Izinhlanganisela zemvelo zikhula ngesidingo ocwaningweni lwesayensi yanamuhla kanye nezimboni zemithi. I-7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), njengenhlanganisela ebalulekile etholakala esitshalweni, idonse ukunaka okusabalele ngenxa yomsebenzi wayo obalulekile wezinto eziphilayo. Kubacwaningi besayensi namabhizinisi, kubalulekile ukuthola abahlinzeki abathembekile be-7,8-Dihydroxyflavone Powder. I-7,8-Dihydroxyflavone Powder ehlinzekwa yi-Suzhou Myland inakhoinombolo ye-CAS ye-38183-03-8 kanye nobumsulwa obufika ku-98%, ikunikeza ukukhetha okuthembekile.
7,8-Dihydroxyflavone(eyaziwa nangokuthi i-7,8-DHF noma i-proflavonoid) i-molecule eyenzeka ngokwemvelo eyingxenye yenhlanganisela ye-flavonoid. Itholakala emaqabunga e-Godmania aesculifolia, i-Tridax procumbens kanye ne-primula.
I-7,8-DHF iyinhlanganisela ye-organic ene-molecular formula C15H10O4. Iyancibilika kuma-organic solvents futhi inombala wesici, iphunga kanye nokunambitheka okuhambisana nezinhlanganisela ze-flavonoid.
I-7,8-DHF ivele njengenhlanganisela ye-nootropic ethembisayo. Ibonise uchungechunge lwemiphumela ye-neuropharmacological ezifundweni zangaphambi komtholampilo, okuhlanganisa ukuthuthukisa inkumbulo, ukugqugquzela i-neurogenesis nokuvimbela ukubola kwe-neurodegeneration.
Njenge-molecule enamandla futhi ekhethayo i-agonist ye-molecule encane ye-tropomyosin receptor kinase B (TrkB), i-proflavin ibonise ukusebenza kahle kumamodeli ezilwane ngokumelene nezifo ezihlukahlukene, kuhlanganise nesifo i-Alzheimer's.
I-Flavonoids iklasi lama-polyphenolic compounds atholakala ezinhlobonhlobo zezithelo, imifino, neminye imithombo yezitshalo. Eminyakeni yamuva nje, bathole ukunakwa okukhulu ngenxa yezakhiwo zabo ze-antioxidant, anti-inflammatory, kanye ne-neuroprotective.
Lezi zinhlanganisela zikhonjiswe ukuthi zinemiphumela enenzuzo ebuchosheni, okuhlanganisa nokuthuthukisa ukusebenza kwengqondo nokuvimbela izifo ze-neurodegenerative. I-7,8-DHF ingenye yezinhlanganisela ze-polyphenolic ezivelele kakhulu ezithola ukunakwa okukhulayo njenge-nootropic. Icutshungulwe ngemiphumela yayo engaba khona kumizwa, inkumbulo, ukufunda, ukukhathazeka, neminye imisebenzi yokuqonda.
Imiphumela yezinzwa ye-7,8-DHF kucatshangwa ukuthi ixhunyaniswa nokuxhumana kwayo nama-receptors athile. Kutholakale ukuthi i-TrkA, isamukeli esibandakanyeka ekuboniseni isici sokukhula kwezinzwa futhi sibalulekile ekusindeni kwe-neuronal kanye nepulasitiki.
I-7,8-DHF yenza ngokulawula ukuvezwa kwama-receptors ahlukahlukene, kufaka phakathi ama-subunits e-glutamate receptor kanye ne-BDNF. Iphinde ithinte ukwakheka kwe-synapse, i-metabolism yamandla, nokukhululwa kwe-acetylcholine ezindaweni ezithile zobuchopho.
Ucwaningo lwe-7,8-dihydroxyflavone lunwebele emiphumeleni yalo empilweni yomuntu, ikakhulukazi ngokubheka ukuthi ulingisa kanjani umsebenzi we-brain-derived neurotrophic factor (BDNF), iphrotheni ebalulekile ekusindeni kwe-neuronal nokusebenza. amaprotheni.
