Njengamanje, kunezithako ezingenakubalwa emakethe, ngasinye sithembisa ukuthuthukisa impilo yakho ngandlela thize. Ngezinketho eziningi ongakhetha kuzo, ukuthola ukuthi yisiphi isengezo esilungele imigomo yakho yezempilo ethile kungaba nzima. Uma ukuthuthukisa impilo yakho iyonke kuwukukhathazeka kwakho okuyinhloko, khona-ke ungase uthande ukucabangela ukwengeza isithasiselo se-deazaflavin esimisweni sakho sansuku zonke. I-Deazaflavin iyinhlanganisela yemvelo ekhonjiswe ukuthi inezinzuzo eziningi zezempilo, okuhlanganisa ukuthuthukisa impilo yenhliziyo nemithambo yegazi, ukwandisa amazinga wamandla, nokusekela impilo yonke.
I-Deazaflavin, eyaziwa nangokuthi i-5-deazaflavin, inokwakheka okufanayo ne-flavin, kodwa ukwakheka kwayo kwamakhemikhali kushintshile uma kuqhathaniswa ne-flavin evamile. Lokhu kuguqulwa kuhilela ukukhishwa kwe-athomu ye-nitrogen eringini ye-flavin, okuholela ku-"denitrified" (okusho ukuthi "i-nitrogen-deficient") i-molecule ye-flavin. Lolu shintsho lunikeza i-deazaflavin izici zamakhemikhali eziyingqayizivele ezihlukanisa namanye ama-flavin. Ucwaningo luye lwabonisa ukuthi i-5-deazaflavin ingakhiqiza ama-radicals mahhala asebenzayo, anamandla aphansi we-5-deazaflavin lapho kukhona ukuvuswa kokukhanya kanye nabanikela ngama-electron (njengotshwala, ama-amine, njll.).
Enye ye-deazaflavin eyaziwa kakhulu i-riboflavin (uvithamini B2), isakhi esibalulekile esidlala indima ebalulekile ekukhiqizeni amandla omzimba kanye ne-metabolism. I-Riboflavin ingumanduleli we-coenzyme i-flavin mononucleotide (FMN) ne-flavin adenine dinucleotide (FAD), ebamba iqhaza ekuphenduleni okuhlukahlukene kwe-enzymatic, ikakhulukazi uchungechunge lokuthutha lwama-electron lokuphefumula kwamaselula. Ngakho-ke, i-riboflavin kanye nokuphuma kwayo kubalulekile ekugcineni impilo nempilo yonke.
Izithasiselo ze-Deazaflavin ziyinhlanganisela ene-antioxidant ne-anti-inflammatory properties, ezenza zibe isikhuthazo esingaba khona sokusekela impilo nokuphila kahle. Lezi zithako kucatshangwa ukuthi zisiza ukukhulisa amazinga wamandla, ukusekela imetabolism enempilo, futhi kukhuthaze impilo yenhliziyo nemithambo yegazi.
Enye yezinzuzo eziyinhloko zezithako ze-deazaflavin yikhono labo lokulwa nokucindezeleka okwenziwe nge-oxidative emzimbeni. Ukucindezeleka kwe-oxidative kwenzeka lapho kunokungalingani phakathi kwama-radicals mahhala nama-antioxidants emzimbeni, okubangela ukulimala kwamangqamuzana nezicubu.
Ama-Deazaflavin ayikilasi lamakhompiyutha ahlobene ngokwesakhiwo ne-riboflavin (eyaziwa nangokuthi uvithamini B2). Lezi zinhlanganisela zidlala indima ebalulekile ezinqubweni ezihlukahlukene ze-metabolic, okuhlanganisa ukukhiqizwa kwe-adenosine triphosphate (ATP), umthombo wamandla oyinhloko wengqamuzana. Kukholakala ukuthi izithasiselo ze-deazaflavin zithuthukisa ukukhiqizwa kwe-ATP ngokusekela umsebenzi wama-enzyme abalulekile abandakanyeka kumetabolism yamandla.
