I-Salidroside: Yembula imfihlo yezakhiwo ze-antioxidant ze-Rhodiola rosea

I-Salidroside iyi-antioxidant yemvelo evikela amangqamuzana ezinzwa ngokukhipha i-ROS futhi ivimbele i-apoptosis yamaseli.

I-Intracellular calcium overload ingenye yezimbangela eziyinhloko ze-neuronal apoptosis. I-Rhodiola rosea ekhishwe kanye ne-salidroside inganciphisa ukwanda kwamazinga e-calcium yamahhala e-intracellular ebangelwa ukucindezeleka kwe-oxidative futhi ivikele amangqamuzana e-cortical yomuntu ku-glutamate. I-Salidroside ingavimbela i-lipopolysaccharide-induced microglial activation, ivimbele ukukhiqizwa kwe-NO, ivimbele umsebenzi we-inducible nitric oxide synthase (iNOS), futhi yehlise i-TNF-α ne-IL-1β, amazinga e-IL-6.

I-Salidroside ivimbela i-NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) kanye nesilawuli sokuphendula sokuthuthukiswa kanye nokulimala kwe-DNA 1 (REDD1)/ithagethi yezilwane ezincelisayo ye-rapamycin (mTOR)/p70 ribosome Indlela yokusayina ye-protein S6 kinase yenza kusebenze okuncike ku-AMP I-protein kinase/isilawuli solwazi esithulile 1, ilungu lomndeni le-RAS lesakhi sofuzo esifana ne-A/MAPK kanye nezindlela zokusayina ze-PI3K/Akt.

1. I-Salidroside iphikisana nomonakalo wama-radical wamahhala futhi ivikela umzimba

Umzimba ungakhiqiza inani elithile lama-radicals mahhala angapheli phakathi nezinqubo ezijwayelekile zomzimba, futhi umthamo othile wokuphila wama-radicals wamahhala uyadingeka ukuze kugcinwe imisebenzi evamile yomzimba. Kukhona futhi uhlelo lokukhipha ama-radical mahhala emzimbeni ukuze kukhishwe ama-radicals mahhala adlula imithamo ye-physiological ukuze angalimazi impilo yomzimba.

Kodwa-ke, ngaphansi kwethonya lezinto ezithile ezikhethekile zemvelo, ama-radicals mahhala omzimba ayoba ngokweqile futhi eqe izinga lokuqothula ama-radical wamahhala wesistimu, okubangela ukungalingani ohlelweni lokukhipha umoya-mpilo wama-radical mahhala, okuholela ekuqoqweni kwama-radicals mahhala komoya-mpilo. emzimbeni, ngaleyo ndlela kubangele ukulimala kwe-cell membrane. umonakalo.

Ucwaningo lubonisa ukuthi imvelo ye-hypoxic ngaphansi kwezimo ze-plateau ingabangela ukungalingani kwe-radical metabolism engenawo umoya-mpilo, kuqongelele ama-intracellular radicals mahhala kanye nokwandisa imikhiqizo ye-lipid peroxidation. Ucwaningo luye lwabonisa ukuthi i-salidroside ingavikela amangqamuzana ezicubu ngokukhipha ama-radicals mahhala emzimbeni.

2. I-Salidroside iphikisana ne-hypoxia ukuze kugcinwe ukuzinza komsebenzi we-mitochondrial

Cishe u-80-90% we-oxygen ye-intracellular isetshenziselwa i-biological oxidation ku-mitochondria ukuze kukhiqizwe i-ATP futhi kwakhiwe izinhlobo ze-oxygen esebenzayo i-ROS ukuze kugcinwe imisebenzi evamile yokuphila kwamaseli. I-10-20% kuphela ye-oxygen ekhululekile ngaphandle kwe-mitochondria ye-biosynthesis, ukuwohloka, i-biotransformation (i-detoxification), njll. Umsebenzi wokuphefumula we-Mitochondrial uthuthukiswa ku-hypoxia encane noma esigabeni sokuqala se-hypoxia, ebonakala njengempendulo yesinxephezelo uhlelo lokuphefumula lomzimba.