Mayelana nokusetshenziswa kwayo, i-7,8-DHF iye yahlolwa ukuze isetshenziswe ekwelapheni izifo zemizwa ngenxa yekhono layo lokungena emgodleni wegazi-ubuchopho.
I-7,8-Dihydroxyflavone yenzeka ngokwemvelo emithonjeni ehlukahlukene yokudla kwezitshalo, okuhlanganisa:
● Izithelo: ama-apula, amajikijolo, amagilebhisi nezithelo ezisawolintshi
● Imifino: u-anyanisi, i-kale, i-broccoli nesipinashi
● Amakhambi: I-Parsley, i-thyme ne-oregano
Ukwengeza kule mithombo yemvelo, i-7,8-DHF iyatholakala futhi efomini lezengezo ukuze isetshenziswe kalula futhi ehleliwe.
Funda ngama-flavonoids
I-Flavonoid yizinhlanganisela ze-polyphenolic ezidlala indima ebalulekile ekushintsheni umbala wezitshalo, ukuhlunga kwe-UV, nokumelana nezifo. Ahlukaniswe abe izigaba eziningana, kuhlanganise flavonols, flavones, isoflavones, flavanones, futhi anthocyanins. Isigaba esingaphansi ngasinye sinezakhiwo zamakhemikhali ezihlukene nemisebenzi yebhayoloji, okuholela ezinzuzweni ezihlukene zezempilo.
Iyini i-7,8-dihydroxyflavone?
I-7,8-Dihydroxyflavone iwuhlobo olukhethekile lwe-flavonoid okuyingxenye ye-flavonoid subclass. Ukwakheka kwayo kwamakhemikhali kunamaqembu amabili e-hydroxyl ezindaweni 7 kanye ne-8 zomgogodla we-flavonoid, obhekene nezakhiwo zayo eziyingqayizivele. Le nhlanganisela itholakala ngokuyinhloko ezitshalweni ezifana ne-dioscorea (yam) futhi iye yafundelwa imiphumela yayo engase ibe khona ye-neuroprotective, izakhiwo zokulwa nokuvuvukala, kanye nokuthuthukiswa kwengqondo.
Umehluko Obalulekile Phakathi kwe-7,8-DHF kanye namanye ama-Flavonoid
1. Isakhiwo samakhemikhali
Umehluko osobala kakhulu phakathi kwe-7,8-DHF namanye ama-flavonoid ukwakheka kwawo kwamakhemikhali. Nakuba ama-flavonoid amaningi ehlanganyela umgogodla ofanayo, ukuba khona kwamaqembu e-hydroxyl ezindaweni ezithile kungathinta kakhulu umsebenzi wabo wezinto eziphilayo. Isibonelo, i-quercetin, i-flavonol eyaziwa kakhulu, inokuhlelwa okuhlukile kwamaqembu e-hydroxyl, okuthinta ukuncibilika kwayo nokusebenzisana nemigomo yezinto eziphilayo.
2. Izinto eziphilayo
I-7,8-DHF iboniswe ukuthi inemisebenzi eyingqayizivele yezinto eziphilayo uma kuqhathaniswa namanye ama-flavonoid. Ucwaningo lubonisa ukuthi luvula indlela yokusayina etholakala ebuchosheni (BDNF), ebaluleke kakhulu ekusindeni kwe-neuron, ukukhula kanye nokuhlukaniswa. Le nqubo ibaluleke kakhulu kumongo wezifo ze-neurodeergenerative kanye nokuncipha kwengqondo.
Ngokuphambene, amanye ama-flavonoid afana nama-catechin (atholakala etiyeni eliluhlaza) kanye nama-anthocyanins (atholakala kumajikijolo) asebenza ngokuyinhloko ngomsebenzi wokulwa ne-antioxidant, akhiphe ama-radicals mahhala futhi anciphise ukucindezeleka okwenziwe nge-oxidative. Nakuba lezi zakhiwo zinenzuzo, zingase zingathinti ngokuqondile izici ze-neurotrophic ngendlela efanayo ne-7,8-DHF eyenza ngayo.