Izithako ze-Deazaflavins zinamandla okuthuthukisa ukusebenza kwe-mitochondrial. I-Mitochondria iyisizinda samandla seseli futhi inesibopho sokukhiqiza i-ATP ngenqubo ye-oxidative phosphorylation. I-Deazaflavin ikhonjiswe ukuthi yandisa ukusebenza kahle kwale nqubo, ngaleyo ndlela yandisa ukukhiqizwa kwamandla kanye nokwenza ngcono ukusebenza kwamaseli. I-Deazaflavin kucatshangwa ukuthi isusa ama-radicals mahhala futhi inciphise umonakalo we-oxidative, ngaleyo ndlela ikhuthaze ukuguga okunempilo futhi yehlise ingozi yezifo ezihlobene neminyaka.
Ngaphezu kwalokho, izithasiselo ze-deazaflavin zitholakale zishintsha umsebenzi wama-sirtuin, umndeni wamaprotheni ahilelekile ekulawuleni umzimba weselula, ukulungiswa kwe-DNA, kanye nezimpendulo zokucindezeleka. Ama-Sirtuin ayaziwa ukuthi adlala indima ebalulekile enqubweni yokuguga futhi umsebenzi wawo ungase uthintwe yizinhlobonhlobo zezinhlanganisela, kuhlanganise ne-deazaflavin. Ngokuvula ama-enzyme e-sirtuin, izithako ze-deazaflavin zingakhuthaza impilo ende kanye nempilo yonke.
I-Deazalavin, eyaziwa nangokuthi i-riboflavin 5-deazaflavin, iwuhlobo lukavithamini B2 olubalulekile ekugcineni impilo yonke. Idlala indima ebalulekile ekukhiqizweni kwamandla, ekusetshenzisweni kwe-metabolism, nasekugcineni isikhumba, iso, kanye nempilo yesistimu yezinzwa. I-Deazalavin ivame ukutholakala ekudleni okunjengobisi, amaqanda, inyama, nemifino eluhlaza, futhi iyatholakala njengesengezo kulabo okungenzeka ukuthi bayantula noma abafuna ukwandisa amazinga abo.
I-NMN, ngakolunye uhlangothi, iphuma ku-niacin, eyaziwa nangokuthi i-vitamin B3, kanye nesandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ehilelekile ezinqubweni ezihlukahlukene zamaselula, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA kanye nokubonakaliswa kofuzo. I-NMN ithole ukunakwa okusabalele ngemiphumela yayo engaba khona yokulwa nokuguga, njengoba iboniswe ukwandisa amazinga e-NAD+ ezicutshini ezihlukahlukene futhi iye yahlotshaniswa nokusebenza okuthuthukisiwe kwe-metabolic kanye nokuphila okuthuthukisiwe ezifundweni zezilwane.
Ngakho-ke, uyini umehluko phakathi kwe-Deazaflavin ne-NMN? Omunye umehluko omkhulu yindlela asebenza ngayo emzimbeni. Umsebenzi oyinhloko we-Deazaflavin unjenge-coenzyme, esiza ekukhiqizeni amandla kanye ne-metabolism, kuyilapho i-NMN iyisandulela se-NAD+, edlala indima ebanzi ekusebenzeni kwamaseli futhi ihlobene nenqubo yokuguga. Ngaphezu kwalokho, lezi zinhlanganisela ezimbili zinezakhiwo zamakhemikhali ezihlukene futhi zicutshungulwa ngendlela ehlukile emzimbeni, kanti i-NMN iyisandulela esiqondile se-NAD+.
Mayelana nezinzuzo ezingaba khona, kokubili i-Deazaflavin ne-NMN kuxhunyaniswe namazinga athuthukisiwe wamandla kanye nokusebenza kwe-metabolic, okungase kube nenzuzo ikakhulukazi kubantu abafuna ukusekela impilo yonke namandla. Kodwa-ke, imiphumela engaba khona yokulwa nokuguga ye-NMN iyenze yanda kakhulu, njengoba ucwaningo lubonisa ukuthi ukukhuphuka kwamazinga e-NAD+ kungasiza ekwehliseni ukwehla okuhlobene nobudala nokwelula isikhathi sokuphila.
