Ezweni lanamuhla elisheshayo, ukunakekela impilo yethu kubaluleke kakhulu kunangaphambili. Njengoba ingcindezi, ukungcola kanye nendlela yokuphila yokunganyakazi kwanda, kubalulekile ukuthatha izinyathelo ezengeziwe ukuze siqinisekise ukuthi sinikeza imizimba yethu ukwesekwa ekudingayo ukuze isebenze kahle. Kungakhathaliseki ukuthi ufuna ukuphatha ukucindezeleka, ukusekela impilo yenhliziyo, noma ukuthuthukisa ukusebenza kwezemidlalo, i-salidroside supplementation ingaba indlela engokwemvelo nephumelelayo yokukusiza ukufeza imigomo yakho yezempilo. Zama ukufaka i-salidroside ohlelweni lwakho lwezempilo lwansuku zonke futhi uzizwele izinzuzo zayo ezingase zibe khona.
I-Salidroside, eyaziwa nangokuthi i-salidroside, ibhekisela kwisithako esiyinhloko esisebenzayo sekhambi elingapheli i-Rhodiola rosea. Ikhona ezimpandeni zesitshalo se-Rhodiola rosea, esaziwa nangokuthi impande yegolide noma impande ye-arctic. I-Salidroside ibonakala iyimpushana ensundu ngokukhanyayo noma emhlophe, inambitheka kamnandi, incibilika kalula emanzini, incibilika kalula ku-methanol, i-ethanol, futhi ayincibiliki ku-ether.
I-Rhodiola rosea isetshenziswe kwezokwelapha zendabuko amakhulu eminyaka, ikakhulukazi ezifundeni ezinesimo sezulu esinzima njenge-Arctic nezintaba zase-Europe nase-Asia. Eminyakeni yamuva nje, i-salidroside ithole ukunakwa ngezinzuzo zayo zezempilo ezingaba khona, okuholela ekuthuthukisweni kwezithako ze-salidroside.
I-Salidroside inezici ezinamandla zokulwa ne-antioxidant ezinganciphisa ukuvuvukala, zivikele amangqamuzana ekucindezelekeni kwe-oxidative, futhi zidambise ukucindezeleka, ukukhathala nokucindezeleka, futhi zidambise ukugula kwe-altitude, okwenza izithako ze-salidroside zilungele labo abaphila impilo ematasa nekhiqizayo. Abantu abaphila ngendlela ecindezelayo bakhanga ngokukhethekile.
Imithombo ye-salidroside okwamanje emakethe iwukukhishwa kwezitshalo, ukuhlanganiswa kwamakhemikhali kanye nokuvutshelwa kwezinto eziphilayo.
1.I-Rhodiola rosea iyimpahla eluhlaza ye-salidroside. Njengohlobo lwesitshalo esihlala isikhathi eside, i-Rhodiola rosea ikhula ikakhulukazi ezindaweni ezinokuphakama okuphezulu, ukubanda okuphezulu, i-hypoxia, ukoma kanye nomehluko omkhulu wokushisa phakathi kwemini nobusuku. Ingesinye sezitshalo zasemathafeni asendle. Kodwa-ke, imikhuba yamanje yokuphila ye-Rhodiola rosea ikhethekile. Akukhona nje kuphela ukuthi kunzima ukuhlakulela ngokwenziwa, kodwa isivuno sezinhlobo zasendle siphansi kakhulu, ngakho-ke kunzima ukuhlinzeka ngesidingo semakethe ngezitshalo zezitshalo.
2.Ngaphandle kwezindlela zokukhipha imvelo, izindlela zokukhiqiza i-salidroside zihlanganisa izindlela zokuhlanganisa amakhemikhali, izindlela zokuvutshelwa kwezinto eziphilayo, njll. Phakathi kwazo, njengoba ubuchwepheshe buqhubeka buvuthwa, ukuvutshelwa kwezinto eziphilayo kuye kwaba yindlela yobuchwepheshe evamile yocwaningo nokuthuthukiswa nokukhiqizwa kwe-salidroside. Esikhathini esizayo, njengoba inqubo yocwaningo nentuthuko yamabhizinisi endawo iqhubeka nokushesha, ukukhiqizwa kwenqwaba yezimboni ze-salidroside sekuseduze, kanye ne-synthetic biology ye-salidroside Ubuchwepheshe buyakhula futhi amandla emakethe makhulu.