3. I-Bioavailability
I-Bioavailability isho izinga nezinga lapho isithako esisebenzayo noma ingxenye esebenzayo imuncwa futhi itholakale endaweni yokwenza. I-7,8-DHF ibonise i-bioavailability enhle ezifundweni zezilwane, okubonisa ukuthi ingawela ngokuphumelelayo umgoqo wegazi nobuchopho, okubalulekile emiphumeleni yayo ye-neuroprotective.
Ngokuphambene, i-bioavailability yamanye ama-flavonoid ingahluka kakhulu. Isibonelo, nakuba i-quercetin isetshenziswa kakhulu, ukumuncwa kwayo kuvame ukukhawulelwa ngenxa yemetabolism yayo esheshayo. Lo mehluko ku-bioavailability uthinta ukusebenza kahle kwalezi zinhlanganisela ekuzuzeni imiphumela yezempilo efiselekayo.
7,8-DHF Indlela yokusebenza: Ukulawulwa kwe-BDNF kanye nokusebenza kwe-Trkb receptor
Ngokwendlela yokusebenza, i-7,8-DHF iyaziwa ngokukhuthaza ukukhiqizwa kwe-BDNF (i-brain-derived neurotrophic factor) ngokubophezela futhi isebenze i-TrkB ye-receptor yayo. Ngaphandle kokuthola ubuchwepheshe kakhulu, lokhu kuholela ekulandelaneni kwemisebenzi yeselula enenzuzo ekugcineni ukusebenza kahle kwe-neuronal kanye nokuthuthukisa i-neurogenesis.
Imodi yesenzo eyinhloko ye-7,8-DHF:
(1) I-brain-derived neurotrophic factor (BDNF) kanye nendima yayo ku-neuroplasticity
Ngokuthola ukuthi isisho se-brain-derived neurotrophic factor (BDNF) siyancishiswa ezifweni ze-neurodegenerative, ikakhulukazi isifo i-Alzheimer's (AD), ukubaluleka kwaso ekulondolozeni nasekuthuthukiseni impilo yobuchopho kuya ngokuya kubonakala .
I-BDNF ibalulekile emisebenzini ehlukahlukene ye-neuronal njengoba ikhuthaza ukudluliswa kwe-synaptic, i-synaptogenesis, ne-synaptic plasticity ngokusebenzisa ukusayina nama-receptors e-TrkB. Lokhu kwenza indlela yokusayina ye-BDNF-TrkB ibe umgomo othembisayo wokuthuthukiswa kokungenelela kokwelapha okuhloswe ukulwa nezifo ze-neurodeergenerative.
(2) I-Tropomyosin receptor kinase B (Trkb) indlela yokubonisa i-receptor
I-tropomyosin receptor kinase B (TrkB) receptor idlala indima ebalulekile ekulamuleni imiphumela ye-BDNF kuma-neurons. Njengesamukeli se-transmembrane tyrosine kinase, i-TrkB iyisamukeli esiyinhloko se-BDNF futhi iqala uchungechunge lwezehlakalo zokusayina ze-intracellular lapho zibophezela izici ze-neurotrophic.
I-BDNF yenza i-TrkB isebenze ukuze iqalise izindlela ezimbalwa ezibalulekile ze-intracellular, okuhlanganisa i-phosphatidylinositol 3-kinase (PI3K)-Akt, i-mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), kanye ne-phospholipase Cγ (PLCγ) -protein kinase ( PKC) indlela. Ngayinye yalezi zindlela inomthelela esicini esihlukile somsebenzi we-neuronal kanye nokuphila kahle.
Indlela ye-PI3K-Akt ibalulekile ekukhuthazeni ukusinda kwe-neuronal kanye nokuvimbela i-apoptosis. Ukusayinda kwe-BDNF-TrkB kwenza le ndlela isebenze ukuze kwandiswe ukusinda kwamangqamuzana ngokuvimbela izici ze-pro-apoptotic kanye nezici ezikhuthazayo eziphikisana ne-apoptotic, ngaleyo ndlela kuqinisekiswe ukulondolozwa kwama-neurons anempilo.