Ukukhetha phakathi kwe-Deazaflavin ne-NMN kungase kuncike ezinhlosweni zezempilo zomuntu ngamunye kanye nokukhathazeka. Kulabo abafuna ngokuyinhloko ukusekela ukukhiqizwa kwamandla kanye nempilo yonke, i-Deazaflavin ingase ibe inketho efanelekile, ikakhulukazi kulabo abanokukhubazeka okwaziwayo noma imikhawulo yokudla engase ithinte ukuthathwa kwe-vitamin B2. Ngakolunye uhlangothi, abantu abanentshisekelo yezinzuzo ezingaba khona zokulwa nokuguga kanye nokukhuthaza impilo yamaselula bangathola i-NMN inketho ephoqelelayo, uma kubhekwa indima yayo ekwandiseni amazinga e-NAD+ kanye nobudlelwano bayo nokuphila isikhathi eside.
Izinzuzo ze-5-deazaflavin ngaphezu kwe-NMN
I-5-Deazaflavin kanye ne-NMN powder ziyizandulela ezibalulekile ze-NAD + futhi zidlala indima ebalulekile ku-cell metabolism. Nokho, uma kuqhathaniswa ne-NMN,5-deazaflavin inezinzuzo ezilandelayo:
1. Ukuzinza: i-5-deazaflavin itholakale izinzile kune-NMN. Lokhu kusho ukuthi igcina ukusebenza kwayo isikhathi eside, okuyenza ibe inketho ethembeke kakhudlwana kulabo abafuna ukuyifaka ekuphileni kwabo kwansuku zonke. Ukuzinza kwe-5-deazaflavin nakho kwenza kube lula ukuyigcina nokuyihambisa, kuyenze ibe ngcono kune-NMN ngokufanele.
2. Ukutholakala: Uma kuqhathaniswa ne-NMN, i-5-deazaflavin iboniswe inokutholakala okuphezulu kwe-bioavailability. Lokhu kusho ukuthi ingxenye enkulu ye-5-deazaflavin idonswa ngumzimba, okuholela emphumeleni ocacile. Ngokutholakala okukhulu kwe-bioavailability, abantu ngabanye bangathola izinzuzo ze-5-deazaflavin ngokushesha nangemithamo ephansi kune-NMN.
3. Amandla e-Redox:5-deazaflavin anamandla okuphindaphinda amabi kakhulu kune-NMN, ayenza ibambe iqhaza ohlangeni olubanzi lokusabela kwamakhemikhali e-biochemical.
4. Ukuhambisana: I-5-deazaflavin igcwalisa amanye ama-coenzymes, njenge-flavin ne-nicotinamide, okwenza i-cell metabolism iphelele futhi iphumelele nakakhulu.
5. Izakhiwo ze-Photocatalytic: i-5-deazaflavin iboniswe ukuthi inezici ze-photocatalytic futhi ingase ibe nezinhlelo zokusebenza ezingaba khona ezimbonini eziningi.
I-6.5-Deazaflavin ikhonjiswe ukuthi yenza kusebenze ama-sirtuin, iqembu lamaprotheni adlala indima ebalulekile ekulawuleni impilo yeselula nempilo yokuphila. Ngokusebenzisa ama-sirtuin, i-5-deazaflavin ingasiza ekukhuthazeni ukulungiswa kwamaseli futhi ithuthukise impilo yonke ezingeni lamaselula. I-NMN, ngakolunye uhlangothi, isebenza ngokuyinhloko ngokukhuphula amazinga e-NAD+, i-molecule ehilelekile ezinqubweni ezihlukahlukene zamaselula kodwa ayiwasebenzisi ngokuqondile ama-Sirtuins.