I-Salidroside iyinhlanganisela yemvelo etholakala e-Rhodiola rosea, isitshalo esiqhakaza esingapheli esimila ezindaweni ezibandayo zomhlaba, kubandakanya ne-Arctic nezintaba zase-Europe nase-Asia. I-Rhodiola rosea isetshenziswe emithini yendabuko amakhulu eminyaka ukusiza ukwakha ukumelana nokucindezeleka ngokomzimba nangokwengqondo, ukwandisa ukukhuthazela, nokuthuthukisa ukusebenza kwengqondo. I-Salidroside kucatshangwa ukuthi ingesinye sezithako ezisebenzayo ezinesibopho sale miphumela.
I-Rhodiola rosea, ngakolunye uhlangothi, isitshalo sesitshalo esiqukethe i-salidroside, kanye nezinye izinhlanganisela ezifana ne-conacetin ne-p-tyrosol. Lezi zinhlanganisela ezengeziwe zingase zibe nomthelela ezinzuzweni zezempilo ezihlobene ne-rhodiola.
Uma uqhathanisa i-salidroside ne-rhodiola rosea, kubalulekile ukucabangela ukuhlanzeka namandla okukhishwa kwe-salidroside. Nakuba i-salidroside iyingxenye ebalulekile ye-Rhodiola rosea, ingenye yezinhlanganisela eziningi ze-bioactive ezitholakala esitshalweni. Ezinye izifundo ziphakamisa ukuthi inhlanganisela ye-salidroside nezinye izinhlanganisela zemvelo ku-Rhodiola rosea ingase ihambisane, okuholela ezinzuzweni ezinkulu zezempilo kune-salidroside iyodwa.
Kodwa-ke, kukhona nobufakazi bokuthi i-salidroside engayodwa ingaba nezinzuzo ezithile ngaphezu kwe-Rhodiola rosea. Isibonelo, ucwaningo lubonisa ukuthi i-salidroside ingaba nezakhiwo ezinamandla ze-antioxidant kanye ne-anti-inflammatory, okwenza kube nenzuzo ekulweni nokucindezeleka okwenziwe nge-oxidative nokuvuvukala emzimbeni. Ukwengeza, ezinye izifundo ziphakamisa ukuthi i-salidroside ingasiza ekuthuthukiseni ukusebenza kwengqondo nokusebenza kwengqondo, ikwenze kube ukwelashwa okungokwemvelo okuthembisayo kokuthuthukisa impilo yobuchopho.
Indlela yokusebenza ye-salidroside iyinkimbinkimbi futhi ihlanganisa izindlela eziningi emzimbeni. Enye yezindlela eziyinhloko i-salidroside esebenza ngayo iwukulawula ukuphendula kokucindezeleka komzimba. Lapho umzimba ucindezelekile, kukhishwa i-hormone ebizwa ngokuthi i-cortisol, engaba nomthelela omubi ezinqubweni ezihlukahlukene zomzimba. I-Salidroside iboniswe ukulawula ukukhululwa kwe-cortisol, ukunciphisa imiphumela emibi yokucindezeleka emzimbeni nokusiza ukugcina impendulo yokucindezeleka elinganiselayo.
Ngaphezu kwemiphumela yayo ekuphenduleni ukucindezeleka, i-salidroside nayo inezakhiwo ze-antioxidant, okusho ukuthi ingasiza ekuvikeleni umzimba emonakalweni we-oxidative. Ukulimala kwe-oxidative kubangelwa ama-radicals mahhala, okungama-molecule angazinzile alimaza amangqamuzana futhi abe nomthelela ekugugeni nasezifweni. Ngokuqeda ama-radicals mahhala, i-salidroside ingasiza ukuvikela amangqamuzana omzimba nezicubu emonakalweni, ikhuthaze impilo nokuphila kahle.
1.Izindawo zokulwa nokuguga
Isihluthulelo semiphumela elwa nokuguga ye-salidroside yizindawo zayo ezinamandla zokulwa ne-antioxidant. Njengoba sikhula, isikhumba sethu sihlala sichayeke kuzinto ezicindezelayo zemvelo njengemisebe ye-UV, ukungcola, nobuthi, okungaholela ekukhiqizeni izinhlobo ze-oxygen esebenzayo (ROS) kanye nengcindezi ye-oxidative. Lokhu-ke kulimaza izingxenye zamangqamuzana esikhumba, okuholela ekulahlekelweni kokunwebeka kanye nokwakheka kwemibimbi. I-Salidroside ikhonjiswe ukuthi inciphisa ngempumelelo izinhlobo ze-oxygen esebenzayo futhi inciphise ukucindezelwa kwe-oxidative, isiza ukuvikela isikhumba ekugugeni ngaphambi kwesikhathi.
