I-Glycerylphosphocholine Ingawandisa Kanjani Amandla Obuchopho Bakho?

I-Glycerylphosphocholine (i-GPC, eyaziwa nangokuthi i-L-alpha-glycerylphosphorylcholine noma i-alphacholine)iwumthombo we-choline otholakala ngokwemvelo ekudleni okuhlukahlukene (kufaka phakathi ubisi lwebele) nakuwo wonke amaseli omuntu. Iqukethe inani elincane le-choline. I-GPC iyi-molecule encibilika emanzini ekhonjiswe ukuthi iwumthombo onamandla kakhulu we-choline yezokwelapha kune-choline noma i-phosphatidylcholine (PC) evela ekudleni noma ezithasiselo.

I-GPC enikezwa ngomlomo imuncwa kahle futhi iqhekeka ngaphakathi kwama-enterocyte ibe yi-glycerol-1-phosphate kanye ne-choline. Ngemva kokungenisa i-GPC, amazinga e-choline ku-plasma akhuphuka ngokushesha futhi ahlala ephezulu amahora ayi-10. Ukuphakama okuphezulu kwe-plasma ye-choline kukhuthaza ukuthutha kwayo okuphumelelayo ngaphesheya kwesithiyo segazi-ubuchopho. Lokhu kwandisa izitolo ze-choline ngaphakathi kwama-neurons, lapho isetshenziselwa khona ukuhlanganisa i-PC kanye ne-acetylcholine.

Ngokwesakhiwo, i-α-GPC iyinhlanganisela ye-choline eboshwe ku-molecule ye-glycerol ngeqembu le-phosphate, futhi iyi-choline equkethe i-phospholipid. Okuqukethwe kwe-choline kuphezulu kakhulu, okulinganiselwa cishe ku-40%, okusho ukuthi i-1000 mg ye-α-GPC ingakhiqiza cishe i-400 mg ye-choline yamahhala.

I-Choline iyisakhi esibalulekile esitholakala emikhiqizweni yobisi nasemaqandeni esiza amangqamuzana ukuba alondoloze ulwelwesi lwawo. I-Choline ngokwayo iyadingeka futhi ekwenzeni i-acetylcholine. Ngenkathi i-alpha-GPC kanye namanye ama-choline afana ne-phosphatidylcholine ne-lecithin kungakhuthaza ukukhiqizwa kwe-acetylcholine, i-alpha-GPC empeleni ingcono ngoba amafutha enikezayo empeleni enza kube lula ngamaseli ukumunca. Ngaphezu kwama-90% e-phosphatidylcholine amuncwa yimithambo ye-lymphatic, kuyilapho i-α-GPC imuncwa kakhulu yi-portal vein, ngakho-ke ukusebenza kahle kokumunca kuphakeme, ngaleyo ndlela kukhuthaza ukukhiqizwa kwe-acetylcholine ngempumelelo enkulu. I-Acetylcholine iyi-neurotransmitter edlala indima ebalulekile ekulawuleni ukusebenza kobuchopho kanye nokulawula imisipha. Nakuba singadla i-choline ngokudla, inani le-acetylcholine liyancipha ngokuguga.

Izinzuzo ze-GPC Esekelwe Ocwaningweni

Umsebenzi wobuchopho

• Kuthuthukisa inkumbulo, ukugxilisa ingqondo kanye nesikhathi sokusabela kubantu abadala nabasebasha
• Ikhuthaza ukukhiqizwa nokukhululwa kwe-acetylcholine (ACh) kuma-neurons kanye nakwamanye amaseli.
• Kunganciphisa ukwehla kwe-ACh okubangelwa ukuguga, ukuntuleka kwe-estrogen (ukunqamuka kokuya esikhathini, kanye nokusetshenziswa kokuvimbela inzalo ngomlomo)
• Thuthukisa amaphethini e-EEG
• Kwandisa ukukhiqizwa kwe-dopamine, i-serotonin kanye ne-GABA18.
• Thuthukisa ukusebenza kwe-mitochondrial ngesikhathi sokucindezeleka kwe-ischemia/oxidative
• Ilwa nokwehla okuhlobene nobudala kwezinombolo zamaseli obuchopho kanye nama-ACh receptor, ukusebenza kwemisipha kanye nokukhiqizwa kwama-hormone okukhula
• Khuthaza ukukhiqizwa kwama-hormone okukhula kubantu abadala abasebasha nabadala
• Kwandisa ukushiswa kwamafutha, amandla emisipha kanye nesikhathi sokusabela, mhlawumbe kuthuthukisa ibhalansi, ikakhulukazi kubantu abadala.

