Namuhla, njengoba isilinganiso sobude bokuphila kwabantu emhlabeni wonke sikhula kancane kancane, ukulwa nokuguga sekuyinto ebalulekile. Muva nje, i-Urolithin A, igama elalingaziwa kangako esikhathini esidlule, liye labonakala kancane kancane emphakathini. Liyinto ekhethekile exutshwe ngamagciwane amathumbu futhi lihlobene eduze nempilo. Lesi sihloko sizodalula imfihlakalo yalesi sithako semvelo esimangalisayo - i-urolithin A.
Umlando wei-urolithin A (UA)kungalandelelwa emuva ku-2005. Kuyi-metabolite yama-microorganisms amathumbu futhi ayikwazi ukwengezwa ngqo ngemigudu yokudla. Kodwa-ke, ama-ellagitannins ayo angaphambili acebile ngezithelo ezahlukahlukene ezifana namapomegranate nama-strawberry.
Indima ye-urolithin A
NgoMashi 25, 2016, ucwaningo olukhulu kumagazini i-"Nature Medicine" lwadonsela ukunaka kwezilaleli ekuxhumaneni kwalo nokubambezeleka kokuguga kwabantu. Selokhu kwatholakala ngo-2016 ukuthi i-UA ingayandisa ngempumelelo isikhathi sokuphila kwe-C. elegans, i-UA isetshenziswe kuwo wonke amazinga (amaseli okuqala e-hematopoietic, izicubu zesikhumba, ubuchopho (izitho zomzimba), isimiso somzimba sokuzivikela, isikhathi sokuphila somuntu ngamunye) kanye nasezinhlotsheni ezahlukene (C. elegans, melanogaster). Imiphumela yokulwa nokuguga iboniswe kakhulu ezimpukaneni zezithelo, emagundwini, nakubantu.
(1) Ukulwa nokuguga nokuthuthukisa ukusebenza kwemisipha
Ukuhlolwa kwezokwelapha okungahleliwe okwanyatheliswa ku-JAMA Network Open, ijenali engaphansi kwe-Journal of the American Medical Association, kubonise ukuthi kubantu asebekhulile noma abantu abanenkinga yokuhamba ngenxa yokugula, izithasiselo ze-UA zingasiza ekuthuthukiseni impilo yemisipha nokwenza izivivinyo ezidingekayo.
(2) Siza ekuthuthukiseni ikhono lokulwa nomdlavuza lokwelashwa nge-immunotherapy
Ngo-2022, ithimba locwaningo likaFlorian R. Greten elivela eGeorg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics eJalimane lathola ukuthi i-UA ingadala i-mitophagy kumaseli e-T, ikhuthaze ukukhululwa kwe-PGAM5, isebenze indlela yokubonisana ye-Wnt, futhi ikhuthaze ukwakheka kwamaseli e-T memory stem., ngaleyo ndlela ikhuthaze ukuzivikela komzimba okulwa nomdlavuza.
(3) Buyisela emuva ukuguga kwamaseli okuqala egazi kanye nesistimu yomzimba yokuzivikela
Esifundweni sango-2023, iNyuvesi yaseLausanne eSwitzerland yafunda ngomphumela wayo ohlelweni lwe-hematopoietic ngokuvumela amagundane anezinyanga ezingu-18 ubudala ukuthi adle ukudla okucebile nge-urolithin A izinyanga ezi-4 kanye nokuqapha izinguquko emaseli awo egazi njalo ngenyanga. Ithonya.
Imiphumela ikhombisile ukuthi ukudla kwe-UA kwandise inani lamaseli okuqala e-hematopoietic kanye namaseli okuzala e-lymphoid, futhi kunciphisa inani lamaseli okuzala e-erythroid. Lokhu okutholakele kusikisela ukuthi lokhu kudla kungase kuguqule ezinye zezinguquko ohlelweni lwe-hematopoietic oluhambisana nokuguga.
(4) Umphumela wokulwa nokuvuvukala
Umsebenzi wokulwa nokuvuvukala we-UA unamandla kakhulu futhi ungavimbela kakhulu izici ezahlukahlukene zokuvuvukala ezifana ne-TNF-α. Yingakho i-UA idlala indima ekwelashweni okuhlukahlukene kokuvuvukala okuhlanganisa izicubu zobuchopho, amafutha, inhliziyo, amathumbu kanye nesibindi. Ingaqeda ukuvuvukala kwezicubu ezahlukahlukene.