Ukwengeza, i-salidroside itholakale ikhuthaza ukukhiqizwa kwe-collagen ne-elastin, amaprotheni amabili abalulekile agcina ukwakheka kobusha besikhumba nokuqina. I-Collagen inesibopho sokuhlinzeka amandla nokunwebeka esikhumbeni, kuyilapho i-elastin ivumela isikhumba ukuba sinwebe futhi siphinde sibuyele endaweni. Njengoba sikhula, ukukhiqizwa kwalawa maprotheni ngokwemvelo kuyehla, kubangele isikhumba sigxumeke futhi sishwabane. Ngokukhuthaza ukwakheka kwe-collagen ne-elastin, i-salidroside isiza ukusekela inqubo yokulungisa yemvelo yesikhumba, okuholela esikhumbeni esibushelelezi, esithambile.
Ngaphezu kwezakhiwo zayo ezisiza ukulwa ne-antioxidant ne-collagen-boosting, i-salidroside itholakale ivimbela ukusebenza kwama-enzyme athile adiliza ukwakheka kwesikhumba. Lokhu kusiza ukuvimbela isikhumba ekulahlekelweni ukuqina futhi kunciphisa ukubukeka kwemigqa emihle nemibimbi. Amandla e-Salidroside ekunakekelweni kwesikhumba okulwa nokuguga agqugquzele ukuthuthukiswa kwezinhlobonhlobo zemikhiqizo yokunakekelwa kwesikhumba kanye nezithasiselo eziqukethe lesi sakhi esinamandla.
2.Yehlisa ukucindezeleka nokukhathazeka
Enye yezindlela i-salidroside ekhulula ngayo ukucindezeleka nokukhathazeka iwukushintsha indlela osabela ngayo ekucindezelekeni komzimba. Lapho sihlangabezana nezimo ezicindezelayo, imizimba yethu ikhipha amahomoni afana ne-cortisol ne-adrenaline, okubangela impendulo "yokulwa noma yokundiza". Nakuba le mpendulo iwusizo esikhathini esifushane, ukucindezeleka okungapheli kungaholela ekuphenduleni kokucindezeleka okunamandla, okungaholela ekukhathazekeni neminye imiphumela emibi yezempilo. I-Salidroside ikhonjiswe ukuthi iyasiza ekulawuleni ukusabela komzimba ekucindezelekeni, isiza ekunciphiseni ukukhiqizwa kwamahomoni okucindezeleka futhi ikhuthaze impendulo engokomzimba elinganiselayo ekucindezelekeni.
Ngaphezu kwemiphumela yayo ekuphenduleni ukucindezeleka, i-salidroside nayo inemiphumela kuma-neurotransmitters ebuchosheni. Ucwaningo lubonisa ukuthi i-salidroside ingakhuphula amazinga e-serotonin ne-dopamine, ama-neurotransmitters amabili adlala indima ebalulekile ekulawulweni kwemizwelo. Ngokulawula lawa ma-neurotransmitters, i-salidroside ingasiza ekuthuthukiseni isimo sengqondo futhi inciphise imizwa yokukhathazeka nokucindezeleka.
3.Izindawo zokulwa nokuvuvukala kanye ne-antioxidant
Ukuvuvukala kuwukusabela kwemvelo komzimba ekulimaleni noma ekuthelelekeni, kodwa lapho kuba okungamahlalakhona, kungaholela ezinkingeni eziningi zempilo, ezihlanganisa nesifo senhliziyo, umdlavuza, kanye nezifo ezihlasela umzimba wokuzivikela ezifweni. I-Salidroside iboniswe ukuthi inemiphumela enamandla yokulwa nokuvuvukala, okwenza kube ikhandidethi elithembisayo lokuthuthukiswa kwezidakamizwa ezintsha zokulwa nokuvuvukala. Ocwaningweni olwanyatheliswa kuyi-International Journal of Molecular Sciences, abacwaningi bathola ukuthi i-salidroside ivimbela ukukhiqizwa kwama-molecule e-pro-inflammatory kumangqamuzana esikhumba somuntu, okusikisela ukuthi ingasetshenziswa ukwelapha izifo zesikhumba ezivuvukalayo njenge-eczema ne-psoriasis.
