Ezweni lanamuhla elisheshayo, ukunakekela impilo yethu kubaluleke kakhulu kunanini ngaphambili. Njengoba ukucindezeleka, ukungcola kanye nendlela yokuphila yokungahlali ndawonye yanda, kubalulekile ukuthatha izinyathelo ezengeziwe ukuqinisekisa ukuthi sinikeza imizimba yethu ukwesekwa ekudingayo ukuze isebenze kahle. Kungakhathaliseki ukuthi ufuna ukuphatha ukucindezeleka, ukusekela impilo yenhliziyo, noma ukuthuthukisa ukusebenza kwezemidlalo, ukwengezwa kwe-salidroside kungaba yindlela yemvelo nephumelelayo yokukusiza ukufeza imigomo yakho yezempilo. Zama ukufaka i-salidroside ohlelweni lwakho lwezempilo lwansuku zonke bese uzwa izinzuzo zayo ezingaba khona kuwe.
I-Salidroside, eyaziwa nangokuthi i-salidroside, ibhekisela esithako esiyinhloko esisebenzayo sesitshalo esihlala isikhathi eside i-Rhodiola rosea. Ikhona ezimpandeni zesitshalo i-Rhodiola rosea, eyaziwa nangokuthi impande yegolide noma impande ye-arctic. I-Salidroside ibonakala njengempuphu ensundu noma emhlophe, inambitheka kamnandi, incibilika kalula emanzini, incibilika kalula ku-methanol, i-ethanol, futhi ayincibiliki ku-ether.
I-Rhodiola rosea ibilokhu isetshenziswa kwezokwelapha zendabuko amakhulu eminyaka, ikakhulukazi ezindaweni ezinesimo sezulu esibi njenge-Arctic kanye nezindawo ezinezintaba zaseYurophu nase-Asia. Eminyakeni yamuva nje, i-salidroside ithole ukunakwa ngezinzuzo zayo zezempilo ezingaba khona, okuholele ekuthuthukisweni kwezithasiselo ze-salidroside.
I-Salidroside inezakhiwo ezinamandla zokulwa ne-antioxidant ezinganciphisa ukuvuvukala, zivikele amangqamuzana ekucindezelekeni kwe-oxidative, futhi zinciphise ukucindezeleka, ukukhathala nokucindezeleka, futhi zinciphise isifo sokuphakama, okwenza izithasiselo ze-salidroside zilungele labo abaphila impilo ematasa nekhiqizayo. Abantu abanezindlela zokuphila ezicindezelayo bakhanga kakhulu.
Imithombo ye-salidroside emakethe njengamanje iwukukhishwa kwezitshalo, ukwenziwa kwamakhemikhali kanye nokubiliswa kwezinto eziphilayo.
1.I-Rhodiola rosea iwuhlobo lwesitshalo esihlala isikhathi eside esikhula ngezitshalo ezimilayo, i-Rhodiola rosea ikhula kakhulu ezindaweni ezinezinga eliphezulu lokuphakama, ukubanda okuphezulu, ukuntuleka komoya okwanele, ukoma kanye nomehluko omkhulu wokushisa phakathi kwemini nobusuku. Ingenye yezitshalo zasendle ezisemaphethelweni. Kodwa-ke, imikhuba yokuphila yamanje ye-Rhodiola rosea ikhethekile. Akukhona nje kuphela ukuthi kunzima ukuyilima ngendlela yokwenziwa, kodwa isivuno sezinhlobo zasendle siphansi kakhulu, ngakho-ke kunzima ukuhlinzeka ngesidingo semakethe ngezithako zezitshalo.
2.Ngaphezu kwezindlela zokukhipha zemvelo, izindlela zokukhiqiza i-salidroside zifaka phakathi nezindlela zokwenziwa kwamakhemikhali, izindlela zokuvubela izinto eziphilayo, njll. Phakathi kwazo, njengoba ubuchwepheshe buqhubeka nokuvuthwa, ukuvubela izinto eziphilayo sekuyindlela yobuchwepheshe eyinhloko yocwaningo nokuthuthukiswa nokukhiqizwa kwe-salidroside. Esikhathini esizayo, njengoba inqubo yocwaningo nokuthuthukiswa kwamabhizinisi endawo iqhubeka nokusheshisa, ukukhiqizwa kwe-salidroside ngobuningi bezimboni kuseduze nje, futhi i-biology yokwenziwa ye-salidroside Ubuchwepheshe buyavuthwa futhi amandla emakethe makhulu.
