Njengamanje, kunezithako eziningi emakethe, ngasinye sithembisa ukuthuthukisa impilo yakho ngandlela thile. Njengoba kunezinketho eziningi ongakhetha kuzo, ukuthola ukuthi yisiphi isithako esilungele imigomo yakho ethile yezempilo kungaba nzima kakhulu. Uma ukuthuthukisa impilo yakho iyonke kuyindaba yakho eyinhloko, khona-ke ungase uthande ukucabanga ngokufaka isithako se-deazaflavin ohlelweni lwakho lwansuku zonke. I-Deazaflavin iyinhlanganisela yemvelo ekhonjiswe ukuthi inezinzuzo eziningi zezempilo, okuhlanganisa ukuthuthukisa impilo yenhliziyo nemithambo yegazi, ukwandisa amazinga amandla, kanye nokusekela impilo iyonke.
I-Deazaflavin, eyaziwa nangokuthi i-5-deazaflavin, inesakhiwo esifana ne-flavin, kodwa isakhiwo sayo samakhemikhali sishintshile uma siqhathaniswa ne-flavin evamile. Lokhu kuguqulwa kuhilela ukususwa kwe-athomu ye-nitrogen eringini ye-flavin, okuholela ku-molecule ye-flavin "engashintshiwe" (okusho ukuthi "engenayo i-nitrogen"). Lolu shintsho lunikeza i-deazaflavin izakhiwo zamakhemikhali ezihlukile ezihlukanisa namanye ama-flavin. Izifundo zibonise ukuthi i-5-deazaflavin ingakhiqiza ama-free radicals asebenzayo kakhulu, anamandla aphansi e-5-deazaflavin lapho kukhona ukukhanya okuvusayo kanye nabanikeli bama-electron (njenge-alcohols, ama-amine, njll.).
Enye ye-deazaflavin eyaziwa kakhulu yi-riboflavin (i-vitamin B2), isakhi esibalulekile esidlala indima ebalulekile ekukhiqizweni kwamandla emzimbeni kanye nokusetshenziswa kwe-metabolism. I-Riboflavin iyisandulela se-coenzyme flavin mononucleotide (FMN) kanye ne-flavin adenine dinucleotide (FAD), ehlanganyela ekuphenduleni okuhlukahlukene kwe-enzyme, ikakhulukazi uchungechunge lokuthuthwa kwama-electron lokuphefumula kwamaseli. Ngakho-ke, i-riboflavin kanye nezinto eziphuma kuyo zibalulekile ekugcineni impilo nokuphila kahle.
Izithako ze-Deazaflavin ziyizakhi ezinezici ze-antioxidant kanye ne-anti-inflammatory, okwenza zibe yisisusa esingaba khona sokusekela impilo yonke kanye nenhlalakahle. Lezi zithako kucatshangwa ukuthi zisiza ukwandisa amazinga amandla, zisekele imetabolism enempilo, futhi zikhuthaze impilo yenhliziyo nemithambo yegazi.
Enye yezinzuzo eziyinhloko zezithako ze-deazaflavin yikhono lazo lokulwa nokucindezeleka kwe-oxidative emzimbeni. Ukucindezeleka kwe-oxidative kwenzeka lapho kunokungalingani phakathi kwama-free radicals nama-antioxidants emzimbeni, okubangela umonakalo kumaseli nezicubu.
Ama-Deazaflavin ayisigaba samakhemikhali ahlobene ne-riboflavin (eyaziwa nangokuthi i-vitamin B2). Lawa makhemikhali adlala indima ebalulekile ezinqubweni ezahlukene ze-metabolic, okuhlanganisa ukukhiqizwa kwe-adenosine triphosphate (ATP), umthombo wamandla oyinhloko weseli. Kukholelwa ukuthi izithako ze-deazaflavin zithuthukisa ukukhiqizwa kwe-ATP ngokusekela umsebenzi wama-enzyme abalulekile ahilelekile ekusetshenzisweni kwamandla.