Ngaphezu kwemiphumela yayo yokulwa nokuvuvukala, i-salidroside nayo inezindawo ezinamandla zokulwa ne-antioxidant. Ama-Antioxidants ayizinhlanganisela ezisiza ukuvikela umzimba ekucindezelekeni kwe-oxidative kanye nokulimala kwama-radical mahhala, okungama-molecule asebenzayo angalimaza amangqamuzana futhi abe nomthelela ekugugeni nasezifo ezihlukahlukene. Ucwaningo oluningi luye lwabonisa ukuthi i-salidroside isusa ama-radicals mahhala futhi inciphisa ukulimala kwe-oxidative kumaseli, angasiza ekuvimbeleni noma ekudambiseni isifo senhliziyo.
Obunye bobufakazi obuqand’ ikhanda bezakhiwo ze-antioxidant ze-salidroside buvela ocwaningweni olushicilelwe kumagazini iFrontiers in Pharmacology. Ocwaningweni, abacwaningi bathola ukuthi i-salidroside ivikela amangqamuzana e-retinal pigment epithelial emonakalweni we-oxidative, ephakamisa ukuthi ingasiza ekuvimbeleni ukuwohloka kwe-macular okuhlobene neminyaka, okuyimbangela ehamba phambili yokulahleka kombono kubantu abadala asebekhulile. Ngaphezu kwalokho, i-salidroside itholakale ivikela inhliziyo ekucindezelekeni kwe-oxidative futhi ithuthukise ukusebenza kwe-vascular, okungase kube nemiphumela ebalulekile ekuvimbeleni nasekwelapheni isifo senhliziyo.
4.Thuthukisa impilo yenhliziyo
I-Salidroside ithuthukisa impilo yenhliziyo ngokuyinhloko ngekhono layo lokunciphisa ukucindezeleka okwenziwe nge-oxidative emzimbeni. Ukucindezeleka kwe-oxidative kwenzeka lapho kunokungalingani phakathi kokukhiqizwa kwama-radicals mahhala kanye nekhono lomzimba lokuwanciphisa. Lokhu kungabangela ukulimala kwamangqamuzana nezicubu zenhliziyo nemithambo yegazi, okuholela ezifweni zenhliziyo nemithambo yegazi njengesifo senhliziyo nesifo sohlangothi. Izakhiwo ezinamandla ze-antioxidant ze-salidroside zisiza ukulwa nengcindezi ye-oxidative futhi zivikele inhliziyo emonakalweni.
Ngaphezu kwemiphumela yayo ye-antioxidant, i-salidroside itholakale inezindawo zokulwa nokuvuvukala. Ukuvuvukala okungapheli kuyisici esiyinhloko ekuthuthukiseni isifo senhliziyo, futhi ukunciphisa ukuvuvukala emzimbeni kungasiza ekuthuthukiseni impilo yenhliziyo. I-Salidroside ikhonjiswe ukuthi ivimbela ukukhiqizwa kwama-molecule avuthayo futhi inciphise ukuvuvukala kwemithambo yegazi, isiza ukuthuthukisa ukujikeleza kwegazi nokunciphisa ingozi yesifo senhliziyo.
Ukwengeza, i-salidroside itholakale inomthelela omuhle kumfutho wegazi kanye namazinga e-cholesterol (izici ezimbili ezibalulekile zempilo yenhliziyo). Ucwaningo lukhombisa ukuthi i-salidroside ingasiza ekwehliseni umfutho wegazi ngokuphumuza imithambo yegazi, ngaleyo ndlela isuse umfutho wenhliziyo futhi yehlise nengozi yomfutho wegazi ophakeme. Ngaphezu kwalokho, i-salidroside itholakale inciphisa amazinga e-LDL cholesterol, i-cholesterol "embi" enomthelela ekwakhekeni kwe-plaque emithanjeni. Ngokukhuphula amazinga e-cholesterol, i-salidroside ingasiza ukunciphisa ingozi yesifo senhliziyo nesifo sohlangothi. Ucwaningo luphinde luveze ukuthi i-salidroside ingasiza ekuvikeleni inhliziyo emonakalweni obangelwa yi-ischemia, isimo lapho ukugeleza kwegazi enhliziyweni kuncipha khona.