Ngakolunye uhlangothi, indlela ye-MAPK-ERK idlala indima ebalulekile ekuhlukaniseni kwe-neuronal nokwanda. Ukusayinda kwe-BDNF-TrkB kukhuthaza ukwenziwa kusebenze kwendlela ye-MAPK-ERK, yona esekela ukuvuthwa kwe-neuronal nokuhlukaniswa kanye nokuhlanganiswa kwayo kumanethiwekhi akhona e-neuronal.
Indlela ye-PLCγ-PKC ibalulekile ekulawuleni i-synaptic plasticity, inqubo eyisisekelo yokufunda nenkumbulo. Ukusayinda kwe-BDNF-TrkB kulungisa umsebenzi wale ndlela, ekugcineni kuholele ezinguqukweni zamandla e-synaptic nokuxhumana.
Lokhu kuguquguquka kukhuthaza ukujwayela nokuhlelwa kabusha kwamasekhethi e-neural ukuphendula okuhlangenwe nakho okusha kanye nezisusa zemvelo.
Ngokusebenza njenge-agonist ye-TrkB, i-7,8-DHF yenza imiphumela yayo ye-nootropic ikakhulukazi ngokulawula izindlela zokubonisa ezihlobene ne-BDNF, ngaleyo ndlela ikhuthaze i-neurogenesis nokuthuthukisa i-synaptic plasticity.
Ngokulingisa imiphumela ye-BDNF, i-7,8-DHF isiza ukuvikela ama-neurons emonakalweni, ikhuthaze ukusinda kwawo, futhi ikhuthaze ukukhula nokugcinwa kokuxhumana okusha kwe-neuronal. Leli khono lokuthuthukisa i-neuroplasticity, ukuthuthukisa ukusebenza kwengqondo, kanye nokukhulula izimpawu zezifo zemizwa kwenza i-7,8-DHF ibe yikhandidethi elithembisayo lokuthuthukiswa kwezidakamizwa kanye nokucwaninga okuqhubekayo.
I-7,8-DHF Izinzuzo ze-Nootropic: Ukuthuthukiswa Komqondo kanye Nokuvikelwa Kwezinzwa
Mayelana nezinzuzo zayo ze-nootropic, i-7,8-DHF isebenza ngezindlela ezi-4 eziyinhloko:
Ukuhlanganiswa kwenkumbulo nokubuyiswa: umsebenzi oncike ku-hippocampus
I-7,8-DHF itholwe ithuthukisa ukuqiniswa kwenkumbulo kanye nokutholwa emisebenzini ehlukahlukene yokufunda encike ku-hippocampus nemisebenzi yenkumbulo kumamodeli wamagundane. Lokhu okutholakele kusikisela ukuthi i-7,8-DHF ingaba i-nootropic ethembisayo, Ingasetshenziswa ukuthuthukisa umsebenzi wenkumbulo kubantu abanempilo kanye nalabo abanokukhubazeka kwenkumbulo.
I-synaptic plasticity: amandla esikhathi eside nokucindezeleka
I-7,8-DHF ikhonjiswe ukuthi ilawula i-synaptic plasticity ngokuthuthukisa i-LTP nokunciphisa i-LTD ku-hippocampus. Le miphumela kucatshangwa ukuthi ixhunyaniswa amandla ayo okwenza kusebenze ama-receptors e-TrkB futhi kamuva athuthukise indlela yokusayina ye-BDNF. Lokhu kuguqulwa kwe-synaptic plasticity kunomthelela ekuthuthukisweni komsebenzi wokuqonda obonwa kulandela ukuphathwa kwe-7,8-DHF.