Izithasiselo ze-Deazaflavin zinekhono lokuthuthukisa ukusebenza kwe-mitochondrial. I-Mitochondria iyisigungu samandla eseli futhi inesibopho sokukhiqiza i-ATP ngenqubo ye-oxidative phosphorylation. I-Deazaflavin iboniswe ukuthi ikhulisa ukusebenza kahle kwale nqubo, ngaleyo ndlela ikhulisa ukukhiqizwa kwamandla futhi ithuthukise ukusebenza kweseli. I-Deazaflavin kucatshangwa ukuthi isusa ama-free radicals futhi inciphise umonakalo we-oxidative, ngaleyo ndlela ikhuthaza ukuguga okunempilo futhi inciphise ingozi yezifo ezihlobene nokuguga.
Ngaphezu kwalokho, izithako ze-deazaflavin zitholakale zilawula umsebenzi we-sirtuins, umndeni wamaprotheni ahilelekile ekulawuleni i-metabolism yamaseli, ukulungiswa kwe-DNA, kanye nezimpendulo zokucindezeleka. Ama-Sirtuins aziwa ngokudlala indima ebalulekile enkambisweni yokuguga futhi umsebenzi wawo ungathinteka yizinhlobo ezahlukene zamakhemikhali, okuhlanganisa ne-deazaflavin. Ngokusebenzisa ama-enzyme e-sirtuin, izithako ze-deazaflavin zingakhuthaza impilo ende kanye nempilo iyonke.
I-Deazalavin, eyaziwa nangokuthi i-riboflavin 5-deazaflavin, iwuhlobo lwe-vitamin B2 olubalulekile ekugcineni impilo iyonke. Idlala indima ebalulekile ekukhiqizweni kwamandla, ekugayweni kwe-metabolism, nasekulondolozeni impilo yesikhumba, amehlo, kanye nesistimu yezinzwa. I-Deazalavin ivame ukutholakala ekudleni okufana nobisi, amaqanda, inyama, kanye nemifino eluhlaza enamaqabunga, futhi iyatholakala futhi njengesengezo kulabo abangase babe nokuntuleka noma abafuna ukwandisa amazinga abo.
Ngakolunye uhlangothi, i-NMN iyi-derivative ye-niacin, eyaziwa nangokuthi i-vitamin B3, futhi iyisandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ehilelekile ezinqubweni ezahlukahlukene zamaseli, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA kanye nokubonakaliswa kwezakhi zofuzo. I-NMN ithole ukunakwa kabanzi ngemiphumela yayo engaba khona yokulwa nokuguga, njengoba iboniswe ukuthi ikhulisa amazinga e-NAD+ ezicutshini ezahlukahlukene futhi ihlotshaniswa nokusebenza okuthuthukisiwe kwe-metabolic kanye nokuphila okuthuthukisiwe ezifundweni zezilwane.
Ngakho-ke, umehluko uyini phakathi kwe-Deazaflavin ne-NMN? Omunye umehluko omkhulu ukuthi zisebenza kanjani emzimbeni. Umsebenzi oyinhloko we-Deazaflavin uyi-coenzyme, esiza ekukhiqizweni kwamandla kanye nokusetshenziswa kwe-metabolism, kuyilapho i-NMN iyisandulela se-NAD+, edlala indima ebanzi ekusebenzeni kweseli futhi ihlobene nenqubo yokuguga. Ngaphezu kwalokho, la ma-compound amabili anezakhiwo zamakhemikhali ezahlukene futhi acutshungulwa ngendlela ehlukile emzimbeni, kanti i-NMN iyisandulela esiqondile se-NAD+.
Ngokuphathelene nezinzuzo ezingaba khona, kokubili i-Deazaflavin ne-NMN kuhlotshaniswa namazinga athuthukisiwe wamandla kanye nomsebenzi we-metabolic, okungaba yinzuzo ikakhulukazi kubantu abafuna ukusekela impilo yonke kanye namandla. Kodwa-ke, imiphumela engaba khona yokulwa nokuguga ye-NMN yenze ukuthi ithandwe kakhulu, njengoba ucwaningo lubonisa ukuthi ukwandisa amazinga e-NAD+ kungasiza ekunciphiseni ukwehla okuhlobene nokuguga nokwandisa isikhathi sokuphila.