I-Salidroside iyinhlanganisela yemvelo etholakala ku-Rhodiola rosea, isitshalo esiqhakaza isikhathi eside esikhula ezindaweni ezibandayo zomhlaba, okuhlanganisa nezindawo zase-Arctic nasezintabeni zaseYurophu nase-Asia. I-Rhodiola rosea ibilokhu isetshenziswa kwezokwelapha zendabuko amakhulu eminyaka ukusiza ekwakheni ukumelana nokucindezeleka ngokomzimba nangokwengqondo, ukwandisa ukukhuthazela, nokuthuthukisa ukusebenza kwengqondo. I-Salidroside kucatshangwa ukuthi ingenye yezithako ezisebenzayo ezibangela le miphumela.
Ngakolunye uhlangothi, i-Rhodiola rosea iyisitshalo esiqukethe i-salidroside, kanye nezinye izinto ezifana ne-conacetin ne-p-tyrosol. Lezi zinto ezengeziwe zingase zibe negalelo ezinzuzweni zezempilo ezihambisana ne-rhodiola.
Uma uqhathanisa i-salidroside ne-rhodiola rosea, kubalulekile ukucabangela ubumsulwa kanye namandla okukhishwa kwe-salidroside. Nakuba i-salidroside iyisici esibalulekile se-Rhodiola rosea, ingenye yamakhemikhali amaningi asebenzayo atholakala esitshalweni. Ezinye izifundo ziphakamisa ukuthi ukuhlanganiswa kwe-salidroside namanye amakhemikhali emvelo ku-Rhodiola rosea kungaba nokusebenzisana, okuholela ezinzuzweni ezinkulu zezempilo kune-salidroside yodwa.
Kodwa-ke, kukhona nobufakazi bokuthi i-salidroside ehlukanisiwe ingaba nezinzuzo ezithile kune-Rhodiola rosea. Isibonelo, ucwaningo lubonisa ukuthi i-salidroside ingaba nezakhiwo ezinamandla zokulwa ne-antioxidant kanye nokulwa nokuvuvukala, okwenza kube wusizo ekulweni nokucindezeleka kwe-oxidative kanye nokuvuvukala emzimbeni. Ngaphezu kwalokho, ezinye izifundo ziphakamisa ukuthi i-salidroside ingasiza ekuthuthukiseni ukusebenza kwengqondo kanye nokusebenza kwengqondo, okwenza kube ukwelashwa kwemvelo okuthembisayo kokuthuthukisa impilo yobuchopho.
Indlela esebenza ngayo i-salidroside iyinkimbinkimbi futhi ihilela izindlela eziningi emzimbeni. Enye yezindlela eziyinhloko i-salidroside esebenza ngayo ukulawula impendulo yokucindezeleka komzimba. Lapho umzimba ucindezelekile, kukhishwa i-hormone ebizwa ngokuthi i-cortisol, engathinta kabi izinqubo ezahlukene zomzimba. I-Salidroside iboniswe ukuthi ilawula ukukhishwa kwe-cortisol, inciphisa imiphumela emibi yokucindezeleka emzimbeni futhi isize ukugcina impendulo yokucindezeleka elinganiselayo.
Ngaphezu kwemiphumela yayo ezimpendulweni zokucindezeleka, i-salidroside nayo inezakhiwo ze-antioxidant, okusho ukuthi ingasiza ekuvikeleni umzimba ekulimaleni kwe-oxidative. Umonakalo we-oxidative ubangelwa ama-free radicals, angama-molecule angazinzile alimaza amangqamuzana futhi anegalelo ekugugeni nasezifweni. Ngokuqeda ama-free radicals, i-salidroside ingasiza ekuvikeleni amangqamuzana nezicubu zomzimba ekulimaleni, ikhuthaze impilo yonke kanye nenhlalakahle.
1. Izakhiwo zokulwa nokuguga
Isihluthulelo semiphumela yokulwa nokuguga ye-salidroside yizakhiwo zayo ezinamandla zokulwa nokuguga. Njengoba siguga, isikhumba sethu sihlala sibhekene nezinto ezicindezela imvelo ezifana nemisebe ye-UV, ukungcola, kanye nobuthi, okungaholela ekwakhiweni kwezinhlobo ze-oxygen ezisabelayo (ROS) kanye nokucindezeleka kwe-oxidative. Lokhu, nakho, kulimaza izingxenye zamaseli esikhumba, okuholela ekulahlekelweni kokunwebeka kanye nokwakheka kwemibimbi. I-Salidroside iboniswe ukuthi iqeda ngempumelelo izinhlobo ze-oxygen ezisabelayo futhi inciphise ukucindezeleka kwe-oxidative, isiza ekuvikeleni isikhumba ekugugeni ngaphambi kwesikhathi.