Izakhiwo ze-Antioxidant: Ukukhishwa kwe-ROS kanye ne-lipid peroxidation
I-7,8-DHF inezinto zokulwa ne-antioxidant njengoba kufakazelwa ikhono layo lokuqothula izinhlobo ze-oxygen esebenzayo (ROS) nokunciphisa i-lipid peroxidation. Le miphumela inomthelela emiphumeleni yayo ye-neuroprotective ngokudambisa ukulimala kwe-neuronal okubangelwa i-oxidative kanye nokungasebenzi kahle.
Umphumela wokulwa nokuvuvukala: ulawula ukusebenza kwe-microglial kanye nokukhiqizwa kwe-cytokine
Ngaphandle kwezakhiwo zayo ze-antioxidant, i-7,8-DHF itholakale inemiphumela yokulwa nokuvuvukala ngokumodela ukusebenza kwe-microglial nokunciphisa ukukhiqizwa kwama-cytokines ane-pro-inflammatory njenge-TNF-α ne-IL-1β. Lokhu kuphinde kube nomthelela emiphumeleni yayo ye-neuroprotective kanye ne-nootropic ngokuvimbela ukulimala kwe-neuronal okuphakathi kokuvuvukala.
Uma ufuna umphakeli we7,8-DihydroxyflavonePowder, ungacabangela izici ezilandelayo:
1. Isithunzi somphakeli
Ukukhetha umphakeli onegama elihle kubalulekile. Ungathola umuzwa wesithunzi somphakeli ngokubheka ukubuyekezwa kwamakhasimende, imibiko yemboni, nezinkundla zobuchwepheshe. I-Suzhou Myland ijabulela idumela elihle embonini, enempendulo eyakhayo yamakhasimende kanye nekhwalithi yomkhiqizo eyaziwa kabanzi.
2. Izinga lomkhiqizo
Qinisekisa ukuthi imikhiqizo ehlinzekwa abahlinzeki ithobela izindinganiso zamazwe ngamazwe kanye nezidingo zokulawula ikhwalithi. I-Suzhou Myland 7,8-Dihydroxyflavone Powder iye yahlolwa ikhwalithi eqinile futhi inobumsulwa obufika ku-98%, iqinisekisa ukusebenza kahle nokuphepha komkhiqizo.
3. Isitifiketi Nokuhambisana
Ukukhetha umphakeli one-GMP (Umkhuba Omuhle Wokukhiqiza) kanye nesitifiketi se-ISO kuqinisekisa ukuthi inqubo yakhe yokukhiqiza ihlangabezana nezindinganiso zamazwe ngamazwe. I-Suzhou Myland ilandela ngokuqinile la mazinga ukuze kuqinisekiswe ukuzinza nokuvumelana kweqoqo ngalinye lemikhiqizo.
4. Ukwesekwa kwezobuchwepheshe nezinkonzo
Umphakeli onokwethenjelwa kufanele anikeze ukwesekwa kobuchwepheshe obuchwepheshile kanye nesevisi yamakhasimende. I-Suzhou Myland inethimba lezobuchwepheshe elichwepheshile elinganikeza amakhasimende iziphakamiso zokusetshenziswa komkhiqizo nesiqondiso sobuchwepheshe ukusiza amakhasimende athole imiphumela engcono ocwaningweni nasekusetshenzisweni kwayo.
5. Intengo nesikhathi sokulethwa
Intengo nesikhathi sokudiliva nakho kuyizinto ezibalulekile lapho ukhetha umphakeli. Ungacela izingcaphuno kubahlinzeki abaningi futhi uqhathanise amanani abo nezikhathi zokulethwa ukuze uthole inketho efanelekile kakhulu. Suzhou Myland
inikeza amanani ancintisanayo kanye nezikhathi zokulethwa eziguquguqukayo ngenkathi iqinisekisa ikhwalithi yomkhiqizo.
Ungayithola Kanjani I-7,8-Dihydroxyflavone Powder
Uma ufuna iPowder yekhwalithi ephezulu engu-7,8-Dihydroxyflavone, iSuzhou Myland iyisinqumo sakho esifanele. Ungasithinta ngokuthi:
Iwebhusayithi esemthethweni: Vakashela i-Iwebhusayithi esemthethweni ye-Suzhou Mylandukuze ufunde kabanzi mayelana nolwazi lomkhiqizo nokusekelwa kobuchwepheshe.