Ukulungiswa Kobuchopho kanye Nokusekelwa Kwe-Alzheimer's/Dementia

• Kuthuthukisa ukululama kobuchopho ngemva kokushaywa yisifo sohlangothi, ukulimala kobuchopho okubuhlungu, kanye nokubulala izinzwa (ngaphambi nangemva kokuhlinzwa).
• Lungisa izicubu ezivimbela igazi ebuchosheni ezonakele ngenxa yomfutho wegazi ophakeme
• Kuthuthukisa ukuqonda kanye nokuziphatha komphakathi kwisifo i-Alzheimer's, i-vascular/senile dementia, kanye nesifo i-Parkinson's.
• Yehlisa ukuncipha komthamo wobuchopho okufana nesifo i-Alzheimer's
• Kungaba wusizo ezifweni ezidinga ukulungiswa kwe-myelin kanye ne-Duchenne muscular dystrophy Imisebenzi ye-Choline ku-metabolism yomuntu kanye ne-GPC

Izakhiwo eziyingqayizivele njengomthombo onamandla we-choline, isakhi se-acetylcholine kanye nento evuselela ukwakheka kwayo kanye nokukhishwa kwayo.

• I-Acetylcholine iyi-neurotransmitter ebuchosheni kanye ne-signal transducer kwenye indawo emzimbeni, ebalulekile ekuqineni kwemisipha, ithoni yesikhumba, ukunyakaza kwesisu, kanye neminye imisebenzi yezicubu. Ngokungafani ne-choline/PC enikezwa ngokudla noma ngokunezela, ukunezela kwe-GPC kuboniswe ukuthi kunomphumela obalulekile wokuvuselela ekwakhiweni kwe-ACh kanye nokukhululwa kwayo kumaseli e-cholinergic.

Ukwengezwa kwe-GPC kuphumela ekuthuthukisweni kokudluliselwa kwe-cholinergic kuma-neurons nakwamanye amaseli angakhiqiza i-acetylcholine. Lokhu kuzuzisa kakhulu lapho inani kanye nomsebenzi osebenzayo wama-neuron e-cholinergic wehliswa ngenxa yokuguga okuvamile noma izinqubo ezahlukahlukene zokuwohloka. Ukwengezwa kwe-GPC kunamandla okulungisa lokhu kuphazamiseka kancane ngoba kubangela ukwanda okusheshayo kwe-plasma choline, okunomthelela omkhulu we-substrate kuma-enzyme kanye nabathuthi kulezi zindlela.

Isakhiwo se-phosphatidylcholine (PC)

• I-PC ingeye-phospholipids futhi iyisici esibalulekile se-membrane yamaseli kanye ne-mitochondrial membranes. Amandla okwengeza i-GPC ukusiza ukululama kwesifo sohlangothi, kanye nokulwa nokwehla okuhlobene nobudala kwenani lama-ACh receptors kumaseli ezinzwa noma ebuchosheni, kuwubufakazi obengeziwe bomnikelo wayo ekugcinweni kwe-membrane ye-neuronal ngokuhlanganiswa kwe-PC.