Ukukhetha phakathi kwe-Deazaflavin ne-NMN kungancika emigomweni yezempilo yomuntu ngamunye kanye nokukhathazeka. Kulabo abafuna kakhulu ukusekela ukukhiqizwa kwamandla kanye nempilo iyonke, i-Deazaflavin ingaba inketho efanelekile, ikakhulukazi kulabo abanokushoda okwaziwayo noma imikhawulo yokudla engathinta ukuthathwa kwe-vitamin B2. Ngakolunye uhlangothi, abantu abanesifiso sezinzuzo ezingaba khona zokulwa nokuguga kanye nokukhuthaza impilo yamaseli bangathola i-NMN iyindlela ekhangayo, ngenxa yendima yayo ekwandiseni amazinga e-NAD+ kanye nobudlelwano bayo nokuphila isikhathi eside.
Izinzuzo ze-5-deazaflavin ngaphezu kwe-NMN
I-5-Deazaflavin kanye ne-NMN powder ziyizinto ezibalulekile ezandulela i-NAD+ futhi zidlala indima ebalulekile ekusetshenzisweni kweseli. Kodwa-ke, uma kuqhathaniswa ne-NMN, i-5-deazaflavin inezinzuzo ezilandelayo:
1. Ukuzinza: 5-deazaflavin kutholakale ukuthi kuzinzile kune-NMN. Lokhu kusho ukuthi igcina ukusebenza kwayo isikhathi eside, okwenza kube yindlela ethembekile kulabo abafuna ukuyifaka empilweni yabo yansuku zonke. Ukuzinza kwe-5-deazaflavin kwenza kube lula ukuyigcina nokuyithutha, okwenza kube nenzuzo kune-NMN maqondana nokulula kwayo.
2. Ukutholakala: Uma kuqhathaniswa ne-NMN, i-5-deazaflavin iboniswe ukuthi inokutholakala okuphezulu kwe-bioavailability. Lokhu kusho ukuthi ingxenye enkulu ye-5-deazaflavin imuncwa ngumzimba, okuholela emphumeleni ocacile. Ngokutholakala okukhulu kwe-bioavailability, abantu bangathola izinzuzo ze-5-deazaflavin ngokushesha futhi ngamanani aphansi kune-NMN.
3. Amandla e-Redox: 5-deazaflavin inamandla e-redox angemahle kune-NMN, okwenza ikwazi ukuhlanganyela ezinhlobonhlobo eziningi zezimpendulo zamakhemikhali.
4. Ukuhambisana: i-5-deazaflavin inezela amanye ama-coenzyme, njenge-flavin ne-nicotinamide, okwenza ukucutshungulwa kweseli kuphelele futhi kusebenze kangcono.
5. Izakhiwo ze-Photocatalytic: i-5-deazaflavin iboniswe ukuthi inezakhiwo ze-photocatalytic futhi ingaba nezicelo ezingaba khona ezimbonini ezahlukahlukene.
I-6.5-Deazaflavin iboniswe ukuthi isebenzisa ama-sirtuin, iqembu lamaprotheni adlala indima ebalulekile ekulawuleni impilo yamangqamuzana kanye nokuphila kwawo. Ngokusebenzisa ama-sirtuin, i-5-deazaflavin ingasiza ekukhuthazeni ukulungiswa kwamangqamuzana nokuthuthukisa impilo iyonke ezingeni lamaseli. I-NMN, ngakolunye uhlangothi, isebenza ngokuyinhloko ngokwandisa amazinga e-NAD+, i-molecule ehilelekile ezinqubweni ezahlukahlukene zamaseli kodwa ayisebenzisi ama-Sirtuin ngokuqondile.
