I-Ketosis yisimo se-metabolic lapho umzimba ushisa khona amafutha agciniwe ukuze uthole amandla futhi siya ngokuya sithandwa namuhla. Abantu basebenzisa izindlela ezahlukene zokufeza nokugcina lesi simo, okuhlanganisa ukulandela ukudla okune-ketogenic, ukuzila ukudla kanye nokuphuza izithasiselo. Kulezi zithasiselo, ama-ketone ester kanye nosawoti we-ketone kuyizinketho ezimbili ezidumile. Ake sifunde kabanzi ngama-ketone ester nokuthi ahluke kanjani kuma-ketone salts, akunjalo?
Ukuze sazi ukuthi ayini ama-ketone ester, okokuqala sidinga ukuthola ukuthi ayini ama-ketone. Ama-ketone ngokuvamile ayinqwaba yamafutha akhiqizwa umzimba wethu lapho eshisa amafutha, ngakho-ke ayini ama-ketone ester? Ama-ketone ester ayimizimba ye-ketone yangaphandle ekhuthaza i-ketosis emzimbeni. Uma umzimba usesimweni se-ketosis, isibindi siphula amafutha sibe yimizimba ye-ketone ecebile ngamandla, bese inika amandla amaseli ngegazi. Ekudleni kwethu, amangqamuzana ethu avame ukusebenzisa i-glucose njengamandla, lapho i-glucose nayo ingumthombo oyinhloko wamafutha emzimbeni, kodwa uma ingekho i-glucose, umzimba ukhiqiza ama-ketone ngenqubo ebizwa ngokuthi i-ketogenesis. Imizimba ye-ketone ingumthombo wamandla osebenza kahle kakhulu kune-glucose futhi iboniswe ukuthi inezinzuzo eziningi zezempilo.
Imizimba ye-ketone yangaphandle yakhiwe yizingxenye ezimbili eziyinhloko, ama-ketone esters kanye nosawoti we-ketone. Ama-ketone esters, aziwa nangokuthi ama-ketone monoesters, ayizinhlanganisela ezikhulisa kakhulu inani lama-ketone egazini. Iyi-ketone yangaphandle ekhiqizwa ngokunamathisela umzimba we-ketone ku-molecule yotshwala. Le nqubo iwenza atholakale kalula, okusho ukuthi amuncwa kalula futhi akhuphula ngokushesha amazinga e-ketone egazini. Usawoti we-ketone ngokuvamile uyimpuphu equkethe i-BHB eboshelwe kusawoti wamaminerali (ngokuvamile i-sodium, i-potassium noma i-calcium) noma ama-amino acid (njenge-lysine noma i-arginine), usawoti we-ketone ovame kakhulu yi-β-hydroxybutyrate (BHB) eboshelwe ku-sodium, kodwa amanye usawoti we-potassium kanye ne-magnesium nawo ayatholakala. Usawoti we-ketone ungakhuphula amazinga egazi e-BHB isoform ye-l-β-hydroxybutyrate (l-BHB).
Ngenxa yokuthi ama-ketone ester kanye nosawoti we-ketone kungama-ketone angaphandle, lokhu kusho ukuthi akhiqizwa ngaphakathi kwe-vitro. Angakhuphula amazinga e-ketone egazini, anikeze amandla, futhi athuthukise ukusebenza kwengqondo. Angakusiza futhi ukuthi ungene esimweni se-ketotic ngokushesha futhi usigcine isikhathi eside. Ngokuphathelene namazinga e-ketone egazini, ama-ketone ester ayiziphuzo ezingenasawoti ze-BHB ngaphandle kwezinye izingxenye ezengeziwe. Aziboshelwe kumaminerali afana nosawoti we-BHB, kodwa kunalokho kuma-ketone precursors (njenge-butanediol noma i-glycerol) ngama-ester bonds, kanti ama-ketone ester angathuthukisa i-d-β- Amazinga egazi e-BHB subtype ye-hydroxybutyric acid (d-BHB) ashesha futhi athinteka kakhulu yi-ketone ester uma kuqhathaniswa nosawoti we-ketone.
1. Ukusebenza kahle kwezemidlalo okuthuthukisiwe
Enye yezinzuzo ezibaluleke kakhulu zama-ketone esters yikhono lawo lokuthuthukisa ukusebenza kwezemidlalo. Lokhu kungenxa yokuthi ama-ketone angumthombo wamandla osebenza kahle kakhulu uma kuqhathaniswa ne-glucose, okuwumthombo oyinhloko wamandla emzimbeni. Ngesikhathi sokuzivocavoca ngamandla amakhulu, umzimba uthembele ku-glucose ukuze ukhiqize amandla, kodwa ukutholakala okulinganiselwe kwe-glucose emzimbeni kuncipha ngokushesha, okuholela ekukhathaleni nasekusebenzeni okunciphile. Ama-ketone esters ahlinzeka ngomthombo wamandla olungele, okwenza kube lula ngabasubathi ukuzicindezela emikhawulweni yabo ngaphandle kokukhathala okwenzeka lapho bethembele ku-glucose kuphela.
2. Kuthuthukisa ukusebenza kobuchopho
Enye inzuzo emangalisayo yama-ketone esters yikhono lawo lokuthuthukisa ukusebenza kobuchopho. Ubuchopho buyisitho esidinga amandla amaningi esidinga ukuhlinzekwa njalo kwe-glucose ukuze sisebenze kahle. Kodwa-ke, ama-ketone nawo angumthombo onamandla wamandla ebuchosheni, futhi izifundo zikhombisile ukuthi lapho ubuchopho busebenza ngama-ketone, bungasebenza kahle kakhulu kunalapho buthembele ku-glucose kuphela. Yingakho ama-ketone esters eboniswe ukuthi athuthukisa ukusebenza kwengqondo, inkumbulo kanye nokunaka, okwenza kube inketho ekhangayo kulabo abafuna ukuthuthukisa ukusebenza kobuchopho.