Ukwakheka kwe-sphingomyelin

• I-Sphingomyelin iyisakhi se-myelin sheath esimboza futhi sivikele ama-neurons nezinzwa. Ngakho-ke, ukwengezwa kwe-GPC kungaba usizo kunoma yisiphi isimo lapho kunesidingo esikhulu sokulungiswa kwe-myelin, njenge-neuropathy, i-multiple sclerosis, nezinye izimo ezihilela ukususwa kwe-myelin kanye nokuzivikela komzimba kwezicubu zezinzwa. Ukuthuthwa kwamafutha ngaphakathi nangaphandle kwamaseli

• I-PC iyadingeka ukuze kuhlanganiswe futhi kukhiqizwe izinhlayiya ze-VLDL. Ama-Triglycerides ashiya isibindi ngaphakathi kwezinhlayiya ze-VLDL, okuchaza ukuthi kungani ukuntuleka kwe-choline kwandisa ingozi yesifo sesibindi esinamafutha. I-PC ingatholakala emithonjeni yokudla noma ezithasiseleni; noma kunjalo, i-PC yama-phospholipid nama-lipoprotein ayitholakali ngqo kwi-PC egwinyiwe noma eyenziwe ngaphambilini. Yenziwa ngezinto ezahlukahlukene ze-choline (kufaka phakathi i-GPC), ngakho-ke ukudla i-PC akuyona indlela ephumelela kakhulu yokwandisa i-PC pool yomzimba.
Sekela ukunyakaza kwesidoda

• I-GPC iyisici esibalulekile ekunamatheleni kwe-DHA (i-docosahexaenoic acid), okwenza i-PC-DHA. I-DHA-PC complex isetshenziswa ezinhlotsheni zamaseli asebenza kakhulu njengamaseli azwa ukukhanya kwe-retinal kanye namaseli esidoda. I-DHA-PC yandisa ukugeleza kwe-membrane, okubalulekile ekusebenzeni kahle kwesidoda. Isidoda siqukethe amazinga aphezulu e-GPC; amaseli e-epididymal akhulisa amaseli esidoda akhishwa echibini le-GPC futhi ahlanganise i-PC-DHA. Amazinga aphansi e-GPC kanye ne-PC-DHA esidoda angandisa ingozi yokuncipha kokunyakaza kwesidoda.

Ukuqhathaniswa kwe-GPC ne-Acetyl-L-Carnitine (ALCAR)

• Ocwaningweni lweziguli ezinesifo i-Alzheimer's esithuthukile, i-GPC iholele ekuthuthukisweni okukhulu kwemingcele eminingi ye-neuropsychological uma kuqhathaniswa ne-ALCAR. Nakuba zombili lezi zinhlanganisela zisekela ukwanda kwe-acetylcholine, kungenzeka ukuthi kungaba nomphumela wokubambisana phakathi kokwengeza lezi zinhlanganisela ezimbili, njengoba i-GPC inikeza i-choline kuyilapho i-ALCAR inikeza ingxenye ye-acetyl yokwenziwa kwe-acetylcholine.

Ukusebenzisana okungenzeka phakathi kwe-GPC nezidakamizwa. Akucatshangwa ukuthi ukwengezwa kwe-GPC kuphazamisa kabi noma yimiphi imithi eyenzelwe ukuthuthukisa ukusebenza kobuchopho. Eqinisweni, ngenxa yezinzuzo zayo ezindleleni ze-cholinergic kanye nokuthuthukisa ukusebenza kwe-neuronal cell membrane, empeleni kungathuthukisa izinzuzo zayo. I-GPC ingathuthukisa imiphumela ye-acetylcholinesterase AChE inhibitors ngoba ingandisa inani le-ACh ku-synaptic cleft, kuyilapho le mithi inciphisa ukuwohloka kwayo.

Ngaphezu kwalokho, ngokusho kwezifundo zezilwane, i-GPC ingathuthukisa ukukhiqizwa kwe-dopamine, i-serotonin, noma i-GABA ebuchosheni, kanti i-GPC ingathuthukisa imiphumela yezithiyo zokuphinda zithathe lezi zinzwa.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu ye-Alpha GPC esezingeni eliphezulu futhi emsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu ye-Alpha GPC ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu ye-Alpha GPC iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.