Ngaphezu kwalokho, i-salidroside itholakale ikhuthaza ukukhiqizwa kwe-collagen ne-elastin, amaprotheni amabili abalulekile agcina isakhiwo sesikhumba sisesincane futhi siqinile. I-Collagen inesibopho sokunikeza amandla nokunwebeka esikhumbeni, kuyilapho i-elastin ivumela isikhumba ukuba seluleke futhi sibuyele endaweni yaso. Njengoba siguga, ukukhiqizwa kwala maprotheni kwehla ngokwemvelo, okubangela ukuba isikhumba sigobe futhi sishwabane. Ngokukhuthaza ukwenziwa kwe-collagen ne-elastin, i-salidroside isiza ukusekela inqubo yemvelo yokulungisa isikhumba, okuholela esikhumbeni esibushelelezi nesithambile.
Ngaphezu kwezakhiwo zayo zokuvikela i-antioxidant kanye nokukhulisa i-collagen, i-salidroside itholakale ivimbela umsebenzi wama-enzyme athile aphula isakhiwo sokusekela kwesikhumba. Lokhu kusiza ukuvimbela isikhumba ekulahlekelweni ukuqina futhi kunciphisa ukubonakala kwemigqa emincane kanye nemibimbi. Amandla e-Salidroside ekunakekelweni kwesikhumba okulwa nokuguga akhuthaze ukuthuthukiswa kwemikhiqizo ehlukahlukene yokunakekelwa kwesikhumba kanye nezithako eziqukethe lesi sithako esinamandla.
2. Ukuqeda ukucindezeleka nokukhathazeka
Enye yezindlela i-salidroside eqeda ngazo ukucindezeleka nokukhathazeka iwukuguqula indlela umzimba osabela ngayo ekucindezelekeni. Lapho sibhekana nezimo ezicindezelayo, imizimba yethu ikhipha ama-hormone afana ne-cortisol ne-adrenaline, okubangela impendulo "yokulwa noma yokubaleka". Nakuba le mpendulo iwusizo esikhathini esifushane, ukucindezeleka okungapheli kungaholela ekuphenduleni kokucindezeleka okusebenza ngokweqile, okungaholela ekukhathazekeni kanye neminye imiphumela emibi yezempilo. I-Salidroside iboniswe ukuthi isiza ukulawula impendulo yomzimba ekucindezelekeni, isiza ekunciphiseni ukukhiqizwa kwama-hormone okucindezeleka futhi ikhuthaze impendulo elinganiselayo yomzimba ekucindezelekeni.
Ngaphezu kwemiphumela yayo ezimpendulweni zokucindezeleka, i-salidroside nayo inemiphumela kuma-neurotransmitter ebuchosheni. Ucwaningo lubonisa ukuthi i-salidroside ingakhuphula amazinga e-serotonin ne-dopamine, ama-neurotransmitter amabili adlala indima ebalulekile ekulawuleni imizwa. Ngokulawula la ma-neurotransmitter, i-salidroside ingasiza ekuthuthukiseni imizwa futhi inciphise imizwa yokukhathazeka nokucindezeleka.
3. Izakhiwo zokulwa nokuvuvukala kanye ne-antioxidant
Ukuvuvukala kuyindlela yemvelo yomzimba yokusabela ekulimaleni noma ekuthelelekeni, kodwa uma kuba okungapheli, kungaholela ezinkingeni eziningi zempilo, okuhlanganisa nesifo senhliziyo, umdlavuza, kanye nezifo ezizimele. I-Salidroside iboniswe inemiphumela enamandla yokulwa nokuvuvukala, okwenza ibe yinto ethembisayo ekuthuthukiseni imithi emisha yokulwa nokuvuvukala. Ocwaningweni olwanyatheliswa kuyi-International Journal of Molecular Sciences, abacwaningi bathole ukuthi i-salidroside ivimbela ukukhiqizwa kwama-molecule abangela ukuvuvukala emangqamuzaneni esikhumba somuntu, okuphakamisa ukuthi ingasetshenziswa ukwelapha izifo zesikhumba ezivuthayo njenge-eczema kanye ne-psoriasis.
