Namuhla, njengoba isilinganiso seminyaka yokuphila kwabantu emhlabeni wonke sikhula kancane kancane, ukulwa nokuguga sekuyisihloko esibalulekile. Muva nje, i-Urolithin A, igama elalingaziwa kangako esikhathini esidlule, liye labonakala kancane kancane emphakathini. Kuyinto ekhethekile eyakhiwe ngama-microorganisms emathunjini futhi ihlobene eduze nempilo. Lesi sihloko sizokwembula imfihlakalo yale nto yemvelo eyisimangaliso - urolithin A.
Umlando wei-urolithin A (UA)ingalandelelwa emuva ku-2005. I-metabolite yama-microorganisms amathumbu futhi ayikwazi ukuxhaswa ngokuqondile ngokusebenzisa iziteshi zokudla. Kodwa-ke, i-ellagitannins eyandulelayo icebile ngezithelo ezihlukahlukene njengamahalananda nama-strawberries.
Indima ye-urolithin A
Ngomhla zingama-25 kuNdasa wezi-2016, ucwaningo olukhulu ephephabhukwini elithi "Nature Medicine" lwadonsela ukunaka kwezilaleli ekuxhumaneni kwalo nokubambezela ukuguga kwabantu. Kusukela kwatholakala ngo-2016 ukuthi i-UA inganweba ngempumelelo isikhathi sokuphila sama-C. elegans, i-UA isetshenziswe kuwo wonke amazinga (ama-hematopoietic stem cell, izicubu zesikhumba, ubuchopho (izitho), amasosha omzimba, ubude bokuphila komuntu ngamunye) nasezinhlotsheni ezihlukahlukene zezilwane. (C. elegans, melanogaster Imiphumela yokulwa nokuguga iboniswe ngokuqinile ezimpukaneni zezithelo, amagundane, nakubantu.
(1) Anti-ukuguga futhi uthuthukise ukusebenza kwemisipha
Ukuhlolwa komtholampilo okungahleliwe okushicilelwe ku-JAMA Network Open, ijenali engaphansi kwe-Journal of the American Medical Association, yabonisa ukuthi kubantu asebekhulile noma abantu abanobunzima bokunyakaza ngenxa yokugula, izithako ze-UA zingasiza ukuthuthukisa impilo yemisipha futhi zenze izivivinyo ezidingekayo.
(2) Ukusiza ekuthuthukiseni ikhono lokulwa nesimila le-immunotherapy
Ngo-2022, ithimba labacwaningi lika-Florian R. Greten wase-Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics eJalimane lathola ukuthi i-UA ingakwazi ukungenisa i-mitophagy kuma-T cells, ikhuthaze ukukhululwa kwe-PGAM5, ivule indlela yokusayina ye-Wnt, futhi ukuthuthukisa amaseli we-memory stem cell. ukwakheka, ngaleyo ndlela kukhuthaze ukuzivikela komzimba okulwa nesimila.
(3) Hlehlisa ukuguga kwamangqamuzana e-hematopoietic stem namasosha omzimba
Ocwaningweni lwango-2023, iNyuvesi yaseLausanne eSwitzerland yafunda umphumela wayo ohlelweni lwe-hematopoietic ngokuvumela amagundane anezinyanga eziyi-18 ukuthi adle ukudla okucebile kwe-urolithin A izinyanga ezi-4 nokuqapha izinguquko kumaseli awo egazi njalo ngenyanga. Ithonya.
Imiphumela yabonisa ukuthi ukudla kwe-UA kwandisa inani lamaseli e-hematopoietic stem kanye namaseli e-lymphoid progenitor, futhi kunciphisa inani lamaseli e-erythroid progenitor. Lokhu kutholakala kusikisela ukuthi lokhu kudla kungase kuguqule ezinye zezinguquko ohlelweni lwe-hematopoietic oluhambisana nokuguga.
(4) Umphumela wokulwa nokuvuvukala
Umsebenzi wokulwa nokuvuvukala we-UA unamandla kakhulu futhi ungavimbela ngokuphawulekayo izinto ezihlukahlukene ezivamile zokuvuvukala njenge-TNF-α. Kungenxa yalesi sizathu ukuthi i-UA ibamba iqhaza ekwelashweni okuhlukahlukene kokuvuvukala okuhlanganisa ubuchopho, amafutha, inhliziyo, amathumbu kanye nezicubu zesibindi. Ingaqeda ukuvuvukala kwezicubu ezihlukahlukene.