(5) Ukuvikelwa kwemizwa
Ezinye izazi ziqinisekisile ukuthi i-UA ingavimbela indlela ye-apoptosis ehlobene ne-mitochondria futhi ilawule indlela yokubonisana ye-p-38 MAPK, ngaleyo ndlela ivimbele i-apoptosis ebangelwa ukucindezeleka kwe-oxidative. Isibonelo, i-UA ingathuthukisa izinga lokusinda kwama-neurons avuselelwa ukucindezeleka kwe-oxidative futhi inomsebenzi omuhle wokuvikela izinzwa.
(6) Umphumela wamafutha
I-UA ingathinta i-metabolism yama-lipid eseli kanye ne-lipogenesis. Izifundo zikhombisile ukuthi i-UA ingadala ukusebenza kwamafutha ansundu kanye nokuba nsundu kwamafutha amhlophe, kuyilapho ivimbela ukunqwabelana kwamafutha okubangelwa ukudla.
(7) Thuthukisa ukukhuluphala
I-UA inganciphisa nokuqongelela kwamafutha kuma-adipocyte kanye namaseli esibindi akhuliswe ngaphandle kokusebenzisa i-vitro futhi yandise ukubola kwamafutha. Ingaguqula i-T4 engasebenzi kahle ku-thyroxine ibe yi-T3 esebenza kakhulu, ithuthukise izinga lokuguqulwa kwe-metabolic kanye nokukhiqizwa kokushisa ngokusebenzisa i-thyroxine signaling. , ngaleyo ndlela idlala indima ekulawuleni ukukhuluphala.
(8) Vikela amehlo
I-mitophagy inducer UA inganciphisa ukucindezeleka kwe-oxidative ku-retina ekhulile; yehlisa izinga le-cytosolic cGAS futhi yehlisa ukusebenza kwamaseli e-glial ku-retina ekhulile.
(9) Ukunakekelwa kwesikhumba
Phakathi kwazo zonke izinto ezitholakala emathunjini ezincelisayo, i-UA inomsebenzi onamandla kakhulu we-antioxidant, owesibili kuphela yi-proanthocyanidin oligomers, ama-catechins, i-epicatechin kanye ne-3,4-dihydroxyphenylacetic acid.
Izimo zokusetshenziswa kwe-Urolithin A
Ngo-2018, i-UA iqokwe yi-US Food and Drug Administration njengento edliwayo "evame ukuqashelwa njengephephile" futhi ingafakwa kuma-protein shake, iziphuzo zokufaka esikhundleni sokudla, i-oatmeal esheshayo, ama-protein bar anempilo kanye neziphuzo zobisi (kufika ku-500 mg/isabelo)), i-yogurt yamaGreki, i-yogurt enamaprotheni amaningi kanye nama-milk protein shake (kufika ku-1000 mg/isabelo).
I-UA ingafakwa futhi emikhiqizweni yokunakekelwa kwesikhumba, okuhlanganisa okhilimu basemini, okhilimu basebusuku kanye nenhlanganisela ye-serum, eyenzelwe ukuthuthukisa umswakama wesikhumba nokunciphisa kakhulu imibimbi, ukuthuthukisa ukuthungwa kwesikhumba kusukela ngaphakathi kuya ngaphandle, kanye nokulwa ngempumelelo nezimpawu ezibonakalayo zokuguga.
Inqubo yokukhiqiza i-Urolithin A
(1) Inqubo yokubilisa
Ukukhiqizwa kwe-UA kwezentengiselwano kuqala kufezwa ngobuchwepheshe bokuvubela, obuvutshelwa kakhulu ngamaxolo epomegranate futhi bunokuqukethwe kwe-urolithin A okungaphezu kuka-10%.
(2) Inqubo yokwenziwa kwamakhemikhali
Ngokusungula izinto ezintsha nokuthuthukiswa kocwaningo okuqhubekayo, ukuhlanganiswa kwamakhemikhali kuyindlela ebalulekile yokukhiqizwa kwezimboni kwe-urolithin A. I-Suzhou Myland Pharm iyinkampani entsha yezinsizakalo zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza enganikeza izinto zokusetshenziswa ze-urolithin A powder ezihlanzekile kakhulu, ezinomthamo omkhulu.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Agasti-23-2024