Ngaphezu kwemiphumela yayo yokulwa nokuvuvukala, i-salidroside nayo inezakhiwo ezinamandla ze-antioxidant. Ama-antioxidants ayizakhi ezisiza ukuvikela umzimba ekucindezelekeni kwe-oxidative kanye nomonakalo wama-free radical, okuyizinto ezisebenza kakhulu ezingalimaza amangqamuzana futhi zinegalelo ekugugeni nasezifweni ezahlukahlukene. Izifundo eziningi zikhombisile ukuthi i-salidroside isusa ama-free radical futhi inciphise umonakalo wama-oxidative kumaseli, okungasiza ukuvimbela noma ukunciphisa izifo zenhliziyo.
Obunye bobufakazi obunamandla kakhulu bezakhiwo ze-salidroside zokulwa ne-antioxidant buvela ocwaningweni olushicilelwe kumagazini i-Frontiers in Pharmacology. Kulolu cwaningo, abacwaningi bathole ukuthi i-salidroside ivikela amangqamuzana e-epithelial epigment ye-retina yomuntu ekulimaleni kwe-oxidative, okuphakamisa ukuthi ingasiza ekuvimbeleni ukuwohloka kwe-macular okuhlobene nokuguga, okuyimbangela ehamba phambili yokulahlekelwa umbono kubantu abadala. Ngaphezu kwalokho, i-salidroside itholakale ivikela inhliziyo ekucindezelekeni kwe-oxidative futhi ithuthukise ukusebenza kwemithambo yegazi, okungaba nemiphumela ebalulekile ekuvimbeleni nasekwelapheni izifo zenhliziyo nemithambo yegazi.
4. Thuthukisa impilo yenhliziyo
I-Salidroside ithuthukisa impilo yenhliziyo ngokuyinhloko ngekhono layo lokunciphisa ukucindezeleka kwe-oxidative emzimbeni. Ukucindezeleka kwe-oxidative kwenzeka lapho kunokungalingani phakathi kokukhiqizwa kwama-free radicals kanye nekhono lomzimba lokuwaqeda. Lokhu kungabangela umonakalo kumaseli nezicubu enhliziyweni nasemithanjeni yegazi, okuholela ezifweni zenhliziyo ezifana nesifo senhliziyo kanye nesifo sohlangothi. Izakhiwo ezinamandla ze-antioxidant ze-salidroside zisiza ukulwa nokucindezeleka kwe-oxidative futhi zivikele inhliziyo ekulimaleni.
Ngaphezu kwemiphumela yayo yokulwa nama-antioxidant, i-salidroside itholakale inezakhiwo zokulwa nokuvuvukala. Ukuvuvukala okungapheli kuyisici esibalulekile ekuthuthukisweni kwesifo senhliziyo, futhi ukunciphisa ukuvuvukala emzimbeni kungasiza ekuthuthukiseni impilo yenhliziyo. I-Salidroside iboniswe ukuthi ivimbela ukukhiqizwa kwama-molecule okuvuvukala futhi inciphise ukuvuvukala kwemithambo yegazi, isiza ekuthuthukiseni ukujikeleza kwegazi futhi inciphise ingozi yesifo senhliziyo.
Ngaphezu kwalokho, i-salidroside itholakale inethonya elihle emazingeni omfutho wegazi kanye ne-cholesterol (izici ezimbili ezibalulekile empilweni yenhliziyo). Ucwaningo lubonisa ukuthi i-salidroside ingasiza ekwehliseni umfutho wegazi ngokukhulula imithambo yegazi, ngaleyo ndlela isuse ukucindezeleka enhliziyweni futhi inciphise ingozi yomfutho wegazi ophezulu. Ngaphezu kwalokho, i-salidroside itholakale inciphisa amazinga e-LDL cholesterol, i-cholesterol "embi" efaka isandla ekwakhekeni kwe-plaque emithanjeni yegazi. Ngokuphakamisa amazinga e-cholesterol, i-salidroside ingasiza ekunciphiseni ingozi yesifo senhliziyo kanye nesifo sohlangothi. Ucwaningo luphinde lusikisele ukuthi i-salidroside ingasiza ekuvikeleni inhliziyo ekulimaleni okubangelwa yi-ischemia, isimo lapho ukugeleza kwegazi enhliziyweni kuncipha khona.
Okokuqala, kubalulekile ukuqonda imigomo yakho yezempilo kanye nezizathu zokucabangela izithasiselo ze-salidroside. Ingabe ufuna ukuthuthukisa impilo yakho iyonke, ukunciphisa ukucindezeleka, ukuthuthukisa ukusebenza komzimba, noma ukuthuthukisa ukusebenza kwengqondo? Ukunquma imigomo yakho ethile yezempilo kuzokusiza ukunciphisa izinketho zakho bese ukhetha isithasiselo esifanelana nezidingo zakho.