3. Kuthuthukisa ukwehla kwesisindo
Okokugcina, ama-ketone ester nawo ayasiza ekunciphiseni isisindo. Uma umzimba usesimweni se-ketosis (okungukuthi, uma ukhuthazwa ama-ketone), ushisa amafutha kahle kakhulu kune-glucose yamandla. Lokhu kusho ukuthi umzimba unamathuba amaningi okushisa amaseli amafutha agciniwe ukuze uthole amandla, okuholela ekunciphiseni isisindo. Ngaphezu kwalokho, ama-ketone angasiza ekunciphiseni isifiso sokudla, okwenza kube lula ngabantu ukunamathela ekudleni okunqunyelwe amakhalori futhi banciphise isisindo ngempumelelo.
● Ukuze sazi ukuthi ama-ketone ester angasiza yini ekunciphiseni isisindo, kumelwe siqale siqonde ukuthi ayini ama-ketone ester. Ama-ketone ester ayizinto zokwenziwa eziqukethe ama-ketone amuncwa kalula ngumzimba womuntu, okwenza abe umthombo osebenza kahle kakhulu wamandla. Uma sisesimweni se-ketotic, ama-ketone angumthombo wamandla akhiqizwa ngumzimba wethu. Le nqubo yenzeka lapho okuqukethwe ushukela egazini kuphansi, futhi umzimba uqala ukuphula amafutha agciniwe ukuze ukhiqize ama-ketone ukuze unikeze amandla.
● Abacwaningi bakhombisile ukuthi abasubathi abathatha ama-Ketone ester njengezithasiselo bathuthukise ukukhuthazela ngesikhathi sokuzivocavoca ngamandla aphezulu. Ucwaningo lwamuva nje luthole ukuthi ama-ketone ester angathuthukisa ukusebenza kwabagibeli bamabhayisikili abaphambili cishe ngo-2%. Kodwa ingabe lokhu kusho ukwehlisa isisindo kubantu abavamile? Impendulo mhlawumbe ingukuthi. Ucwaningo lukhombisile ukuthi ama-ketone ester angavimbela isifiso sokudla, okuholela ekunciphiseni ukudla kwamakhalori kanye nokwehla kwesisindo okungenzeka. Kodwa-ke, kudingeka ucwaningo olwengeziwe ukuze kutholakale ukuthi lo mthelela wanele yini ukuthinta umphumela wokulahlekelwa isisindo jikelele.
●Ngaphezu kwalokho, ama-ketone ester angakhulisa nokukhiqizwa kwehomoni ebizwa ngokuthi i-leptin. I-Leptin idlala indima ebalulekile ekulawuleni isifiso sokudla, i-metabolism, kanye nokusetshenziswa kwamandla. Amazinga aphezulu e-leptin emzimbeni anganciphisa isifiso sokudla futhi asize ekunciphiseni ukudla okuphelele.
● Ngaphezu kokucindezela isifiso sokudla, ukusetshenziswa kwama-ketone esters kungaholela ekwandeni kwamandla kanye nesivinini sokugaya ukudla. Lokhu kuzoholela ekusetshenzisweni kwamakhalori aphezulu kanye nokusetshenziswa okuphumelelayo kwamafutha agciniwe ukuthola amandla. Lokhu, kuhlanganiswe nekhono lokucindezela isifiso sokudla, kungasiza ekukhiqizeni ukuntuleka kwamakhalori okudingekayo ukuze wehlise isisindo.
●Kodwa-ke, kumelwe kukhunjulwe ukuthi ama-ketone ester awawona umuthi wokunciphisa isisindo. Ukudla okunempilo kanye nokuzivocavoca njalo kuseyizindlela eziphumelela kakhulu zokunciphisa isisindo. Ama-ketone ester angasetshenziswa kuphela njengesengezo, hhayi ukuphela kwendlela yokunciphisa isisindo.
●Ngamafuphi, ama-ketone ester angaba nezinzuzo ezithile zokwehlisa isisindo, kodwa ukusebenza kwawo kusadinga ucwaningo olwengeziwe. Angasiza ekunciphiseni isifiso sokudla, akhiqize amakhalori anganele, futhi andise amazinga amandla, kodwa kufanele asetshenziswe ngokuqapha hhayi njengendlela yokuphela kokunciphisa isisindo. Ukudla okunempilo, ukuzivocavoca njalo, kanye nendlela yokuphila elinganiselayo kuseyizindlela eziphumelela kakhulu zokufeza nokugcina isisindo esinempilo.
I-ketone ester itholakala ngesimo soketshezi futhi ingathathwa ngomlomo. Kodwa-ke, uma usebenzisa i-ketone ester, kubalulekile ukulandela imiyalelo yomthamo weseluleko sochwepheshe. Ngokuvamile kunconywa ukuthi uqale ngomthamo omncane bese ukhulisa kancane kancane umthamo kuze kube yilapho umphumela oyifunayo ufinyelelwa.
Kubalulekile futhi ukuqaphela ukuthi ama-ketone ester kufanele asetshenziswe kanye nokudla kwe-ketogenic ukuze kutholakale imiphumela emihle. Ukudla kwe-ketogenic kuwukudla okunamafutha amaningi, amaprotheni aphakathi nendawo, nama-carbohydrate aphansi okufaka umzimba esimweni se-ketosis.
Isikhathi sokuthunyelwe: Juni-09-2023