Ngokuvamile, i-5-deazaflavin powder iye yaba yindlela entsha ephumayo ye-NMN futhi inamandla amakhulu. Ngokungafani ne-NMN, isebenza ngqo njenge-coenzyme ngaphandle kokuguqulwa ibe yi-NAD+. Le mpahla eyingqayizivele iyenza isebenze kangcono kune-NMN, ngemibiko ethi i-5-deazaflavin powder inamandla aphindwe izikhathi ezingu-40 kuya kweziyi-100 kune-NMN. Ngakho-ke, ibhekwa njengesikhundla esithembisayo sesizukulwane esilandelayo se-NMN.
1. Sekela ukukhiqizwa kwamandla
Enye yezinzuzo eziyinhloko zezithako ze-deazaflavin indima yazo ekusekeleni ukukhiqizwa kwamandla emzimbeni. I-Deazaflavin idlala indima ebalulekile ekukhiqizweni kwe-ATP, imali eyinhloko yamandla yeseli. Ngokwandisa ukukhiqizwa kwe-ATP, izithako ze-deazaflavin zingasiza ekwandiseni amazinga amandla aphelele futhi zilwe nemizwa yokukhathala nokudinwa.
2. Izakhiwo ze-Antioxidant
Ama-antioxidants ayizakhi ezisiza ekunciphiseni ama-free radical ayingozi emzimbeni afaka isandla ekugugeni nasezifweni. Ngokusebenza njenge-antioxidant, izithasiselo ze-deazaflavin zingasiza ekuvikeleni umzimba ekucindezelekeni kwe-oxidative futhi zinciphise ingozi yezifo ezingamahlalakhona njengesifo senhliziyo nesifo sikashukela.
3. Isekela impilo yesimiso sezinzwa.
I-Deazaflavin idlala indima ebalulekile ekukhiqizweni kwama-neurotransmitter, izithunywa zamakhemikhali ezivumela amangqamuzana ezinzwa ukuthi axhumane. Ngokusekela ukukhiqizwa kwama-neurotransmitter, izithasiselo ze-deazaflavin zingasiza ekuthuthukiseni ukusebenza kwengqondo, isimo sengqondo, kanye nempilo yengqondo iyonke.
4. Isekela impilo yenhliziyo nemithambo yegazi.
I-Deazaflavin iboniswe ukuthi isekela ukugeleza kwegazi okunempilo futhi ingasiza ekunciphiseni ingozi yomfutho wegazi ophakeme kanye nesifo senhliziyo. Ngokukhuthaza ukugeleza kwegazi okunempilo, izithasiselo ze-Deazaflavin zingasiza futhi ekuthuthukiseni ukusebenza kwezemidlalo nokusekela ukukhuthazela komzimba jikelele.
5. Sekela ukusebenza komzimba
Ucwaningo lubonisa ukuthi i-deazaflavin ingasiza ekulawuleni amasosha omzimba futhi ingasiza ekusekeleni impendulo enempilo yamasosha omzimba. Ngokusekela ukusebenza kwamasosha omzimba, izithasiselo ze-deazaflavin zingasiza ekunciphiseni ingozi yokutheleleka futhi zisekele impilo iyonke.
6. Ukulwa nokuguga
Izifundo zithole ukuthi i-5-deazaflavin isebenza kahle ngokuphindwe kayi-100 kune-NMN futhi ingasiza kangcono ekulungiseni i-DNA nasekulweni nokuguga.
Ukuthola isithasiselo se-deazaflavin esifanele kubalulekile ekuqinisekiseni ukuthi uthola umkhiqizo osezingeni eliphezulu nosebenza kahle kakhulu.
Okokuqala, kubalulekile ukucabangela umthombo wesithasiselo sakho se-deazaflavin. Funa inkampani ehloniphekile esebenzisa izithako ezisezingeni eliphezulu futhi ecacile mayelana nezinqubo zayo zokuthola nokukhiqiza. Funda ukubuyekezwa kwamakhasimende bese wenza ucwaningo ngenkampani ukuqinisekisa ukuthi banedumela elihle embonini. Ngaphezu kwalokho, kuyazuzisa ukukhetha izithasiselo ezihlolwe ngumuntu wesithathu ukuze zihlole ubumsulwa namandla.