I-hypoxia enzima izoqale ithinte umoya-mpilo wangaphandle we-mitochondria kanye nokuphazamiseka kwe-metabolic emzimbeni, kunciphise ukukhiqizwa kwama-neurotransmitters, futhi kwenze buthaka amandla e-biotransformation, ngaleyo ndlela kuthinte imisebenzi yezicubu nezitho. Ucwaningo luye lwabonisa ukuthi i-salidroside ingase ivikele ukugcinwa komsebenzi we-mitochondrial ngokunciphisa okuqukethwe kwe-ROS ku-cell mitochondria, ukwandisa umsebenzi we-SOD, nokwandisa inani le-mitochondria.

3. Umphumela wokuvikela we-Myocardial we-salidroside

Ucwaningo luye lwabonisa ukuthi uhlelo lwenhliziyo luwuhlelo oluyinhloko olushintsha indawo ye-hypoxic. Indawo ene-hypoxic izobangela ukuthi umzimba we-aerobic metabolism ube buthaka kanye nokungatholakali kwamandla okwanele, okuholela ezimpawu ezifana ne-hypoxia, ischemia, kanye ne-apoptosis yamaseli e-myocardial. Ucwaningo luye lwabonisa ukuthi i-salidroside ingathuthukisa ukusebenza kwenhliziyo futhi ithuthukise i-microcirculation ngokuvula imithambo yegazi ye-arterial kanye ne-venous, ithuthukise ukugcwala kwegazi le-myocardial, iguqule i-hemodynamics yenhliziyo, inciphise umthwalo wenhliziyo, futhi inciphise ukulimala kwe-myocardial ischemic.
Ngamafuphi, i-salidroside ingakwazi ukusebenza ohlelweni lwenhliziyo ngokusebenzisa izindlela eziningi, izindlela, kanye nemigomo, ivikele i-apoptosis yeseli ye-myocardial ebangelwa izimbangela eziningi, futhi ithuthukise izimo ze-ischemia ne-hypoxia yomzimba. Endaweni ye-hypoxic, ukungenelela kwe-Rhodiola rosea kubaluleke kakhulu ekuvikeleni izicubu nezitho zomzimba kanye nokugcina ukuzinza kwemisebenzi yamaseli. Idlala indima ebalulekile ekuvimbeleni nasekunciphiseni ukugula kokuphakama kwendawo.
Isimo samanje sokukhiqizwa kwe-salidroside

1)Thembela kakhulu ekukhishweni kwezitshalo

I-Rhodiola rosea iyimpahla eluhlazai-salidroside.Njengohlobo lwesitshalo se-herbaceous perennial, i-Rhodiola rosea ikhula ikakhulukazi ezindaweni ezibandayo kakhulu, i-anoxia, ukoma, nomehluko omkhulu wokushisa phakathi kwemini nobusuku endaweni engamamitha ayi-1600-4000. Ingesinye sezitshalo zasemathafeni asendle. I-China ingenye yezindawo ezikhiqiza kakhulu i-Rhodiola rosea emhlabeni, kodwa imikhuba yokuphila ye-Rhodiola rosea ikhethekile kakhulu. Akukhona nje kuphela ukuthi kunzima ukuhlakulela ngokwenziwa, kodwa isivuno sezinhlobo zasendle siphansi kakhulu. Igebe lonyaka lokufunwa kwe-Rhodiola rosea liphakeme kakhulu lifinyelela kumathani ayi-2,200.

2) Ukuhlanganiswa kwamakhemikhali kanye nokuvutshelwa kwezinto eziphilayo

Ngenxa yokuqukethwe okuphansi kanye nezindleko eziphezulu zokukhiqiza ezitshalweni, ngaphezu kwezindlela zokukhipha imvelo, izindlela zokukhiqiza i-salidroside zihlanganisa izindlela zokuhlanganisa amakhemikhali, izindlela zokuvutshelwa kwezinto eziphilayo, njll. Phakathi kwazo, njengoba ubuchwepheshe buqhubeka buvuthwa, ukuvutshelwa kwezinto eziphilayo kuye kwaba okujwayelekile. indlela yobuchwepheshe yokuthuthukiswa kocwaningo nokukhiqizwa kwe-salidroside. Njengamanje, i-Suzhou Mailun isizuze imiphumela yocwaningo nentuthuko futhi isizuze ukuthuthukiswa kwezimboni.