantu abadala asebekhulile.

Ukulungisa Ubuchopho kanye Nokwesekwa kwe-Alzheimer's/Dementia

• Ithuthukisa ukululama kobuchopho ngemva kokushaywa unhlangothi, ukulimala kobuchopho okubuhlungu, kanye nezinzwa (ngaphambi nangemuva kokuhlinzwa).
• Lungisa izicubu zokuvimbela igazi ebuchosheni ezilinyazwe umfutho wegazi ophezulu
• Ithuthukisa ukuqonda kanye nokuziphatha komphakathi ku-Alzheimer's disease, ukuwohloka komqondo kwemithambo/ukuqina, kanye nesifo sika-Parkinson.
• Yehlisa ukuncipha komthamo wobuchopho okufana nesifo i-Alzheimer's
• Ingase ibe yinzuzo ezifweni ezidinga ukulungiswa kwe-myelin kanye ne-Duchenne muscular dystrophy Imisebenzi ye-Choline kumetabolism yomuntu kanye ne-GPC

Izakhiwo eziyingqayizivele njengomthombo onamandla we-choline, ibhulokhi yokwakha ye-acetylcholine kanye nento evuselela ukuhlanganiswa kwayo nokuphuma kwayo.

• I-Acetylcholine iyi-neurotransmitter ebuchosheni kanye ne-transducer yesignali kwenye indawo emzimbeni, ebaluleke kakhulu ekufinyezweni kwemisipha, ithoni yesikhumba, ukuhamba kwamathumbu, kanye neminye imisebenzi yezicubu. Ngokungafani ne-choline/PC ehlinzekwe ngokudla noma ukwesekwa, ukwesekwa kwe-GPC kuboniswe ukuthi kunomphumela obalulekile oshukumisayo ekuhlanganiseni kwe-ACh nokukhululwa kwayo kumaseli e-cholinergic.

Ukwengezwa kwe-GPC kubangela ukubonakaliswa kwe-cholinergic okuthuthukisiwe kuma-neurons namanye amaseli angase akhiqize i-acetylcholine. Lokhu kunenzuzo ikakhulukazi lapho inombolo kanye nomsebenzi osebenzayo we-cholinergic neurons kuncipha ngenxa yokuguga okuvamile noma izinqubo ezihlukahlukene zokuwohloka. Ukwengeza nge-GPC kunamandla okunxephezela kancane lokhu kuphazamiseka ngoba kubangela ukukhuphuka okusheshayo kwe-plasma choline, enomthelela oqinile we-substrate kuma-enzyme nabathuthi kule mizila.

Isakhiwo se-phosphatidylcholine (PC)

• I-PC ingeyama-phospholipids futhi iyingxenye ebalulekile yolwelwesi lwamaseli kanye nolwelwesi lwama-mitochondrial. Ikhono lokwengezwa kwe-GPC ukuze kusize ukutakula kwe-stroke, kanye nokubhekana nokuncipha okuhlobene neminyaka yobudala enanini lama-ACh receptors kumaseli ezinzwa noma ubuchopho, kuwubufakazi obengeziwe bomnikelo wayo ekunakekeleni ulwelwesi lwe-neuronal ngokusebenzisa ukuhlanganiswa kwe-PC.

Ukwakhiwa kwe-sphingomyelin

• I-Sphingomyelin iyingxenye ye-myelin sheath evala futhi ivale ama-neurons nezinzwa. Ngakho-ke, ukwesekwa kwe-GPC kungase kube usizo kunoma yisiphi isimo ngesidingo esikhulayo sokulungiswa kwe-myelin, njenge-neuropathy, i-multiple sclerosis, nezinye izimo ezihilela ukuchithwa kwe-demyelination kanye nokuzivikela komzimba kwezicubu zezinzwa. Ukuthuthwa kwamafutha ngaphakathi nangaphandle kwamaseli

• I-PC iyadingeka ekuhlanganiseni nasekukhiqizweni kwezinhlayiya ze-VLDL. I-Triglycerides ishiya isibindi ngaphakathi kwezinhlayiya ze-VLDL, okuchaza ukuthi kungani ukuntuleka kwe-choline kwandisa ingozi yesifo sesibindi esinamafutha. I-PC ingatholakala emithonjeni yokudla noma izithasiselo; Nokho, i-PC ye-phospholipids nama-lipoprotein ayitholakali ngokuqondile ku-PC edliwe noma eyenziwe ngaphambilini. Ihlanganiswe kusuka kuma-precursors e-choline ahlukahlukene (kuhlanganise ne-GPC), ngakho-ke ukufaka i-PC akuyona indlela ephumelela kakhulu yokwandisa i-PC yomzimba.
Sekela i-sperm motility

• I-GPC iyisici esibalulekile ekunamathiselweni kwe-DHA (docosahexaenoic acid), okwenza i-PC-DHA. I-DHA-PC complex isetshenziswa ezinhlotsheni zamaseli asebenza kakhulu njengamaseli azwa ukukhanya kwe-retina namaseli wesidoda. I-DHA-PC inyusa uketshezi lwe-membrane, okubalulekile ekusebenzeni kahle kwesidoda. Isidoda siqukethe ukugxila okuphezulu kwe-GPC; amaseli e-epididymal ahlakulela amaseli esidoda akhishwa echibini le-GPC futhi ahlanganise i-PC-DHA. Amazinga aphansi e-GPC kanye ne-PC-DHA esidodeni angase anyuse ingozi yokuncipha kokuhamba kwesidoda.

Ukuqhathaniswa kwe-GPC ne-Acetyl-L-Carnitine (ALCAR)

• Ocwaningweni lweziguli ezinesifo i-Alzheimer's advanced, i-GPC ibe nomphumela wokuthuthuka okukhulu kumapharamitha amaningi we-neuropsychological uma kuqhathaniswa ne-ALCAR. Nakuba zombili izinhlanganisela zisekela ukwanda kwe-acetylcholine, kucatshangwa ukuthi kungase kube nomphumela we-synergistic phakathi kokugcwalisa lezi zinhlanganisela ezimbili, njengoba i-GPC inikeza i-choline kuyilapho i-ALCAR inikeza ingxenye ye-acetyl yokuhlanganiswa kwe-acetylcholine.

Ukusebenzisana okungaba khona phakathi kwe-GPC nezidakamizwa. I-GPC supplementation akucatshangwa ukuthi iphazamisa kabi noma yimiphi imithi eklanyelwe ukuthuthukisa ukusebenza kobuchopho. Eqinisweni, ngenxa yezinzuzo zayo ezindleleni ze-cholinergic kanye nokuthuthukisa umsebenzi we-neuronal cell membrane, empeleni kungase kuthuthukise izinzuzo zabo. I-GPC ingase ithuthukise imiphumela ye-acetylcholinesterase AChE inhibitors ngoba ingase inyuse inani le-ACh ku-synaptic cleft, kuyilapho le mithi ibambezela ukuwohloka kwayo.

Ngaphezu kwalokho, ngokusho kwezifundo zezilwane, i-GPC ingase ithuthukise ukukhiqizwa kwe-dopamine, i-serotonin, noma i-GABA ebuchosheni, futhi i-GPC ingase ithuthukise imiphumela ye-reuptake inhibitors yalezi zinzwa.

I-Suzhou Myland Pharm & Nutrition Inc.ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-Alpha GPC yekhwalithi ephezulu kanye nobumsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-Alpha GPC yethu powder ihlolelwa ngokuqinile ubumsulwa namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongasethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba noma uthuthukise impilo yonke, i-Alpha GPC yethu powder iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.