Uma ukhetha isithasiselo se-deazaflavin, kubalulekile futhi ukucabangela uhlobo lwesithasiselo. Abanye abantu bangase bakhethe ama-capsule noma amaphilisi, kanti abanye bangase bakhethe uhlobo lwempuphu. Uma ukhetha ifomu lesithasiselo, cabanga ngezintandokazi zakho nendlela yakho yokuphila. Khumbula ukuthi izinhlobo ezahlukene zezithasiselo zingase zibe namazinga ahlukene okumuncwa kanye nokutholakala kwezinto eziphilayo.
Esinye isici esibalulekile okufanele usicabangele lapho ukhetha isithasiselo se-deazaflavin umthamo. Isilinganiso esifanele singahluka ngokusekelwe ezicini ezifana nobudala, isisindo, kanye nempilo iyonke. Kungcono ukubonisana nochwepheshe wezempilo noma uchwepheshe wezokudla ukuze anqume umthamo ofanele izidingo zakho. Gwema ukuthatha izithasiselo ezinomthamo ophezulu kakhulu ngoba zingase zingadingeki futhi zingase zibangele imiphumela emibi.
Ngaphezu komthamo, kubalulekile futhi ukufuna isithasiselo se-deazaflavin esingenazo izithasiselo noma izithasiselo ezingadingekile. Izithasiselo eziningi emakethe ziqukethe imibala yokwenziwa, izithasiselo, kanye nezinto ezibangela ukungezwani komzimba ezingaba yingozi empilweni yakho. Funa izithasiselo ezihlanzekile, ezimsulwa, futhi ezinezithako ezimbalwa ezengeziwe.
I-Suzhou Myland Pharm & Nutrition Inc.ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, le nkampani iphinde ibe ngumkhiqizi obhalisiwe yi-FDA, eqinisekisa impilo yabantu ngekhwalithi ezinzile kanye nokukhula okusimeme. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi ziyakwazi ukukhiqiza amakhemikhali esikalini esingu-milligram kuya ku-ton ngokuhambisana nezindinganiso ze-ISO 9001 kanye nemikhuba yokukhiqiza ye-GMP.
U: Iyini i-deazaflavin supplement futhi ingangisiza kanjani ngemigomo yami yezempilo?
A: I-Deazaflavin iyinhlanganisela esekela imisebenzi ehlukahlukene ye-metabolic emzimbeni, okuhlanganisa ukukhiqizwa kwamandla kanye nempilo yamaseli. Ingasekela inhlalakahle iyonke futhi isize ngemigomo ethile yezempilo efana namazinga amandla athuthukisiwe kanye nokusekelwa kwe-antioxidant.
U: Ngingayikhetha kanjani i-deazaflavin efanelekile ngokwezidingo zami?
A: Uma ukhetha isithasiselo se-deazaflavin, kubalulekile ukucabangela izici ezifana nekhwalithi, ubumsulwa, kanye namandla. Funa uhlobo lomkhiqizo oludumile olusebenzisa izithako ezisezingeni eliphezulu futhi olunokuhlolwa komuntu wesithathu ukuqinisekisa amandla nobumsulwa. Ngaphezu kwalokho, cabanga ngemigomo yakho ethile yezempilo bese ubheka isithasiselo esenzelwe ukusekela leyo migomo.
U: Kuthatha isikhathi esingakanani ukubona imiphumela ngokuthatha isithasiselo se-deazaflavin?
A: Isikhathi esithathayo ukubona imiphumela ngokuthatha isithasiselo se-deazaflavin singahluka kuye ngezici zomuntu ngamunye njengempilo iyonke, ukudla, nendlela yokuphila. Abanye abantu bangase babone ukuthuthuka emazingeni amandla kanye nenhlalakahle iyonke ngokushesha, kanti abanye bangase bathathe isikhathi eside ukuzwa izinzuzo ezigcwele. Kubalulekile ukuhambisana nokuthatha isithasiselo njengoba kuqondiswe futhi usinike isikhathi sokusebenza.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Jan-17-2024
