I-Salidroside: Ukwembula imfihlo yezakhiwo ze-antioxidant ze-Rhodiola rosea

I-Salidroside iyi-antioxidant yemvelo evikela amangqamuzana ezinzwa ngokususa i-ROS nokuvimbela i-apoptosis yamangqamuzana.

Ukwanda ngokweqile kwe-calcium ngaphakathi kweseli kungenye yezimbangela eziyinhloko ze-neuronal apoptosis. I-Rhodiola rosea extract kanye ne-salidroside kunganciphisa ukwanda kwamazinga e-calcium yamahhala ngaphakathi kweseli okubangelwa ukucindezeleka kwe-oxidative futhi kuvikele amaseli e-cortical womuntu ku-glutamate. I-Salidroside ingavimbela ukusebenza kwe-microglial okubangelwa yi-lipopolysaccharide, ivimbele ukukhiqizwa kwe-NO, ivimbele umsebenzi we-nitric oxide synthase (iNOS) ongasebenzi kahle, futhi inciphise amazinga e-TNF-α kanye ne-IL-1β, IL-6.

I-Salidroside ivimbela i-NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) kanye nomlawuli wempendulo yentuthuko kanye nomonakalo we-DNA 1 (REDD1)/ithagethi ye-rapamycin (mTOR)/p70 ribosome. Indlela yokusayina ye-protein S6 kinase isebenzisa umlawuli wolwazi oluthule we-protein kinase/AMP oxhomeke ku-AMP, i-RAS homologous gene member A/MAPK kanye ne-PI3K/Akt signaling pathways.

1. I-Salidroside ilwa nomonakalo wama-free radical futhi ivikela umzimba

Umzimba ungakhiqiza inani elithile lama-free radical angokwemvelo ngesikhathi sezinqubo ezijwayelekile zomzimba, futhi kudingeka umthamo othile womzimba wama-free radical ukuze kulondolozwe imisebenzi evamile yomzimba. Kukhona futhi uhlelo lokususa ama-free radical emzimbeni ukuze kususwe ama-free radical adlula imithamo yomzimba ukuze kungalimazi impilo yomzimba.

Kodwa-ke, ngaphansi kwethonya lezinto ezithile ezikhethekile zemvelo, ama-free radicals omzimba angaphandle azoba ngokweqile futhi adlule izinga lokususa ama-free radicals ohlelweni, okubangela ukungalingani ohlelweni lokususa ama-oxygen-free radicals emzimbeni, okuholela ekuqongeleleni kwama-free radicals emzimbeni, ngaleyo ndlela kubangele umonakalo kulwelwesi lweseli.

Ucwaningo lubonisa ukuthi indawo engcolile ngaphansi kwezimo ze-plateau ingabangela ukungalingani kwe-metabolism yama-radical angenayo i-oxygen, iqoqe ama-free radical angaphakathi kweseli futhi ikhulise imikhiqizo ye-lipid peroxidation. Izifundo zibonise ukuthi i-salidroside ingavikela amangqamuzana ezicubu ngokukhipha ama-free radical emzimbeni.

2. I-Salidroside ivimbela i-hypoxia ukuze igcine ukuzinza komsebenzi we-mitochondrial

Cishe u-80-90% we-oxygen yangaphakathi kweseli usetshenziselwa i-oxidation yezinto eziphilayo ku-mitochondria ukukhiqiza i-ATP futhi kwakhiwe izinhlobo ze-oxygen ezisebenzayo i-ROS ukuze kugcinwe imisebenzi evamile yokuphila kwamaseli. U-10-20% kuphela we-oxygen ukhululekile ngaphandle kwe-mitochondria ukuze kwenziwe i-biosynthesis, degradation, biotransformation (detoxification), njll. Umsebenzi wokuphefumula we-Mitochondrial uyathuthukiswa ku-hypoxia encane noma esigabeni sokuqala se-hypoxia, okubonakaliswa njengempendulo yokubuyisela uhlelo lokuphefumula lomzimba.