Okokuqala, kubalulekile ukuqonda imigomo yakho yezempilo kanye nezizathu zokucabangela izithasiselo ze-salidroside. Ingabe ubheke ukuthuthukisa impilo yakho yonke, ukunciphisa ingcindezi, ukuthuthukisa ukusebenza komzimba, noma ukuthuthukisa ukusebenza kwengqondo? Ukunquma imigomo yakho yezempilo ethile kuzokusiza ukuthi unciphise izinketho zakho futhi ukhethe isengezo esifanelana nezidingo zakho.
Uma usuqonda ngokucacile imigomo yakho yezempilo, yisikhathi sokuhlola ikhwalithi nokuhlanzeka kwezithako ze-salidroside emakethe. Kubalulekile ukubheka izithasiselo ezenziwe abakhiqizi abahloniphekile. Ukufunda amalebula omkhiqizo kanye nokucwaninga inqubo yokukhiqiza kungakusiza ukuthi unqume ikhwalithi nokuhlanzeka kwezithako zakho ezithathiwe.
Futhi cabangela umthamo kanye nokuhlushwa kwe-salidroside ku-supplement. Izithako ezihlukene zingaqukatha amanani ahlukahlukene e-salidroside, ngakho-ke kubalulekile ukukhetha eyodwa enikeza umthamo owanele ukusekela imigomo yakho yezempilo.
Esinye isici esibalulekile okufanele sicatshangelwe uhlobo lwesengezo. Izithasiselo ze-salidroside zitholakala ngezindlela ezihlukahlukene, okuhlanganisa amaphilisi, izimpushana, nezikhishiwe. Lapho ukhetha ifomu lesithasiselo, cabangela izinto ozikhethayo kanye nendlela yokuphila.
Kubalulekile ukuthintana nochwepheshe bezempilo ngaphambi kokuqala uhlobo olusha lomuthi wokungezelela, ikakhulukazi uma okwamanje uthatha noma yimiphi imithi noma unesimo sezempilo. Bangakunikeza isiqondiso mayelana nokusebenzisana okungaba khona futhi bakusize wenze isinqumo esinolwazi mayelana nokufaka izithako ze-salidroside empilweni yakho yansuku zonke.
Inkampani engu-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lezithako zokudla okunomsoco kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Umbuzo: Iyini i-evodiamine?
A: I-Evodiamine iyinhlanganisela yemvelo etholakala esithelweni sesitshalo se-Evodia rutaecarpa, Sekungamakhulu eminyaka isetshenziswa emithini yendabuko yamaShayina futhi yaziwa ngezinzuzo zayo zezempilo ezingaba khona.
Q: Yiziphi izinzuzo ezingaba khona ze-evodiamine supplements?
A: Izithako ze-Evodiamine kukholakala ukuthi zinezinhlobonhlobo zezinzuzo zezempilo ezingaba khona, okuhlanganisa ukusekelwa kokulawulwa kwesisindo, umzimba, kanye nokuphila kahle jikelele. Ukwengeza, bangase babe ne-anti-inflammatory kanye ne-antioxidant.
Q: Kufanele ngizihlanganise kanjani izithasiselo ze-evodiamine ohlelweni lwami lwezempilo kanye nokudla?
IMP: Ngaphambi kokufaka noma yisiphi isithasiselo esisha ohlelweni lwakho lwezempilo kanye nokudla, kubalulekile ukubonisana nochwepheshe bezempilo. Bangakusiza ukuthi unqume umthamo ofanele futhi uhlole noma yikuphi ukusebenzelana okungaba khona neminye imithi noma izithasiselo ongase uzithathe.
Q: Ingabe ikhona imiphumela emibi engaba khona yezithako ze-evodiamine?
A: Nakuba izithako ze-evodiamine ngokuvamile zibhekwa njengeziphephile kubantu abaningi uma zithathwa ngemithamo efanelekile, abanye abantu bangase babe nemiphumela engemihle efana nokucasuka kokugaya ukudla noma ukucasuka. Kubalulekile ukulandela umthamo onconyiwe futhi uqaphe impendulo yomzimba wakho esithasiselweni.
Q: Ingabe zikhona izindlela zokuphepha okufanele uzicabangele lapho uthatha izithasiselo ze-evodiamine?
IMPENDULO: Uma ukhulelwe, umhlengikazi, noma unezimo zempilo ezicashile, kubalulekile ukukhuluma nochwepheshe bezempilo ngaphambi kokuthatha izithasiselo ze-evodiamine. Ukwengeza, kubalulekile ukuthenga izithasiselo emthonjeni onedumela elihle ukuze uqinisekise ikhwalithi nokuphepha.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Feb-18-2024