(5) I-Neuroprotection
Ezinye izifundiswa ziqinisekisile ukuthi i-UA ingavimbela indlela ye-apoptosis ehlobene ne-mitochondria futhi ilawule indlela yokusayina ye-p-38 MAPK, ngaleyo ndlela ivimbele i-apoptosis ebangelwa ukucindezeleka okwenziwe nge-oxidative. Isibonelo, i-UA ingathuthukisa izinga lokusinda lama-neurons avuswa ingcindezi ye-oxidative futhi inomsebenzi omuhle we-neuroprotective.
(6) Umphumela wamafutha
I-UA ingathinta i-lipid metabolism yamaselula kanye ne-lipogenesis. Ucwaningo luye lwabonisa ukuthi i-UA ingenza kusebenze amafutha ansundu kanye nokubansundu kwamafutha amhlophe, kuyilapho ivimbela ukunqwabelana kwamafutha okubangelwa ukudla.
(7) Thuthukisa ukukhuluphala
I-UA futhi inganciphisa ukuqoqwa kwamafutha kuma-adipocyte namaseli esibindi akhuliswe ku-vitro futhi andise i-oxidation yamafutha. Ingakwazi ukuguqula i-T4 engasebenzi kancane ku-thyroxine ibe i-T3 esebenza kakhulu, ithuthukise izinga lomzimba kanye nokukhiqizwa kokushisa ngokusayina kwe-thyroxine. , ngaleyo ndlela ibambe iqhaza ekulawuleni ukukhuluphala.
(8) Vikela amehlo
I-mitophagy inducer UA inganciphisa ukucindezeleka kwe-oxidative ku-retina endala; kunciphisa izinga le-cytosolic cGAS futhi kunciphisa ukusebenza kwe-glial cell ku-retina endala.
(9) Ukunakekelwa kwesikhumba
Phakathi kwawo wonke ama-metabolites amathumbu ezilwane ezincelisayo atholakele, i-UA inomsebenzi onamandla wokulwa ne-antioxidant, okwesibili kuphela kuma-oligomers e-proanthocyanidin, ama-catechin, ama-epicatechin kanye ne-3,4-dihydroxyphenylacetic acid. linda.
I-Urolithin A izimo zohlelo lokusebenza
Ngo-2018, i-UA yaqokwa yi-US Food and Drug Administration njengento edliwayo "eyaziwa ngokujwayelekile njengephephile" futhi ingangezwa kuma-protein shakes, iziphuzo ezithatha indawo yokudla, i-oatmeal esheshayo, ama-protein bars kanye neziphuzo zobisi (kufika ku-500 mg. /ukukhonza) ), iyogathi yesiGrikhi, iyogathi enephrotheni ephezulu kanye nama-protein amaprotheni obisi (kufika ku-1000 mg/ukukhonza).
I-UA ingabuye yengezwe emikhiqizweni yokunakekelwa kwesikhumba, okuhlanganisa okhilimu bosuku, okhilimu basebusuku nezinhlanganisela ze-serum, eziklanyelwe ukuthuthukisa ukugeleza kwesikhumba nokunciphisa kakhulu imibimbi, ukuthuthukisa ukuthungwa kwesikhumba kusuka ngaphakathi nangaphandle, futhi kulwe ngokuphumelelayo nezimpawu zokuguga ezibonakalayo. , ukusiza isikhumba sihlale sisebasha.
Inqubo yokukhiqiza i-Urolithin A
(1) Inqubo yokuvutshelwa
Ukukhiqizwa kwezentengiselwano kwe-UA kuqala kufinyelelwa ngobuchwepheshe bokuvutshelwa, obuvutshelwa kakhulu emakhasini ehalananda futhi inokuqukethwe kwe-urolithin A engaphezu kuka-10%.
(2) Inqubo yokuhlanganisa amakhemikhali
Ngokusungulwa okusha okuqhubekayo nokuthuthukiswa kocwaningo, ukuhlanganiswa kwamakhemikhali kuyindlela ebalulekile yokukhiqiza kwezimboni i-urolithin A. I-Suzhou Myland Pharm iyisengezo sesayensi yempilo emisha, ukuhlanganiswa ngokwezifiso kanye nenkampani yezinsizakalo zokukhiqiza engahlinzeka nge-High-purity, i-urolithin A yevolumu enkulu. powder impahla eluhlaza.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Aug-23-2024