Ngokuvamile, i-5-deazaflavin powder kancane kancane ibe enye indlela evelayo ku-NMN futhi inamandla amakhulu. Ngokungafani ne-NMN, isebenza ngokuqondile njenge-coenzyme ngaphandle kokuguqulwa ku-NAD +.Le ndawo eyingqayizivele yenza iphumelele kakhulu kune-NMN, nemibiko ethi i-5-deazaflavin powder inamandla izikhathi ezingu-40 kuya kwezingu-100 kune-NMN. Ngakho-ke, kuthathwa njengokuthembisayo esikhundleni sesizukulwane esilandelayo se-NMN.
1. Sekela ukukhiqizwa kwamandla
Enye yezinzuzo eziyinhloko zezithako ze-deazaflavin indima yazo ekusekeleni ukukhiqizwa kwamandla emzimbeni. I-Deazaflavin idlala indima ebalulekile ekukhiqizeni i-ATP, imali eyinhloko yengqamuzana yamandla. Ngokwandisa ukukhiqizwa kwe-ATP, izithasiselo ze-deazaflavin zingasiza ukukhulisa amazinga wamandla wonkana futhi kulwe nemizwa yokukhathala nokukhathala.
2. Izakhiwo ze-Antioxidant
Ama-Antioxidants ayizinhlanganisela ezisiza ukunciphisa ama-radicals mahhala ayingozi emzimbeni anomthelela ekugugeni nasezifweni. Ngokusebenza njenge-antioxidant, izithako ze-deazaflavin zingasiza ukuvikela umzimba ekucindezelekeni kwe-oxidative futhi kunciphise ingozi yezifo ezingapheli njengesifo senhliziyo nesifo sikashukela.
3. Isekela impilo yesistimu yezinzwa.
I-Deazaflavin idlala indima ebalulekile ekukhiqizeni ama-neurotransmitters, izithunywa zamakhemikhali ezivumela amangqamuzana ezinzwa ukuthi axhumane. Ngokusekela ukukhiqizwa kwama-neurotransmitters, izithasiselo ze-deazaflavin zingasiza ekuthuthukiseni ukusebenza kwengqondo, imizwa, kanye nempilo yengqondo iyonke.
4. Isekela impilo yenhliziyo nemithambo yegazi.
I-Deazaflavin ikhonjiswe ukuthi isekela ukugeleza kwegazi okunempilo futhi ingasiza ekwehliseni ubungozi bomfutho wegazi ophakeme nesifo senhliziyo nemithambo yegazi. Ngokukhuthaza ukugeleza kwegazi okunempilo, izithako ze-Deazaflavin zingasiza futhi ukuthuthukisa ukusebenza kwezemidlalo futhi zisekele ukukhuthazela komzimba jikelele.
5. Sekela umsebenzi wokuzivikela komzimba
Ucwaningo lubonisa ukuthi i-deazaflavin ingasiza ekulawuleni amasosha omzimba futhi ingasiza ekusekeleni impendulo enempilo yokuzivikela komzimba. Ngokusekela umsebenzi wokuzivikela komzimba, izithako ze-deazaflavin zingasiza ukunciphisa ingozi yokutheleleka futhi zisekele impilo yonke.
6. Anti-ukuguga
Ucwaningo luthole ukuthi i-5-deazaflavin iyasebenza izikhathi eziyi-100 kune-NMN futhi ingasiza kangcono ukulungisa i-DNA nokulwa nokuguga.
Ukuthola isithasiselo esilungile se-deazaflavin kubalulekile ekuqinisekiseni ukuthi uthola umkhiqizo osezingeni eliphezulu nosebenza ngempumelelo.
Okokuqala, kubalulekile ukucabangela umthombo wesithasiselo sakho se-deazaflavin. Bheka inkampani enedumela elihle esebenzisa izithako zekhwalithi ephezulu futhi esobala mayelana nezinqubo zayo zokuthola nokukhiqiza. Funda ukubuyekezwa kwamakhasimende futhi wenze ucwaningo ngenkampani ukuze uqiniseke ukuthi banegama elihle embonini. Ukwengeza, kuyazuzisa ukukhetha izithasiselo eziye zahlolelwa ukuhlanzeka namandla.