Uma usuqonda kahle imigomo yakho yezempilo, sekuyisikhathi sokuhlola ikhwalithi kanye nobumsulwa bezithako ze-salidroside emakethe. Kubalulekile ukubheka izithako ezenziwe ngabakhiqizi abadumile. Ukufunda amalebula omkhiqizo nokucwaninga ngenqubo yokukhiqiza kungakusiza ukuthi unqume ikhwalithi kanye nobumsulwa bezithako zakho.
Futhi cabangela umthamo kanye nokuhlushwa kwe-salidroside esithasiselweni. Izithasiselelo ezahlukene zingase zibe namanani ahlukene e-salidroside, ngakho-ke kubalulekile ukukhetha eyodwa enikeza umthamo owanele ukusekela imigomo yakho yezempilo.
Esinye isici esibalulekile okufanele sicatshangelwe uhlobo lwesithasiselo. Izithasiselo ze-salidroside zitholakala ngezindlela ezahlukene, okuhlanganisa ama-capsule, impuphu, kanye nezithasiselo. Lapho ukhetha ifomu lesithasiselo, cabanga ngezintandokazi zakho kanye nendlela yakho yokuphila.
Kubalulekile ukubonisana nochwepheshe wezempilo ngaphambi kokuqala uhlelo olusha lwezithasiselo, ikakhulukazi uma okwamanje uthatha noma yimiphi imithi noma unesifo esithile. Bangakunikeza isiqondiso mayelana nokusebenzisana okungenzeka futhi bakusize wenze isinqumo esinolwazi mayelana nokufaka izithako ze-salidroside empilweni yakho yansuku zonke.
I-Suzhou Myland Pharm & Nutrition Inc. ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, le nkampani iphinde ibe ngumkhiqizi obhalisiwe yi-FDA, eqinisekisa impilo yabantu ngekhwalithi ezinzile kanye nokukhula okusimeme. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi ziyakwazi ukukhiqiza amakhemikhali esikalini esingu-milligram kuya ku-ton ngokuhambisana nezindinganiso ze-ISO 9001 kanye nemikhuba yokukhiqiza ye-GMP.
U: Kuyini i-evodiamine?
A: I-Evodiamine iyinhlanganisela yemvelo etholakala esithelweni sesitshalo se-Evodia rutaecarpa, Ibilokhu isetshenziswa emithini yendabuko yaseShayina amakhulu eminyaka futhi yaziwa ngezinzuzo zayo ezingaba khona kwezempilo.
U: Yiziphi izinzuzo ezingaba khona zezithako ze-evodiamine?
A: Izithako ze-Evodiamine kukholakala ukuthi zinezinzuzo eziningi ezingaba khona kwezempilo, okuhlanganisa ukwesekwa kokuphathwa kwesisindo, ukugaya ukudla, kanye nokuphila kahle. Ngaphezu kwalokho, zingaba nezakhiwo zokulwa nokuvuvukala kanye nezokulwa nokuvuvukala.
U: Ngingazifaka kanjani izithasiselo ze-evodiamine ohlelweni lwami lwezempilo nokudla okunempilo?
A: Ngaphambi kokufaka noma yisiphi isithasiselo esisha ohlelweni lwakho lwezempilo nokudla okunempilo, kubalulekile ukubonisana nochwepheshe wezempilo. Bangakusiza ukunquma umthamo ofanele futhi bahlole noma yikuphi ukusebenzisana okungenzeka neminye imithi noma izithasiselo ongase uzithathe.
U: Ingabe ikhona imiphumela emibi engaba khona yezithako ze-evodiamine?
A: Nakuba izithasiselo ze-evodiamine ngokuvamile zibhekwa njengeziphephile kubantu abaningi uma zithathwa ngemithamo efanele, abanye abantu bangase babe nemiphumela emibi njengokuphazamiseka kokugaya ukudla noma ukucasuka. Kubalulekile ukulandela umthamo onconywayo nokuqapha impendulo yomzimba wakho kulesi sithasiselo.
U: Ingabe zikhona izinyathelo zokuphepha okufanele uzicabangele lapho uthatha izithasiselo ze-evodiamine?
A: Uma ukhulelwe, uncelisa, noma unezinkinga zempilo eziyisisekelo, kubalulekile ukukhuluma nochwepheshe wezempilo ngaphambi kokuthatha izithasiselo ze-evodiamine. Ngaphezu kwalokho, kubalulekile ukuthenga izithasiselo emthonjeni othembekile ukuqinisekisa ikhwalithi nokuphepha.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Feb-18-2024