Ukubonisana nge-inthanethi: Xhumana ngokuqondile nethimba lethu elisebenzela amakhasimende ngokusebenzisa umsebenzi wokubonisana nge-inthanethi ohlinzekwa yiwebhusayithi ukuze uthole ulwazi lomkhiqizo namakhotheshini owadingayo.
Othintana naye ngocingo: Shayela inombolo yethu yokuxhumana ukuze uxhumane nabasebenzi bokuthengisa abaqeqeshiwe futhi uthole ulwazi oluningiliziwe lomkhiqizo kanye neziphakamiso zokuthenga.
Umbuzo we-imeyili: Ungaphinda usicele ulwazi lomkhiqizo nge-imeyili, futhi sizokuphendula ngokushesha okukhulu.
Ukuthola abahlinzeki be-Powder be-7,8-Dihydroxyflavone abathembekile akulula, kodwa ngokunaka idumela lomphakeli, ikhwalithi yomkhiqizo, isitifiketi nokuhambisana, ukusekelwa kwezobuchwepheshe kanye nesevisi, kanye nesikhathi samanani nesikhathi sokulethwa, ungenza isinqumo esihlakaniphile. khetha. I-Suzhou Myland inguzakwethu okahle onophawu lwayo oluphakeme lwe-7,8-Dihydroxyflavone Powder kanye nenkonzo yamakhasimende enhle kakhulu. Sibheke ngabomvu ekusebenzisaneni nawe ukuhlola amandla amaningi wohlelo lokusebenza lwe-7,8-Dihydroxyflavone.
Q:Ingabe i-proflavin ingathuthukisa ikhono lokufunda?
A:Yebo, i-proflavin ikhonjisiwe ukuthuthukisa amandla okufunda ezifundweni zezilwane ngokuthuthukisa i-neurogenesis kanye nokuxhumana kwe-synaptic. Ilawula izinhlelo ze-neurotransmitter ezibalulekile enqubweni yokufunda, ikakhulukazi ku-hippocampus, isifunda esibalulekile sobuchopho sokufunda.
Q:Ingabe i-7,8-DHF iyasiza ukululama kwengqondo ngemva kokulimala?
A:Yebo, izifundo zangaphambi komtholampilo ziphakamisa ukuthi i-7,8-DHF ingasiza ekubuyiseleni kwengqondo ngemva kokulimala kobuchopho ngokugqugquzela ukuvikela kwe-neuroprotection kanye nokuvuselelwa kwemizwa. Yehlisa ukufa kwe-neuronal futhi isekele ukukhula kwama-neuron amasha, okungase kube ngcono ukusebenza kwengqondo okonakala ngokuhlukumezeka noma ukulimala kwe-ischemic.
Q: Iyiphi indima edlalwa yi-7,8-dihydroxyflavone ekwehleni komqondo okuhlobene nokuguga?
A: Ucwaningo olukhulayo luphakamisa ukuthi i-7,8-DHF ingase ibambezele ukwehla kwengqondo okuhambisana nokuguga ngokuvikela ekucindezelekeni kwe-oxidative nokuvuvukala, izici ezivamile ezifweni zengqondo ezihlobene neminyaka.
Ngokuthuthukisa amazinga e-BDNF kanye nokusebenza kwe-TrkB receptor, kusiza ukugcina ukuqina kwengqondo, nakuba izifundo eziningi zabantu zidingeka ukuze kuhlolwe kahle le miphumela.
Q:Ingabe i-7,8-DHF ingathuthukisa ukunaka nomsebenzi wokuphatha?
A:Ucwaningo lokuqala lwezilwane luphakamisa ukuthi i-7,8-DHF ingase ithuthukise ukunaka nokusebenza kokuphatha ngokuthuthukisa ukulawulwa kwe-neurotransmitter kanye nokuxhumana kwe-neural ezindaweni zobuchopho ezihilelekile kulezi zinqubo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Oct-16-2024