Lapho ukhetha isengezo se-deazaflavin, kubalulekile futhi ukucabangela uhlobo lwesithasiselo. Abanye abantu bangase bathande amaphilisi noma amaphilisi, kanti abanye bangase bakhethe uhlobo lwempushana. Lapho uthatha isinqumo ngefomu lokwengeza, cabangela izinto ozikhethayo kanye nendlela yokuphila. Khumbula ukuthi izinhlobo ezahlukene zezithasiselo zingase zibe namazinga ahlukene okumuncwa kanye ne-bioavailability.
Esinye isici esibalulekile okufanele sicatshangelwe lapho ukhetha isengezo se-deazaflavin umthamo. Umthamo ofanelekile ungahluka ngokuya ngezinto ezifana neminyaka, isisindo, kanye nempilo iyonke. Kungcono ukubonana nochwepheshe bezokunakekelwa kwempilo noma isazi sokudla ukuze uthole umthamo ofanele wezidingo zakho. Gwema ukuthatha izithasiselo zomthamo ophezulu kakhulu njengoba zingase zingadingeki futhi zingadala imiphumela emibi.
Ngaphezu komthamo, kubalulekile futhi ukubheka isithasiselo se-deazaflavin esingaqukethe izithasiselo ezingadingekile noma izigcwalisi. Izithasiselo eziningi emakethe ziqukethe imibala yokwenziwa, izilondolozi, nezinto ezingezwani nomzimba ezingaba yingozi empilweni yakho. Bheka izithasiselo ezihlanzekile, ezimsulwa, futhi ezinezithako ezincane ezingeziwe.
Inkampani engu-Suzhou Myland Pharm & Nutrition Inc.ibambe iqhaza ebhizinisini lezithako zokudla okunomsoco kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Umbuzo: Iyini isengezo se-deazaflavin futhi singazizuzisa kanjani izinjongo zami zezempilo?
A: I-Deazaflavin iyinhlanganisela esekela imisebenzi ehlukahlukene ye-metabolic emzimbeni, okuhlanganisa ukukhiqizwa kwamandla kanye nempilo yamaselula. Ingasekela inhlalakahle iyonke futhi isize ngezinjongo ezithile zezempilo ezifana namazinga athuthukisiwe wamandla nokwesekwa kwe-antioxidant.
Q: Ngisikhetha kanjani isithasiselo se-deazaflavin esifanele ngezidingo zami?
A: Uma ukhetha isithasiselo se-deazaflavin, kubalulekile ukucabangela izici ezifana nekhwalithi, ukuhlanzeka, namandla. Bheka uhlobo oluthembekile olusebenzisa izithako zekhwalithi ephezulu futhi olunokuhlolwa okuvela eceleni ukuze uqinisekise amandla nobumsulwa. Ukwengeza, cabangela imigomo yakho yezempilo ethile futhi ubheke isengezo esakhelwe ukusekela leyo migomo.
Q: Kuthatha isikhathi esingakanani ukubona imiphumela yokuthatha isithasiselo se-deazaflavin?
IMP: Isikhathi esisithathayo ukubona imiphumela yokuthatha isithasiselo se-deazaflavin singahluka kuye ngezici ngazinye njengempilo iyonke, ukudla, nendlela yokuphila. Abanye abantu bangase baqaphele ukuthuthuka kumazinga wamandla kanye nempilo yonke ngokushesha uma kuqhathaniswa, kuyilapho abanye kungase kuthathe isikhathi eside ukuze bathole izinzuzo ezigcwele. Kubalulekile ukuhambisana nokuthatha isithasiselo njengoba kuyalelwe futhi usinikeze isikhathi sokusebenza.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Jan-17-2024