I-hypoxia enamandla izoqala ngokuthinta i-oxygenation yangaphandle ye-mitochondria kanye nokuphazamiseka kokusebenza komzimba, inciphise ukukhiqizwa kwama-neurotransmitters, futhi yenze buthaka amakhono okuguqulwa kwe-bio, ngaleyo ndlela ithinte imisebenzi yezicubu nezitho zomzimba. Izifundo zibonise ukuthi i-salidroside ingavikela ukugcinwa komsebenzi we-mitochondrial ngokunciphisa okuqukethwe yi-ROS ku-mitochondria yeseli, yandise umsebenzi we-SOD, futhi yandise inani le-mitochondria.

3. Umphumela wokuvikela we-salidroside emyocardial

Izifundo zikhombisile ukuthi uhlelo lwenhliziyo luyisistimu eyinhloko eshintsha indawo engenawo umoya-mpilo. Indawo engenawo umoya-mpilo izokwenza ukuthi i-metabolism yomzimba ibe buthaka futhi ingatholakali ngokwanele amandla, okuholela ezimpawini ezifana ne-hypoxia, ischemia, kanye ne-apoptosis yamaseli enhliziyo. Izifundo zikhombisile ukuthi i-salidroside ingathuthukisa ukusebenza kwenhliziyo futhi ithuthukise i-microcirculation ngokwandisa imithambo yegazi yemithambo yegazi neyemithambo yegazi, ithuthukise ukugeleza kwegazi lenhliziyo, ishintshe i-hemodynamics yenhliziyo, inciphise umthwalo wenhliziyo, futhi inciphise umonakalo wenhliziyo.
Ngamafuphi, i-salidroside ingasebenza ohlelweni lwezinhliziyo ngezindlela eziningi, izindlela, kanye nezinhloso, ivikele i-apoptosis yamaseli e-myocardial ebangelwa izimbangela eziningi, futhi ithuthukise izimo ze-ischemia kanye ne-hypoxia yomzimba. Endaweni engena-hypoxia, ukungenelela kukaRhodiola rosea kubaluleke kakhulu ekuvikeleni izicubu nezitho zomzimba kanye nokugcina ukuzinza kwemisebenzi yamaseli. Idlala indima ebalulekile ekuvimbeleni nasekunciphiseni ukugula okuphezulu.
Isimo samanje sokukhiqizwa kwe-salidroside

1) Ngokuyinhloko ngithembele ekukhishweni kwezitshalo

I-Rhodiola rosea iyinto eluhlaza ye-i-salidroside.Njengohlobo lwesitshalo esihlala isikhathi eside esinamakhambi, i-Rhodiola rosea ikhula kakhulu ezindaweni ezinomkhuhlane omkhulu, i-anoxia, ukoma, kanye nomehluko omkhulu wokushisa phakathi kwemini nobusuku endaweni ephakeme ngamamitha ayi-1600-4000. Ingenye yezitshalo zasendle ezisemaphethelweni. I-China ingenye yezindawo ezikhiqiza kakhulu i-Rhodiola rosea emhlabeni, kodwa imikhuba yokuphila ye-Rhodiola rosea ikhethekile impela. Akukhona nje kuphela ukuthi kunzima ukuyilima ngendlela yokwenziwa, kodwa isivuno sezinhlobo zasendle siphansi kakhulu. Igebe lesidingo saminyaka yonke se-Rhodiola rosea liphezulu ngamathani angu-2,200.

2) Ukwenziwa kwamakhemikhali kanye nokubiliswa kwezinto eziphilayo

Ngenxa yokuqukethwe okuphansi kanye nezindleko eziphezulu zokukhiqiza ezitshalweni, ngaphezu kwezindlela zokukhipha zemvelo, izindlela zokukhiqiza i-salidroside zifaka phakathi nezindlela zokwenziwa kwamakhemikhali, izindlela zokuvubela izinto eziphilayo, njll. Phakathi kwazo, njengoba ubuchwepheshe buqhubeka nokuvuthwa, ukuvubela izinto eziphilayo sekuyindlela yobuchwepheshe eyinhloko yokuthuthukiswa kocwaningo kanye nokukhiqizwa kwe-salidroside. Njengamanje, iSuzhou Mailun ithole imiphumela yocwaningo nentuthuko futhi ifinyelele ekwakhiweni kwezimboni.